DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8336 and Ranbp2

DIOPT Version :9

Sequence 1:NP_001261636.1 Gene:CG8336 / 39121 FlyBaseID:FBgn0036020 Length:383 Species:Drosophila melanogaster
Sequence 2:NP_035370.2 Gene:Ranbp2 / 19386 MGIID:894323 Length:3053 Species:Mus musculus


Alignment Length:173 Identity:78/173 - (45%)
Similarity:114/173 - (65%) Gaps:8/173 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 KSTNPLVYLDISIGKEDAGRMIIELRKDVVPKTAENFRALCTGECGIGTLGKPLHYKGTKFHKIK 75
            |.|||:|:.|:....|..||:|:||..::||:||||||||||||.|.|       :|.:.||::.
Mouse  2889 KDTNPVVFFDVCADGEPLGRIIMELFSNIVPQTAENFRALCTGEKGFG-------FKNSIFHRVV 2946

  Fly    76 RVFVVQSGDVVKNDGSSGESIYGPVFDDENFELSHNEEGVVSMANYGKPNSNNSQFFISAAGCEN 140
            ..|:.|.||:.|.:|:.|:||||..||||||:|.|...|::||||||: |:|:|||||:....|:
Mouse  2947 PDFICQGGDITKYNGTGGQSIYGDKFDDENFDLKHTGPGLLSMANYGQ-NTNSSQFFITLKKAEH 3010

  Fly   141 LNGTNVVVGRVLRGLGIVAEMEQNCTDEGDPTAPIVIRDCGEI 183
            |:..:||.|.|..|:..|.::|...:.:|..:..|.|.:||::
Mouse  3011 LDFKHVVFGFVKDGMDTVRKIESFGSPKGSVSRRICITECGQL 3053

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8336NP_001261636.1 cyclophilin 15..181 CDD:294131 73/165 (44%)
TPR repeat 285..315 CDD:276809
TPR_19 300..369 CDD:291240
TPR_1 320..353 CDD:278916
TPR repeat 320..346 CDD:276809
Ranbp2NP_035370.2 TPR 1 26..59
TPR_11 59..126 CDD:290150
TPR repeat 59..89 CDD:276809
TPR 2 60..93
TPR_1 60..92 CDD:278916
TPR 3 94..128
TPR 4 165..201
TPR 5 288..319
TPR 6 583..616
TPR 7 648..681
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 773..802
RCR <839..925 CDD:304939
20 X 2 AA repeats of F-G. /evidence=ECO:0000305 1000..3035 73/153 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1147..1171
RanBD1_RanBP2-like 1180..1296 CDD:270203
zf-RanBP 1345..1374 CDD:279035
RanBP2-type Zn finger 1350..1369 CDD:275375
zf-RanBP 1410..1438 CDD:279035
RanBP2-type Zn finger 1414..1433 CDD:275375
zf-RanBP 1469..1498 CDD:279035
RanBP2-type Zn finger 1473..1492 CDD:275375
zf-RanBP 1499..1524 CDD:279035
RanBP2-type Zn finger 1502..1521 CDD:275375
zf-RanBP 1558..1587 CDD:279035
RanBP2-type Zn finger 1562..1581 CDD:275375
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1587..1609
zf-RanBP 1617..1645 CDD:279035
RanBP2-type Zn finger 1621..1640 CDD:275375
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1648..1675
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1744..1772
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1819..1846
RanBD2_RanBP2-like 1864..1980 CDD:269998
Interaction with BICD2. /evidence=ECO:0000250|UniProtKB:P49792 1984..2124
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2030..2060
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2111..2144
RanBD3_RanBP2-like 2161..2277 CDD:270204
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2316..2348
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2394..2430
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2443..2463
IR1-M 2468..2529 CDD:288995
Interaction with sumoylated RANGAP1. /evidence=ECO:0000250 2468..2472
2 X 50 AA approximate repeats 2470..2596
Required for E3 SUMO-ligase activity. /evidence=ECO:0000250 2470..2545
Interaction with UBE2I. /evidence=ECO:0000250 2470..2522
Interaction with SUMO1. /evidence=ECO:0000250 2523..2596
IR1-M 2544..2602 CDD:288995
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2598..2666
RanBD4_RanBP2-like 2754..2870 CDD:269999
cyclophilin_ABH_like 2893..3051 CDD:238907 73/165 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0652
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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