Protein Alignment LAMB1 and MCM21

DIOPT Version :10

• Sequence 1: XP_054214165.1
• Gene: LAMB1 / 3912
• HGNCID: 6486
• Length: 1810
• Species: Homo sapiens
• Sequence 2: NP_010604.4
• Gene: MCM21 / 851916
• SGDID: S000002726
• Length: 368
• Species: Saccharomyces cerevisiae
• Alignment Length: 380
• Identity: 89/380 - (23%)
• Similarity: 151/380 - (39%)
• Gaps: 110/380 - (28%)

Human  1470 DLDQDVLSALAEVEQLSKMVSEAKLRA---DEAK--QSAEDILLKTNATKEKMDKSNEELRNLIK 1529
            ||.||:.|.|:|:..|.:  |..||:|   |:.|  :||..|:           :..|:|.:...
Yeast     6 DLQQDIESLLSEINSLEE--SREKLKAKIKDKRKNEESANPIV-----------QEFEDLFDQFP 57

Human  1530 QIRNFLTQDSADLDSIEAVANEVLKMEMPSTP--------QQLQNLTEDIRERVESLSQVEVILQ 1586
            |:.|||..:..:|:..:.......:.::|:||        .:|:|  |:|....|.:.:.:.::|
Yeast    58 QLNNFLFNEHPELEETDDKDISRAQADIPATPIPYEPKKRAKLEN--EEILPEQEWVLKTQPMVQ 120

Human  1587 H-----SAADIARAEMLLEEAKRASKSATDVKVTADMVKEALEEAEKAQVAAEKA---------- 1636
            |     ..||:...::|...:||..|...|...|:|  :..||:    .:..|..
Yeast   121 HQMFDPGVADLLDTDILTSPSKRKRKLKIDDISTSD--RSELED----YIVLENVYRMFGITFFP 179

Human  1637 --------IKQADEDIQGTQNLLTSIESETAASEETLFNASQRISELER-NVEELKRKAAQNSGE 1692
                    ||.|..:|        .::.|.......:|  |:|.|:.|: :...||::...||.
Yeast   180 LVDPIDLKIKDASGEI--------FVDREMLGIRLEVF--SERTSQFEKPHYVLLKKRIKSNSW- 233

Human  1693 AEYIEKVVYTVKQSAEDVKKTLD---GEL----DEKYKKVENLIAKKTEESADARRKAEMLQNEA 1750
              ::.|  :|: .|..||:...|   |.|    |:.|     |.||:.           .||
Yeast   234 --FLFK--HTI-PSFIDVQGIFDDTNGGLVISHDDAY-----LFAKRV-----------FLQ--- 274

Human  1751 KTLLAQANSKLQLLKDLERKYEDNQRYLEDKAQELARLEGEVRSLLKDISQKVAV 1805
               |.:...:.|:.||||.|     :.:.|...:|.  ...|...:|||..::.|
Yeast   275 ---LVEVQKRRQIFKDLEAK-----KIIHDLDLDLE--SSMVSFFVKDIKVELFV 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LAMB1	XP_054214165.1	Laminin_N	59..293	CDD:459653
		EGF_Lam	295..347	CDD:238012
		EGF_Lam	359..411	CDD:238012
		Laminin_EGF	422..479	CDD:395007
		Laminin_EGF	482..536	CDD:395007
		EGF_Lam	533..>572	CDD:238012
		EGF_Lam	797..842	CDD:214543
		Laminin_EGF	845..893	CDD:395007
		Laminin_EGF	891..938	CDD:395007
		Laminin_EGF	941..997	CDD:395007
		Laminin_EGF	1000..1044	CDD:395007
		Laminin_EGF	1052..1106	CDD:395007
		Laminin_EGF	1108..1156	CDD:395007
		Laminin_EGF	1156..>1195	CDD:395007
		PTZ00121	<1248..1802	CDD:173412	88/375 (23%)
		cc_LAMB1_C	1738..1810	CDD:411971	16/68 (24%)
MCM21	NP_010604.4	CwlO1	2..>56	CDD:443091	19/62 (31%)
		DRWD-N_Mcm21	161..271	CDD:467664	29/134 (22%)
		DRWD-C_Mcm21	276..363	CDD:467667	13/51 (25%)