DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LAMB1 and wb

DIOPT Version :10

Sequence 1:XP_054214165.1 Gene:LAMB1 / 3912 HGNCID:6486 Length:1810 Species:Homo sapiens
Sequence 2:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster


Alignment Length:2283 Identity:506/2283 - (22%)
Similarity:792/2283 - (34%) Gaps:850/2283 - (37%)


- Green bases have known domain annotations that are detailed below.


Human    57 GSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIE 121
            |..||...: ::.||| :||.:|||.:..|.||   .....|.|.|||:    |.:.......|:
  Fly   151 GGLYPPLFN-VVPRAQ-ISVNATCGQNGAEEYC---KQVGAKPCGICNA----HSSDRAKQRSIQ 206

Human   122 NVVTT---------FAPNRLKIWWQS---ENG--VENVTIQLDLEAEFH-FTHLIMTFKTFRPAA 171
            :::::         |...    ||||   :.|  .|.|||.|||:..|. |:..:.:..:.|||:
  Fly   207 SLISSGSGSGSGSGFEEG----WWQSPTLQGGRQFEYVTILLDLKQTFQIFSVWLKSANSPRPAS 267

Human   172 MLIERSSDFGKTWGVYRYFAY---DCEASFPGISTGPMKKV----DDIICDSRYSDIEPSTEGEV 229
            .::|:|.| |..:..::||..   ||:..: .:|....|.|    .:|||.:::|...|...| |
  Fly   268 WILEKSLD-GINFEPWQYFGLSDADCQRRW-NLSGQNGKYVFQNDTEIICSTQFSKPGPLENG-V 329

Human   230 IFRALDPAFKIEDPYSPRIQNLLKITNLRIKFVKLHTLG--DNLLDSRME---IREKYYYAVYDM 289
            :..:|..........||.:...:....:||:...:|:..  ||.||..::   :.:..:|::..:
  Fly   330 LHASLLKNRPGATDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQL 394

Human   290 VVRGNCFCYGHA--SECAPVDGFNEEVEGMVHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRN 352
            .|.....|.|||  |..:|.|...:         |:|:|||.|..||.|...:.|.|:     :.
  Fly   395 KVSARLDCNGHANRSHESPDDPLMQ---------CICQHNTCGAQCEQCCPLFQDRPY-----QM 445

Human   353 SNACKKCNCNEHSISCHFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPN 417
            ...|:.|.|..|:.||.:|..       :..|:|..|.:||.|..||.|:..:|:..:..:.|| 
  Fly   446 GGECEICQCYGHAESCTYDPF-------LDKGICQSCSNNTAGIECEFCEMGFYRELDAPLTDP- 502

Human   418 FCERCTCDPA----GSQNEGICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFG 478
             |..|:|:||    |.|::|              |.|.|....:|::|:.|..|:|   .:|   
  Fly   503 -CLPCSCNPARSTGGCQSDG--------------GSCNCLEGFQGKNCEECAPGYY---GDD--- 546

Human   479 CKSCACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGLS-NDLDGCRPCDCDLGGAL 542
            ||.|.|:..|::.....|   :|.|.||..|.|..|.:|.|.::.|| .:.:||..|.|   ..:
  Fly   547 CKRCECDERGSLGSTGSC---SGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCTSCWC---SGV 605

Human   543 NNSCFAESGQC---------------SCRPHMI-----------GRQCNEVEPGYYFATLDHYLY 581
            :.:|.:...|.               ..:|..|           ..:.:|||..|:         
  Fly   606 SQTCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRLIFANELDEVEAIYW--------- 661

Human   582 EAEEANLGPGVSIVERQYIQDRIPSWTGAGFVRVPEGAYLEFFIDNIPYSMEYDILIRYEPQLPD 646
               :|:||         |:.:|:.|:          |:.|:..:.                    
  Fly   662 ---QASLG---------YLGNRLTSY----------GSRLQLVLS-------------------- 684

Human   647 HWEKAVITVQRPGRIPTS-------SRCGNTIPDDDNQVVSLSPGSRYVVLPRPVCFEKGTNYTV 704
             |:  ||...|.|: ||:       .:.|..|...|..:..|                 |.|..|
  Fly   685 -WD--VIRGDRSGK-PTTGPNVILVGKNGLKIAFGDESLDGL-----------------GINLNV 728

Human   705 RL-ELPQYTSSDSDVESPYTLIDSLVLMPYCKSLD----------IFTVGGSGDGVVTNSAWETF 758
            .| |:..|       ..|.|::|....:...:..|          ..:|..|.|.|:..:|:.|.
  Fly   729 TLTEVGWY-------HVPPTVVDIKTRLRRTEGGDYHGESVTRSQFLSVLVSLDAVLIRAAFHTD 786

Human   759 QRYRCLENSRSVVKTPMTDV---------------------CRNIIFSISALLHQTG-------- 794
            |....||  |:|:.:...::                     |....|....:...|.        
  Fly   787 QGETSLE--RAVIYSGGVELGGKSSSQVEQCLCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKC 849

Human   795 LACECDPQGSLSSVCDPNGGQC-QCRPNVVGRTCNRCAPGTFG----FGPSGCKPCECHLQGSVN 854
            :.|.|:..   |:.||...|.| .|..|..|..|.||..|.:|    ..|:.||.|.|.|....|
  Fly   850 IPCPCNGH---SNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDSN 911

Human   855 AF---C----------NP----------VTGQCHCFQGVYARQCDRCLPGHWGFP-----SCQPC 891
            .|   |          ||          :..||.  :|.....|..|..|::|.|     |||.|
  Fly   912 NFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCP--EGYTGDHCQVCDDGYFGNPRQPGSSCQRC 974

Human   892 QCNGHADDCDPVTGECLNCQDYTMGHNCERCLAGYYGDPIIGSGDHCRPCPC-PDGPDSGRQFAR 955
            .|.|  ..|:..||||:.|:..|.|.:||||..||:|||.:|    |.||.| .:|.:||     
  Fly   975 DCAG--GPCNVTTGECITCRGNTEGWHCERCKLGYWGDPAVG----CDPCHCHTEGSESG----- 1028

Human   956 SCYQDPVTLQLACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNIDTTDP------EAC 1014
            .|  |....|  |:|.|.|.|.:||:|..||    :.|...|..|.|       ||      :.|
  Fly  1029 LC--DSTDGQ--CLCKPRYAGQKCDECDVGY----ANVELRCPSCNC-------DPLGSLVQDRC 1078

Human  1015 DKETGRCLKCLYHTEGEHCQFCRFGYYG-----------DALRQD-------------------- 1048
            |..||:| .|.....|..|..|:.||:|           .||||:                    
  Fly  1079 DPHTGQC-HCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSE 1142

Human  1049 ----CRKCVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQNCDRCAPNTWQLASGTGCDPCN 1109
                |.:|.|:.:|::     .||  |||.||||.||.||.|:.||:|.|..|.|.:|.||..|.
  Fly  1143 STVACEECHCSSVGSL-----SSD--CDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCR 1200

Human  1110 CNAAHSFGPSCNEFTGQCQCMPGFGGRTCSECQELFWG-------------------DPD----- 1150
            |:...|.|..||.:||||.|..|.||:.|:||.|.|:|                   ||.     
  Fly  1201 CDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCI 1265

Human  1151 -----------------------VECRACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDKCTRG 1192
                                   :.||.|:||..|....||....|||.|.||..|.:||.|..|
  Fly  1266 CPKFTRGLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIG 1330

Human  1193 YSGVFPDC--------------------------------------------------TP--CHQ 1205
            |.| :|:|                                                  .|  |.:
  Fly  1331 YFG-YPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTR 1394

Human  1206 CFAL------------WDVI-IAELTNRT---------------------------HRFLEKAKA 1230
            ||..            |..| :||..|.:                           ||  |.|:.
  Fly  1395 CFCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHR--EDAEI 1457

Human  1231 LKISGV-----------IGPYRE----------------------------TVDSVERKVSEIKD 1256
            .:::.:           ||.|.:                            .:.....|..| ::
  Fly  1458 QRMNDLSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLE-RN 1521

Human  1257 ILAQSPAAEPLKNIGNLFEEAEKLIKDVTE-------MMAQVEVKLSDTTSQSNSTAKELDSLQT 1314
            ||.|.|..:        .....||:.|..|       :.....|.|.::..:.:.|::.:|.   
  Fly  1522 ILGQYPLVQ--------LHAHSKLLLDFYEYEEFEYSLNVTHRVPLHESFWKYHHTSQAVDR--- 1575

Human  1315 EAESLDNTVKELAEQLE--FIK---------------NSD----IRGALDSITKYFQMSLEAEER 1358
                  ||:....:.:.  ||:               :.|    |:|:.:.|.|..:.....:..
  Fly  1576 ------NTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRF 1634

Human  1359 VNASTTEP--------NSTVEQSALMRDRVEDVMMERESQFKEKQEEQARLLDELA-----GKLQ 1410
            ...|..:|        |:|:.:|..:.|                      |:...|     |:..
  Fly  1635 DGLSCQDPGRSFYRWRNTTIVESVFIED----------------------LIGRAAPCHCNGRSS 1677

Human  1411 SLDLSAAAEMTCGTPPGA----SCSETECGGPN--------------------CRTDEGERKC-- 1449
            ..|........|....|.    .|:|...|.||                    |...:||..|  
  Fly  1678 DCDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGCNVWDGEVSCVC 1742

Human  1450 -----------------GGP---------------------GCG-------------GL------ 1457
                             |.|                     ||.             ||      
  Fly  1743 KPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQ 1807

Human  1458 ------------------------VTVAHNAWQKAMDLDQDVLSALAEVEQLSKM---------- 1488
                                    :.:..|..::.|. :.|:....|...:||:.          
  Fly  1808 AERHHLVDNGCKICDNCTLLLLDYMELVGNKLRRGMH-NMDLTGIPAPYRKLSEYESAYEKWNGR 1871

Human  1489 ---VSEAKLRADEAKQSAEDILLKTNATKEKMDKSNEELRNL------IKQIR-NFLTQDSADLD 1543
               .|:.|.|..: ..||:.:.|:.:|...|. :|.:.:..:      ||.:| :.:||.    .
  Fly  1872 HWDFSQTKRRLQD-YDSADILKLEAHAENLKF-QSRKAVATIGKREFAIKSMREDAVTQQ----H 1930

Human  1544 SIEAVANEVLK--------------MEMPSTPQQLQNLTEDIRERVESLSQV----EVILQH--- 1587
            |:..:.:|:|:              :.:|:..:|.:...:.|||..:.:..:    :...:|   
  Fly  1931 SVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHFYA 1995

Human  1588 --SAADIA-----RAEMLLEEAKRASKSATDVKVTADMVKEALEEAEKAQVAAEKAIKQADEDIQ 1645
              :|:|.:     |.|||..:..:.:....|:::..|.|:|...||               ||:.
  Fly  1996 MGNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEA---------------EDVL 2045

Human  1646 GTQNLLTSIESETAASEETLFNASQRISELERNVEELKRKAAQNSGEAEYIEK----VVYTVKQS 1706
                             |.:.|.|.|:.|..:.::||.::.:.:. :..|:|:    :..||::.
  Fly  2046 -----------------EHVRNLSIRVGESHQELDELNQRISDHL-DPGYLEQGEGLLRLTVQRQ 2092

Human  1707 AEDVKKTLDGELD--EKYKKVEN-LIAKKTEESADARR----KAEMLQNEAKTLLAQANSKLQLL 1764
            .     .|:|.|:  :.|:.:.| .:..|||:..:.|:    |||   ..|..|||::|      
  Fly  2093 I-----MLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAE---KHASHLLARSN------ 2143

Human  1765 KDLERKYE 1772
             :..||::
  Fly  2144 -EYARKFQ 2150

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LAMB1XP_054214165.1 Laminin_N 59..293 CDD:459653 68/260 (26%)
EGF_Lam 295..347 CDD:238012 18/53 (34%)
EGF_Lam 359..411 CDD:238012 16/51 (31%)
Laminin_EGF 422..479 CDD:395007 16/60 (27%)
Laminin_EGF 482..536 CDD:395007 18/54 (33%)
EGF_Lam 533..>572 CDD:238012 9/64 (14%)
EGF_Lam 797..842 CDD:214543 16/49 (33%)
Laminin_EGF 845..893 CDD:395007 20/75 (27%)
Laminin_EGF 891..938 CDD:395007 21/46 (46%)
Laminin_EGF 941..997 CDD:395007 19/56 (34%)
Laminin_EGF 1000..1044 CDD:395007 16/60 (27%)
Laminin_EGF 1052..1106 CDD:395007 25/53 (47%)
Laminin_EGF 1108..1156 CDD:395007 24/94 (26%)
Laminin_EGF 1156..>1195 CDD:395007 18/38 (47%)
PTZ00121 <1248..1802 CDD:173412 123/732 (17%)
cc_LAMB1_C 1738..1810 CDD:411971 11/39 (28%)
wbNP_723870.1 Laminin_N 153..398 CDD:459653 68/260 (26%)
EGF_Lam 401..450 CDD:238012 18/62 (29%)
EGF_Lam 505..552 CDD:238012 19/66 (29%)
Laminin_EGF 550..597 CDD:395007 15/49 (31%)
Laminin_B 660..813 CDD:459652 41/233 (18%)
EGF_Lam 851..900 CDD:238012 16/51 (31%)
Laminin_EGF <943..971 CDD:395007 8/29 (28%)
Laminin_EGF 974..1018 CDD:395007 22/49 (45%)
EGF_Lam 1017..1065 CDD:238012 21/60 (35%)
Laminin_EGF 1065..>1105 CDD:395007 15/47 (32%)
EGF_Lam 1150..1197 CDD:238012 25/53 (47%)
Laminin_EGF 1199..1247 CDD:395007 20/47 (43%)
EGF_Lam 1247..1292 CDD:238012 2/44 (5%)
Laminin_EGF 1294..1342 CDD:395007 21/48 (44%)
Laminin_EGF 1340..1392 CDD:395007 1/51 (2%)
Laminin_B 1486..1626 CDD:459652 23/157 (15%)
EGF_Lam 1669..1716 CDD:238012 9/46 (20%)
Laminin_EGF 1718..1767 CDD:395007 6/48 (13%)
EGF_Lam 1772..1819 CDD:238012 4/46 (9%)
YhaN <1907..2141 CDD:443752 54/278 (19%)
SMC_prok_B <2123..>2390 CDD:274008 11/38 (29%)
Laminin_II 2279..2400 CDD:368703
LamG 2399..>2492 CDD:473984
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.