Protein Alignment LAMB1 and LanB2

DIOPT Version :10

• Sequence 1: XP_054214165.1
• Gene: LAMB1 / 3912
• HGNCID: 6486
• Length: 1810
• Species: Homo sapiens
• Sequence 2: NP_524006.1
• Gene: LanB2 / 39118
• FlyBaseID: FBgn0267348
• Length: 1639
• Species: Drosophila melanogaster
• Alignment Length: 1939
• Identity: 521/1939 - (26%)
• Similarity: 828/1939 - (42%)
• Gaps: 487/1939 - (25%)

Human    30 LLPVLPAALCRARVRAQEPEFS---------------------YGCAEGSCYPATGDLLIGRAQK 73
            |:.||.|:...|.:.||.|..:                     ||..: .|.|.    .|..|.:
  Fly    18 LIGVLFASCSTAILGAQRPPINSAGGHELRGTTFMPALECYDPYGRPQ-KCLPE----FINAAYQ 77

Human    74 LSV--TSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIENVVTTFAPNRLKIWW 136
            |.:  |:|||......:||.:..|..|.|..|...|  |   ||      :.:|.....:...||
  Fly    78 LQIESTNTCGEQNDNHFCIQTMNQNHKNCEFCKYND--H---NP------SFLTDLHDPQSPTWW 131

Human   137 QSE---NGVEN---VTIQLDLEAEFHFTHLIMTFKTFRPAAMLI-ERSSDFGKTWGVYRYFAYDC 194
            |||   .|:::   |.:.|.|...:..|::.:.|::.||.:..| :|:|:.| .|..|::::..|
  Fly   132 QSETMFEGIQHPNYVNLTLHLGKSYDITYVRILFRSPRPESFTIYKRTSESG-PWIPYQFYSATC 195

Human   195 EASFPGISTGPMKKVD---DIICDSRYSDIEPSTEGEVIFRALD--PAFKIEDPYSPRIQNLLKI 254
            ..::....:..::|.:   ..:|.|.||||.|..:||:.|..|:  |: .|....|..:|..:..
  Fly   196 RDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPS-GINFERSGELQEWVTA 259

Human   255 TNLRIKFVKLHTLGDNLL-DSRMEIREKYYYAVYDMVVRGNCFCYGHASECAPVDGFNEEVEGMV 318
            |::||...:|:|.||.|. ||  ::.:.|:||:.|:.|...|.|.||||:|.|..|        :
  Fly   260 TDIRITLDRLNTFGDELFGDS--QVLKSYFYAISDIAVGARCKCNGHASKCVPSTG--------M 314

Human   319 HGH----CMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNCNEHSISCHFDMAVYLATG 379
            ||.    |.|||||.|.:|:.|:..|:||.|:.:.....|.||.||||..:..|.||..::..||
  Fly   315 HGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANLFNRTG 379

Human   380 NVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPAGSQNEGICDSYTDFSTG 444
            :  ||.|.||:.|..|.|||:||..:|      :||..:|..|.|||.||::.. |:|:
  Fly   380 H--GGHCLDCRENRDGPNCERCKENFY------MRDDGYCVNCACDPVGSRSLQ-CNSH------ 429

Human   445 LIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFGCKSCACNPLGTIPGGNPCDSETGHCYCKRLV 509
               |:|:||..|.|:.||.|...:|...   |.||:.|.|:..|:......||:|||.|:||..|
  Fly   430 ---GKCQCKPGVTGDKCDRCDNNYYQFG---PHGCQQCGCDSGGSHQNTPACDTETGICFCKENV 488

Human   510 TGQHCDQCLPEHWGL-SNDLDGCRPCDCDLGGALNNSCFAESGQCSCRPHMIGRQCNEVEPGYYF 573
            .|:.|::|.|..:.| .|:..||.||          .|:..:.:|.            ..|||..
  Fly   489 EGRRCNECKPGFFNLDKNNRFGCTPC----------FCYGHTSECM------------TAPGYSI 531

Human   574 ATLDHYLYEAEEANLGPGVSIVERQYIQDRIPSWTGAGFVRVPEGAYLEFFIDNIPYSMEYDILI 638
            .::.....:.:|                    .||.|..                   .:.::.|
  Fly   532 VSVTSNFNKFKE--------------------RWTAADL-------------------NQREVDI 557

Human   639 RYEPQLPDHWEKAVITVQRPGRIPTSSRCGNTIPDDDNQVVSLSPGSRYVVLPRPVCF--EKGTN 701
            :|     :.:.:::               |.|           :.|:.:|....|..|  ::..:
  Fly   558 KY-----NQYSRSI---------------GTT-----------AQGNEHVYFQAPDRFLGDQRAS 591

Human   702 YT----VRLELPQYTS----SDSDVESPYTLIDSLVLMPYCKSLDIFTVGGSGDGVVTNSAWE-T 757
            |.    .:|:|....:    ||..:|...:.|          ||.||   ..|:|:......| |
  Fly   592 YNRDLKFKLQLVGQVANTGVSDVILEGAGSRI----------SLPIF---AQGNGIPDQGVKEYT 643

Human   758 FQ-------RYRCLENSRSVVKTPMTDVCRNIIFSISALLHQTGLACECDPQGSLSSVCDPNGGQ 815
            |:       :::..:::|..:         :|:.:::|:    .:......||  .::.|
  Fly   644 FRLHEHHDYQWQPSQSARGFL---------SILSNLTAI----KIRATYSVQG--EAILD----- 688

Human   816 CQCRPNVVGRTCNRCAPGTFGFGPSGCKPCECHLQGSVNAFCNPVT--GQCHCFQGVYARQCDRC 878
                 :|..:|.:|.|.|                        :|.|  .||.|.:|...:.|:.|
  Fly   689 -----DVELQTAHRGAAG------------------------HPATWIEQCTCPEGYLGQFCESC 724

Human   879 LPGHWGFPS-------CQPCQCNGHADDCDPVTGECLNCQDYTMGHNCERCLAGYYGDPIIGSGD 936
            .||:...|:       |.||.|:||||.||..||.|: ||..|.|.||::|..|:||:.:.|:.:
  Fly   725 APGYRHSPARGGPFMPCIPCDCHGHADICDSETGRCI-CQHNTHGDNCDQCAKGFYGNALGGTPN 788

Human   937 HCRPCPCP-DGPDSGRQFARSCYQDPVTLQLACVCDPGYIGSRCDDCASGYFGNPSEVGG---SC 997
            .|:.|||| ||         :|.|......:...|..||.||||:.|:.|:||:|:.:.|   :|
  Fly   789 DCKRCPCPNDG---------ACLQINEDTVICTECPKGYFGSRCEQCSDGFFGDPTGLLGEVQTC 844

Human   998 QPCQCHNNIDTTDPEACDKETGRCLKCLYHTEGEHCQFCRFGYYGDAL---RQDCRKCVCNYLGT 1059
            :.|.|:.|:|......|::.||.||||:::|.||||..|..|::||.|   ...|.:|.|...||
  Fly   845 KSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSGHFGDPLALPHGRCDRCSCYEAGT 909

Human  1060 VQEHCNGSDCQCDKATGQCLCLPNVIGQNCDRCAPNTWQLASGTGCDPCNCNAAHSFGPSCNEFT 1124
            .|:  ..|..:||:.||||.|.|||||::|..|.|..:.:.||.||:.|.|:...|:..:|:.::
  Fly   910 EQD--EQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIRSGNGCENCLCDPVGSYNSTCDRYS 972

Human  1125 GQCQCMPGFGGRTCSECQELFWGDPDVECRACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDKC 1189
            |||.|.||..|:.|.:|:..|:|.....|:.|:||..|.:..||||: |||.|.:.|||.|||:|
  Fly   973 GQCHCRPGVMGQRCDQCENYFYGFSSEGCKPCECDESGSKGFQCDQN-GQCPCNDNVEGRRCDRC 1036

Human  1190 TRGYSGVFPDCTPCHQCFALWDVIIAELTNRTHRFLEKAKALKISGVIGPYRETVDSVERKVSEI 1254
            ..........|..|..|:.|    :.:..:     |.:||...:|       :|:|.:.|
  Fly  1037 KENKYDRHRGCIDCPDCYNL----VQDAAD-----LHRAKLFNLS-------QTLDEIAR----- 1080

Human  1255 KDILAQSPAAEPLKNIGNLFEEAEKLIKDVTEMMAQVEVKLSDTTSQSNSTAKELDSLQTEAESL 1319
                      .|:.| .:.||...|.:::...::||        .::.||.    |..||.||.:
  Fly  1081 ----------TPVTN-DDEFEAKLKAVQEKVAVLAQ--------DARDNSG----DGGQTYAEVI 1122

Human  1320 DNTVKEL---------AEQLEFIKNSDIRGALDSITKYFQMSLEAEERVNASTTEPNSTVEQSAL 1375
            |:..|.|         |::.:...|.:|..|..:.|...|::..|::.:..:....|....| ||
  Fly  1123 DDLHKHLDSVREHLVSADKFQADANGEIDRARQNYTILDQITENAKKELQQALDLLNDEGAQ-AL 1186

Human  1376 MRDRVEDVMMERES-QFKEKQEEQARLLDELAGKLQSLDLSAAAEMTCGTPPGASCSETECGGPN 1439
            .|.:.:.|...::| |..:...|...|.|:|..:.| .||..|.:
  Fly  1187 ARAKEKSVEFGQQSEQISDISREARALADKLESEAQ-FDLKNAKD-------------------- 1230

Human  1440 CRTDEGERKCGGPGCGGLVTVAHNAWQKAMDLDQDVLSALAEVEQLSKMVSEAKLRADEAKQSAE 1504
             ..|..|:             ||...:.|:||...:.:.|.         ||..|.....|||..
  Fly  1231 -AKDAVEK-------------AHQLAKSAIDLQLKIGTELR---------SEVGLELSHVKQSLG 1272

Human  1505 DILLKTNATKEKMDKSNEELRNLIKQIR--NFLTQDSADLDSI--EAV-----ANEVLKM--EMP 1558
            .::   ..:||.:.|:||.....:..:.  |..||...|:..:  :||     |:|:||.  |:.
  Fly  1273 TVV---QTSKEALRKANEVYDTALTLLNDVNRQTQPEIDISQLKKDAVAANERADELLKQITELS 1334

Human  1559 STPQQL-------QNLTEDIRERVESLSQVEVILQHSAADIARAEMLLEEAKRASKSATDVKVTA 1616
            ::..:|       |.|||.:.:|.|         |....||.    |||.||.|...||......
  Fly  1335 NSNGELFADFETEQELTEALLKRAE---------QQQLEDIE----LLERAKAAHDKATKAVEQG 1386

Human  1617 D-MVKEA----------LEEAEKAQVAAEKAIK---QADEDIQGTQNLLTSIESETAASEETLFN 1667
            | .:|||          ..:.:::..:||||::   ..:::||..::|::.       :||.|..
  Fly  1387 DNTLKEANNTYEKLAGFQSDVQRSSESAEKALQTVPNIEKEIQNAESLISQ-------AEEALDG 1444

Human  1668 ASQRISELERNVEELKRK-AAQNSGEAEYIEKVVYTVKQSAEDVKKTLDGELDEKYKKVENLIAK 1731
            |::..:|.::|.:|.:.| |.|.|.:||.|.:.....|.:|.::::..| :|:.:.|..|..|.|
  Fly  1445 ANKNANEAKKNAQEAQLKYAEQASKDAELIRRKANETKVAARNLREEAD-QLNHRVKLTEMDIFK 1508

Human  1732 KTEESA-------DARRK---AEMLQNEAKTLLAQANSKLQLLKD-LERKYEDNQRYLEDKAQEL 1785
            ..|.|.       ||:||   |:....||:..:.:||:.|..:|| ||...:.|...|:.....|
  Fly  1509 LEESSTKDDNLVDDAKRKVGQAKADTQEAQKQIEKANADLTAIKDELENLKDINTGDLDRLENRL 1573

Human  1786 ARLEGEVRSL-----------------------------LKDISQKVAVYSTCL 1810
            |.:|||:..:                             |||..|.:.:.|..|
  Fly  1574 ATVEGEINRVNLTGRIEKYREQRTIQKNLIDKYDAELRELKDEVQNIGLISKAL 1627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LAMB1	XP_054214165.1	Laminin_N	59..293	CDD:459653	71/248 (29%)
		EGF_Lam	295..347	CDD:238012	24/55 (44%)
		EGF_Lam	359..411	CDD:238012	22/51 (43%)
		Laminin_EGF	422..479	CDD:395007	19/56 (34%)
		Laminin_EGF	482..536	CDD:395007	22/54 (41%)
		EGF_Lam	533..>572	CDD:238012	6/38 (16%)
		EGF_Lam	797..842	CDD:214543	8/44 (18%)
		Laminin_EGF	845..893	CDD:395007	14/56 (25%)
		Laminin_EGF	891..938	CDD:395007	22/46 (48%)
		Laminin_EGF	941..997	CDD:395007	21/59 (36%)
		Laminin_EGF	1000..1044	CDD:395007	19/43 (44%)
		Laminin_EGF	1052..1106	CDD:395007	24/53 (45%)
		Laminin_EGF	1108..1156	CDD:395007	16/47 (34%)
		Laminin_EGF	1156..>1195	CDD:395007	19/38 (50%)
		PTZ00121	<1248..1802	CDD:173412	148/636 (23%)
		cc_LAMB1_C	1738..1810	CDD:411971	26/104 (25%)
LanB2	NP_524006.1	LamNT	61..296	CDD:214532	72/254 (28%)
		EGF_Lam	298..347	CDD:238012	24/56 (43%)
		Laminin_EGF	359..414	CDD:395007	25/62 (40%)
		EGF_Lam	414..458	CDD:214543	19/56 (34%)
		Laminin_EGF	461..511	CDD:395007	18/49 (37%)
		LamB	572..697	CDD:214597	28/162 (17%)
		EGF_Lam	743..791	CDD:238012	23/48 (48%)
		EGF_Lam	793..836	CDD:214543	20/51 (39%)
		Laminin_EGF	847..897	CDD:395007	21/49 (43%)
		Laminin_EGF	902..953	CDD:395007	23/52 (44%)
		EGF_Lam	956..1001	CDD:214543	15/44 (34%)
		Laminin_EGF	1004..1046	CDD:395007	19/42 (45%)
		SMC_prok_B	<1054..1621	CDD:274008	156/679 (23%)