Protein Alignment LAMB1 and SP2353

DIOPT Version :10

• Sequence 1: XP_054214165.1
• Gene: LAMB1 / 3912
• HGNCID: 6486
• Length: 1810
• Species: Homo sapiens
• Sequence 2: NP_611082.2
• Gene: SP2353 / 36771
• FlyBaseID: FBgn0034070
• Length: 1361
• Species: Drosophila melanogaster
• Alignment Length: 1524
• Identity: 266/1524 - (17%)
• Similarity: 412/1524 - (27%)
• Gaps: 694/1524 - (45%)

Human   460 HCD-VCKEGFYDLSSEDPFGCKSCACNPLGTIPGGNPCDSE-TGHC--------YCKRLVTGQH- 513
            ||. ||......|||      .|.|...:|.||  .|.::. .|||        .|..:..|.:
  Fly    10 HCRVVCVWLLLVLSS------LSSASIAVGAIP--EPEEAAFQGHCGHTSPCEQLCYEIHDGMYE 66

Human   514 CDQCLPEHWGL-------------SNDLDGCRPCDCDL-----------------GGALNNSCFA 548
            || |: |.:.|             ||.|||....|.|:                 |.::..|.||
  Fly    67 CD-CI-EGYELNKNGYSCQVINATSNSLDGRGKSDEDVLYQKGASFSAKLANDDGGKSMAKSTFA 129

Human   549 ESGQCSCRPHMIGRQCNEVEPGYYFATLDHYLY-EAEEAN------LGPGVSIVERQYIQDRIPS 606
            .|...|..|  .|.:..|.|.|   :..|.|.| |.|::|      ....:::.::|..|.::.|
  Fly   130 LSAAQSASP--AGNENGEDESG---SEGDSYDYGELEDSNSETQEQKQKSLNLQQQQQQQQKVNS 189

Human   607 WTGAGFVRVPEGAYLEFFI--DNIPYSMEYDILIRYEPQLPDHWEKAVITVQRPGRIPTSSRCGN 669
                          .:::|  ::|.::.|.:  .:.:..:.|.  ||..|:......||.||
  Fly   190 --------------NDYYISAESINFNSESE--GQEQQDVADF--KAASTMLPSSVPPTPSR--- 233

Human   670 TIPDDDNQVVSLSPGSRYVVLPRPVCFEKGTNYTVRLELPQYTSSDSDVESPYTLIDSLVLMPYC 734
                                        ..|..|........|:..|...:|...:|    :.|
  Fly   234 ----------------------------STTRATASTTTTTTTTRRSPTRAPKQRVD----VDY- 265

Human   735 KSLDIFTVGGSGDG------------------------VVTNSAWETFQRYRCLENSRSVVKTPM 775
                     |.|||                        :..||..:|:|:......:::..|.|
  Fly   266 ---------GEGDGSDDYSYSYKSDMSVYDDVNNNQLNLRRNSKSQTYQQTSNTNTAKNRRKYP- 320

Human   776 TDVCRNIIFSISALLHQTGLACECDPQGSLSSVCDPNGGQCQCRPNVVG--RTCNRCAPGTFGFG 838
             :|..|.:        |..:..|.:...::|:          ..|.|||  .|.:|..|
  Fly   321 -NVTSNKV--------QMHITRETNRLENISA----------AEPAVVGAAMTTDRSTP------ 360

Human   839 PSGCKPCECHLQGSVNAFC----NPVTGQCHCFQGVYARQCDRCLPGH--------W-GFPSCQP 890
                   .|:|....:..|    ...:.:|.|..|.....|...:..|        | .||:...
  Fly   361 -------TCNLDCGSDGICALEATAASSRCLCPFGKTGNGCQEDIRAHVPRFAKRSWLAFPALHG 418

Human   891 CQ-------------------CNGHAD--------------------DCDPVTGECLNCQDYTMG 916
            ..                   .:|..|                    ||....|...:.:...:.
  Fly   419 AYKHVQLRIEFRPESFDGIILLSGERDDLTGDFMALLLNKGFVEFWFDCGSGVGSVRSRETILLN 483

Human   917 ---------HNCERCLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPV---------- 962
                     |..:..|...:|..:.|.              |...|:|..:::||
  Fly   484 EWNSVIIYRHRWDAWLVLNHGTKVQGR--------------SNGLFSRITFREPVFLGGIGNITG 534

Human   963 ---TLQLACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPC-QCHNNIDTTDPEACDKETGRCL- 1022
               .|.||    .|:.|     |...:..|..:...:..|. ...|..|..|   |  .|.:|:
  Fly   535 LAKRLPLA----EGFAG-----CIRRFVANEHDYKFTEHPLGDVINGFDIQD---C--STDKCVR 585

Human  1023 -------KCLYHTEGEHCQFCRFGYYGD--ALRQDCRKCVCNYLGTVQEHCNGSDCQCDKATGQC 1078
                   |||...:|..| .|..|:.||  .:|.|
  Fly   586 YPCQHGGKCLPSDQGAIC-LCPIGFVGDLCEIRMD------------------------------ 619

Human  1079 LCLPNVIGQNCDRCAP-----NTW-------------------------------------QLAS 1101
            |.:|...|.:..|.||     ..|                                     :.|.
  Fly   620 LQVPAFNGSSFLRYAPLGDSALIWLELKVTLKPEQADGLILYSGPEHRGDFIALYLNDGFVEFAF 684

Human  1102 GTGCDPCNCNAAHS---------------------------------------------FGPSCN 1121
            ..|..|....:.||                                             |....|
  Fly   685 DLGSGPALVRSEHSLSLGQWHTIKISRTARLAVLKVDKHQEVLTISSNGFWHLSLDQNLFVGGVN 749

Human  1122 E-------------FTGQCQ-----------CMPGFGGRTCSECQELFWGDPDVECRACDCDPRG 1162
            .             |.|..|           .....||.....|..        .|.|..|.|..
  Fly   750 HVDRLPLDLKYKPFFVGCIQRIDINGHSLGIVAEALGGSNIGNCPH--------ACVARPCGPLA 806

Human  1163 IETPQCDQSTGQCVCVEGVEGPRCDKCTRGYSGVFPDCTPCHQCFALWDVIIAELTNRTHRFLEK 1227
            ...||.:  :.:|.|  .:...||:|...    |.|:..|             ||.      |.|
  Fly   807 ECVPQME--SYECRC--SIHNERCNKAAE----VPPEQLP-------------ELA------LHK 844

Human  1228 AKALKISGVIGPYRETVDSVE--RKVSEIKDILAQSPAAEPLKNIGNLFEEAEKLIKDVTEMMAQ 1290
            :|.|          ||.|:.|  :|||.    ||....::..:|:                   .
  Fly   845 SKVL----------ETKDNGEAAKKVSG----LAHKKHSKKHRNL-------------------H 876

Human  1291 VEVKLSDTTSQSNSTAKELDSLQTEAESLDNTVKELAEQLEFIKNSDIRGALDSITKYFQMSLEA 1355
            .....:.||:.:.||.    :..|||.|
  Fly   877 KPTPATSTTTSTTSTT----TTTTEAPS------------------------------------- 900

Human  1356 EERVNASTTEPNSTVEQSALMRDRVEDVMMERESQFKEKQEEQARLLDELAGKLQSLDLSAAAEM 1420
             ||...:|.        .||..:.:||.::.|..|.:::|:|                |....:.
  Fly   901 -ERTEEATA--------GALSNEEIEDDIIFRLVQQQQQQKE----------------LKKQHQQ 940

Human  1421 TCGTPPGASCSETECGGPNCRTDEGERKCGGPGCGGLVTVAHNAWQKAMDLDQDVLSALAEVEQL 1485
            |..|.|..|   |...||
  Fly   941 TTTTAPATS---TTSSGP----------------------------------------------- 955

Human  1486 SKMVSEAKLR-ADEAKQSAEDILLKTNATKEKMDKSNEELRNLIKQIRNFLTQDSADLDSIEAVA 1549
                |:||.| :.:...|..:..||.||.      ...:|..|.....:|.|...:|:
  Fly   956 ----SKAKPRLSGKHHASKHEHHLKPNAA------FTRKLSRLPTHYESFQTNPDSDI------- 1003

Human  1550 NEVLKMEMPSTPQQLQNLT-EDIRERVESLSQVEVILQHSAADIARAEMLLEEAK----RASKSA 1609
                             || ||..:.|.||.|.|   ...|...::..:..|:|.    |:|.:.
  Fly  1004 -----------------LTFEDNNDWVTSLQQQE---YGDAMAASQVPLAFEDASPGTPRSSDNN 1048

Human  1610 TDVKVTADMVKEAL-------EEAEKAQVA-----------AEKAIKQADEDI--QGTQNLLTSI 1654
            .|.: .|.:..|:|       ||.::.|:|           |..:.|:|:...  ||:|.:.|:.
  Fly  1049 EDDE-NAFVFDESLFDASDGTEEYQRKQLAQDMKRIMSNSNAHSSHKKAEVQFPPQGSQEVGTAN 1112

Human  1655 ESETAASEETLFNASQRISELERNVEELK 1683
            |..:..|::  :|..:.::.:.:..||:|
  Fly  1113 EDTSQYSDD--YNDDELLTPVMQGGEEVK 1139

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LAMB1	XP_054214165.1	Laminin_N	59..293	CDD:459653
		EGF_Lam	295..347	CDD:238012
		EGF_Lam	359..411	CDD:238012
		Laminin_EGF	422..479	CDD:395007	7/19 (37%)
		Laminin_EGF	482..536	CDD:395007	20/76 (26%)
		EGF_Lam	533..>572	CDD:238012	13/55 (24%)
		EGF_Lam	797..842	CDD:214543	9/46 (20%)
		Laminin_EGF	845..893	CDD:395007	11/79 (14%)
		Laminin_EGF	891..938	CDD:395007	9/94 (10%)
		Laminin_EGF	941..997	CDD:395007	12/68 (18%)
		Laminin_EGF	1000..1044	CDD:395007	15/54 (28%)
		Laminin_EGF	1052..1106	CDD:395007	9/95 (9%)
		Laminin_EGF	1108..1156	CDD:395007	11/116 (9%)
		Laminin_EGF	1156..>1195	CDD:395007	9/38 (24%)
		PTZ00121	<1248..1802	CDD:173412	83/464 (18%)
		cc_LAMB1_C	1738..1810	CDD:411971
SP2353	NP_611082.2	FXa_inhibition	53..82	CDD:464251	7/30 (23%)
		LamG	404..555	CDD:238058	23/173 (13%)
		EGF	583..612	CDD:394967	8/29 (28%)
		LamG	625..774	CDD:238058	15/148 (10%)
		LamG	1205..1340	CDD:214598