Protein Alignment LAMB1 and Lamb1

DIOPT Version :10

• Sequence 1: XP_054214165.1
• Gene: LAMB1 / 3912
• HGNCID: 6486
• Length: 1810
• Species: Homo sapiens
• Sequence 2: XP_003750185.1
• Gene: Lamb1 / 298941
• RGDID: 1306311
• Length: 1834
• Species: Rattus norvegicus
• Alignment Length: 1841
• Identity: 1664/1841 - (90%)
• Similarity: 1744/1841 - (94%)
• Gaps: 38/1841 - (2%)

Human     1 MDCPLSA-PTPPPPLVRFFRAPL------------PACVP--------PTL----LPVLPA---- 36
            |:.|||: ||       |..:||            .||:|        |.|    :.||..
  Rat     1 MERPLSSLPT-------FAFSPLYLSRKEDTKKRRAACLPRPPSRAASPRLQGLDMGVLQVFAFG 58

Human    37 --ALCRARVRAQEPEFSYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKK 99
              ||...||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    59 VLALWGTRVCAQEPEFSYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKK 123

Human   100 CFICNSQDPYHETLNPDSHLIENVVTTFAPNRLKIWWQSENGVENVTIQLDLEAEFHFTHLIMTF 164
            ||||:|:||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||
  Rat   124 CFICDSRDPYHETLNPDSHLIENVVTTFAPNRLKIWWQSENGVENVTVQLDLEAEFHFTHLIMTF 188

Human   165 KTFRPAAMLIERSSDFGKTWGVYRYFAYDCEASFPGISTGPMKKVDDIICDSRYSDIEPSTEGEV 229
            |||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||
  Rat   189 KTFRPAAMLIERSSDFGKTWGVYRYFAYDCESSFPGISTGPMKKVDDIICDSRYSDIEPSTEGEV 253

Human   230 IFRALDPAFKIEDPYSPRIQNLLKITNLRIKFVKLHTLGDNLLDSRMEIREKYYYAVYDMVVRGN 294
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   254 IFRALDPAFKIEDPYSPRIQNLLKITNLRIKFVKLHTLGDNLLDSRMEIREKYYYAVYDMVVRGN 318

Human   295 CFCYGHASECAPVDGFNEEVEGMVHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKC 359
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   319 CFCYGHASECAPVDGFNEEVEGMVHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKC 383

Human   360 NCNEHSISCHFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNFCERCTC 424
            ||||||.||||||||:||||||||||||:|||||||||||||||||:|||||||||||.||.|||
  Rat   384 NCNEHSSSCHFDMAVFLATGNVSGGVCDNCQHNTMGRNCEQCKPFYFQHPERDIRDPNLCEPCTC 448

Human   425 DPAGSQNEGICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFGCKSCACNPLGT 489
            |||||:|.||||.|||||.|||||||||||:||||.||||||||||||:||||||||||||||||
  Rat   449 DPAGSENGGICDGYTDFSVGLIAGQCRCKLHVEGERCDVCKEGFYDLSAEDPFGCKSCACNPLGT 513

Human   490 IPGGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGLSNDLDGCRPCDCDLGGALNNSCFAESGQCS 554
            ||||||||||||:||||||||||.||||||:||||||||||||||||||||||||||..:|||||
  Rat   514 IPGGNPCDSETGYCYCKRLVTGQRCDQCLPQHWGLSNDLDGCRPCDCDLGGALNNSCSEDSGQCS 578

Human   555 CRPHMIGRQCNEVEPGYYFATLDHYLYEAEEANLGPGVSIVERQYIQDRIPSWTGAGFVRVPEGA 619
            |.||||||||||||.||||.|||||:||||||||||||.:|||:|||||||||||.|||||||||
  Rat   579 CLPHMIGRQCNEVESGYYFTTLDHYIYEAEEANLGPGVVVVERRYIQDRIPSWTGPGFVRVPEGA 643

Human   620 YLEFFIDNIPYSMEYDILIRYEPQLPDHWEKAVITVQRPGRIPTSSRCGNTIPDDDNQVVSLSPG 684
            ||||||||||:||||:|||||||||||||||||||||||||||||||||||:|||||||||||||
  Rat   644 YLEFFIDNIPHSMEYEILIRYEPQLPDHWEKAVITVQRPGRIPTSSRCGNTVPDDDNQVVSLSPG 708

Human   685 SRYVVLPRPVCFEKGTNYTVRLELPQYTSSDSDVESPYTLIDSLVLMPYCKSLDIFTVGGSGDGV 749
            |||||||||||||||.||||||||||||:|.|||||||||||||||||||||||||||||||||.
  Rat   709 SRYVVLPRPVCFEKGMNYTVRLELPQYTASGSDVESPYTLIDSLVLMPYCKSLDIFTVGGSGDGE 773

Human   750 VTNSAWETFQRYRCLENSRSVVKTPMTDVCRNIIFSISALLHQTGLACECDPQGSLSSVCDPNGG 814
            ||||||||||||||||||||||||||||||||||||||||:||.|||||||||||||||||||||
  Rat   774 VTNSAWETFQRYRCLENSRSVVKTPMTDVCRNIIFSISALIHQAGLACECDPQGSLSSVCDPNGG 838

Human   815 QCQCRPNVVGRTCNRCAPGTFGFGPSGCKPCECHLQGSVNAFCNPVTGQCHCFQGVYARQCDRCL 879
            |||||||||||||||||||||||||:|||||:|||||||:|||:.||||||||||:|||||||||
  Rat   839 QCQCRPNVVGRTCNRCAPGTFGFGPNGCKPCDCHLQGSVSAFCDAVTGQCHCFQGIYARQCDRCL 903

Human   880 PGHWGFPSCQPCQCNGHADDCDPVTGECLNCQDYTMGHNCERCLAGYYGDPIIGSGDHCRPCPCP 944
            ||.|||||||||||||||:|||.||||||:|||||.|||||||||||||||||||||||||||||
  Rat   904 PGFWGFPSCQPCQCNGHAEDCDTVTGECLSCQDYTTGHNCERCLAGYYGDPIIGSGDHCRPCPCP 968

Human   945 DGPDSGRQFARSCYQDPVTLQLACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNIDTT 1009
            ||||||||||||||||||||||||||||||||||||.||||||||||:.||||||||||:|||||
  Rat   969 DGPDSGRQFARSCYQDPVTLQLACVCDPGYIGSRCDGCASGYFGNPSDFGGSCQPCQCHHNIDTT 1033

Human  1010 DPEACDKETGRCLKCLYHTEGEHCQFCRFGYYGDALRQDCRKCVCNYLGTVQEHCNGSDCQCDKA 1074
            |||||||||||||||||||||:|||||:.||||||||||||||||||||||:||||||||.|||.
  Rat  1034 DPEACDKETGRCLKCLYHTEGDHCQFCQHGYYGDALRQDCRKCVCNYLGTVREHCNGSDCHCDKT 1098

Human  1075 TGQCLCLPNVIGQNCDRCAPNTWQLASGTGCDPCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCS 1139
            ||||.|||||||||||||||:||||||||||:||||||.||||||||||||||||||||||||||
  Rat  1099 TGQCSCLPNVIGQNCDRCAPHTWQLASGTGCEPCNCNAVHSFGPSCNEFTGQCQCMPGFGGRTCS 1163

Human  1140 ECQELFWGDPDVECRACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDKCTRGYSGVFPDCTPCH 1204
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1164 ECQELFWGDPDVECRACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDKCTRGYSGVFPDCTPCH 1228

Human  1205 QCFALWDVIIAELTNRTHRFLEKAKALKISGVIGPYRETVDSVERKVSEIKDILAQSPAAEPLKN 1269
            ||||||||||.|||||||:|||||||||||||||||||||||||:||:||:||||||||||||||
  Rat  1229 QCFALWDVIIGELTNRTHKFLEKAKALKISGVIGPYRETVDSVEKKVNEIRDILAQSPAAEPLKN 1293

Human  1270 IGNLFEEAEKLIKDVTEMMAQVEVKLSDTTSQSNSTAKELDSLQTEAESLDNTVKELAEQLEFIK 1334
            ||.||||||||.|||||.|||||||||||.|:|||||.|||:||.||.|||.||.||||||||||
  Rat  1294 IGILFEEAEKLTKDVTEKMAQVEVKLSDTASRSNSTAGELDALQAEAGSLDKTVNELAEQLEFIK 1358

Human  1335 NSDIRGALDSITKYFQMSLEAEERVNASTTEPNSTVEQSALMRDRVEDVMMERESQFKEKQEEQA 1399
            ||||:|||||||||||:|||||:|||||||:||||||||||.||||||:|:||||||||||||||
  Rat  1359 NSDIQGALDSITKYFQISLEAEKRVNASTTDPNSTVEQSALTRDRVEDLMLERESQFKEKQEEQA 1423

Human  1400 RLLDELAGKLQSLDLSAAAEMTCGTPPGASCSETECGGPNCRTDEGERKCGGPGCGGLVTVAHNA 1464
            |||||||||||||||||||||||||.|||.|||:|||||||||||||:|||||||||||||||:|
  Rat  1424 RLLDELAGKLQSLDLSAAAEMTCGTHPGADCSESECGGPNCRTDEGEKKCGGPGCGGLVTVAHSA 1488

Human  1465 WQKAMDLDQDVLSALAEVEQLSKMVSEAKLRADEAKQSAEDILLKTNATKEKMDKSNEELRNLIK 1529
            ||||||.|:|||:||||||||||||||||:|||||||:|:|:|||||||:||:|:|||:||||||
  Rat  1489 WQKAMDFDRDVLNALAEVEQLSKMVSEAKVRADEAKQNAQDVLLKTNATREKVDRSNEDLRNLIK 1553

Human  1530 QIRNFLTQDSADLDSIEAVANEVLKMEMPSTPQQLQNLTEDIRERVESLSQVEVILQHSAADIAR 1594
            |||:|||:|||||||||||||||||||||||||||||||||||||||:|||||||||.|||||||
  Rat  1554 QIRDFLTEDSADLDSIEAVANEVLKMEMPSTPQQLQNLTEDIRERVETLSQVEVILQQSAADIAR 1618

Human  1595 AEMLLEEAKRASKSATDVKVTADMVKEALEEAEKAQVAAEKAIKQADEDIQGTQNLLTSIESETA 1659
            ||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1619 AELLLEEAKRASKSATDVKVTADMVKEALEEAEKAQVAAEKAIKQADEDIQGTQNLLTSIESETA 1683

Human  1660 ASEETLFNASQRISELERNVEELKRKAAQNSGEAEYIEKVVYTVKQSAEDVKKTLDGELDEKYKK 1724
            ||||||.|||||||:|||||||||||||||||||:|||||||:|||||::|||||||||||||||
  Rat  1684 ASEETLTNASQRISKLERNVEELKRKAAQNSGEADYIEKVVYSVKQSADEVKKTLDGELDEKYKK 1748

Human  1725 VENLIAKKTEESADARRKAEMLQNEAKTLLAQANSKLQLLKDLERKYEDNQRYLEDKAQELARLE 1789
            ||:|||:|||||||||||||:|||||||||||||||||||:||||||||||:|||||||||.|||
  Rat  1749 VESLIAQKTEESADARRKAELLQNEAKTLLAQANSKLQLLEDLERKYEDNQKYLEDKAQELVRLE 1813

Human  1790 GEVRSLLKDISQKVAVYSTCL 1810
            |||||||||||:|||||||||
  Rat  1814 GEVRSLLKDISEKVAVYSTCL 1834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LAMB1	XP_054214165.1	Laminin_N	59..293	CDD:459653	229/233 (98%)
		EGF_Lam	295..347	CDD:238012	51/51 (100%)
		EGF_Lam	359..411	CDD:238012	47/51 (92%)
		Laminin_EGF	422..479	CDD:395007	49/56 (88%)
		Laminin_EGF	482..536	CDD:395007	50/53 (94%)
		EGF_Lam	533..>572	CDD:238012	33/38 (87%)
		EGF_Lam	797..842	CDD:214543	43/44 (98%)
		Laminin_EGF	845..893	CDD:395007	41/47 (87%)
		Laminin_EGF	891..938	CDD:395007	42/46 (91%)
		Laminin_EGF	941..997	CDD:395007	52/55 (95%)
		Laminin_EGF	1000..1044	CDD:395007	39/43 (91%)
		Laminin_EGF	1052..1106	CDD:395007	48/53 (91%)
		Laminin_EGF	1108..1156	CDD:395007	46/47 (98%)
		Laminin_EGF	1156..>1195	CDD:395007	38/38 (100%)
		PTZ00121	<1248..1802	CDD:173412	499/553 (90%)
		cc_LAMB1_C	1738..1810	CDD:411971	66/71 (93%)
Lamb1	XP_003750185.1	Laminin_N	83..317	CDD:459653	229/233 (98%)
		EGF_Lam	319..371	CDD:238012	51/51 (100%)
		EGF_Lam	383..435	CDD:238012	47/51 (92%)
		Laminin_EGF	446..503	CDD:395007	49/56 (88%)
		EGF_Lam	505..556	CDD:238012	47/50 (94%)
		EGF_Lam	557..>596	CDD:238012	33/38 (87%)
		EGF_Lam	821..866	CDD:214543	43/44 (98%)
		Laminin_EGF	869..917	CDD:395007	41/47 (87%)
		EGF_Lam	914..959	CDD:238012	40/44 (91%)
		Laminin_EGF	965..1021	CDD:395007	52/55 (95%)
		Laminin_EGF	1024..1068	CDD:395007	39/43 (91%)
		Laminin_EGF	1076..1129	CDD:395007	47/52 (90%)
		Laminin_EGF	1132..1180	CDD:395007	46/47 (98%)
		Laminin_EGF	1180..>1219	CDD:395007	38/38 (100%)
		YhaN	1250..>1723	CDD:443752	427/472 (90%)
		SMC_prok_B	1504..>1824	CDD:274008	294/319 (92%)
		cc_LAMB1_C	1762..1834	CDD:411971	66/71 (93%)