DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG3335 and RBM19

DIOPT Version :9

Sequence 1:NP_648337.1 Gene:CG3335 / 39119 FlyBaseID:FBgn0036018 Length:918 Species:Drosophila melanogaster
Sequence 2:NP_001140170.1 Gene:RBM19 / 9904 HGNCID:29098 Length:960 Species:Homo sapiens


Alignment Length:1004 Identity:379/1004 - (37%)
Similarity:582/1004 - (57%) Gaps:135/1004 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSRIIVKQLPKHITEDKLRQIFGAQGTITDLQLKYTPDGKFRQFCFVGYSTEEEAQSAIRHFDNT 65
            |||:|||.||..:.|::.||:|.|.||:||..||:|.|||||:|.|:|:.:|||||.|.:||:.:
Human     1 MSRLIVKNLPNGMKEERFRQLFAAFGTLTDCSLKFTKDGKFRKFGFIGFKSEEEAQKAQKHFNKS 65

  Fly    66 CIQTSRVRVESCAALGSEDKPQSWSKYAKDSKKNLDKLKEKEREAAAKAKESEKKKKKDKVDKVD 130
            .|.|||:.||.|.:.|...||::|||:|:  |.:..|...|:.......|:.:|||...:::|: 
Human    66 FIDTSRITVEFCKSFGDPAKPRAWSKHAQ--KPSQPKQPPKDSTTPEIKKDEKKKKVAGQLEKL- 127

  Fly   131 QILSRHKDDPEFQEFLEAHDK--SRTLWGNDLGINKNRENEEEDDEEQEESRAARDDSGVDADAG 193
                  |:|.||||||..|.:  ....|.|| |:        :.:..:.:|:.|.|....|:|:|
Human   128 ------KEDTEFQEFLSVHQRRAQAATWAND-GL--------DAEPSKGKSKPASDYLNFDSDSG 177

  Fly   194 ---DEDGSGDEADEEEDTDKLA--EKPISDLEYMKSLMATTSGEATAKK---------------- 237
               :|:|:|::.:||...:..|  :|.:||::|:||.|......:::::                
Human   178 QESEEEGAGEDLEEEASLEPKAAVQKELSDMDYLKSKMVKAGSSSSSEEEESEDEAVHCDEGSEA 242

  Fly   238 --------------------------------PKAKAD-------KSNLELFTIKIHNVPYNTKR 263
                                            |:|:|:       |......|:|:...|:|...
Human   243 EEEDSSATPVLQERDSKGAGQEQGMPAGKKRPPEARAETEKPANQKEPTTCHTVKLRGAPFNVTE 307

  Fly   264 QEVLKFFKPLKPYSVRLPSKVH----GFCYVGFKTEKDMAKGMLKNKSFIKGKQVFFSDFTEKNK 324
            :.|::|..||||.::|:....|    |:.:|.|..|:::.:.:..|:.::.|:  :...|.|||.
Human   308 KNVMEFLAPLKPVAIRIVRNAHGNKTGYIFVDFSNEEEVKQALKCNREYMGGR--YIEVFREKNV 370

  Fly   325 VTKASKSGQPLAPAAVDAGNAKWKHQQDSLSKEDDISESGRIFFRNLAYTTTEEDLRKLFEQFGP 389
            .|   ..|.|........|....::::     |:|::||||:|.|||.||:|||||.|||.::||
Human   371 PT---TKGAPKNTTKSWQGRILGENEE-----EEDLAESGRLFVRNLPYTSTEEDLEKLFSKYGP 427

  Fly   390 VVEVNLPLDKLTRKIKGFGTVTYMMPEHALKAFNTLDGTDFHGRLLHLLPSKDIEKNPKEDLDEN 454
            :.|::.|:|.||:|.|||..:|:|.||||:||::.:||..|.||:||:||| .|:|...||....
Human   428 LSELHYPIDSLTKKPKGFAFITFMFPEHAVKAYSEVDGQVFQGRMLHVLPS-TIKKEASEDASAL 491

  Fly   455 DASLSFKEKKALKLKKNAQKPIGWNTLFLGANAVAEILAKQFKTSKERILDTSDGGSSAAVRLAL 519
            .:| |:|:||..:.|.|:.....|||||:|.||||:.:|:::..:|.::.|....| |.|||:||
Human   492 GSS-SYKKKKEAQDKANSASSHNWNTLFMGPNAVADAIAQKYNATKSQVFDHETKG-SVAVRVAL 554

  Fly   520 GETQVVIEMKRFLEEEGVRLDAFDEPAKKRSNTVILAKNLPAATEISEITPIFSRFGPIGRIVLP 584
            ||||:|.|::|||.:.||.||:|.:.|.:||.||||.|||||.|..:::...|..||.:||::||
Human   555 GETQLVQEVRRFLIDNGVSLDSFSQAAAERSKTVILVKNLPAGTLAAQLQETFGHFGSLGRVLLP 619

  Fly   585 PSGVTALIEYCDPLEARQAFKKLAYSKFKNAPLYLEWAPEQVFTKT--------------LSGEP 635
            ..|:||::|:.:|||||:||:.||||||.:.||||||||..||:.|              :..:|
Human   620 EGGITAIVEFLEPLEARKAFRHLAYSKFHHVPLYLEWAPVGVFSSTAPQKKKLQDTPSEPMEKDP 684

  Fly   636 VIPKSEP--KPKEEVKPEEKPIVNDAKPDEEDSRAEDADDEPEPNTTLFLRNLNFKTVQETVEKH 698
            ..|::.|  :..|:..|.|:...|.:...||:...|:.::|..|..|||::||||.|.:|.:::.
Human   685 AEPETVPDGETPEDENPTEEGADNSSAKMEEEEEEEEEEEESLPGCTLFIKNLNFDTTEEKLKEV 749

  Fly   699 FRHLGSIHTVEIAKRRDPENPREFKSLGYGFIQFKKSSVAEHALKNLQLTHIDGNPVELKRSDRV 763
            |..:|::.:..|:|:::...  ...|:|:||::::|...|:.|||.||...:||:.:|::.|:|.
Human   750 FSKVGTVKSCSISKKKNKAG--VLLSMGFGFVEYRKPEQAQKALKQLQGHVVDGHKLEVRISERA 812

  Fly   764 LKTQDNDGAQRRLASQKKQTGTKILVRNIPFQAQYREVRDIFKAFGELRSLRIPKKATTGEDAHR 828
            .|....  ..|:....:|||.:|||||||||||..||:|::|..||||:::|:||| .||...||
Human   813 TKPAVT--LARKKQVPRKQTTSKILVRNIPFQAHSREIRELFSTFGELKTVRLPKK-MTGTGTHR 874

  Fly   829 GFGFVDYMSKAEAKRAFDALSASTHLYGRRLVLEWSANDDNQDVEELRKRTAAKFDGSQAATAAK 893
            ||||||:::|.:|||||:||..|||||||||||||:  |....::.||::|||.|.     ...|
Human   875 GFGFVDFLTKQDAKRAFNALCHSTHLYGRRLVLEWA--DSEVTLQALRRKTAAHFH-----EPPK 932

  Fly   894 RSRKSFFD-----VEGSVQPNQDDDEEEE 917
            :.|....|     :|||     |.|.||:
Human   933 KKRSVVLDEILEQLEGS-----DSDSEEQ 956

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3335NP_648337.1 RRM1_RBM19 2..77 CDD:241008 41/74 (55%)
RRM_SF 250..314 CDD:302621 18/67 (27%)
RRM3_RBM19 362..440 CDD:241011 45/77 (58%)
RRM4_RBM19 552..623 CDD:241013 40/70 (57%)
RRM <638..845 CDD:223796 82/208 (39%)
RRM5_RBM19_like 679..760 CDD:240764 27/80 (34%)
RRM6_RBM19 785..864 CDD:241015 53/78 (68%)
RBM19NP_001140170.1 RRM <2..>104 CDD:223796 51/103 (50%)
RRM1_RBM19 2..77 CDD:241008 41/74 (55%)
RRM_u2 82..286 CDD:293257 49/221 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 85..119 11/35 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 149..294 27/153 (18%)
RRM <270..450 CDD:223796 61/189 (32%)
RRM2_RMB19 294..365 CDD:240946 18/72 (25%)
RRM <400..>500 CDD:223796 54/101 (53%)
RRM3_RBM19 400..478 CDD:241011 45/77 (58%)
RRM 477..801 CDD:223796 131/328 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..513 7/22 (32%)
RRM4_RBM19 587..658 CDD:241013 40/70 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 667..729 11/61 (18%)
RRM5_RBM19_like 730..809 CDD:240764 27/80 (34%)
RRM6_RBM19 832..910 CDD:241015 53/78 (68%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147350
Domainoid 1 1.000 104 1.000 Domainoid score I6758
eggNOG 1 0.900 - - E1_KOG0110
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H7158
Inparanoid 1 1.050 637 1.000 Inparanoid score I826
Isobase 1 0.950 - 0 Normalized mean entropy S1863
OMA 1 1.010 - - QHG54158
OrthoDB 1 1.010 - - D1428854at2759
OrthoFinder 1 1.000 - - FOG0003677
OrthoInspector 1 1.000 - - oto88765
orthoMCL 1 0.900 - - OOG6_102169
Panther 1 1.100 - - LDO PTHR23147
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R745
SonicParanoid 1 1.000 - - X3041
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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