Protein Alignment CG3335 and MRD1

DIOPT Version :10

• Sequence 1: NP_648337.1
• Gene: CG3335 / 39119
• FlyBaseID: FBgn0036018
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_015437.1
• Gene: MRD1 / 856228
• SGDID: S000006316
• Length: 887
• Species: Saccharomyces cerevisiae
• Alignment Length: 979
• Identity: 301/979 - (30%)
• Similarity: 488/979 - (49%)
• Gaps: 156/979 - (15%)

  Fly     1 MSRIIVKQLPKHITEDKLRQIF-----------GAQGT----ITDLQLKYTPDGKFRQFCFVGYS 50
            |||||||.||.::|:|.||:.|           ...|:    |||:::....:|:.|:|.|:||.
Yeast     1 MSRIIVKGLPVYLTDDNLREHFTKRLRQKHSHQAVNGSGPDLITDVKILRDRNGESRRFGFIGYR 65

  Fly    51 TEEEAQSAIRHFDNTCIQTSRVRVESCAALGSEDKPQSWSKYAKDSKKNLDKLKEKEREAAAKAK 115
            .||:|..|:.:|:.:.|.||::.|....:......||              .:|||.|||..:.:
Yeast    66 NEEDAFDAVEYFNGSFINTSKIEVSMAKSFADPRVPQ--------------PMKEKRREALKRFR 116

  Fly   116 ESEKK------KKKDKVDK-----VDQILSRHKDDPEFQEFLEAHDKSR--TLWGNDLGINKNRE 167
            |.|:|      :||.|||:     :|..:.::|   :.|||:|....|.  |.| ..:||:|:.|
Yeast   117 EKEEKLLQEENRKKKKVDENKHSNIDDEIRKNK---QLQEFMETMKPSSQVTSW-EKVGIDKSIE 177

  Fly   168 NEEEDDEEQEES----------RAARDDSGVD-------ADAGDEDGSGDEADEEEDTDKLAEKP 215
            :|:...||::.|          .|.::::..|       .:..|::.|....:.:||.:...|:
Yeast   178 DEKLKREEEDSSVQGNSLLAHALALKEENNKDEAPNLVIENESDDEYSALNRNRDEDQEDAGEE- 241

  Fly   216 ISDLEYMKSLMATTSGEATAKKPKAKADKSNLELFTIKIHNVPYNTKRQEVLKFFKPLKPYSVRL 280
                |.|.|:......:.......|.:|:...|    |..|:..:.|..: |.:||..:   ||:
Yeast   242 ----EKMISISNLKDTDIGLVNDDANSDEKENE----KRRNLAQDEKVSD-LDWFKQRR---VRI 294

  Fly   281 PSKVHGFCYVGFKTEKDMAKGMLKNKSFIKGKQVFFSDFTEKNKVTKASKSGQP--LAPAAVDAG 343
                          ::..|:...|:.|:.          ||:|:.....|..||  ..|...|
Yeast   295 --------------KESEAETREKSSSYA----------TEQNESLDTKKEEQPERAVPQKTD-- 333

  Fly   344 NAKWKHQQDSLSKEDDISESGRIFFRNLAYTTTEEDLRKLFEQFGPVVEVNLPLDKLTRKIKGFG 408
                    :.|:.| .|:::||:|.||:.||:.|||.||||..||.:.||::.||..|.:.|||.
Yeast   334 --------EELAIE-KINQTGRLFLRNILYTSKEEDFRKLFSPFGELEEVHVALDTRTGQSKGFA 389

  Fly   409 TVTYMMPEHALKAFNTLDGTDFHGRLLHLLPSKDIEKNPKEDLDEND-ASLSFKEKKALKLKKNA 472
            .|.:...::|:.|:..||...|.|||||:||.   |:.....|||.| .::..|::|.||.|..|
Yeast   390 YVLFKDSKNAVNAYVELDKQIFQGRLLHILPG---EEKKSHRLDEFDLKNMPLKKQKELKRKAAA 451

  Fly   473 -QKPIGWNTLFLGANAVAEILAKQFKTSKERILDTSDGGSSAAVRLALGETQVVIEMKRFLEEEG 536
             ::...||:|::..:||...:|.:....|.:::|..:  ||:||:.||.|..|:.:::::.|.:|
Yeast   452 SRQTFSWNSLYMNQDAVLGSVAAKLGLEKSQLIDAEN--SSSAVKQALAEAHVIGDVRKYFESKG 514

  Fly   537 VRLDAFDE--PAKKRSNTVILAKNLPAATEISEITPIFSRFGPIGRIVLPPSGVTALIEYCDPLE 599
            |.|..|.:  ...:|.:.|||.||.|..|...|:..:|..:|.:.|:::||:|..|::::.|...
Yeast   515 VDLTKFSQLKSTNQRDDKVILVKNFPFGTTREELGEMFLPYGKLERLLMPPAGTIAIVQFRDTTS 579

  Fly   600 ARQAFKKLAYSKFKNAPLYLEWAPEQVFTKTLSGEPVIPKSEPKPKE---EVKPEEKPIVNDAKP 661
            ||.||.||:|.:||:..:|||..|:..|||....:.:|..:..|.:|   ||||....:: :|..
Yeast   580 ARAAFTKLSYKRFKDGIIYLERGPKDCFTKPAEADDLINNTSAKEEENPVEVKPSSNDLM-EANK 643

  Fly   662 D--EEDSRAEDADDEPEPNTTLFLRNLNFKTVQETVEKHFRHLGSIHTVEIAKRRDPENPREFKS 724
            |  |..|.|.|.|....|..::|::||||.|..:.:...|:........::..:.||::..:..|
Yeast   644 DVTEGSSNAHDEDVIDGPTVSIFIKNLNFSTTNQNLTDRFKVFTGFVVAQVKTKPDPKHQGKTLS 708

  Fly   725 LGYGFIQFKKSSVAEHALKNLQLTHIDGNPVELKRSDRVLKTQDNDGAQRRLASQKKQTGTKILV 789
            :|:||::|:....|...:..:..|.|||:.::||.|.|    |.:.....:..|.||  ..||:|
Yeast   709 MGFGFVEFRTKEQANAVIAAMDGTVIDGHKIQLKLSHR----QASQSGNTKTKSNKK--SGKIIV 767

  Fly   790 RNIPFQAQYREVRDIFKAFGELRSLRIPKKATTGEDAHRGFGFVDYMSKAEAKRAFDALSASTHL 854
            :|:||:|..::|.::|.:||:|:|:|:|||.   :.:.|||.||:::...||:.|.|.|. ..||
Yeast   768 KNLPFEATRKDVFELFNSFGQLKSVRVPKKF---DKSARGFAFVEFLLPKEAENAMDQLH-GVHL 828

  Fly   855 YGRRLVLEWSANDDNQDVEELRKRTAAKFDGSQAAT---AAKRS---RKSFFDVEGSVQPNQDDD 913
            .|||||::: |.:|..|.||...|...|. ..|.||   ||.|:   ||. .||         ||
Yeast   829 LGRRLVMQY-AEEDAVDAEEEIARMTKKV-RKQVATNEMAALRNGGGRKK-LDV---------DD 881

  Fly   914 EEEE 917
            ||.|
Yeast   882 EENE 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3335	NP_648337.1	RRM1_RBM19	2..77	CDD:409980	32/89 (36%)
		PABP-1234	<245..>435	CDD:130689	55/191 (29%)
		RRM3_RBM19	362..440	CDD:409983	36/77 (47%)
		RRM4_RBM19	552..623	CDD:409984	28/70 (40%)
		PRK10819	<634..>680	CDD:236768	15/50 (30%)
		RRM5_RBM19_like	679..760	CDD:409757	21/80 (26%)
		RRM6_RBM19	785..864	CDD:409985	34/78 (44%)
MRD1	NP_015437.1	RRM1_RBM19_MRD1	2..92	CDD:409754	32/89 (36%)
		PABP-1234	4..>498	CDD:130689	159/564 (28%)
		RRM2_MRD1	343..421	CDD:409982	36/77 (47%)
		RRM3_MRD1	532..603	CDD:241012	28/70 (40%)
		RRM4_MRD1	663..746	CDD:409758	22/82 (27%)
		RRM5_MRD1	763..837	CDD:241014	34/77 (44%)