DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3335 and AT4G19610

DIOPT Version :9

Sequence 1:	NP_648337.1	Gene:	CG3335 / 39119	FlyBaseID:	FBgn0036018	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_193696.3	Gene:	AT4G19610 / 827703	AraportID:	AT4G19610	Length:	816	Species:	Arabidopsis thaliana

Alignment Length:	959	Identity:	327/959 - (34%)
Similarity:	486/959 - (50%)	Gaps:	202/959 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRIIVKQLPKHITEDKLRQIFGAQGTITDLQLKYTPDGKFRQFCFVGYSTEEEAQSAIRHFDNT 65
            ||||.||.||||:.||:||..|..:|.|||.:|..:.|||.|||.|:|:.:.:|||.||::|:||
plant     1 MSRICVKNLPKHVKEDQLRDHFSQKGEITDAKLMRSNDGKSRQFGFIGFRSAQEAQQAIKYFNNT 65

  Fly    66 CIQTSRVRVESCAALGSEDKPQSWSKYAKDSKKNLDKLKEKEREAAAKAKESEK-------KKKK 123
            .:.||.:.||....:|.|:.|:.||:.:          .:||.||...:.|..|       ||:|
plant    66 YLGTSLIIVEIAHKVGDENAPRPWSRLS----------HKKEEEAKKSSSEGLKDGNAKGGKKRK 120

  Fly   124 DKVDKVDQILSRHKDDPEFQEFLEAHDKSRT-LWGNDLGINKNRENEEEDDEEQEESRAARD--- 184
            .:|           ||||||||||.|.:|:: :|.||:.|   ....||..:|:...:.|.:
plant   121 AEV-----------DDPEFQEFLEVHQRSKSKIWSNDMSI---PPAPEETGKEKVLVKKADEQIV 171

  Fly   185 DSGVDADAGDEDGSGDEADEEEDTDK-------LAEKPISDLEYMKSLMA--------------T 228
            .:||:.         .:|.:..||:|       .|...:||:||.||.:.              :
plant   172 SNGVEP---------KKAKKSSDTEKTKKSKVVAASDDVSDMEYFKSRIKKNLSDSESDNESEDS 227

  Fly   229 TSGEATAKKPKAKADKSNLELFTIKIHNVPYNTKRQEVLKFFKPLKPYSVRLPSKVHGFCYVGFK 293
            :..||.....||:.|..:.:                  :::| |:
plant   228 SEDEAGDDDGKAETDGQDAD------------------IRYF-PI-------------------- 253

  Fly   294 TEKDMAKGMLKNKSFIKGKQVFFSDFTEKNKVTKASKSGQPLAPAAVDAGNA-----KWKHQQDS 353
             :.|:..|.:       ||.                           |.|:|     ..|..|:|
plant   254 -DGDVEAGGV-------GKD---------------------------DDGDAMEVEGDGKVAQES 283

  Fly   354 LSKEDDISESGRIFFRNLAYTTTEEDLRKLFEQFGPVVEVNLPLDKLTRKIKGFGTVTYMMPEHA 418
            .:..||:.::||:|.|||.||.|||:|.:.|..||.:.||:|.|||.|::.:|...:.|::||.|
plant   284 KAVSDDVLDTGRLFVRNLPYTATEEELMEHFSTFGKISEVHLVLDKETKRSRGIAYILYLIPECA 348

  Fly   419 LKAFNTLDGTDFHGRLLHLLPSKDIEKNPKEDLDENDASLSFKEKKALKLKKNAQKPIG----WN 479
            .:|...||.:.|.|||||:||:|..|.:.|:..|.::...:||:|:  :.::.|.:..|    ||
plant   349 ARAMEELDNSSFQGRLLHILPAKHRETSDKQVNDTSNLPKTFKQKR--EEQRKASEAGGDTKAWN 411

  Fly   480 TLFLGANAVAEILAKQFKTSKERILDTSDGGSSAAVRLALGETQVVIEMKRFLEEEGVRLDAFDE 544
            :||:..:.:.|.:.:.:..||..:||..  ....|||||||||:|:.|.|..|.:.||.:.:.::
plant   412 SLFMRPDTILENIVRVYGVSKSELLDRE--AEDPAVRLALGETKVIAETKEALAKAGVNVTSLEK 474

  Fly   545 PA------KKRSNTVILAKNLPAATEISEITPIFSRFGPIGRIVLPPSGVTALIEYCDPLEARQA 603
            .|      |.||..::|.||||.|:...|:..:|.:||.:.:|:|||:...||..:.:|.|||.|
plant   475 FATRNGDEKNRSKHILLVKNLPFASTEKELAQMFGKFGSLDKIILPPTKTMALAVFLEPAEARAA 539

  Fly   604 FKKLAYSKFKNAPLYLEWAPEQVFTKTLSGEPVIPKSEPKPKEEVKPEEKPIVNDAKPDEEDSRA 668
            .|.:||.::|:|||||||||         |..:.||:.|...||....|:   |..:....:.:.
plant   540 LKGMAYKRYKDAPLYLEWAP---------GNILEPKNLPDTNEERSDIEE---NGVRRVNLEQQV 592

  Fly   669 EDADDEPEPNTTLFLRNLNFKTVQETVEKHFRHL---GSIHTVEIAKRRDPENPREFKSLGYGFI 730
            |...|..|.| .|.::||:|||..|.::|||..|   |.|.:|.|.|.:..|   ::.|.||||:
plant   593 EIDPDVTESN-VLNVKNLSFKTTDEGLKKHFTKLVKQGKILSVTIIKHKKNE---KYLSSGYGFV 653

  Fly   731 QFKKSSVAEHALKNLQLTHIDGNPV-----ELKRSDRVLKTQDNDGAQRRLASQKKQTGTKILVR 790
            :|.....|....::||.|.:||:.:     |.||||:|.|.           |.|.:..||:.|:
plant   654 EFDSVETATSVYRDLQGTVLDGHALILRFCENKRSDKVGKD-----------SNKDKPCTKLHVK 707

  Fly   791 NIPFQAQYREVRDIFKAFGELRSLRIPKKATTGEDAHRGFGFVDYMSKAEAKRAFDALSASTHLY 855
            ||.|:|..||:|.:|..||:::|:|:||| ..|:  :.|:.||::::|.||..|..|| ||||.|
plant   708 NIAFEATKRELRQLFSPFGQIKSMRLPKK-NIGQ--YAGYAFVEFVTKQEALNAKKAL-ASTHFY 768

  Fly   856 GRRLVLEWSANDDNQDVEELRKRTAAKFDGSQAATAAKRSRKSFFDVEG 904
            ||.||||| ||||| .:|.:|||:|||||......   |.|||...|||
plant   769 GRHLVLEW-ANDDN-SMEAIRKRSAAKFDEENDNA---RKRKSSKAVEG 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3335	NP_648337.1	RRM1_RBM19	2..77	CDD:241008	39/74 (53%)
		RRM_SF	250..314	CDD:302621	6/63 (10%)
		RRM3_RBM19	362..440	CDD:241011	37/77 (48%)
		RRM4_RBM19	552..623	CDD:241013	32/70 (46%)
		RRM	<638..845	CDD:223796	74/214 (35%)
		RRM5_RBM19_like	679..760	CDD:240764	31/88 (35%)
		RRM6_RBM19	785..864	CDD:241015	39/78 (50%)
AT4G19610	NP_193696.3	RRM1_MRD1	2..77	CDD:241009	39/74 (53%)
		ELAV_HUD_SF	6..367	CDD:273741	138/467 (30%)
		RRM3_RBM19_RRM2_MRD1	295..368	CDD:240762	35/72 (49%)
		ELAV_HUD_SF	296..686	CDD:273741	149/409 (36%)
		RRM4_RBM19_RRM3_MRD1	488..559	CDD:240763	32/70 (46%)
		RRM5_RBM19_like	603..683	CDD:240764	29/82 (35%)
		RRM6_RBM19_RRM5_MRD1	702..777	CDD:240766	40/79 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	73	1.000	Domainoid score	I3280
eggNOG	1	0.900	-	-		E1_KOG0110
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7158
Inparanoid	1	1.050	480	1.000	Inparanoid score	I337
OMA	1	1.010	-	-		QHG54158
OrthoDB	1	1.010	-	-		D1428854at2759
OrthoFinder	1	1.000	-	-		FOG0003677
OrthoInspector	1	1.000	-	-		otm3346
orthoMCL	1	0.900	-	-		OOG6_102169
Panther	1	1.100	-	-	LDO	PTHR23147
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3041
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840