DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3335 and AT5G08695

DIOPT Version :9

Sequence 1:	NP_648337.1	Gene:	CG3335 / 39119	FlyBaseID:	FBgn0036018	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_001119193.1	Gene:	AT5G08695 / 6241377	AraportID:	AT5G08695	Length:	690	Species:	Arabidopsis thaliana

Alignment Length:	839	Identity:	247/839 - (29%)
Similarity:	396/839 - (47%)	Gaps:	207/839 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRIIVKQLPKHITEDKLRQIFGAQGTITDLQLKYTPDGKFRQFCFVGYSTEEEAQSAIRHFDNT 65
            :||||||.:||::|||:||.||..:|.|||::||...||:.|||.::|:.:|::||.||.:|:..
plant     3 VSRIIVKNVPKYVTEDQLRGIFSEKGEITDVKLKRLSDGRSRQFAYIGFRSEQKAQDAITYFNKN 67

  Fly    66 CIQTSRVRVESCAALGSEDKPQSWSKYAKDSKKNLDKLKEKEREAAAKAKESEKKKKKDKVDKVD 130
            ...:.::.|     |.::..|                 :..:.:..|.||..::.:|||  .:||
plant    68 FKHSHQISV-----LVADPPP-----------------RRTQGKVDAYAKGDKQIQKKD--PEVD 108

  Fly   131 QILSRHKDDPEFQEFLEAHDKSRTLWGNDLGINKNRENEEEDDEEQEESRAARDDSGVDADAGDE 195
            .       ||:.||||....|.: .|.||:.|:.:  |..:|     .::|.|  |.:|:....:
plant   109 H-------DPQLQEFLHQEHKLK-FWSNDMCIHPS--NGADD-----PNKAKR--SFLDSKKTRK 156

  Fly   196 DGSGDEADEEEDTDKLAEKPISDLEYMKSLMATTSGEATAKKPKAKADKSNLELFTIKIHNVPYN 260
            ...||:              :||:||.||.:                 |.||:       :....
plant   157 SKVGDD--------------VSDMEYFKSRI-----------------KKNLD-------SDCET 183

  Fly   261 TKRQEVLKFFKPLKPYSVRLPSKVHGFCYVGFKTEKDMAKGMLKNKSFIKGKQVFFSDFTEKNKV 325
            ..|::.:..| |:                          .|.:|            :|..:|:
plant   184 DSREDAINVF-PI--------------------------DGEVK------------ADRVDKD-- 207

  Fly   326 TKASKSGQPLAPAAVDAGNAKWKHQQDSLSKEDDISESGRIFFRNLAYTTTEEDLRKLFEQFGPV 390
                           |.|:|    .:......||:.::||:|...|.|:||||:|.:.|.:||.:
plant   208 ---------------DDGHA----MEVEADGSDDVLDAGRLFVHGLPYSTTEEELMEHFSKFGDI 253

  Fly   391 VEVNLPLDKLTRKIKGFGTVTYMMPEHALKAFNTLDGTDFHGRLLHLLPSKDIEKNPKEDLDEND 455
            .||:|.|||.||..:|...|.|::||.|..|.:.||...|.||.||:||:|....:.|:  .:|.
plant   254 SEVHLVLDKDTRSCRGMAFVLYLIPESAKMAMDKLDKLPFQGRTLHILPAKPRAMSAKQ--VDNS 316

  Fly   456 ASLSFKEKKALKLKKNAQKPIG----WNTLFLGANAVAEILAKQFKTSKERILDTSDGGSSAAVR 516
            ::|....||..:.::.|.:..|    ||:.|:..:.:.|.|.:.:..:|..:||..  ....|||
plant   317 SNLPKSFKKEREEQRKASEACGNTNAWNSFFMRPDTILENLVRSYGVTKSELLDRE--CEDPAVR 379

  Fly   517 LALGETQVVIEMKRFLEEEGVRLDAFDEPA------KKRSNTVILAKNLPAATEISEITPIFSRF 575
            ||||||:|::|.|..|.:.|||:.:.:|.|      |.||..::|.|:||.|:...|:..:|.:|
plant   380 LALGETRVIMETKEALAKAGVRVTSLEEFAARKGDVKNRSKHILLVKHLPFASTEKELAQMFRKF 444

  Fly   576 GPIGRIVLPPSGVTALIEYCDPLEARQAFKKLAYSKFKNAPLYLEWAPEQVFTKTLSGEPVIPKS 640
            |.:.:|||||:...||:.:.:..|||.|...|||:::|:|||||||||..:.
plant   445 GSLDKIVLPPTKTMALVVFLEAAEARAAMNGLAYTRYKDAPLYLEWAPRDIL------------- 496

  Fly   641 EPKPKEEVKPEEKPIV--NDAKPDEEDSRAEDADDEPEPNTTLFLRNLNFKTVQETVEKHFRHL- 702
            |||...:.| |:|..|  |||:....|.:.....|..|.| .|.::||:|||..|.::||...:
plant   497 EPKALADNK-EKKSAVEENDARRVNLDQQVGIYSDITESN-VLHVKNLSFKTTDEGLKKHLTGVV 559

  Fly   703 --GSIHTV-----EIAKRRDPENPREFKSLGYGFIQFKKSSVAEHALKNLQLTHIDGNPV----- 755
              |.|.:|     :..:||         |.||||::|.....|....::|....:||:.:
plant   560 KQGKILSVKQIIRDWTRRR---------SSGYGFVEFDSVETATSVYRDLPGNVLDGHSLILNFS 615

  Fly   756 ELKRSDRVLKTQDNDGAQR--RLASQKKQTGTKILVRNIPFQAQYREVRDIFKAFGELR 812
            |.|||:.|     .:|:.:  :||        |:.|:|:.|:|..:|:|.:|..||:::
plant   616 ENKRSETV-----GEGSDKVTKLA--------KLHVKNVAFEATKKELRQLFSPFGQIQ 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3335	NP_648337.1	RRM1_RBM19	2..77	CDD:241008	34/74 (46%)
		RRM_SF	250..314	CDD:302621	5/63 (8%)
		RRM3_RBM19	362..440	CDD:241011	36/77 (47%)
		RRM4_RBM19	552..623	CDD:241013	31/70 (44%)
		RRM	<638..845	CDD:223796	56/192 (29%)
		RRM5_RBM19_like	679..760	CDD:240764	26/93 (28%)
		RRM6_RBM19	785..864	CDD:241015	10/28 (36%)
AT5G08695	NP_001119193.1	RRM1_MRD1	4..79	CDD:241009	35/79 (44%)
		ELAV_HUD_SF	6..300	CDD:273741	116/432 (27%)
		RRM3_RBM19_RRM2_MRD1	228..301	CDD:240762	34/72 (47%)
		ELAV_HUD_SF	229..618	CDD:273741	144/416 (35%)
		RRM4_RBM19_RRM3_MRD1	421..492	CDD:240763	31/70 (44%)
		RRM_SF	536..615	CDD:302621	24/87 (28%)
		RRM_SF	635..>661	CDD:302621	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	73	1.000	Domainoid score	I3280
eggNOG	1	0.900	-	-		E1_KOG0110
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7158
Inparanoid	1	1.050	480	1.000	Inparanoid score	I337
OMA	1	1.010	-	-		QHG54158
OrthoDB	1	1.010	-	-		D1428854at2759
OrthoFinder	1	1.000	-	-		FOG0003677
OrthoInspector	1	1.000	-	-		otm3346
orthoMCL	1	0.900	-	-		OOG6_102169
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3041
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.740