DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3335 and rbm19

DIOPT Version :9

Sequence 1:	NP_648337.1	Gene:	CG3335 / 39119	FlyBaseID:	FBgn0036018	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_944597.2	Gene:	rbm19 / 387255	ZFINID:	ZDB-GENE-031125-3	Length:	927	Species:	Danio rerio

Alignment Length:	978	Identity:	381/978 - (38%)
Similarity:	580/978 - (59%)	Gaps:	112/978 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRIIVKQLPKHITEDKLRQIFGAQGTITDLQLKYTPDGKFRQFCFVGYSTEEEAQSAIRHFDNT 65
            |||:|||.||..:.||:.|::|...||:||..||:|.|||||:|.|||:.|||:||.|::||:.:
Zfish     1 MSRLIVKNLPNGMKEDRFRKMFADFGTLTDCALKFTKDGKFRKFGFVGFKTEEDAQKALKHFNKS 65

  Fly    66 CIQTSRVRVESCAALGSEDKPQSWSKYAK--DSKKNLDKLKEKEREAAAKAKESEKKKKKDKVDK 128
            .:.||||.||.|...|..:|.:.|||:.:  .|||:.::.|..|        :.||:|||.|  |
Zfish    66 FVDTSRVTVELCTDFGDPNKARPWSKHTRQPSSKKDTEEKKTHE--------QGEKEKKKPK--K 120

  Fly   129 VDQILSRHKDDPEFQEFLEAHDKSRTL--WGNDLGINKNRENEEEDDEEQEESRAARDD-SGVDA 190
            :..:|...:.|..|||||..|.|...:  |.||.........|.|..:|:::..|..|| ...|:
Zfish   121 ILNVLGDLEKDESFQEFLAVHQKRGQVPTWANDTVEATAVRPEMEKKKEKKQKAAVEDDYLNFDS 185

  Fly   191 DAGDE--DGSGDEADEE--EDTDKLAEKP-ISDLEYMKSLM------------------------ 226
            |..:|  |...|.||||  :|.:|.|.|. :||::|::|.|
Zfish   186 DESEESSDDGEDAADEEDKQDNEKEALKTGLSDMDYLRSKMVEKSDMLDEKDDDSSASAADENEE 250

  Fly   227 ----------------ATTSGEATAKKPKAKADKSNLELFTIKIHNVPYNTKRQEVLKFFKPLKP 275
                            |..|||.|:.:...:........||:|:...|:|.|.|:|.:|..||||
Zfish   251 DEGKEEEESIVQHADSAYESGEKTSSQKSTRPAIEPTTEFTVKLRGAPFNVKEQQVKEFMMPLKP 315

  Fly   276 YSVRL----PSKVHGFCYVGFKTEKDMAKGMLKNKSFIKGK--QVF-FSDFTEKNKVTKASKSGQ 333
            .::|.    ..:..|:.||..::|.::.:.:..:|.::.|:  :|| .::|....:..|.|:..:
Zfish   316 VAIRFAKNSDGRNSGYVYVDLRSEAEVERALRLDKDYMGGRYIEVFRANNFKNDRRSAKRSEMEK 380

  Fly   334 PLAPAAVDAGNAKWKHQQDSLSKEDDISESGRIFFRNLAYTTTEEDLRKLFEQFGPVVEVNLPLD 398
            .......|.            .:|:|::||||:|.||:.||.|||||:::|.:.||:.||..|:|
Zfish   381 NFVRELKDD------------EEEEDVAESGRLFIRNMPYTCTEEDLKEVFSKHGPLSEVLFPID 433

  Fly   399 KLTRKIKGFGTVTYMMPEHALKAFNTLDGTDFHGRLLHLLPSKDIEKNPKEDLDENDASLSFKEK 463
            .||:|.|||..||||:||:|:.|...|||..|.||:||::.|: ::|...:...:...|.|:|.|
Zfish   434 SLTKKPKGFAFVTYMIPENAVSALAQLDGHTFQGRVLHVMASR-LKKEKADQGPDAPGSSSYKRK 497

  Fly   464 KALKLKKNAQKPIGWNTLFLGANAVAEILAKQFKTSKERILD-TSDGGSSAAVRLALGETQVVIE 527
            |..|.|..:.....|||||||.:|||:.:|:::.|:|.::|| .|||  |.|||:||||||:|.|
Zfish   498 KDAKDKAASGSSHNWNTLFLGTSAVADAIAEKYNTTKSQVLDHESDG--SLAVRMALGETQIVQE 560

  Fly   528 MKRFLEEEGVRLDAFDEPAKKRSNTVILAKNLPAATEISEITPIFSRFGPIGRIVLPPSGVTALI 592
            .::||.:.||.||:|.:.:.:||..|||.||||:..:::::..:||..|.:||::|||||:||::
Zfish   561 TRQFLLDNGVSLDSFSQASGERSKCVILVKNLPSGVQVADLEALFSPHGSLGRVLLPPSGLTAIV 625

  Fly   593 EYCDPLEARQAFKKLAYSKFKNAPLYLEWAPEQVFTKTLSGEPVIPKSEPKPKEEVKPEEKPIVN 657
            |:.:|.||::||.||||:||::.||||||||..|||     .|..|:.||:.|     |:..:.|
Zfish   626 EFLEPTEAKRAFMKLAYTKFQHVPLYLEWAPVAVFT-----TPSAPRPEPQTK-----EKSAVKN 680

  Fly   658 DAKPDEEDSRAEDADDEPEPNTTLFLRNLNFKTVQETVEKHFRHLGSIHTVEIAKRRDPENPREF 722
            |:..:||:...|:.||:..|.:|||::||||.|.:||::|.|...|.:.:..|:|:||...  :.
Zfish   681 DSVQNEEEEEEEEEDDQILPGSTLFIKNLNFITSEETLQKTFSKCGVVKSCTISKKRDKAG--KL 743

  Fly   723 KSLGYGFIQFKKSSVAEHALKNLQLTHIDGNPVELKRSDRVLKTQDNDG---AQRRLASQKKQTG 784
            .|:||||:|:|....|:.|::.||...:|.:.:|:|.|:|.:|:    |   |:|:..:.:|||.
Zfish   744 LSMGYGFVQYKTPEAAQKAMRQLQHCTVDEHQLEVKISEREVKS----GVAQAKRKKQTARKQTT 804

  Fly   785 TKILVRNIPFQAQYREVRDIFKAFGELRSLRIPKKATTGEDAHRGFGFVDYMSKAEAKRAFDALS 849
            :|||||||||||..:|:|::|..||||:::|:|||...|  :||||||:|:::|.:||:||.||.
Zfish   805 SKILVRNIPFQATVKELRELFCTFGELKTVRLPKKGIGG--SHRGFGFIDFLTKQDAKKAFSALC 867

  Fly   850 ASTHLYGRRLVLEWSANDDNQDVEELRKRTAAKFDGSQAATAAKRSRKSFFDVEGSVQPNQDDDE 914
            .|||||||||||||:  |..:.|::||::||..|.     .|.|:.||:.. :||.::..:..|.
Zfish   868 HSTHLYGRRLVLEWA--DAEETVDDLRRKTAQHFH-----DAPKKKRKAEV-LEGILEQMEVGDG 924

  Fly   915 EEE 917
            :.|
Zfish   925 DGE 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3335	NP_648337.1	RRM1_RBM19	2..77	CDD:241008	41/74 (55%)
		RRM_SF	250..314	CDD:302621	20/69 (29%)
		RRM3_RBM19	362..440	CDD:241011	43/77 (56%)
		RRM4_RBM19	552..623	CDD:241013	37/70 (53%)
		RRM	<638..845	CDD:223796	86/209 (41%)
		RRM5_RBM19_like	679..760	CDD:240764	31/80 (39%)
		RRM6_RBM19	785..864	CDD:241015	49/78 (63%)
rbm19	NP_944597.2	RRM	<2..>108	CDD:223796	51/105 (49%)
		RRM1_RBM19	2..77	CDD:241008	41/74 (55%)
		RRM_u2	129..>235	CDD:293257	35/105 (33%)
		RRM2_RMB19	290..361	CDD:240946	20/70 (29%)
		RRM	<356..>492	CDD:223796	53/148 (36%)
		RRM3_RBM19	397..475	CDD:241011	43/77 (56%)
		RRM4_RBM19	585..656	CDD:241013	37/70 (53%)
		RRM5_RBM19_like	702..781	CDD:240764	31/80 (39%)
		RRM6_RBM19	805..882	CDD:241015	49/78 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580887
Domainoid	1	1.000	97	1.000	Domainoid score	I7235
eggNOG	1	0.900	-	-		E1_KOG0110
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7158
Inparanoid	1	1.050	633	1.000	Inparanoid score	I818
OMA	1	1.010	-	-		QHG54158
OrthoDB	1	1.010	-	-		D1428854at2759
OrthoFinder	1	1.000	-	-		FOG0003677
OrthoInspector	1	1.000	-	-		oto39288
orthoMCL	1	0.900	-	-		OOG6_102169
Panther	1	1.100	-	-	LDO	PTHR23147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R745
SonicParanoid	1	1.000	-	-		X3041
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800