Protein Alignment CG3335 and mrd1

DIOPT Version :10

• Sequence 1: NP_648337.1
• Gene: CG3335 / 39119
• FlyBaseID: FBgn0036018
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_595599.1
• Gene: mrd1 / 2541303
• PomBaseID: SPBP22H7.02C
• Length: 833
• Species: Schizosaccharomyces pombe
• Alignment Length: 957
• Identity: 302/957 - (31%)
• Similarity: 476/957 - (49%)
• Gaps: 190/957 - (19%)

  Fly     1 MSRIIVKQLPKHITEDK----LRQIFGAQGTITDLQLKYTPDGKFRQFCFVGYSTEEEAQSAIRH 61
            |||||:|.:|::..::|    |:.:......|||:.:..|.:|..|:|.|:|:..||:|..|||:
pombe     1 MSRIIIKNIPRYYDKEKLSTYLKSLPQLDAEITDVSVAKTKEGVSRRFAFIGFKNEEDADKAIRY 65

  Fly    62 FDNTCIQTSRVRVESCAALGS-EDKPQSWSKYAKDSKKNLD-KLKEKEREAAAKAKESEK-KKKK 123
            .:.:.::|||:.|.......| .:|.:.:||||   .||:: ||::||:|...:..|.|| ||||
pombe    66 LNKSYVETSRIEVHRALDYRSANEKLRPYSKYA---SKNIELKLQKKEKEEELRNLEEEKAKKKK 127

  Fly   124 D---KVDKVDQILSRHKDDPEFQEFLEAHDKSRTLWGNDLGINKNRENEE--------------E 171
            |   |...:|.:      ||:.:|||:.        .:.:..:::.||||              |
pombe   128 DANLKRKFLDTL------DPKAREFLKL--------SSSISNSRSWENEEVFDTEITNPVIPADE 178

  Fly   172 DDEEQEESRAARD---------------DSGVDADAGDEDGSGDEADEEE-------DTDKL--- 211
            ||:|.::..||:.               ||||..|..::  |..|..|||       ||.|.
pombe   179 DDDEYQDLPAAKRHEGDSIKSTEHDSTLDSGVVIDGREK--SSSELHEEESEQAAEGDTAKNSGT 241

  Fly   212 -AEKPISDLEYMKSLMATTSGEATAKKPKAKADKSNLELFTIKIHNVPYNTKRQEVLKFFKPLKP 275
             |:.|:||.|::: |..|...|   |:|:.:......||
pombe   242 DAQAPLSDDEWLR-LHRTRIKE---KQPEEEVSVVGDEL-------------------------- 276

  Fly   276 YSVRLPSKVHGFCYVGFKTEKDMAKGMLKNKSFIKGKQVFFSDFTEKNKVTKASKSGQPLAPAAV 340
                                          |||.|.......:....:|:..||
pombe   277 ------------------------------KSFDKENNDEHLERVTNDKIADAS----------- 300

  Fly   341 DAGNAKWKHQQDSLSKEDD----ISESGRIFFRNLAYTTTEEDLRKLFEQFGPVVEVNLPLDKLT 401
                 ..:..::::|:::.    |||:.|:|.|||.|:..|:||:.||..||.:.:|::|:||.|
pombe   301 -----MLQKAENNVSEQERNIQLISETKRLFLRNLTYSCAEDDLKSLFGPFGQLEQVHMPIDKKT 360

  Fly   402 RKIKGFGTVTYMMPEHALKAFNTLDGTDFHGRLLHLLPSKDIEKNPKEDLDENDASLS---FKEK 463
            ...|||..:.:...:.|::|:..||...|.|||||:||:|     .:..:..:|.:||   .|::
pombe   361 NNPKGFAYIDFHDADDAVRAYLELDAKPFQGRLLHVLPAK-----ARSSILLDDYALSKLPLKKQ 420

  Fly   464 KALKLKKN-AQKPIGWNTLFLGANAVAEILAKQFKTSKERILDTSDGGSSAAVRLALGETQVVIE 527
            :.||.|.. |.....||:|::.|:||...||.:....|..|||.:  .|.:||:.||.||.|:.|
pombe   421 RELKRKNTAASSTFSWNSLYMNADAVVTSLASRLGVKKTDILDPT--SSDSAVKQALTETHVIQE 483

  Fly   528 MKRFLEEEGVRLDAFDEPAKKRSNTVILAKNLPAATEISEITPIFSRFGPIGRIVLPPSGVTALI 592
            .|.|.||.||.||||...|  ||:.|:|.||.|..|...|:|.:||.||.:|||::||:|..|:|
pombe   484 TKNFFEEHGVDLDAFKNAA--RSDNVLLVKNFPYGTSAEELTSLFSPFGELGRILIPPAGTIAII 546

  Fly   593 EYCDPLEARQAFKKLAYSKFKNAPLYLEWAPEQVFTKTLSGEPVIPKSEPKPKEEVKPEEKPIVN 657
            |:.:..:.||||.||||::.|::.||||.||..|||.:.             |:..|||....||
pombe   547 EFLNAPDCRQAFSKLAYTRIKSSILYLEKAPRDVFTTSF-------------KQSGKPELAQKVN 598

  Fly   658 DAKPDEEDSRAEDADDEPEPNTTLFLRNLNFKTVQETVEKHFRHLGSIHTVEIAKRRDPENPREF 722
            ..:....: :....|.|.....|::::||||.|.||..:|.|:.|....:..|..:.||:.|.::
pombe   599 AVEATTSE-KVGTEDIESLDTATIYVKNLNFSTKQEEFQKVFKPLEGYLSAVIRAKPDPKRPGKY 662

  Fly   723 KSLGYGFIQFK-KSS--VAEHALKNLQLTHIDGNPVELKRSDRVLKTQDNDGAQRRLASQKKQTG 784
            .|:|:||::|| |:|  .|.||:....|   ||:.:|:|.|.:.:    :..|:.|.....|..|
pombe   663 LSMGFGFVEFKDKASAVAAMHAMNGFVL---DGHKLEIKLSHQGV----DAAAEVRKQDSSKPKG 720

  Fly   785 TKILVRNIPFQAQYREVRDIFKAFGELRSLRIPKKATTGEDAHRGFGFVDYMSKAEAKRAFDALS 849
            ||||::|:||:|..::|:.:..|:|:|||:|:|||.   :.:.|||.|.::::..||..|..||.
pombe   721 TKILIKNLPFEATKKDVQSLLGAYGQLRSVRVPKKF---DRSARGFAFAEFVTAREAANAMRALK 782

  Fly   850 ASTHLYGRRLVLEWSANDDNQDVEELRKRTAAKFDGSQAATAAKRSR 896
             :|||.||.|||::::|....|::...::.|.:.:...||.:....|
pombe   783 -NTHLLGRHLVLQYASNATMDDMQHAIEKMAKEANAEAAAPSITGKR 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3335	NP_648337.1	RRM1_RBM19	2..77	CDD:409980	27/78 (35%)
		PABP-1234	<245..>435	CDD:130689	41/193 (21%)
		RRM3_RBM19	362..440	CDD:409983	33/77 (43%)
		RRM4_RBM19	552..623	CDD:409984	34/70 (49%)
		PRK10819	<634..>680	CDD:236768	8/45 (18%)
		RRM5_RBM19_like	679..760	CDD:409757	31/83 (37%)
		RRM6_RBM19	785..864	CDD:409985	35/78 (45%)
mrd1	NP_595599.1	RRM1_MRD1	2..81	CDD:409981	27/78 (35%)
		PABP-1234	<309..>479	CDD:130689	64/176 (36%)
		RRM2_MRD1	321..399	CDD:409982	33/77 (43%)
		RRM3_MRD1	506..577	CDD:241012	34/70 (49%)
		RRM4_MRD1	619..702	CDD:409758	32/85 (38%)
		RRM5_MRD1	721..796	CDD:241014	35/78 (45%)