DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanB2 and ntn5

DIOPT Version :9

Sequence 1:	NP_001287009.1	Gene:	LanB2 / 39118	FlyBaseID:	FBgn0267348	Length:	1639	Species:	Drosophila melanogaster
Sequence 2:	XP_001920036.4	Gene:	ntn5 / 796299	ZFINID:	ZDB-GENE-130530-593	Length:	839	Species:	Danio rerio

Alignment Length:	749	Identity:	200/749 - (26%)
Similarity:	280/749 - (37%)	Gaps:	266/749 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SRWSHSGSSTARLLLIGVLFASCSTAILG--AQRPPINSAGGHELRGTTFMPALECYDPYGRPQK 66
            ||:......|...||: .||.....::|.  ..:.|::....|:          .||...|||:.
Zfish     2 SRYHSPPFQTLSFLLL-FLFTLFPLSLLSPILSQSPLSWTSPHD----------PCYHLDGRPRH 55

  Fly    67 CLPEFINAAYQLQIESTNTCGEQNDNHFCIQTMNQNHKNCEFCKYNDHNPSFLTDLHDPQSPTWW 131
            ||.||||.||.:.:              .::.:.|..|.         |.|.|||||:|.:.|.|
Zfish    56 CLSEFINTAYGVPV--------------TMEDLQQGPKT---------NISTLTDLHNPHNLTCW 97

  Fly   132 QSETMFEGIQHPNYVNLTLHLGKSYDITYVRILF----RSPRPESFTIYKRTSESGPWIPYQFYS 192
               |..||....:: .|.:.||:.::|||:.:.|    .|....|.||.|.......|.|.||||
Zfish    98 ---TASEGSSGGDW-TLMVPLGRRFEITYISLQFCQQVDSVESYSITILKSMDFGQSWRPLQFYS 158

  Fly   193 ATCRDTYSLP-DSRAIRKGEGEAHALCTSEYSDISPLRD--GEI--AFSTLEGRPSGINFERSGE 252
            ..|..::..| .|.|:.|.: |...||    ||..||:.  |.|  |||||:||||..:|:.|..
Zfish   159 NDCMGSFGRPAQSIALTKHQ-ETEPLC----SDPRPLQKHRGNIVLAFSTLDGRPSSPDFDYSPG 218

  Fly   253 LQEWVTATDIRITL---------------------------DRLNTFGD--------ELFGDSQ- 281
            ||:|||||||:|..                           |:...||:        :::|:|:
Zfish   219 LQDWVTATDIKIVFHQSMDKMKKQEEKMNEVGGAYRWRERGDKALRFGEKNTGTKATDVWGNSRE 283

  Fly   282 -------------VL-------------------------------------------------- 283
                         ||
Zfish   284 KQTSTQRFKNKSTVLQSGHNVTRKEMGSQGRVGRGHRKDNSRPCQDGTCDRSLNIQQQSSKGREL 348

  Fly   284 ----------KSYF----------------------YAISDIAVGARCKCNGHASKCVPSTGMHG 316
                      ||:|                      .|:||:.||.|||||||||:|......|.
Zfish   349 RRRRNNGGRGKSHFKQRKNGSRQLVPSSLYAPTKPTLALSDLQVGGRCKCNGHASRCRRDNQGHA 413

  Fly   317 ERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANLFNRTGH- 380
                ||:|.|:|.|||||.|...:.|..|:|:|.::.:.|..|.|||.::||.|...::.::|.
Zfish   414 ----VCQCEHHTSGPDCDMCEQFFYDRPWQRATPSQPHPCVPCECNGHSNKCRFSMAVYQQSGRV 474

  Fly   381 -GGHCLDCRENRDGPNCERCKENFYMRDDGYCVN--CACDPVGSRSLQCNSHGKCQCKP-GVTGD 441
             ||.||.||.:..|.:|:.| :|.||||....:|  .||.|             |||.| |..|.
Zfish   475 SGGVCLKCRHHTTGRHCQFC-QNGYMRDHSKALNHRKACQP-------------CQCHPVGAVGR 525

  Fly   442 KCDRCDNNYYQFGPHGCQQCGCDSGGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLDKN 506
            .|::                                .||.|.|:|.|.|:|||.|.||:    |.
Zfish   526 WCNQ--------------------------------STGQCLCREGVIGQRCNRCAPGY----KQ 554

  Fly   507 NRFGCTPCF--------------CYGHTSECMTAPGYSIVSVTSNFNKF--KERWTAADLNQREV 555
            ......||.              .|....||::....|...|..|...:  |:......:..:|.
Zfish   555 GHSPLRPCIRIQEVAPPTPVYQPQYSIGEECVSYCPPSQARVRMNLETYCLKDYVLKVQVKSKER 619

  Fly   556 DIKYNQYSRSIGTT-AQGNEHVY--FQA---PDR 583
            ...:.|:|..:.:. ..|:.||.  .||   |||
Zfish   620 SGPWWQFSILVQSVFRMGSSHVKRGLQALWVPDR 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB2	NP_001287009.1	LamNT	61..296	CDD:214532	92/374 (25%)
		EGF_Lam	298..347	CDD:238012	24/48 (50%)
		Laminin_EGF	359..414	CDD:278482	23/58 (40%)
		EGF_Lam	414..458	CDD:214543	10/44 (23%)
		Laminin_EGF	461..511	CDD:278482	14/49 (29%)
		LamB	572..697	CDD:214597	8/17 (47%)
		TNFRSF	<721..848	CDD:304602
		CRD2	724..771	CDD:276900
		EGF_Lam	743..791	CDD:238012
		Laminin_EGF	847..897	CDD:278482
		Laminin_EGF	902..953	CDD:278482
		Laminin_EGF	956..1004	CDD:278482
		Laminin_EGF	1004..1050	CDD:278482
		V_Alix_like	1122..1443	CDD:187408
		Tar	1139..1521	CDD:223910
		BAR	1308..1469	CDD:299863
		vATP-synt_E	1474..>1629	CDD:304907
ntn5	XP_001920036.4	Laminin_N	51..233	CDD:322101	79/213 (37%)
		EGF_Lam	395..440	CDD:238012	24/48 (50%)
		EGF_Lam	451..509	CDD:238012	23/58 (40%)
		Laminin_EGF	515..557	CDD:278482	21/77 (27%)
		NTR_netrin-1_like	603..718	CDD:239634	12/51 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910