Protein Alignment LanB2 and lamb3

DIOPT Version :10

• Sequence 1: NP_524006.1
• Gene: LanB2 / 39118
• FlyBaseID: FBgn0267348
• Length: 1639
• Species: Drosophila melanogaster
• Sequence 2: XP_073792955.1
• Gene: lamb3 / 572057
• ZFINID: ZDB-GENE-081104-69
• Length: 1161
• Species: Danio rerio
• Alignment Length: 1741
• Identity: 345/1741 - (19%)
• Similarity: 545/1741 - (31%)
• Gaps: 732/1741 - (42%)

  Fly    16 LLLIGVLFASCSTAILGAQRPPINSAGGHELRGTTFMPALECYDPYGRPQKCLPEFINAAYQLQI 80
            ||.:..|.|.||     ||:         :.|.....||::.. ..||.|             .:
Zfish     6 LLSLAALSAMCS-----AQQ---------DCRRGACYPAMDDL-LLGREQ-------------NL 42

  Fly    81 ESTNTCGEQNDNHFCIQTMNQNHKNCEFC------KYNDHNPSFLTDLHDPQSPTWWQSETMFEG 139
            .:::|||.......|........|.|. |      .||.|....:.....|.  .||||:
Zfish    43 RASSTCGLMGSEVVCSPHGQWKMKCCP-CDSRNPAAYNAHTIQNVISSAGPN--RWWQSK----- 99

  Fly   140 IQHPNYVNLTLHLGKSYDITYVRILFRSPRPESFTIYKRTSESGPWIPYQFYSATCRDTYSLPDS 204
             :..|.|.|.|.|...|.:..|.:.|:.|||::..|.:.......|.|..:.:..|..|:....:
Zfish   100 -KDVNPVTLQLDLNGQYHLETVFLSFKGPRPDALIIERSRDYGRSWQPVLYMATNCPSTFPRVST 163

  Fly   205 RAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPSGINFERSGELQEWVTATDIRITLDRL 269
            ...|..| |.:.......:| .|.:|.:|.|..|. :.:.||.....:::.....|.:|:.|.:|
Zfish   164 SFPRSFE-ETYCYTLPSTAD-DPYKDQKIHFYPLR-QFADINLPNEYKIEVASGFTGLRVNLTQL 225

  Fly   270 NTF----GDELFGDSQVLKSYFYAISDIAVGARCKCNGHASKC--------VPSTGMHGERTLVC 322
            ...    |..|        |.:||:.::.|...|.|:|||::|        :|:|.:.|    :|
Zfish   226 GPVPSLPGRGL--------SQYYALREMKVIGSCFCHGHANRCLQDTSNNYLPNTPVGG----MC 278

  Fly   323 ECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANLFNRTGH--GGHCL 385
            ||:|||.|.:||||...||||.|:.:.|...:.||.|.||..:::|.||...:..||.  ||.|.
Zfish   279 ECQHNTAGVNCDRCDDFYNDLPWRPAESGNTHACKRCECNNHSERCHFDPERYEATGRSSGGVCD 343

  Fly   386 DCRENRDGPNCERCKENFY------MRDDGYCVNCACDPVGSRSLQCNSHGKCQCKPGVTGDKCD 444
            .|..:..||.||||:.|:|      ||....|:.|.|||.||
Zfish   344 ACAHHTTGPQCERCERNYYPNPLSDMRSADACLRCLCDPAGS----------------------- 385

  Fly   445 RCDNNYYQFGPHGCQQCGCDSGGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLDKNNRF 509
                               ::||.      ||..||:|.||:||||.||:.||.||:||:.||..
Zfish   386 -------------------ENGGQ------CDAGTGVCVCKQNVEGERCDRCKAGFYNLNANNPL 425

  Fly   510 GCTPCFCYGHTSECMTAPGYSIVSVTSNFNKFKERWTAADLNQREVDIKYNQYSRSIGTTAQGNE 574
            ||:.|.|
Zfish   426 GCSKCSC---------------------------------------------------------- 432

  Fly   575 HVYFQAPDRFLGDQRASYNRDLKFKLQLVGQVANTGVSDVILEGAGSRISLPIFAQGNGIPDQGV 639
                                                                             
Zfish   433 ----------------------------------------------------------------- 432

  Fly   640 KEYTFRLHEHHDYQWQPSQSARGFLSILSNLTAIKIRATYSVQGEAILDDVELQTAHRGAAGHPA 704
                                                                             
Zfish   433 ----------------------------------------------------------------- 432

  Fly   705 TWIEQCTCPEGYLGQFCESCAPGYRHSPARGGPFMPCIPCDCHGHADICDSETGRCICQHNTHGD 769
                                                                             
Zfish   433 ----------------------------------------------------------------- 432

  Fly   770 NCDQCAKGFYGNALGGTPNDCKRCPCPNDGACLQINEDTVICTECPKGYFGSRCEQCSDGFFGDP 834
                                                                             
Zfish   433 ----------------------------------------------------------------- 432

  Fly   835 TGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSGHFGDPLALPHGRC 899
                                 ::||:                       |||
Zfish   433 ---------------------SSVGS-----------------------LSG------------- 440

  Fly   900 DRCSCYEAGTEQDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIRSGNGCENCLCDPVGSY 964
                              .|:|:||||.|:.|:.|..|..|..||:|..|.:||:.|.|||..:.
Zfish   441 ------------------VCNQLTGQCVCRSNMEGLSCDRCAAGYWNPTSPSGCQPCGCDPDNAR 487

  Fly   965 NSTCDRYSGQCHCRPGVMGQRCDQCENYFYGFSSEGCKPCECDESGSKGFQCD-QNGQCPCNDNV 1028
            ::|||:.:|||.||||..|:.|..|.:..||....||:.|:||:.|::.  || :.|.|.|...|
Zfish   488 SATCDQRTGQCQCRPGNGGRTCSGCPDNTYGDPLIGCRRCDCDQLGTEA--CDKRTGVCRCKPGV 550

  Fly  1029 EGRRCDRCKENKYDRHRGCIDCPDCY----NLVQD-AADLHRAKLFNLSQTLDEIARTPVTNDDE 1088
            .|.|||.|..........|..||.|:    :.:|| ..||.|     |:..|......|.:.:.
Zfish   551 TGPRCDACSRGHCASFPQCPACPSCFFSMSSQLQDLTVDLER-----LTNQLLWSGGQPTSGNT- 609

  Fly  1089 FEAKLKAVQEKVAVLAQDARDNSGDGGQTYAEVIDDLHKHLDSVREHLVSADKFQADANGEIDRA 1153
             ...::.:|:.:.::.|...| :.:.|:|    ::|..:.|:::|.
Zfish   610 -SRWIQTLQQTLTLIQQSLGD-TPESGRT----VNDALQKLNTLRS------------------- 649

  Fly  1154 RQNYTILDQI-TENAKKELQQALDLLNDEGAQALAR----AKEKSVEFGQQSEQISDISREARAL 1213
             |..|:.|.: ::...::|:::||.|  |...:..|    .|...:..|.:|...|..
Zfish   650 -QMKTLRDDLPSQPLDRDLERSLDDL--ENLLSSLRLDFFTKRHGINGGGESINASAF------- 704

  Fly  1214 ADKLESEAQFDLKNAKDAKDAVEKAHQLAKSAIDLQLKIGTELRSEVGLELSHVKQSLGTVVQTS 1278
               :..:..||     .:.||:::|:                                     .:
Zfish   705 ---VAIQRSFD-----KSTDAIKRAN-------------------------------------AT 724

  Fly  1279 KEALRKANEVYDTALTLLNDVNRQTQP--EIDISQLKKD------------AVAANERADELLKQ 1329
            ::.|:|:..:.:.||:.|.||    ||  ..|:.:||||            .|...:|.:....:
Zfish   725 EDTLKKSEGIRENALSGLYDV----QPGNTKDLEKLKKDLATRPNLTPTAVKVCGGDRVEPCTPE 785

  Fly  1330 ---------------------ITELSNSNGELFADFETE----QELTEALLKRAEQ-QQLEDIEL 1368
                                 ...|.|:| ..|.|.:..    |||.:.:.|.|.| |:.||  .
Zfish   786 RCTGDMCPPNGAPPCGAEDNCAGALPNAN-RAFQDADEVKAKLQELNDKITKAAAQIQEAED--S 847

  Fly  1369 LERAKAAHDKATKAVEQG----DNTLKEANNTYEKLAGFQSDVQRSSESAEKALQ---------T 1420
            ..|.:.:.||....::|.    |..||:..:....|..|.||.|...:..::...         :
Zfish   848 ANRVRLSTDKLANQIKQARADVDGDLKDTKDFINTLRDFLSDPQSDPDQVQRVCDGVLEAQFPAS 912

  Fly  1421 VPNIE---KEIQNAESLISQAEEALDGANKNANEAKK------NAQEAQ----------LKYAEQ 1466
            |.|::   ||||:|...:..:..||:.:.....|||:      |.::|.          ||..::
Zfish   913 VENLKKKLKEIQDAMKSVPDSSGALEDSRAQLEEAKQLLKRAINTRDAAFGIQQDAESILKTMDE 977

  Fly  1467 ASKDAELIRRKANETKVAARNLREEADQLNHRVKLTEMDIFKLEESSTKDDNLVDDAKRKVGQAK 1531
            .....:.::.|.|::...|.|::::..|:...:...|..|..:.|...:...|:|..|..:...|
Zfish   978 NENILDDLKDKINQSGTIAENVKKDIQQIEDALTPAEQGIVGIPELLDEMRPLLDSLKTDLPTGK 1042

  Fly  1532 ADTQEAQKQ-------IEKANADLTAIKDELENLKDINTGDLDRLENRLATVEGEINRVNLTGRI 1589
            ....:||||       .::|..||..:|..||.:|      |...||..|. |..:..:||....
Zfish  1043 TLANDAQKQANLAQDEADRAAEDLEELKQALEQMK------LAAAENTQAG-EDSVRLLNLQKEA 1100

  Fly  1590 EK-YREQRTIQKNLIDK--------------------YDAELRELKDEVQN 1619
            |. ..:...|.|.|.||                    .||::.:|:|:::|
Zfish  1101 ESLMTDTSDIIKALKDKEVSIQQRAADIEGNSTRLLGLDAQVEKLRDDIRN 1151

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanB2	NP_524006.1	LamNT	61..296	CDD:214532	54/244 (22%)
		EGF_Lam	298..347	CDD:238012	25/56 (45%)
		Laminin_EGF	359..414	CDD:395007	23/62 (37%)
		EGF_Lam	414..458	CDD:214543	6/43 (14%)
		Laminin_EGF	461..511	CDD:395007	23/49 (47%)
		LamB	572..697	CDD:214597	0/124 (0%)
		EGF_Lam	743..791	CDD:238012	0/47 (0%)
		EGF_Lam	793..836	CDD:214543	0/42 (0%)
		Laminin_EGF	847..897	CDD:395007	5/49 (10%)
		Laminin_EGF	902..953	CDD:395007	15/50 (30%)
		EGF_Lam	956..1001	CDD:214543	19/44 (43%)
		Laminin_EGF	1004..1046	CDD:395007	15/42 (36%)
		SMC_prok_B	<1054..1621	CDD:274008	133/676 (20%)
lamb3	XP_073792955.1	None