DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB2 and lama1

DIOPT Version :10

Sequence 1:NP_524006.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster
Sequence 2:NP_001030158.1 Gene:lama1 / 569971 ZFINID:ZDB-GENE-060118-1 Length:3075 Species:Danio rerio


Alignment Length:2072 Identity:529/2072 - (25%)
Similarity:796/2072 - (38%) Gaps:635/2072 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 PEFINAAYQLQIESTNTCGEQNDNHFC-----IQTMNQNHKNCEFCKYNDHNPSF---LTDLHDP 125
            |..:|.|...:|.:..|||:.:...||     :......:..|..|..|..||..   :|:..|.
Zfish    31 PAILNLASNAEISTNATCGDPDPEMFCKLVEHVPGRRIRNPQCRICDANSQNPKEQHPITNAIDG 95

  Fly   126 QSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRI-LFRSPRPESFTIYKRTSESGPWIPYQ 189
            .: .||||.::..|.|. ::|.:||.|.:.:.:.|:.| ...||||.:: |.:|:.:...:.|:|
Zfish    96 TN-LWWQSPSIKNGRQF-HWVTVTLDLRQVFQVAYIIIKAANSPRPGNW-ILERSLDGVNFQPWQ 157

  Fly   190 FYSAT---CRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPSGINFERSG 251
            ||:.:   |...|::.........:.:...:|||.||.:.||..|||..|.:.||||..:.  :.
Zfish   158 FYAISDTECLTRYNITPRIGPPTYKRDDEVICTSYYSRLVPLEHGEIHTSLINGRPSADDL--TP 220

  Fly   252 ELQEWVTATDIRITLDRLNTFGDELFG---------DSQVLKSYFYAISDIAVGARCKCNGHASK 307
            ||.|:.:|..||:.|.|:.|...:|..         |..|.:.|:|:|.||:||..|.|.|||..
Zfish   221 ELLEFTSARFIRLRLQRIRTLNADLMTLSYRDPKDVDPIVTRRYYYSIKDISVGGMCICYGHAQS 285

  Fly   308 CV--PSTGMHGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFF 370
            |.  |.|     :.|.|.|.|||.|..|:.|.|.|:...|:..|.::.|.|:.|||:..||.||:
Zfish   286 CPWDPVT-----KKLQCVCEHNTCGESCNECCPGYHQEPWQPGTLSDGNTCEKCNCHNKADDCFY 345

  Fly   371 DANL------FNRTGH---GGHCLDCRENRDGPNCERCKENFYMRD------DGYCVNCACDPVG 420
            :..:      .|..|.   ||.|::||.|..|.|||.|.:.:|...      :..||.|.||..|
Zfish   346 NQTVADLKLSMNTHGQFTGGGVCVNCRHNTAGVNCETCADGYYRPHQVSPYAEEPCVECQCDMRG 410

  Fly   421 SRSLQC---NSH---------GKCQCKPGVTGDKCDRCDNNYYQFGPHGCQQCGCDSGGSHQNTP 473
            |.|..|   ::|         |:|.||.|..|:|||||...:..|..  |.:|.|:..|||...|
Zfish   411 SVSPVCIRDDNHANPDAGLSPGQCVCKEGFAGEKCDRCAFGFRDFPV--CSRCECNLDGSHNTDP 473

  Fly   474 ACDTETGICFCKENVEGRRCNECKPGFFNLDKNNRFGCTPCFCYGHTSECMTAPGY--SIVSVTS 536
            ..:     |.||.||.|..|:.||.||:||..:|..|||.|||:|.:..|.::..:  |:|....
Zfish   474 CME-----CVCKANVMGSHCDLCKQGFYNLQASNPEGCTECFCFGVSDVCESSTWFSSSVVHRDG 533

  Fly   537 NFNKFKER----WTAAD-----LNQREVDIKYNQYSRSIGTTAQGNEHVYFQAPDRFLGDQRASY 592
            ..::..:.    |:...     ::.|..|..    ..|:.|.|         ||:.||.::..||
Zfish   534 VLHRLHQTSISFWSPVSDENLIISNRSTDAD----PSSVWTWA---------APEPFLNNKLTSY 585

  Fly   593 NRDLKFKLQLVGQVANTGVSDVILEGAGSRISLPIFAQGNGIPDQGVKEYTFRLHEH-HD---YQ 653
            ...|.:.:.......|.   |..|     |....:..:|||...:..:.....|:.| |.   .|
Zfish   586 GSFLNYSVAYDTSEENV---DKTL-----RSHFSVIIEGNGRTLRQAQSARLLLNAHTHQRVFVQ 642

  Fly   654 WQP-----SQSARG-----FLSILSNLTAIKIRATY--SVQGEAILDDVELQTAHRGA-AGHPAT 705
            ..|     |.|.|.     .:::|:::.|:::||..  |.:|...|..|.|......: ....:.
Zfish   643 MLPQIFIDSHSGRSVQRDELMTVLADVAALRVRAELEDSAEGTLRLSHVSLGVGDSNSDVSKISL 707

  Fly   706 WIEQCTCPEGYLGQFCESCAPGYRHSPARGGPFM--PCIPCDCHGHADICDSETGRCI-CQHNTH 767
            .:|.|.||.||.|..||.|.||:...   ||...  .|:||:|:.||..||. .|.|: |.|||.
Zfish   708 DVEHCECPWGYSGTSCELCIPGFYRV---GGILFGGNCLPCECNDHATECDI-NGECLGCAHNTT 768

  Fly   768 GDNCDQCAKGFYGNALGGTPNDCKRCPCP------NDGACLQIN-EDTVICTECPKGYFGSRCEQ 825
            |.:||||..||||:|..|||:||:||.||      |.....|:. ....||.:|..||.|.:|::
Zfish   769 GPHCDQCLPGFYGDASEGTPDDCQRCSCPLTLASNNFSPTCQLQAPGEFICDQCQSGYTGDKCQR 833

  Fly   826 CSDGFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSGHFGD 890
            |:||:||:|. :.|  |.|..|:|||||||:..|.|:..|||||||:.:|||.||::|..|::||
Zfish   834 CADGYFGEPV-VPG--QRCSPCECNGNVDPSEAGRCDTHTGECLKCVGHTAGPHCERCRDGYYGD 895

  Fly   891 PLALPHGRCDRCSCYEAGTEQDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIRSGNGCEN 955
              |:....|..|.||..|:..     |.|:.:||||:||.||:|:.|..||.||..|.||.||..
Zfish   896 --AIQEKNCQACGCYSNGSLS-----TICNLITGQCECKHNVVGKTCDRCQEGYHGINSGEGCRP 953

  Fly   956 CLCDPVGSYNSTCDRYSGQCHCRPGVMGQRCDQCENYFYGFSSEGCKPC---------------- 1004
            |.|:..|:.:::||. .|:|.|..||.|.:||:|.:.:|.|...||..|                
Zfish   954 CECNQSGALSASCDE-EGRCQCITGVTGDKCDRCHHGYYNFKENGCTACDCAHTHGNCNGQTGEC 1017

  Fly  1005 ------------ECDES------------------GSKGFQCD---------------------- 1017
                        :|||.                  ||...|||                      
Zfish  1018 ICPPHTHGLKCEQCDEGHWGHDGVSGCKVCNCSVVGSSSSQCDLSSGQCVCALQFSGLTCDRCAL 1082

  Fly  1018 ---------------------------------QNGQCPCNDNVEGRRCDRCKENKYD----RHR 1045
                                             .:|||.|.|||.||.||.||...:.    ...
Zfish  1083 GYRNFPQCSACDCNPNGTRAQFCDEALGVCGCEDHGQCSCKDNVGGRGCDECKSGSFGLSALNPA 1147

  Fly  1046 GCIDCPDCYNL---VQDAADLHRAKLF--------------NLSQTLDEIARTPVTNDDEFEAKL 1093
            ||..| .|:.|   .::.:.|.||.:.              :|..||:.:    ..:|||....:
Zfish  1148 GCSPC-FCFGLSDVCEELSGLVRAPIVLGSSPALLRVVSQSDLQGTLEGV----YYSDDEMLLDV 1207

  Fly  1094 KAVQEKVAVLAQD----------------------------ARDNSGDGGQTYAEVIDDLHKHLD 1130
            ..: .|:::|...                            |:|..|...|....::...|    
Zfish  1208 DQL-NKLSLLTGPYYWRLPQKYNGNKLLSYGGRLSYTLTFFAQDGVGLANQEPQVLMRGGH---- 1267

  Fly  1131 SVREHLVSADKFQADANGEIDRARQNYTILDQITENAKKELQQALDLLNDEGAQALARAKEKSV- 1194
             :|:.::..|. .|.|||  .|:.|.:.    :||:..|......|       :|::.|...|| 
Zfish  1268 -LRKLVIYTDA-SAPANG--IRSTQEHA----LTEHKWKYFNSVSD-------EAVSHADFMSVL 1317

  Fly  1195 ---EF---------GQQSEQISDISREARALADKL------------------------------ 1217
               |:         |.|..:||:||.|....||:|                              
Zfish  1318 SNLEYVIIKASYGSGLQQSRISNISMETALEADELPEGGDVARLVEICECPPGYAGLSCQECAPG 1382

  Fly  1218 ---ESEAQFDLK----------------NAKDAKD-------------AVEKAHQLAK------- 1243
               ::.::.::|                |...:.|             |.|..|..|.       
Zfish  1383 YYRQAVSELNMKGRNRPLIQPCVPCRCSNHSQSCDLHTGQCLGCQHNTAGEHCHVCAAGYYGKVQ 1447

  Fly  1244 -SAIDLQL---------------------------KIGTELR----------------------- 1257
             |..|..|                           :.|.|.|                       
Zfish  1448 GSVSDCSLCACPLRGQSFSSTCVLEGAGDFRCDRCEEGYEGRYCERCAVGYFGNPSEPGGRCQVC 1512

  Fly  1258 --SEVG--------------------------LELSHV---------KQSLGTVVQTSKEALRKA 1285
              ||.|                          .|..||         ..|...|:....:||   
Zfish  1513 ACSESGSVHSVCDAHTGRCECKPGVRGHLCDQCEERHVLVHEQCVSCNDSCTGVLLDDLDAL--- 1574

  Fly  1286 NEVYDTALTLLN-------------DVNRQTQPEIDISQLKK-------DAVAANERADELLKQI 1330
                |.::|.:|             .:..||:   :::.|..       ...|..|.:..|..||
Zfish  1575 ----DVSITSVNLTGVILAPYSQLMTIQNQTR---ELTSLMSWNQTPDYQLTAGEEHSRNLSGQI 1632

  Fly  1331 TELSNSNGELFADFETEQELTEALLKRAEQQQLEDIELLERAKAAHDKATKAVEQG-------DN 1388
            |:|......:|.|       :..:|..:||:..:..:|||.....|......|||.       |.
Zfish  1633 TDLQQQVQSVFED-------SGDVLLTSEQRFTQGKQLLELINNIHSAIHGLVEQVSSVNVTLDE 1690

  Fly  1389 TLKEANNTY---------EKLAGFQ-------SDVQRSSESAEKALQTVPNIEKEIQ-------- 1429
            .|.|||:|:         ||:..|.       :::|.||     |:..:..:|.||.        
Zfish  1691 GLDEANSTFLLEETSETLEKIRSFNLTHCRNAAEIQLSS-----AVSVLEKVEDEISKPYRNNQI 1750

  Fly  1430 ---------NAESL-ISQAEEALDGANKNANEAKK----------------------------NA 1456
                     |..:| :.|.:|:|..|..:.|::::                            ..
Zfish  1751 RRENISTTLNTHNLSLQQVQESLYTAKTHNNQSRRLLQDIQSNTHTLTISRNNVSSLNHELETQV 1815

  Fly  1457 QEAQ------LKYAEQASKDAELIRRKANETKVAARNLREEADQLNHRVKLTEMDIFKLEESSTK 1515
            ||||      |..||.....|..:....|:.::.:.:||:..|.|       .||:.|       
Zfish  1816 QEAQDLLTDALNIAEDMDNGATTLDELKNDLELWSPSLRKHVDSL-------VMDLTK------- 1866

  Fly  1516 DDNLVDDAKRKVGQAKADTQEAQKQIEKANADLTAIKDELENLKDINTGDLDRLEN-------RL 1573
                 .||.:.|.:|:...|...||.:..|:.|:.:.....|:......:.:..||       .|
Zfish  1867 -----RDALQLVYRAEDHAQALSKQAQALNSSLSEVSSASVNISIATRTNANIRENIQLAADLAL 1926

  Fly  1574 ATVEGEINRVNLTGRIEKYREQRTIQKN--LIDKYDAELRELKDE-VQNIGLISKAL 1627
            |..:...:.:|:|...|  :|:|.:||:  ::|: .|.|:...|. :||:..::..|
Zfish  1927 AANQNASSALNMTSLTE--QEKRRLQKSSEILDR-AALLKNHTDGLMQNVSAVTSRL 1980

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB2NP_524006.1 LamNT 61..296 CDD:214532 72/247 (29%)
EGF_Lam 298..347 CDD:238012 20/50 (40%)
Laminin_EGF 359..414 CDD:395007 23/69 (33%)
EGF_Lam 414..458 CDD:214543 20/55 (36%)
Laminin_EGF 461..511 CDD:395007 20/49 (41%)
LamB 572..697 CDD:214597 31/140 (22%)
EGF_Lam 743..791 CDD:238012 27/48 (56%)
EGF_Lam 793..836 CDD:214543 18/49 (37%)
Laminin_EGF 847..897 CDD:395007 27/49 (55%)
Laminin_EGF 902..953 CDD:395007 23/50 (46%)
EGF_Lam 956..1001 CDD:214543 16/44 (36%)
Laminin_EGF 1004..1046 CDD:395007 22/146 (15%)
SMC_prok_B <1054..1621 CDD:274008 158/886 (18%)
lama1NP_001030158.1 LamNT 25..275 CDD:214532 73/248 (29%)
EGF_Lam 277..324 CDD:238012 20/51 (39%)
EGF_Lam <364..390 CDD:238012 12/25 (48%)
Laminin_EGF 404..463 CDD:395007 22/60 (37%)
Laminin_EGF 461..506 CDD:395007 20/49 (41%)
Laminin_B 571..710 CDD:459652 32/155 (21%)
EGF_Lam 744..792 CDD:238012 27/48 (56%)
Laminin_EGF 809..849 CDD:395007 16/42 (38%)
EGF_Lam 851..903 CDD:238012 27/53 (51%)
Laminin_EGF 905..951 CDD:395007 23/50 (46%)
Laminin_EGF 954..1001 CDD:395007 18/47 (38%)
EGF_Lam 1000..1045 CDD:238012 4/44 (9%)
Laminin_EGF 1047..1095 CDD:395007 5/47 (11%)
Laminin_EGF 1093..1149 CDD:395007 13/55 (24%)
Laminin_B 1221..1363 CDD:459652 32/160 (20%)
EGF_Lam <1365..1385 CDD:238012 0/19 (0%)
Laminin_EGF 1407..1453 CDD:395007 7/45 (16%)
Laminin_EGF 1456..1509 CDD:395007 3/52 (6%)
Laminin_EGF 1512..>1549 CDD:395007 4/36 (11%)
Laminin_I 1580..1842 CDD:310534 54/276 (20%)
COG4372 1722..2043 CDD:443500 58/286 (20%)
Laminin_II 2015..2148 CDD:368703
LamG 2133..2281 CDD:238058
LamG 2310..2466 CDD:238058
LamG 2491..2641 CDD:238058
Laminin_G_1 2750..2877 CDD:395008
LamG 2897..3048 CDD:238058
Blue background indicates that the domain is not in the aligned region.

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