DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanB2 and lamc2

DIOPT Version :9

Sequence 1:	NP_001287009.1	Gene:	LanB2 / 39118	FlyBaseID:	FBgn0267348	Length:	1639	Species:	Drosophila melanogaster
Sequence 2:	XP_003197932.2	Gene:	lamc2 / 567928	ZFINID:	ZDB-GENE-110222-3	Length:	1182	Species:	Danio rerio

Alignment Length:	1357	Identity:	376/1357 - (27%)
Similarity:	580/1357 - (42%)	Gaps:	292/1357 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 CDRCL--PLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANLFNRTGHGGHCLDCRENRDGPN 395
            |..|:  |::..:   ||:|       ||:|:|.|..|..|.       .|.:||:|:.|..|.:
Zfish    55 CAFCIWTPVHGTV---RSSS-------ACSCHGKARFCRADQ-------LGLYCLNCQGNTQGRH 102

  Fly   396 CERCKENFY-MRDDGYCVNCACDPVGSRSLQCNSHGKCQCKPGVTGDKCDRCDNNYYQFGPHGCQ 459
            ||.|||.:| .|....||.|.|:|.||:...|:|:|:|.||.|:.|||||||.:
Zfish   103 CESCKEGYYHQRAGDNCVPCNCNPAGSQGPVCSSNGQCTCKQGIHGDKCDRCHD----------- 156

  Fly   460 QCGCDSGGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLDKNNRFGCTPCFCYGHTSECM 524
                   ||......|:.....|:.:.|  ||..       :|.::     |.||||.||::.|.
Zfish   157 -------GSPVTANGCEPLRLRCWSRNN--GRLT-------YNTEE-----CLPCFCNGHSNVCS 200

  Fly   525 TAPGYSIVSVTSNFNKFKERW---TAADLNQREVDIKYNQYSRSIGTTAQGNEHVYFQAPDRFLG 586
            :|.|||:.::||.|....|.|   ||..:|..:|..:::...:.:...::....||..||..:||
Zfish   201 SAEGYSVYNITSPFENGPEGWRAATAQGVNPSQVQFRWSPTHKDLEVISKEILPVYLFAPATYLG 265

  Fly   587 DQRASYNRDLKFKLQLVGQVANTGVSDVILEGAGSRISLPIFAQGNGIPDQGVKEYTFRLHEHHD 651
            ::..||.:.|.|.|:|...|.....|||:|||||.::|..:......:|......|||||.|...
Zfish   266 NRALSYGQTLTFSLRLDRGVRRPSTSDVVLEGAGLKVSASLGDLRTVVPCGKKITYTFRLDEQPG 330

  Fly   652 YQWQPSQSARGFLSILSNLTAIKIRATYSVQGEAILDDVELQTAHRGAAGHPATWIEQCTCPEGY 716
            .:|:|..|:..|.::||||||||||.|:...|...||||.|.:|..| .|.||.|:|:|.||..|
Zfish   331 SKWKPQLSSAEFQTLLSNLTAIKIRGTFGENGRGYLDDVSLVSAKLG-PGTPALWVEKCRCPAEY 394

  Fly   717 LGQFCESCAPGYRHSPARGGPFMPCIPCDCHGHADICDSETGRCICQHNTHGDNCDQCAKGFYGN 781
            .|.|||.||.|:|......||..||:||.|.|.|  ||.|||.|......  .|...|.:|:|.|
Zfish   395 DGHFCEHCATGFRRLIPGQGPRSPCVPCSCQGGA--CDPETGGCYSADEI--PNLQMCPRGYYVN 455

  Fly   782 ALGGTPNDCKRCPCPNDGACLQI-NEDTVICTECPKGYFGSRCEQCSDGFFGDPTGLLGEVQTCK 845
            .  ...|.|::|||....:|..| ....|.||.||:|..|||||.|.|||:|||.|..|..:.|:
Zfish   456 R--QLSNSCQKCPCREGDSCYVIGGTQEVTCTRCPRGTTGSRCEICDDGFYGDPLGEYGPRKQCQ 518

  Fly   846 SCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSGHFGDPLALPHGRCDRCSCYEAGTE 910
            .|.|.|:||.||||||:|.||:|.||::::.|.:|:.|                      |||
Zfish   519 PCQCYGHVDQNAVGNCDRRTGQCRKCLNHSTGPNCEYC----------------------EAG-- 559

  Fly   911 QDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIRSGNGCENCLCDPVGSYNSTCDRYSGQC 975

Zfish   560 ----------------------------------------------------------------- 559

  Fly   976 HCRPGVMGQRCDQCENYFYGFSSEGCKPCECDESGSKGFQCDQNGQCPCNDNVEGRRCDRCKENK 1040
                            |.:.:.:|.|:.|.|:..||....|...|||.|.:..:|.||:..
Zfish   560 ----------------YHHNYPTEPCQACNCNRQGSVSNSCSDKGQCECKEGYDGLRCEES---- 604

  Fly  1041 YDRHRGCIDCPDCYNLVQDAADLHRAKLFNLSQTLDEIAR------TPVTNDDEFEAKLKAVQEK 1099
                    .||.|:|.|:...:::..:|    |.::::.:      .|| :|.:.:..::|.:
Zfish   605 --------TCPSCFNPVKSKIEVYARQL----QEMEDLFKGFGGNEAPV-SDAQMDQAVRAAE-- 654

  Fly  1100 VAVLAQDARDNSGDGGQTYAEVIDDLHKHLDSVREHLVSADKFQADANGE-----IDRARQNYTI 1159
              |:.::....:.:...|..::.|.|..         :|..:.:.|.|.|     ::..|.|
Zfish   655 --VMVRNLESRANELTNTEKQLQDKLAS---------ISRSQLREDRNMEALLTSVNGIRNN--- 705

  Fly  1160 LDQITENAKKELQQALDLLNDEGAQALARAKEKSVEFGQQ---SEQISDISREARALADKLESEA 1221
             ||.......|:::.:..:..:..||....:|..:..|..   |..:||:.:.|..||::.:.||
Zfish   706 -DQQYRTEVSEIRKLISDVRSKLQQAKRDMQEIEIPSGDAVPGSGTLSDLVQRAADLAEQHQGEA 769

  Fly  1222 QFDLKNAKDAKDAVEKAHQLAKSAIDLQLKIGTELRSEVGLELSHVKQSLGTVVQTSKEALRKAN 1286
            ......|.::....|||..|.:..|:.:.|:..|:|.        :|:.....|....:..||||
Zfish   770 LTVEGIADNSLAQSEKALDLIRGIINRENKVKDEIRD--------LKREYEADVNKVLDMDRKAN 826

  Fly  1287 EVYD----------TALTLLNDVNRQTQPEIDISQLKKDAVAANERADELLKQITELSNSNGELF 1341
            ::.|          .||..|:|:.::..     ..|.|:........|. ||.:.|   .|...:
Zfish   827 QLTDAAGKESGEAQNALQQLSDLEKKLP-----KPLTKEIAGVVSMFDN-LKGLVE---GNLSQY 882

  Fly  1342 ADFE----TEQELTEALLKRAEQ-QQLEDIELLERAKAAHDKATKAVEQGDNTLKEANNTYEKLA 1401
            :|.:    .||:.|..||.:|:. ||::| |||.||.||.....:::|...|.......|.|.|.
Zfish   883 SDLQQYMLNEQKETGDLLIKAKNFQQIQD-ELLARANAAEAVKNQSLEIFANNKDSLEKTLETLK 946

  Fly  1402 GFQSDVQRSSESAEKALQTVPNIEKEIQNAESLISQAEEALDGANKNANEAKKNAQEAQLKYAEQ 1466
            ||...:....:.|:.|:..:|.:...||.|.:...|.::.||.    ..:..::|||.
Zfish   947 GFDDQIGVKKDLADAAISKLPAVNATIQKAIADNMQTQDILDA----MADPFRDAQET------- 1000

  Fly  1467 ASKDAELIRRKANETKVAARNLREEADQLNHRVKLTE-MDIFKLEESSTKD--DNLVDDAKRKVG 1528
                .:.:.....:.:....:|...:|.|....||.| :|..|.|.|:|:|  :.....||.::.
Zfish  1001 ----IDTLTSNVYKLEGMTSSLPSSSDILEAASKLKEDVDGLKTEASATRDRLNEEKSKAKAQIN 1061

  Fly  1529 QAKADTQEAQKQIEKANADLTAIKDELENLKDI-----NTGDLDRLENRLATVEGEINRVNLTGR 1588
            :||....|:...:|.|.....|:.|.|:::.||     ..|.:|  :.|:|.:|..|.:..  .|
Zfish  1062 EAKNAVVESNGVLENAKKARNAVNDTLQDIADIMSSLGTPGTID--DKRVADLENAITKSR--RR 1122

  Fly  1589 IE-----KYRE-------QRTIQKNLIDKYDAELRELKDEVQNIGLISKALPDSCFS 1633
            :|     |.||       ||.....:|:..|..|.    ::.|:..|.|.:|:.||:
Zfish  1123 VEDELRPKLRELEAKDAQQRATITGMINDIDTILA----DIANLEEIHKNIPEGCFN 1175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB2	NP_001287009.1	LamNT	61..296	CDD:214532
		EGF_Lam	298..347	CDD:238012	3/15 (20%)
		Laminin_EGF	359..414	CDD:278482	21/55 (38%)
		EGF_Lam	414..458	CDD:214543	19/43 (44%)
		Laminin_EGF	461..511	CDD:278482	8/49 (16%)
		LamB	572..697	CDD:214597	51/124 (41%)
		TNFRSF	<721..848	CDD:304602	54/127 (43%)
		CRD2	724..771	CDD:276900	19/46 (41%)
		EGF_Lam	743..791	CDD:238012	17/47 (36%)
		Laminin_EGF	847..897	CDD:278482	20/49 (41%)
		Laminin_EGF	902..953	CDD:278482	3/50 (6%)
		Laminin_EGF	956..1004	CDD:278482	3/47 (6%)
		Laminin_EGF	1004..1050	CDD:278482	12/45 (27%)
		V_Alix_like	1122..1443	CDD:187408	81/343 (24%)
		Tar	1139..1521	CDD:223910	95/407 (23%)
		BAR	1308..1469	CDD:299863	43/165 (26%)
		vATP-synt_E	1474..>1629	CDD:304907	43/174 (25%)
lamc2	XP_003197932.2	Laminin_EGF	73..122	CDD:278482	21/55 (38%)
		EGF_Lam	121..166	CDD:238012	21/62 (34%)
		Laminin_B	256..374	CDD:278481	49/117 (42%)
		Laminin_EGF	465..509	CDD:278482	23/43 (53%)
		EGF_Lam	519..570	CDD:238012	25/155 (16%)
		EGF_Lam	572..>603	CDD:214543	12/30 (40%)
		MCPsignal	647..868	CDD:278444	48/250 (19%)
		V_Alix_like	648..943	CDD:187408	73/329 (22%)
		TACC	783..944	CDD:282818	46/178 (26%)
		LXG	817..1017	CDD:282581	52/224 (23%)
		COG1340	889..1137	CDD:224259	70/267 (26%)
		ApoLp-III_like	991..1141	CDD:304399	38/164 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10738
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D156553at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920