DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanB2 and si:ch211-241e1.3

DIOPT Version :9

Sequence 1:	NP_001287009.1	Gene:	LanB2 / 39118	FlyBaseID:	FBgn0267348	Length:	1639	Species:	Drosophila melanogaster
Sequence 2:	XP_696031.6	Gene:	si:ch211-241e1.3 / 567640	ZFINID:	ZDB-GENE-030131-230	Length:	1368	Species:	Danio rerio

Alignment Length:	1037	Identity:	228/1037 - (21%)
Similarity:	371/1037 - (35%)	Gaps:	321/1037 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   657 SQSARGFLSILSNLTAIKIRATYSVQGEAILDDVELQTA-----HRGAAGHPATWIEQCTCPEGY 716
            |...||....::..||: :||.  :.|...|    |.:|     ||......|.||::....:..
Zfish    27 SNKQRGMSESMAWRTAV-LRAL--ISGTLFL----LVSAGPRPEHRSPQREEAEWIQRAQLNDAQ 84

  Fly   717 LGQF----------------CESCAPGYRHSPARGGPFMPCIPCDCHGHADICDSETGRCI-CQH 764
            ..||                .:.|..|  |...|.|.|..|:||.|:||::.|:..||||: |..
Zfish    85 RVQFPSLHDTQQVQIPTLEDGQRCPAG--HYLDRSGLFPRCVPCSCNGHSNECEENTGRCLNCAD 147

  Fly   765 NTHGDNCDQCAKGFYGNALGGTPNDCKRCPCPNDGACLQINEDTVICTE--------CPKGYFGS 821
            ||.|..|:.|.:|||.:.   ....|..||||...   |.|...|.|||        |..|:.|.
Zfish   148 NTAGQRCELCKEGFYWSE---ARRKCTACPCPLGN---QDNNFAVGCTETQSRIQCVCKTGHAGE 206

  Fly   822 RCEQCSDGFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSG 886
            |||:|:.|::|||....|   .|:.|.|.||:       |:..||.|
Zfish   207 RCERCASGYYGDPLVYGG---GCRPCRCAGNL-------CDSKTGAC------------------ 243

  Fly   887 HFGDPLALPHGRCDRCSCYEAGTEQDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIRSGN 951
                          |.|.....|..:||                      |.||          :
Zfish   244 --------------RNSLELQDTNTEEQ----------------------CEEC----------D 262

  Fly   952 GCENCLCDPVGSYNSTCDRYSGQCHCRPGVMGQRCDQCENYFYGFSSEGCKPCECDESGSKGFQC 1016
            .|...|.:.:........|..||.
Zfish   263 NCAQTLLNDLEKLEMELRRIKGQA----------------------------------------- 286

  Fly  1017 DQNGQCPCNDNVEGRRCDRCKENKYDRHRGCIDCPDCYNLVQDAADLHRAKLFNLSQTLDEIART 1081
                                   .:|..|     |....|::...|...|.. ||..|
Zfish   287 -----------------------DFDSLR-----PSSKALLKQLEDAITATK-NLVNT------- 315

  Fly  1082 PVTNDDEFEAKLKAVQEKVAVLAQDARDNSGDGGQTYAEVIDDLHKHLDSVREHLVSADKFQADA 1146
                   |...:.:...|:..|.||.           ..:.||:....:.||:....:.|..|:|
Zfish   316 -------FSFAVNSQMPKIVQLEQDV-----------INLADDMDSLKEEVRKRSGDSQKALANA 362

  Fly  1147 NGEIDRARQNYTILDQITENAKKELQQALDLLND---EGAQA----LARAKEKSVEFGQQSEQIS 1204
            .....||:.    ||..|:|...::::.|..|.|   :|:..    ||:..|||....:..|:.|
Zfish   363 ENSHQRAKD----LDTETQNLLTKIRELLKQLMDAKSDGSSLPSADLAKLLEKSENMVKDMEKRS 423

  Fly  1205 -----DISREARALADK-LESEAQFDLKNAKDAKDAVEKAHQLAKSAIDLQLKIGTELRSEVGLE 1263
                 |.:::.:|.|:| ||     |:||.....|..|:|   :|....|.....|:|:
Zfish   424 FTTQKDAAKKEQAEANKFLE-----DVKNIVKQCDQNEEA---SKRVDGLLSNYETKLK------ 474

  Fly  1264 LSHVKQSLGTVVQTSKEALRKANEVYDTALTLLNDVNRQTQPEI-----DISQLKKDAVAANERA 1323
                  .|..:::.::..::||..        |||||.|...:|     |: |.::|.|     .
Zfish   475 ------ELEDLLKQAENMVKKAKN--------LNDVNAQGLKDILKRVNDL-QRERDVV-----R 519

  Fly  1324 DELLKQITELSNSNG--ELFADFETEQELTEALLKRAEQQQLEDIELLERAKAAHDKATKAVEQG 1386
            |:::....:|.::..  ::|.|.:||.|...|.|..|:....:.::.:.:|.|..    |.|:|.
Zfish   520 DQIVLATDQLKDTQDLLKMFNDGKTEYEQLAAQLNGAKTDLKKKLQTVSQAAAKE----KLVQQA 580

  Fly  1387 DNTLKEANNTYEKLAGFQSDVQRSS-----ESAEKALQTVPNIEKEIQNAESLISQAEEALDGAN 1446
            :   :.|.|.|:.....|..||..|     :.|...::...||...:..||....:|:||.|.|.
Zfish   581 E---EHAENMYKLAKELQDAVQNVSGRSGVQDALSGIEAYKNITDAVNAAEEAAKKAKEAADKAL 642

  Fly  1447 KN---------ANEAKKNAQEAQLKYAEQASKDAELIRRKANETKVAARNLREEADQL---NHRV 1499
            .:         |.:.|.|.... ||.|:..:||          .|.|.::|.|:.::|   ..:.
Zfish   643 NDVSQGDLINRAQDLKTNGSNL-LKTAKNTAKD----------LKGATKDLTEQKNRLQDAEKKK 696

  Fly  1500 KLTEMDIFKLEE---SSTKDD--NLVDDAKRKVGQAKADTQEAQKQIE--KANADLTAIKDELEN 1557
            |..|.::.|:::   ...:||  .::|.||:....|...|.:...|:.  ||.....:|...:.|
Zfish   697 KALEEELLKIQDGLKGIQRDDIAKIIDAAKKTAAAANRSTSDTMDQLNDIKAEVKKISITPTVSN 761

  Fly  1558 LKDINTGDLDRLENRLATVEGEINRVNLTGRIEKYREQRTIQKNLIDKYDAELRELKDEVQN 1619
            :.::    |:.::..:..|.|.|  .:|..:|::...|.....|:.|..: :::||.::.::
Zfish   762 MDNV----LNNVDMTVKNVSGSI--PSLLDKIDELNNQINYGNNVSDNIN-KIKELIEQARD 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB2	NP_001287009.1	LamNT	61..296	CDD:214532
		EGF_Lam	298..347	CDD:238012
		Laminin_EGF	359..414	CDD:278482
		EGF_Lam	414..458	CDD:214543
		Laminin_EGF	461..511	CDD:278482
		LamB	572..697	CDD:214597	11/44 (25%)
		TNFRSF	<721..848	CDD:304602	50/135 (37%)
		CRD2	724..771	CDD:276900	21/47 (45%)
		EGF_Lam	743..791	CDD:238012	19/48 (40%)
		Laminin_EGF	847..897	CDD:278482	8/49 (16%)
		Laminin_EGF	902..953	CDD:278482	7/50 (14%)
		Laminin_EGF	956..1004	CDD:278482	4/47 (9%)
		Laminin_EGF	1004..1050	CDD:278482	2/45 (4%)
		V_Alix_like	1122..1443	CDD:187408	84/345 (24%)
		Tar	1139..1521	CDD:223910	100/423 (24%)
		BAR	1308..1469	CDD:299863	42/176 (24%)
		vATP-synt_E	1474..>1629	CDD:304907	31/156 (20%)
si:ch211-241e1.3	XP_696031.6	EGF_Lam	125..>162	CDD:238012	17/36 (47%)
		TNFRSF	142..>263	CDD:328932	50/200 (25%)
		Laminin_EGF	<196..226	CDD:278482	12/32 (38%)
		Laminin_I	293..541	CDD:310534	69/311 (22%)
		OmpH	520..>599	CDD:332039	19/85 (22%)
		Laminin_II	733..850	CDD:283628	17/91 (19%)
		LamG	873..1011	CDD:214598
		LamG	1043..1186	CDD:238058
		LamG	1215..1340	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1836
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810