Protein Alignment LanB2 and ntng2a

DIOPT Version :10

• Sequence 1: NP_524006.1
• Gene: LanB2 / 39118
• FlyBaseID: FBgn0267348
• Length: 1639
• Species: Drosophila melanogaster
• Sequence 2: NP_001429168.1
• Gene: ntng2a / 560014
• ZFINID: ZDB-GENE-081105-186
• Length: 1256
• Species: Danio rerio
• Alignment Length: 1322
• Identity: 239/1322 - (18%)
• Similarity: 390/1322 - (29%)
• Gaps: 445/1322 - (33%)

  Fly    53 PALECYDPYGRPQKCLPEFINAAYQLQIESTN-TCGEQNDNHFCIQTMNQNHKNCE-FCKYNDHN 115
            |..|.|....:|.. :.|::    |:::|..: |||...:.:..::........|: ..|...|.
Zfish    40 PTWEYYACQPKPMS-MKEYM----QIRVEPPDITCGNPPERYCTLENPYLCSDECDASTKELAHP 99

  Fly   116 PSFLTDLHDPQSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDIT-YVRILFRSPRPESFTIYKRT 179
            |..:.|.......|:||:.| :.....|...|::|...||.::| .::|.|...||....:.|..
Zfish   100 PELMQDSERTGLITYWQTVT-WSRYPEPLLANISLSWNKSLELTDDIQISFEYGRPTIMVLDKSL 163

  Fly   180 SESGPWIPYQFYSATCRDTYSLPDSRA-IRKGEGEAHALCTSEYSD-ISPLRDGEIAFSTLE--- 239
            :....|.|||:|:..|.:.:.:...|. ..........:||.:||. :....:..:.|...|
Zfish   164 NYGRTWQPYQYYADDCMEAFGMLAKRVQDLSATNVTRVICTEQYSRWVGSKNEKNVRFEVRERFA 228

  Fly   240 ----GRPSGIN-----FERSGELQEWVTATDIRITLDRLNTFGDELFGDSQVLKSYFYAISDIAV 295
                .:...::     .|....|:::.|.|::|:.|.|....|..:..|:  |..||||||:|.:
Zfish   229 IFAGAKLQNMDNLYTRMESMKGLRDFFTFTNLRLRLLRPALGGTYVQKDN--LLKYFYAISNIDI 291

  Fly   296 GARCKCNGHASKCVPSTGMHGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRST-----STEVNE 355
            .||||||.||.:|....|     ||.|:|.|||.|.||..|...:....||..:     :...|.
Zfish   292 PARCKCNLHAGQCSLRDG-----TLQCDCEHNTTGQDCLVCERGFKAKSWKPGSYLPTPNGSPNI 351

  Fly   356 CKACNCNGLADKCFFDANLFNRTGHGGHCLDCRENRDGPNCERCKENFYMRDDGYCVNCACDPVG 420
            |:|...:|:.                                             .:....||..
Zfish   352 CEASGTSGMP---------------------------------------------TLAVTLDPAT 371

  Fly   421 SR------------SLQCNSHGKCQCKP-------------GVTGDKCDRCDNNYYQFGPHGCQQ 460
            :.            .|..:|..|...:|             ....|.....|.:
Zfish   372 APVLITTSISPFIVQLTSDSTTKGSVQPISVPQTPDPSASLDTITDTATSSDTS----------- 425

  Fly   461 CGCDSGGSH-----QNTPAC------DTET----------------------------------- 479
               .:|||.     .||||.      ||.|
Zfish   426 ---TAGGSAIPESLTNTPAATISSQTDTSTLTTMPSPSNPALTVIPTTPDQPVSAAPDVIPDAAT 487

  Fly   480 --------GICFCKENVEG---------RRCNECKPGFFNLDKNNRFGCTPCFCYG-------HT 520
                    ...|...|...         ...::......|:........||.....       :|
Zfish   488 TATDTVFATTAFGASNPRSALPEVTDALASSSDATATTLNMVIRATMATTPSVTMATSETTSDNT 552

  Fly   521 SECMTAPGYSIVSVTSNFNKFKERWTAADLNQR-----------------EVDIKYNQYSRSIGT 568
            .:..|:|....||..      .|..||...|..                 ::|:..:..|..:.:
Zfish   553 IQLPTSPSNDAVSPP------VETSTAGSENMAAVPSTDATMKTVDELPPDIDVVVSATSVPLPS 611

  Fly   569 TAQGNEHV------YFQAPDRFLGDQRASYNRD----LKFKLQLVGQVANTGVSD---VILEGAG 620
            .:..:..|      ...||....|....:.:.|    ....|:.......|.|||   ...||.|
Zfish   612 PSDRDAPVIDADPTITDAPAPEAGSIAPARDADAPATAAVALETDEDAEVTNVSDETKAAPEGPG 676

  Fly   621 ----------SRISLPIFAQGNGI------------------PDQGVKEYTFRLHEHHDYQWQ-P 656
                      ..:|..:.:..:|:                  |....||......:....:.| |
Zfish   677 DGAEVVMRSEETVSTDVDSPTSGVTLLTGEPVPDATPPPESKPPPETKEEKTEAKDKDTPEIQAP 741

  Fly   657 SQSARGFLSILSNLTAIK--------------IRATYSVQGEAILDDVELQTAHRGAAGHPATWI 707
            |:.......:|..:...|              |:.:..|:.:..:..||::..      ..||.:
Zfish   742 SEVEEKIEELLVEIKEDKTETDLVNEDEDAPDIKPSSEVEEKRDVPLVEIKEK------ETATNL 800

  Fly   708 EQCTCPEGYLGQFCESCAPGYRHSPARGGPFMPCIPCDCHGHADICDSETGRCICQHNTHGDNCD 772
            |.            |.........|:.....|..:|.:....             :..|:.:|.|
Zfish   801 EN------------EDKDASDIKLPSEVEEKMEDLPVEIQEE-------------KQKTNVENED 840

  Fly   773 QCAKGFYGNA---------LGGTPNDCKRCPCPNDGACLQI---------NEDTVICT------- 812
            :.......::         ||.|..| |.....:|...|.:         |||.::.|
Zfish   841 KDTPDIKPSSEVEEKSEVPLGETTED-KPSTKLDDKDTLDVKTSPEIEEKNEDPLVETKEEKTTK 904

  Fly   813 -----------------------ECPKGYFGSRCEQCSDGFFGDPTGLLGEVQTC---------- 844
                                   |.|:.....:.....|.......|...|:...
Zfish   905 KDEDASDSKPPFKVRENSEEPKMEKPETNLEKKDNNTPDIKLSSEVGEKSELPIAETKEKKEIKN 969

  Fly   845 ---KSCDCNGNVDPNAVGNCNRTTGECLKCIHN-TAGEHCDQCLSGHFGDPLALPHGRCDRC--- 902
               |..|.......:.||..:..:.|....::: ...:..:..:||.      :.:.:.|:.
Zfish   970 LEKKDKDAPDRKPLSKVGENSEESKESKTALNSEKKDKDAEASVSGD------IKNDKLDKTREA 1028

  Fly   903 ----SCYEAGTEQDEQ---------------------------SITR----------CDQVTGQC 926
                ...||..|:.|:                           .::|          |:..:.:|
Zfish  1029 EKTEKSKEAKEEKKEKEKHKEKEFKEYEKKVVARILIPGGPKTQLSRIAYIKFQDCECNGHSNRC 1093

  Fly   927 ------------QCKPNVIGRDCGECQPGYFNIRSG-----NGCENCLCDPVGSYNSTCDRYSGQ 974
                        .||.|..|::|..|:.|||...|.     |.|..|.|:.:||.::.|:. :|.
Zfish  1094 SYIDFINIVTCVSCKHNTRGQNCQHCRLGYFRNASAELDDENVCIECNCNQLGSIHARCND-TGF 1157

  Fly   975 CHCRPGVMGQRCDQCENYFYGFS-SEGCKPCECDES---GSKGFQCDQNGQCPCNDNVEGRRCD- 1034
            |.||.|..||:|:.|   ..|:: .:||.|..||:.   ...|..|.||.:|.|..|..|..|:
Zfish  1158 CQCRDGTAGQKCEDC---LPGYTWKQGCVPNVCDDEFLLCQNGGSCIQNQKCVCPPNFRGVLCEQ 1219

  Fly  1035 -RCKENKYDRHRGCID-CPDCY 1054
             ||:..|     |||| ...||
Zfish  1220 PRCQGEK-----GCIDGASACY 1236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanB2	NP_524006.1	LamNT	61..296	CDD:214532	57/251 (23%)
		EGF_Lam	298..347	CDD:238012	21/48 (44%)
		Laminin_EGF	359..414	CDD:395007	1/54 (2%)
		EGF_Lam	414..458	CDD:214543	8/68 (12%)
		Laminin_EGF	461..511	CDD:395007	13/112 (12%)
		LamB	572..697	CDD:214597	27/180 (15%)
		EGF_Lam	743..791	CDD:238012	8/56 (14%)
		EGF_Lam	793..836	CDD:214543	9/81 (11%)
		Laminin_EGF	847..897	CDD:395007	6/50 (12%)
		Laminin_EGF	902..953	CDD:395007	18/111 (16%)
		EGF_Lam	956..1001	CDD:214543	15/45 (33%)
		Laminin_EGF	1004..1046	CDD:395007	14/46 (30%)
		SMC_prok_B	<1054..1621	CDD:274008	1/1 (100%)
ntng2a	NP_001429168.1	None