DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanB2 and lamc3

DIOPT Version :9

Sequence 1:	NP_001287009.1	Gene:	LanB2 / 39118	FlyBaseID:	FBgn0267348	Length:	1639	Species:	Drosophila melanogaster
Sequence 2:	XP_687343.5	Gene:	lamc3 / 558958	ZFINID:	ZDB-GENE-060531-121	Length:	1643	Species:	Danio rerio

Alignment Length:	1751	Identity:	621/1751 - (35%)
Similarity:	889/1751 - (50%)	Gaps:	245/1751 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SSTARLLLIGVLFASCSTAILGAQRPPINSAGGHELRGTTFMPALECYDPYGRPQKCLPEFINAA 75
            ||....||: :||||......|..                     .|||..|.|..|||:|.|||
Zfish     3 SSALHSLLL-LLFASVYFVFAGMD---------------------SCYDENGVPSLCLPKFENAA 45

  Fly    76 YQLQIESTNTCGEQNDNHFCIQTMNQNHKNCEFCKYND----HNPSFLTDLHDPQSPTWWQSETM 136
            :...:..:|.||...:: :|:||  .:.::|..|...|    .|.::|||.|..:.||||||::|
Zfish    46 FNHSVMVSNMCGIPPED-YCMQT--GSTRSCHHCDAFDSELNRNATYLTDFHTDEEPTWWQSQSM 107

  Fly   137 FEGIQHPNYVNLTLHLGKSYDITYVRILFRSPRPESFTIYKRTSESGPWIPYQFYSATCRDTYSL 201
            |.|:|:||.||:||||||:::|||||:.|.:.|||||.|||||.|:|||.|||:|||:||.||..
Zfish   108 FYGVQYPNSVNITLHLGKAFEITYVRLKFYTSRPESFAIYKRTDENGPWQPYQYYSASCRKTYGR 172

  Fly   202 PDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPSGINFERSGELQEWVTATDIRITL 266
            .:...||.|:.|...|||.|:||||||..|.:||||||||||..||::|..||:|||||||.|:|
Zfish   173 DNKGFIRPGDNERTPLCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDQSLVLQDWVTATDILISL 237

  Fly   267 DRLNTFGDELFGDSQVLKSYFYAISDIAVGARCKCNGHASKCVPSTGMHGERTLVCECRHNTDGP 331
            |||||||||.|.|::||:||||||||.:||.|||||||||:||    ::.|...||.|.|||.|.
Zfish   238 DRLNTFGDEFFKDAKVLRSYFYAISDFSVGGRCKCNGHASECV----VNEEGRSVCVCEHNTAGV 298

  Fly   332 DCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANLFNRTGHGGHCLDCRENRDGPNC 396
            ||..|.|.|.|..|.|:|:...|||..|||:||||:|.||...:..||.||.||.||||..||:|
Zfish   299 DCQLCAPFYQDRPWARATAHSANECVRCNCSGLADECVFDVEQYRSTGQGGRCLGCRENTAGPHC 363

  Fly   397 ERCKENFYMRDDGY--CVNCACDPVGSRSLQCNSHGKCQCKPGVTGDKCDRCDNNYYQFGPHGCQ 459
            |:|:|| |.|....  |.||.|:.:||.||||::.|.|.|.|.|:|.|||.|.:.::..||.||:
Zfish   364 EQCREN-YFRSSALQPCQNCNCNALGSVSLQCDADGVCVCWPSVSGVKCDICKSGFHSLGPGGCR 427

  Fly   460 QCGCDSGGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLDKNNRFGCTPCFCYGHTSECM 524
            .|.||..||   ...|..|.|.|.||.||||:.||.||||.|||...|..||..|||:||:..|.
Zfish   428 LCDCDERGS---VGVCSAEDGRCHCKANVEGQSCNRCKPGSFNLQLENPDGCNKCFCFGHSLACF 489

  Fly   525 TAPGYSIVSVTSNFNKFKERWTAADLNQREVDIKYNQYSRSIGTTAQGNEHVYFQAPDRFLGDQR 589
            ::..|:.:.:||:|.:..:.|........|..:.:.:  ..:.......|:.:::|||::||:..
Zfish   490 SSNQYTPIYITSDFLEDPDGWKGVFSRAHEQSLIWKE--GEVYLLPYREENGFYKAPDKYLGNML 552

  Fly   590 ASYNRDL--KFKLQLVGQVANTGVSDVILEGAGSRISLPIFAQG---NGIPDQGVKEYTFRLHEH 649
            .||.|.|  .|..:| .::....|: |.|||:|..:|..:..|.   :.:....:..::.||.|.
Zfish   553 LSYGRTLSMSFTAEL-EELLPRSVT-VRLEGSGMSVSADLHTQQEPYSQLEKTPINSFSLRLTEK 615

  Fly   650 HDYQWQPSQSARGFLSILSNLTAIKIRATYSVQGEAILDDVELQTAHRGAAGHP-----ATWIEQ 709
            |   ..||.|:..||.:|.||||:.|.........:.|..|.|::|.: .|.||     |.|:|.
Zfish   616 H---VNPSVSSFEFLRMLYNLTALHISNAGGQNYTSQLSRVSLESAVQ-KAYHPDVLPHALWVEV 676

  Fly   710 CTCPEGYLGQFCESCAPGYRHSPARGGPFMPCIPCDCHGHADICDSETGRCICQHNTHGDNCDQC 774
            |:||.|:.||||:.||||:......||||.||:||:|:.|. .|..|||.|.|...|.|.:|::|
Zfish   677 CSCPAGFAGQFCQLCAPGFTRETPDGGPFSPCVPCNCNQHG-TCHPETGVCACTDFTTGRHCERC 740

  Fly   775 AKGFYGNALGGTPNDCKRCPCPNDGACLQINE-DTVICTECPKGYFGSRCEQCSDGFFGDPTGLL 838
            ..|:|||||.|:|.||..||||:...|.|:.| ..||||.||.|..|.|||.|.|||:|:|.|..
Zfish   741 EDGYYGNALTGSPGDCLPCPCPDRTTCAQVPETGDVICTNCPTGQRGVRCELCEDGFYGNPLGWG 805

  Fly   839 GEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSGHFGDPLA---LPHGRCD 900
            |.||.|..|.||||||.||||.|:..||.||||:.:|.|:||::|..|::|:.||   .|..:|.
Zfish   806 GTVQPCVKCQCNGNVDANAVGVCDHMTGRCLKCLGHTTGDHCEKCRLGYYGNALANQLNPERKCK 870

  Fly   901 RCSCYEAGTEQDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIRSGNGCENCLCDPVGSYN 965
            .|:|..|||   ..|...|...||.|.|..:|.|||||:|:.||||::.|.|||.|.|:|:||.:
Zfish   871 PCACNVAGT---SGSPNDCHPNTGNCVCLGHVTGRDCGQCEAGYFNLQPGLGCEMCNCNPIGSLS 932

  Fly   966 STCDRYSGQCHCRPGVMGQRCDQCENYFYGFSSEGCKPCECDESGSKGFQCDQNGQCPCNDNVEG 1030
            |.|...:|||.||.||.|..||.|...|:||||.||:.|.||..||...||..||.|.|.:...|
Zfish   933 SACHPITGQCMCRTGVEGMSCDTCRMGFFGFSSRGCRACNCDPMGSTSMQCHNNGTCSCRNGFVG 997

  Fly  1031 RRCDRCKENKYDR---HRGCIDCPDCYNLVQDAADLHRAKLFNLSQTLDEIARTPVTNDDEFEAK 1092
            .:||:|::|.|..   |: |.:||.||::::|.|...:|:|..|...|           ..::..
Zfish   998 YKCDKCEQNYYQNRLSHQ-CEECPVCYSIIRDQASKLKARLQELELLL-----------SSYDCN 1050

  Fly  1093 LKAVQEKVAVLAQDARDNSGDGGQTYAEVIDDLHKHL--DSVREHLVSA-DKFQADANGEIDRAR 1154
            ..:.|.:              |.|.:....:||..|:  |.|.::|.:| :...|     |..||
Zfish  1051 RYSRQYR--------------GHQQHRHQHNDLDNHIQKDQVEDYLPNALEDLLA-----IQEAR 1096

  Fly  1155 QNYTILDQITENAKKELQQALDLLNDEGAQALARAKEKSV-EFGQQSEQ--ISDISREARALADK 1216
            :.:.......|.:.:.||  |.|.|      :|.|...:: .|.:..|:  ...:..|.|.|.|.
Zfish  1097 EAFIKQFSQLETSAQTLQ--LQLRN------IATALNCNLTNFAKHPEEGKTQKVENECRELVDT 1153

  Fly  1217 LESEAQFDLKNAKDAKDAVEKAHQLAKSAIDL-QLKIGTEL------------RSEVGLELSHVK 1268
            |.:              |:....||.|..::| .:.|...:            .||| |..||..
Zfish  1154 LST--------------ALNMQDQLQKMTVELNSMAIPAVIPKEPNKWNAIVNESEV-LVKSHTD 1203

  Fly  1269 QSLGTVVQTSKEALRKANEVYDTALTLLND------VNRQTQPEIDISQLKKDAVAA-------- 1319
            .: ..:.|.:::..:.||..|...:|||.|      :...|:...::.|||::....
Zfish  1204 MA-AHIEQVAEDVFKMANRTYLQLVTLLEDNSTESHIQDLTEKLEEMQQLKENLTLEVNETLVTH 1267

  Fly  1320 ------NERADELLKQIT----ELSNSNGELFADFET------EQELTEALLKRAEQQQL-EDIE 1367
                  |....::|..||    ||..::|......|.      .|...:..:..|:..|| |..:
Zfish  1268 LSLQKHNAEIADILHNITASLSELRRTDGNFTLVVEETNMTSFSQTFNQTNVTAAQNPQLTESED 1332

  Fly  1368 LLER--------------AKAAHDKATKAVEQGDNTLKEANNTYEKLAGFQ-------------S 1405
            |:.|              .....::....::...|.||......:..|..:             .
Zfish  1333 LMNRTTNLDISVQSKEHLVNKTREEIQPDMDSAKNNLKTVQELKQLTAAVEGLKVSAVSSVVTGK 1397

  Fly  1406 DVQRSSESAEKALQ-------TVPNIEKEIQNAESL------------ISQAEEALDGANKNANE 1451
            :|:....|.:|:||       .:|.:.|.....|.:            :.|.|:.:..:.:||.:
Zfish  1398 EVEAEILSLQKSLQDMEQDWPQLPTLSKSFLKREKMLNEKTLVEVKKRVKQTEKMIKPSVENATD 1462

  Fly  1452 AKKNAQEAQLKYAEQASKDAELIRRKANETKVAARNLR-------EEADQLNHRVKLTEMDIFKL 1509
            |...|::|:.. |:..:|||:....:....|.|:..||       |:..:|..:..|.:..: :.
Zfish  1463 ADSTAKQAEAS-ADTVAKDAKASFTQGKRIKHASGQLRSALDVTLEQLSELESQTALKQATL-EA 1525

  Fly  1510 EESSTKDDNLVDDAKRKVGQAKADTQEAQKQIEKANADLTAIKDELENLKDINTGDLDRLEN--- 1571
            ||......:::|           ..:.|:.|:|.....||.:..::|  .|:...:.||:.|
Zfish  1526 EEDMVSSSSVID-----------SMETAKNQLESFTDMLTLLLSQME--ADVVLENYDRILNETA 1577

  Fly  1572 -RLATVEGEINRVNLTGRIEKYREQRTIQKNLIDKYDAELRELKDEVQNIGLISKALPDSC 1631
             ||..::|.:...:|||:|::.|...:.|:..:...:..|::::.|..::..|::.||.:|
Zfish  1578 VRLRVLQGAVESPSLTGKIQRLRNAASDQEKQMQNLEESLQDIRKERDSLTDIAQNLPKTC 1638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB2	NP_001287009.1	LamNT	61..296	CDD:214532	133/238 (56%)
		EGF_Lam	298..347	CDD:238012	26/48 (54%)
		Laminin_EGF	359..414	CDD:278482	30/56 (54%)
		EGF_Lam	414..458	CDD:214543	20/43 (47%)
		Laminin_EGF	461..511	CDD:278482	25/49 (51%)
		LamB	572..697	CDD:214597	39/129 (30%)
		TNFRSF	<721..848	CDD:304602	64/127 (50%)
		CRD2	724..771	CDD:276900	22/46 (48%)
		EGF_Lam	743..791	CDD:238012	23/47 (49%)
		Laminin_EGF	847..897	CDD:278482	28/52 (54%)
		Laminin_EGF	902..953	CDD:278482	23/50 (46%)
		Laminin_EGF	956..1004	CDD:278482	25/47 (53%)
		Laminin_EGF	1004..1050	CDD:278482	19/48 (40%)
		V_Alix_like	1122..1443	CDD:187408	79/416 (19%)
		Tar	1139..1521	CDD:223910	91/482 (19%)
		BAR	1308..1469	CDD:299863	38/231 (16%)
		vATP-synt_E	1474..>1629	CDD:304907	33/165 (20%)
lamc3	XP_687343.5	Laminin_N	46..268	CDD:278484	125/224 (56%)
		EGF_Lam	269..314	CDD:238012	26/48 (54%)
		Laminin_EGF	326..382	CDD:278482	30/56 (54%)
		EGF_Lam	382..426	CDD:214543	20/43 (47%)
		Laminin_EGF	429..476	CDD:278482	25/49 (51%)
		Laminin_B	540..659	CDD:278481	37/123 (30%)
		EGF_Lam	710..751	CDD:238012	20/41 (49%)
		Laminin_EGF	814..861	CDD:278482	26/46 (57%)
		EGF_Lam	871..921	CDD:238012	24/52 (46%)
		Laminin_EGF	923..971	CDD:278482	25/47 (53%)
		EGF_Lam	970..1010	CDD:238012	17/39 (44%)
		ApoLp-III_like	1233..1386	CDD:304399	23/152 (15%)
		PspA	1388..1607	CDD:224755	47/233 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	297	1.000	Domainoid score	I1431
eggNOG	1	0.900	-	-		E1_KOG1836
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48740
OrthoDB	1	1.010	-	-		D156553at2759
OrthoFinder	1	1.000	-	-		FOG0002861
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102334
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.830