DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanB2 and CCDC186

DIOPT Version :9

Sequence 1:	NP_001287009.1	Gene:	LanB2 / 39118	FlyBaseID:	FBgn0267348	Length:	1639	Species:	Drosophila melanogaster
Sequence 2:	NP_001308758.1	Gene:	CCDC186 / 55088	HGNCID:	24349	Length:	898	Species:	Homo sapiens

Alignment Length:	745	Identity:	151/745 - (20%)
Similarity:	281/745 - (37%)	Gaps:	203/745 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   987 DQCENYFYGFSSEGCKPCECDESGSKGFQCDQNGQCPCNDNVEGRRCDRCKENKYDRHRGCIDCP 1051
            |.| |.|.|..|...:    :||.......|:.   .|..|....|.: .:||....|.|..|
Human    25 DSC-NLFSGNESSKLE----NESKLLSLNTDKT---LCQPNEHNNRIE-AQENYIPDHGGGED-- 78

  Fly  1052 DCYNLVQDAADLHRAKLFNLSQTLDEIARTPVTNDDEFEAKLKAVQEKVAVLAQDARDNS---GD 1113
            .|            ||....|:..::||..|..|..:..:|....::||..:..:.|.::   ..
Human    79 SC------------AKTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILVELRSSTFPESA 131

  Fly  1114 GGQTYAEV---IDDLHKHLDSVREHLVSADKFQADANGEI------------------------- 1150
            ..:||:|.   .|...|.:..::....|.|..: :...|:
Human   132 NEKTYSESPYDTDCTKKFISKIKSVSASEDLLE-EIESELLSTEFAEHRVPNGMNKGEHALVLFE 195

  Fly  1151 ----DRARQNYTILDQITENAKKELQQALDL------LNDEGAQALARAKEKSVEFGQQSEQISD 1205
                |:..|...|:.::.:..||..:..:|:      |.:|..:.....|:......|...:|.:
Human   196 KCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEE 260

  Fly  1206 ISREARALADKLESEAQFDLKNAKDAKDAVEKAHQLAKSAIDLQLKIGTELRSE-VGLELSHV-- 1267
            :::|.:|..|:|.::   |:    .||:||::.|:.....::...|...|.|.| ..:.:.:|
Human   261 LNKEVKASRDQLIAQ---DV----TAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRG 318

  Fly  1268 -KQSLGTVVQTSKEALRKANEVYDTALTLLNDVNRQTQPEIDISQLKKDAVAANERADELLKQIT 1331
             |:||.  ::..||.|.|.          |.|.|:         :|:|:.           .:|.
Human   319 EKESLD--LRKEKETLEKK----------LRDANK---------ELEKNT-----------NKIK 351

  Fly  1332 ELSNSNGELFADFETEQELTEALLKRAEQQQLEDI----------------------ELLERAKA 1374
            :||...|.|...:||::..|..|::..::.: |||                      |..::.|.
Human   352 QLSQEKGRLHQLYETKEGETTRLIREIDKLK-EDINSHVIKVKWAQNKLKAEMDSHKETKDKLKE 415

  Fly  1375 AHDKATKAVEQGDNTLKEANN---TYEKLAGFQSDVQRSSESAEKALQTVPNIEKEIQ------- 1429
            ...|.|:|.|:.|...|...:   ||:     :|:..:|:|...|...|...:||::|
Human   416 TTTKLTQAKEEADQIRKNCQDMIKTYQ-----ESEEIKSNELDAKLRVTKGELEKQMQEKSDQLE 475

  Fly  1430 -------NAESLISQAEEALDGANKNANEAKKNAQEAQLKYAEQASKDAELIRRKANETKVAARN 1487
                   ..|.|....:|.:|.. :......|..::.:|:..::.||..|:|.|:    |...:|
Human   476 MHHAKIKELEDLKRTFKEGMDEL-RTLRTKVKCLEDERLRTEDELSKYKEIINRQ----KAEIQN 535

  Fly  1488 LREE---ADQLNHRVKLTEMDIFKLEESSTKDDNLVDDAKR---------------------KVG 1528
            |.::   ||||..:::..:.:|..|:|.....::|::|.::                     |..
Human   536 LLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNA 600

  Fly  1529 QAKADTQEAQKQIEKANADLTAIKDELENLKDINTGDLDRLENRLATVEGEINRVNLTGRIEKYR 1593
            |.::::...|.|.:|.:...:.::.:.|.:|..|.    .||:||.. |.|:.:          .
Human   601 QLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNI----NLESRLLK-EEELRK----------E 650

  Fly  1594 EQRTIQKNL------IDKYDAELRELKDEV 1617
            |.:|:|..|      :.....::.|||||:
Human   651 EVQTLQAELACRQTEVKALSTQVEELKDEL 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB2	NP_001287009.1	LamNT	61..296	CDD:214532
		EGF_Lam	298..347	CDD:238012
		Laminin_EGF	359..414	CDD:278482
		EGF_Lam	414..458	CDD:214543
		Laminin_EGF	461..511	CDD:278482
		LamB	572..697	CDD:214597
		TNFRSF	<721..848	CDD:304602
		CRD2	724..771	CDD:276900
		EGF_Lam	743..791	CDD:238012
		Laminin_EGF	847..897	CDD:278482
		Laminin_EGF	902..953	CDD:278482
		Laminin_EGF	956..1004	CDD:278482	6/16 (38%)
		Laminin_EGF	1004..1050	CDD:278482	10/45 (22%)
		V_Alix_like	1122..1443	CDD:187408	76/398 (19%)
		Tar	1139..1521	CDD:223910	92/462 (20%)
		BAR	1308..1469	CDD:299863	38/199 (19%)
		vATP-synt_E	1474..>1629	CDD:304907	37/174 (21%)
CCDC186	NP_001308758.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..95		9/40 (23%)
		SMC_N	208..>594	CDD:330553	89/435 (20%)
		SMC_N	454..>737	CDD:330553	51/247 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	702..749
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1836
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900