DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LanB2 and LAMA3

DIOPT Version :9

Sequence 1:NP_001287009.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster
Sequence 2:XP_011524280.1 Gene:LAMA3 / 3909 HGNCID:6483 Length:3342 Species:Homo sapiens


Alignment Length:2527 Identity:509/2527 - (20%)
Similarity:790/2527 - (31%) Gaps:1081/2527 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 LLLIGVLFASCSTAILGAQRPPINSAGGHELRGTTFMPALECYDPYGRPQKCLPEFINAAYQLQI 80
            ||::.||.|..:||     |.| .:|.|..|.                     |.:.|.|...:|
Human    23 LLVLRVLPACGATA-----RDP-GAAAGLSLH---------------------PTYFNLAEAARI 60

  Fly    81 ESTNTCGEQNDNH-------FC--------------IQTMNQNHKNCEFCKYNDHNPSF-LTDLH 123
            .:|.||||:....       :|              ||     .:.|::|...|...:. :|:..
Human    61 WATATCGERGPGEGRPQPELYCKLVGGPTAPGSGHTIQ-----GQFCDYCNSEDPRKAHPVTNAI 120

  Fly   124 DPQSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRILF-RSPRPESFTIYKRTSESGPWIP 187
            | .|..||||..:..|.|: |.|||||.||:.:.:.|:.|.| .||||:.:.:.:.......:.|
Human   121 D-GSERWWQSPPLSSGTQY-NRVNLTLDLGQLFHVAYILIKFANSPRPDLWVLERSVDFGSTYSP 183

  Fly   188 YQFYS---ATCRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPSGINFER 249
            :|:::   ..|...:....:.|:.:.:   ..||.:|||.|.||.:||:..|.:.|||...||..
Human   184 WQYFAHSKVDCLKEFGREANMAVTRDD---DVLCVTEYSRIVPLENGEVVVSLINGRPGAKNFTF 245

  Fly   250 SGELQEWVTATDIRITLDRLNTFGDELFGDSQ----VLKSYFYAISDIAVGARCKCNGHASKCVP 310
            |..|:|:..||:||:...|.||....|...:|    |.:.|:|:|.||::|.:|.|||||..|..
Human   246 SHTLREFTKATNIRLRFLRTNTLLGHLISKAQRDPTVTRRYYYSIKDISIGGQCVCNGHAEVCNI 310

  Fly   311 STGMHGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANL- 374
            :   :.|:...|||:|:|.|..||||...||..:|:.:...:.:||:||||:|.|..|::|.:: 
Human   311 N---NPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHGHASNCYYDPDVE 372

  Fly   375 -----FNRTG---HGGHCLDCRENRDGPNCERCKENFYM-------RDDGYCVNCACDP------ 418
                 .|..|   .||.|::|:.|..|.|||:|.:.:|.       ..|| |:.|:|||      
Human   373 RQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDAPDG-CIPCSCDPEHADGC 436

  Fly   419 ----------------------------------------------------------------- 418
                                                                             
Human   437 EQGSGRCHCKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPE 501

  Fly   419 ---------------------------------------VGSRSLQCNS-HGKCQCKPGVTGDKC 443
                                                   :||..:.|:| .|:|:|:|||||.:|
Human   502 ICDAHGRCLCRPGVEGPRCDTCRSGFYSFPICQACWCSALGSYQMPCSSVTGQCECRPGVTGQRC 566

  Fly   444 DRCDNNYYQF-----------------------------------------------GPHGCQQC 461
            |||.:..|.|                                               .|.||.:|
Human   567 DRCLSGAYDFPHCQGSSSACDPAGTINSNLGYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSEC 631

  Fly   462 GCDSGGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLDKNNRFGCTPC----------FC 516
            .|...|:...|..|....|.|.||.:|.|..|:.|:.|:|.|:|:|.|||..|          .|
Human   632 KCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYFALEKSNYFGCQGCQCDIGGALSSMC 696

  Fly   517 YGHTSEC---------------------------------------------------------- 523
            .|.:..|                                                          
Human   697 SGPSGVCQCREHVVGKVCQRPENNYYFPDLHHMKYEIEDGSTPNGRDLRFGFDPLAFPEFSWRGY 761

  Fly   524 --MTA---------------------------PGYSIVS-------------------------- 533
              ||:                           ||...||                          
Human   762 AQMTSVQNDVRITLNVGKSSGSLFRVILRYVNPGTEAVSGHITIYPSWGKARAAQSKEIIFLPSK 826

  Fly   534 ----VTSNFNKFKER-------WTA---------------------------------------- 547
                ||...|.|.:.       |.|                                        
Human   827 EPAFVTVPGNGFADPFSITPGIWVACIKAEGVLLDYLVLLPRDYYEASVLQLPVTEPCAYAGPPQ 891

  Fly   548 ----------------------------------------------------ADLNQREVDIKYN 560
                                                                .||:.|||::...
Human   892 EKSVWGRSCLLYQHLPVTRFPCTLACEARHFLLDGEPRPVAVRQPTPAHPVMVDLSGREVELHLR 956

  Fly   561 -------------QYS-------------RSIGTTAQGNEHVY---------------------- 577
                         :||             :|.|:...|..::|                      
Human   957 LRIPQVGHYVVVVEYSTEAAQLFVVDVNVKSSGSVLAGQVNIYSCNYSVLCRSAVIDHMSRIAMY 1021

  Fly   578 -------FQAPD---RFLGDQ--------------------RASYNRDLKFKLQLVGQVANTGVS 612
                   .|...   |||..|                    .|||.|.:......|.....|..:
Human  1022 ELLADADIQLKGHMARFLLHQVCIIPIEEFSAEYVRPQVHCIASYGRFVNQSATCVSLAHETPPT 1086

  Fly   613 DVILEGAGSRISLPIFAQGNG-----------------------IPDQGVKEYTFRLHEHH---- 650
            .:||:....| ..|...|.:.                       :|..|  .|.|.:|.:.    
Human  1087 ALILDVLSGR-PFPHLPQQSSPSVDVLPGVTLKAPQNQVTLRGRVPHLG--RYVFVIHFYQAAHP 1148

  Fly   651 --------DYQWQPSQS-----------------ARGFLSILSNLTAIKIRATYSV-QGEAIL-- 687
                    |..|..:.|                 |.|  .|..:::..::.||..| :|::::  
Human  1149 TFPAQVSVDGGWPRAGSFHASFCPHVLGCRDQVIAEG--QIEFDISEPEVAATVKVPEGKSLVLV 1211

  Fly   688 -------DDVELQTAHRGAAGHPATWIEQCTCPEGYL-----GQFCESCA---PGYRHSPARGGP 737
                   ::.:.|..|:.:......:|..|.....||     .:||::.|   ..:.|..|    
Human  1212 RVLVVPAENYDYQILHKKSMDKSLEFITNCGKNSFYLDPQTASRFCKNSARSLVAFYHKGA---- 1272

  Fly   738 FMPCIPCDCH---GHADICDSETGRCICQHNTHGDNCDQCAKGFYGNALGGTPNDCKRCPCPNDG 799
                :||:||   .....|..|.|:|.||.|..|..|.:||.|.|     |.|. ||.|.|..  
Human  1273 ----LPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHY-----GFPR-CKPCSCGR-- 1325

  Fly   800 ACLQINEDTVICTECPKGYFGSRCEQCSDGFFGDPTGLLGEVQTCKSCDCN--GNVDPNAVGNCN 862
               ::.|:......||......:||.|....|.     ...:..|:.|:|:  |.::. |:..|:
Human  1326 ---RLCEEMTGQCRCPPRTVRPQCEVCETHSFS-----FHPMAGCEGCNCSRRGTIEA-AMPECD 1381

  Fly   863 RTTGECLKCIHNTAGEHCDQCLSGHFGDPLALPHGRCDRCSCYEAGTEQDEQSITRCDQVTGQCQ 927
            |.:|:| :|.....|..||:|.||.:..|..:|      |:|...|||...     ||..||.|.
Human  1382 RDSGQC-RCKPRITGRQCDRCASGFYRFPECVP------CNCNRDGTEPGV-----CDPGTGACL 1434

  Fly   928 CKPNVIGRDCGECQPGYFNIRSGN--GCENCLC------------------DPVGSYNSTCDR-- 970
            ||.||.|.:|..|:.|.|::...|  ||.:|.|                  |.:|.:..|.||  
Human  1435 CKENVEGTECNVCREGSFHLDPANLKGCTSCFCFGVNNQCHSSHKRRTKFVDMLGWHLETADRVD 1499

  Fly   971 -----------------------------------------YSGQ-------------------- 974
                                                     |.|.                    
Human  1500 IPVSFNPGSNSMVADLQELPATIHSASWVAPTSYLGDKVSSYGGYLTYQAKSFGLPGDMVLLEKK 1564

  Fly   975 ----------------------------------------------------------------- 974
                                                                             
Human  1565 PDVQLTGQHMSIIYEETNTPRPDRLHHGRVHVVEGNFRHASSRAPVSREELMTVLSRLADVRIQG 1629

  Fly   975 ---------------------------------CHCRPGVMGQRCDQCENYFY----GFSSEGCK 1002
                                             |.|.|...|..|..|...:|    |..:..|.
Human  1630 LYFTETQRLTLSEVGLEEASDTGSGRIALAVEICACPPAYAGDSCQGCSPGYYRDHKGLYTGRCV 1694

  Fly  1003 PCECDESGSKGFQC-DQNGQC-PCNDNVEGRRCDRCKENKYDR--HRGCIDCP------------ 1051
            ||.|:...:   || |.:|.| .|..|..|..|:||:|..|..  |..|..||            
Human  1695 PCNCNGHSN---QCQDGSGICVNCQHNTAGEHCERCQEGYYGNAVHGSCRACPCPHTNSFATGCV 1756

  Fly  1052 --------------------------------------------------------DCYNLVQDA 1060
                                                                    ||.|  |:.
Human  1757 VNGGDVRCSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLGSCHPLTGDCIN--QEP 1819

  Fly  1061 ADLHRAK-----------LFNLSQTLDEIARTPVTNDDEFEAKLKAVQEKVAVL---------AQ 1105
            .|...|:           |.|...|:.|..|.       .:::|:.:.....:|         |:
Human  1820 KDSSPAEECDDCDSCVMTLLNDLATMGEQLRL-------VKSQLQGLSASAGLLEQMRHMETQAK 1877

  Fly  1106 DARD----------NSGDGGQTYAEVIDDLHKHLDSVREHL-VSADKFQADANGEIDRARQNYTI 1159
            |.|:          |.|...:.....:.||::..::::|.. |::.|.|. .|..::||.|:...
Human  1878 DLRNQLLNYRSAISNHGSKIEGLERELTDLNQEFETLQEKAQVNSRKAQT-LNNNVNRATQSAKE 1941

  Fly  1160 LDQITENAKKELQQALDLLNDEGAQALARAKEKSVEFGQQSEQISDISREARALAD----KLESE 1220
            ||...:|..:.:...|..::....:.      .:|..|..|.:.::..|..|.|.:    |...|
Human  1942 LDVKIKNVIRNVHILLKQISGTDGEG------NNVPSGDFSREWAEAQRMMRELRNRNFGKHLRE 2000

  Fly  1221 AQFDLKNAKDAKDAV---EKAHQ-----LAKSAID----LQLKIGTELRSEVGLELSHVKQSLGT 1273
            |:.|.:.::...:.:   :|.||     ||.|..|    .:.|: ::||:.:....:..||:.| 
Human  2001 AEADKRESQLLLNRIRTWQKTHQGENNGLANSIRDSLNEYEAKL-SDLRARLQEAAAQAKQANG- 2063

  Fly  1274 VVQTSKEAL----RKANEV------YDTALTLLNDVNRQTQPEIDI-----SQLKKDAVAANERA 1323
            :.|.::.||    |:..|:      :...||..:....||...:.:     .:.:|.|.:.||..
Human  2064 LNQENERALGAIQRQVKEINSLQSDFTKYLTTADSSLLQTNIALQLMEKSQKEYEKLAASLNEAR 2128

  Fly  1324 DELLKQITELSNSNGELFADFETE------QELTEALLKRAEQQQLEDIELL----ERAKAAHDK 1378
            .||..::.|||.|.|:.....|.|      |||.         :|||:|:..    |..:.|.|.
Human  2129 QELSDKVRELSRSAGKTSLVEEAEKHARSLQELA---------KQLEEIKRNASGDELVRCAVDA 2184

  Fly  1379 ATKAVEQGDNTLKEANNTYEKLAGFQSDVQRSSESAEKALQTVPNIEKEI-QNAESLISQAEEAL 1442
            || |.|...|.:|.|.:.          ..|::.::|.|||||  |:::: :.|::|.|.:::.|
Human  2185 AT-AYENILNAIKAAEDA----------ANRAASASESALQTV--IKEDLPRKAKTLSSNSDKLL 2236

  Fly  1443 DGANKNANEAKKNAQEAQLKYAEQASKDAELIRRKAN----ETKVAARNLREEADQLNHRVKLTE 1503
                   ||||.    .|.|..::.|.....:::..|    :.:|...||....|.| |.::..:
Human  2237 -------NEAKM----TQKKLKQEVSPALNNLQQTLNIVTVQKEVIDTNLTTLRDGL-HGIQRGD 2289

  Fly  1504 MDIFKLEESSTKDDNLVDDAKRKVGQAKADTQEAQKQIEKANADLTAIKD-----ELENLKDINT 1563
            :|.            ::..||..|.:|...|.|....:.....|:..|||     :.|:.|...|
Human  2290 IDA------------MISSAKSMVRKANDITDEVLDGLNPIQTDVERIKDTYGRTQNEDFKKALT 2342

  Fly  1564 GDLDRLENRLATVEGEINRV-NLTGRIEKYREQRTIQKNLIDKYDAELRELKDEVQN 1619
             |.|...|:|.      |:: :|..:||...:|.....|:.|..| .:|||..:.::
Human  2343 -DADNSVNKLT------NKLPDLWRKIESINQQLLPLGNISDNMD-RIRELIQQARD 2391

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB2NP_001287009.1 LamNT 61..296 CDD:214532 77/264 (29%)
EGF_Lam 298..347 CDD:238012 21/48 (44%)
Laminin_EGF 359..414 CDD:278482 23/70 (33%)
EGF_Lam 414..458 CDD:214543 23/201 (11%)
Laminin_EGF 461..511 CDD:278482 19/49 (39%)
LamB 572..697 CDD:214597 34/238 (14%)
TNFRSF <721..848 CDD:304602 35/132 (27%)
CRD2 724..771 CDD:276900 15/52 (29%)
EGF_Lam 743..791 CDD:238012 19/50 (38%)
Laminin_EGF 847..897 CDD:278482 17/51 (33%)
Laminin_EGF 902..953 CDD:278482 20/52 (38%)
Laminin_EGF 956..1004 CDD:278482 18/230 (8%)
Laminin_EGF 1004..1050 CDD:278482 17/49 (35%)
V_Alix_like 1122..1443 CDD:187408 87/363 (24%)
Tar 1139..1521 CDD:223910 99/427 (23%)
BAR 1308..1469 CDD:299863 48/176 (27%)
vATP-synt_E 1474..>1629 CDD:304907 36/156 (23%)
LAMA3XP_011524280.1 LamNT 46..297 CDD:214532 78/281 (28%)
EGF_Lam 299..344 CDD:238012 21/47 (45%)
Laminin_EGF 356..423 CDD:278482 22/67 (33%)
EGF_Lam 425..465 CDD:238012 4/39 (10%)
Laminin_EGF 491..538 CDD:278482 0/46 (0%)
EGF_Lam 535..577 CDD:238012 17/41 (41%)
Laminin_EGF 585..628 CDD:278482 1/42 (2%)
EGF_Lam 631..682 CDD:238012 20/50 (40%)
EGF_Lam 684..727 CDD:238012 4/42 (10%)
Laminin_EGF 1275..1323 CDD:278482 21/53 (40%)
EGF_Lam 1365..1410 CDD:238012 15/46 (33%)
EGF_Lam 1413..1463 CDD:238012 22/60 (37%)
LamB 1523..1650 CDD:214597 2/126 (2%)
EGF_Lam 1695..1741 CDD:238012 17/48 (35%)
Laminin_EGF 1743..1793 CDD:278482 2/49 (4%)
Laminin_I 1854..2113 CDD:283627 53/267 (20%)
Laminin_I 2071..2357 CDD:283627 83/338 (25%)
ApoLp-III_like 2101..2265 CDD:304399 52/196 (27%)
Laminin_II 2297..2425 CDD:283628 28/103 (27%)
LamG 2444..2579 CDD:214598
LamG 2611..2751 CDD:238058
LamG 2778..2910 CDD:238058
LamG 3003..3143 CDD:238058
LamG 3167..3318 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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