DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LanB2 and LAMA2

DIOPT Version :9

Sequence 1:NP_001287009.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster
Sequence 2:XP_016866340.1 Gene:LAMA2 / 3908 HGNCID:6482 Length:3212 Species:Homo sapiens


Alignment Length:2294 Identity:553/2294 - (24%)
Similarity:825/2294 - (35%) Gaps:818/2294 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 HELRGTTFMPALECYDPYGRPQKCLPEFINAAYQLQIESTNTCGEQNDNHFC-----IQTMNQNH 103
            ||||.....||:                :|.|....|.:..||||:....:|     :......:
Human    34 HELRARGLFPAV----------------LNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRN 82

  Fly   104 KNCEFCKYNDHNPSF---LTDLHDPQSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRI-L 164
            ..|..|..|..||:.   :|:..|.:: |||||.::..||:: :||.:||.|.:.:.|.||.: .
Human    83 PQCRICNQNSSNPNQRHPITNAIDGKN-TWWQSPSIKNGIEY-HYVTITLDLQQVFQIAYVIVKA 145

  Fly   165 FRSPRPESFTIYKRTSESGPWIPYQFYSAT---CRDTYSL-----PDSRAIRKGEGEAHALCTSE 221
            ..||||.:: |.:|:.:...:.|:|:::.|   |...|::     |.|.|     .:...:|||.
Human   146 ANSPRPGNW-ILERSLDDVEYKPWQYHAVTDTECLTLYNIYPRTGPPSYA-----KDDEVICTSF 204

  Fly   222 YSDISPLRDGEIAFSTLEGRPSGINFERSGELQEWVTATDIRITLDRLNTFGDELFG-------- 278
            ||.|.||.:|||..|.:.||||.  .:.|.||.|:.:|..||:...|:.|...:|..        
Human   205 YSKIHPLENGEIHISLINGRPSA--DDPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPRE 267

  Fly   279 -DSQVLKSYFYAISDIAVGARCKCNGHASKCVPSTGMHGERTLVCECRHNTDGPDCDRCLPLYND 342
             |..|.:.|:|::.||:||..|.|.|||..|......:..|   |||.|||.|..||:|.|.::.
Human   268 IDPIVTRRYYYSVKDISVGGMCICYGHARACPLDPATNKSR---CECEHNTCGDSCDQCCPGFHQ 329

  Fly   343 LKWKRSTSTEVNECKACNCNGLADKCFFDANLFNRT------GH---GGHCLDCRENRDGPNCER 398
            ..|:..|.....||:||||:|.|::|::|.|:..|.      |.   ||.|::|.:|..|.|||.
Human   330 KPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCET 394

  Fly   399 CKENFYMRDDGY-------CVNCACDPVGSRSLQC---NSH-------GKCQCKPGVTGDKCDRC 446
            |.:.|: |..|.       |..|.|||:||.:..|   ..|       |.|.||.|..|..||||
Human   395 CTDGFF-RPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRC 458

  Fly   447 DNNYYQFGPHGCQQCGCDSGGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLDKNNRFGC 511
            ...|  .|...|:.|.|...||....|.    .|.|.|||||||..|:.||.|||||.::|..||
Human   459 ARGY--TGYPDCKACNCSGLGSKNEDPC----FGPCICKENVEGGDCSRCKSGFFNLQEDNWKGC 517

  Fly   512 TPCFCYGHTSECMTAPGYSIVSVTSNFNKFKER--WTAADL--------NQREVDIKYNQYSRSI 566
            ..|||.|.::.|.        |....:.|.::.  |...||        .|.::| ...|.|.|.
Human   518 DECFCSGVSNRCQ--------SSYWTYGKIQDMSGWYLTDLPGRIRVAPQQDDLD-SPQQISISN 573

  Fly   567 GTTAQGNEHVYF-QAPDRFLGDQRASYNRDLKFK---------------LQLVGQVANTGVSDVI 615
            ....|...|.|: .||..:||::..:....|.|.               |||:          :|
Human   574 AEARQALPHSYYWSAPAPYLGNKLPAVGGQLTFTISYDLEEEEEDTERVLQLM----------II 628

  Fly   616 LEGAGSRISLPIFAQGNGI--PDQG------VKEYTFRLHEHHDYQWQPSQSARGFLSILSNLTA 672
            |||....||.   ||....  |.:.      :||.:|.:|..|    .|.: .:.|:::|:||..
Human   629 LEGNDLSIST---AQDEVYLHPSEEHTNVLLLKEESFTIHGTH----FPVR-RKEFMTVLANLKR 685

  Fly   673 IKIRATYSVQGEAI--LDDVELQTAHRGAAGHP-----ATWIEQCTCPEGYLGQFCESCAPGYRH 730
            :.::.|||...:||  |..|.|::    |..:|     |..:|.|.||.||.|..||||.|  ||
Human   686 VLLQITYSFGMDAIFRLSSVNLES----AVSYPTDGSIAAAVEVCQCPPGYTGSSCESCWP--RH 744

  Fly   731 SPARGGPFMP-CIPCDCHGHADICDSETGRCI-CQHNTHGDNCDQCAKGFYGNALGGTPNDCKRC 793
            ....|..|.. |.||.|.|||:.||..||.|: |:.:|.|..||:|..||||....||..||:.|
Human   745 RRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPC 809

  Fly   794 PCP------NDGACLQINEDT-VICTECPKGYFGSRCEQCSDGFFGDPTGLLGEVQTCKSCDCNG 851
            .||      |......::... :||..||.||.|.|||:|::|:||.|:...|   :|:.|.||.
Human   810 ACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGG---SCQPCQCND 871

  Fly   852 NVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSGHFGDPLALPHGRCDRCSCYEAGTEQDEQSI 916
            |:|.:..|:|:..:|.||.|...|.|.:|:.|..|:|||  |:....|..|.|...|:..:.   
Human   872 NLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGD--AVDAKNCQPCRCNAGGSFSEV--- 931

  Fly   917 TRCDQVTGQCQCKPNVIGRDCGECQP--------------------------------------- 942
              |...||||:|:.||.|:.|.:|:|                                       
Human   932 --CHSQTGQCECRANVQGQRCDKCKPNMWRDPEKRFCVLCDCDPVGSVSPQCDITGRCVCKSGFV 994

  Fly   943 -------------------------------------------------GYFNIRSGNGCENCLC 958
                                                             |.|.::|..||..|.|
Human   995 GKQCNLGRQVHQQEEQPRRAQRVLGSPQRWAIGSSSGCPRGAYRAPAPAGTFGLQSARGCVPCNC 1059

  Fly   959 DPVGSYNSTCDRYSGQCHCRPGVMGQRCDQCENYFYGFS-------------------------- 997
            :..||.:..|:. ||||.|:|||.|::||:|.:.::.|.                          
Human  1060 NSFGSKSFDCEE-SGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLGNNCDPKTGRCICP 1123

  Fly   998 --------------------SEGCKPCECDESGSKGFQC-------------------------- 1016
                                :.|||.|.|...||..|||                          
Human  1124 PNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTECSRGHW 1188

  Fly  1017 ------------------------------DQNGQCPCNDNVEGRRCDRCKENKYDRH-RGCIDC 1050
                                          ||.|||.|..||||..||||:..|:... :..:.|
Human  1189 NYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGC 1253

  Fly  1051 PDCY-----NLVQDAADLHRAKL-FNLSQTL----DE-----------------IARTPVTNDD- 1087
            ..||     ....:|..|.|..: ....||:    ||                 :|...:..:| 
Human  1254 SSCYCFGTTTQCSEAKGLIRTWVTLKAEQTILPLVDEALQHTTTKGIVFQHPEIVAHMDLMREDL 1318

  Fly  1088 -----------EFEA-KLKAVQEKVA-VLAQDARDNSG-----------DGGQTYAEVI------ 1122
                       :||. ||.|...|:. .:..:||:.:|           .|..|:|.:|      
Human  1319 HLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFEAREETGFSTYNPQVIIRGGTPTHARIIVRHMAA 1383

  Fly  1123 ----------------------DDLHKHLDSVREHLVS--------------------------- 1138
                                  ||...|....||..:.                           
Human  1384 PLIGQLTRHEIEMTEKEWKYYGDDPRVHRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEIS 1448

  Fly  1139 ---------------ADKFQ--------------------------------------------- 1143
                           ||..:                                             
Human  1449 MEVAEQGRGTTMTPPADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCN 1513

  Fly  1144 -----ADANGEIDRARQNYTILD----------QITENAKKELQQ----------------ALDL 1177
                 .|....|.:..|::|..|          .|.:....:.||                ..:.
Human  1514 GHSSLCDPETSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEG 1578

  Fly  1178 LNDEGAQALARAKEKSVEFGQQSEQ---------------------------------------- 1202
            |:|....|..|..|     ||..|:                                        
Human  1579 LDDYRCTACPRGYE-----GQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTC 1638

  Fly  1203 ----------------------------------ISDISREARALAD---------------KLE 1218
                                              :.|::|..:.:..               .||
Human  1639 RPGATGRKCDGCKHWHAREGWECVFCGDECTGLLLGDLARLEQMVMSINLTGPLPAPYKMLYGLE 1703

  Fly  1219 SEAQFDLKNAKDAKDAVEKAHQLAKSAIDLQLKIGTELRS----------EVGLELSHVK---QS 1270
            :..| :||:....:.|.|:..|||:..::..:....||.:          :.|.:.....   :|
Human  1704 NMTQ-ELKHLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKS 1767

  Fly  1271 LGTVVQTSKEALRKANEVYDTALTLLNDVNRQ----------TQPEID--ISQLKK------DAV 1317
            ||..:   ||..|.|..|.:.|:.|...:..:          .|.|||  |.:|::      ..:
Human  1768 LGEFI---KELARDAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQKEI 1829

  Fly  1318 AANE--RADELLKQITEL-SNSNGELFADFETEQELTEAL------------LKRAEQQQLEDIE 1367
            |.:|  .|:.|||::.:| ..|.||   :.|.|::|.|.|            |.|....::.:..
Human  1830 AEDELVAAEALLKKVKKLFGESRGE---NEEMEKDLREKLADYKNKVDDAWDLLREATDKIREAN 1891

  Fly  1368 LL----ERAKAAHDKATKAVEQG----DNTLKEANNTYEK----------LAGFQSDVQ-RSSES 1413
            .|    ::...|.:|..:|||.|    :|||||.|:..::          :..:..|:| :....
Human  1892 RLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPM 1956

  Fly  1414 AEKALQTVPNIEKEIQN---AESLISQAEE----------ALDGANKNANEAKKNAQEAQLKY-- 1463
            :|:....:.::.:||::   ||. :||||.          .|||....|.....||..|...|  
Human  1957 SEELNDKIDDLSQEIKDRKLAEK-VSQAESHAAQLNDSSAVLDGILDEAKNISFNATAAFKAYSN 2020

  Fly  1464 -------AEQASKDAELIRRKA--------------------------NETKVAARNLREEADQL 1495
                   ||:.:|:|:.:..:|                          ||.|..|.:::|..|.|
Human  2021 IKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVKENEDHL 2085

  Fly  1496 NH-RVKLTEMDIFKLEESSTKDDNL-------------VDDAKRKVGQAKADTQEAQKQIEKANA 1546
            |. :.::...|....:...|.:|.|             :...|.|..||....::...||.:.:.
Human  2086 NGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQAVKDKARQANDTAKDVLAQITELHQ 2150

  Fly  1547 DLTAIKDELENLKD----INTGDLDRLENRL-----ATV---EGEINRVNLTGRIEKYREQRTIQ 1599
            :|..:|.....|.|    .|....|..:|::     |||   |.|.:|:     |:|.:..:.::
Human  2151 NLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVKNLEQEADRL-----IDKLKPIKELE 2210

  Fly  1600 KNLIDKYDAELRELKDEVQ 1618
            .|| .|..:|::||.::.:
Human  2211 DNL-KKNISEIKELINQAR 2228

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB2NP_001287009.1 LamNT 61..296 CDD:214532 76/260 (29%)
EGF_Lam 298..347 CDD:238012 19/48 (40%)
Laminin_EGF 359..414 CDD:278482 24/70 (34%)
EGF_Lam 414..458 CDD:214543 20/53 (38%)
Laminin_EGF 461..511 CDD:278482 23/49 (47%)
LamB 572..697 CDD:214597 38/150 (25%)
TNFRSF <721..848 CDD:304602 56/135 (41%)
CRD2 724..771 CDD:276900 21/48 (44%)
EGF_Lam 743..791 CDD:238012 24/48 (50%)
Laminin_EGF 847..897 CDD:278482 20/49 (41%)
Laminin_EGF 902..953 CDD:278482 18/138 (13%)
Laminin_EGF 956..1004 CDD:278482 21/93 (23%)
Laminin_EGF 1004..1050 CDD:278482 22/102 (22%)
V_Alix_like 1122..1443 CDD:187408 96/633 (15%)
Tar 1139..1521 CDD:223910 115/673 (17%)
BAR 1308..1469 CDD:299863 54/224 (24%)
vATP-synt_E 1474..>1629 CDD:304907 40/197 (20%)
LAMA2XP_016866340.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.