DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB2 and Megf8

DIOPT Version :9

Sequence 1:NP_001287009.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster
Sequence 2:NP_609180.3 Gene:Megf8 / 34099 FlyBaseID:FBgn0031981 Length:2892 Species:Drosophila melanogaster


Alignment Length:1276 Identity:256/1276 - (20%)
Similarity:380/1276 - (29%) Gaps:520/1276 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 LLLIGVLFASCSTAILGAQRPPINSAGGHELRGTTFMPALEC--YDPY----GRPQ--------K 66
            ||::|....:.:..:...:.|.:     ..:..|.:.|.:.|  :..:    ..|:        .
  Fly   617 LLIVGGYHGNVNADLFAYELPQV-----LRVENTLYNPEISCRLHSSHTACLSNPECGWCSADSS 676

  Fly    67 CLPEFINAAYQLQIEST---NTCGEQNDNHFCIQTMNQNHKN-----------------CEFCKY 111
            |....|.|.....:::|   ..|....|.|.|:...:|..|:                 |.:|..
  Fly   677 CYGRTIGANCTTNLQTTRCPGICPSLGDCHSCLVHGSQWGKSSGNKAAFSVASKLGLNECTWCVQ 741

  Fly   112 N------DHNPSFLTDLHDPQSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRILFRSPRP 170
            |      |.|.....|     |..||..:.  ..|:.|:....|   .:...:||::..|    |
  Fly   742 NAKCHHRDDNYGICGD-----SSGWWGDKG--TEIRRPSLCTST---DRRPGLTYIKYHF----P 792

  Fly   171 ESFTIYKRTSESGPWIPYQFYSATCRDTYSLPDSRAI-RKGEGE------------------AHA 216
            .::|:.....         ..:||..|..|.|.:... .|.|||                  |..
  Fly   793 INYTMPDYVG---------IVNATMVDFASPPFTTYFEHKLEGEMLARLVGFVRPQHQWNNSAIQ 848

  Fly   217 LCTSEYSDISPLRDGEIAFSTLEGRPSGINFERSGELQEWVT--------------ATDIRITLD 267
            :|||..|.:  ||.|           .|:|.:   ||....|              .|:...|:|
  Fly   849 VCTSYSSAV--LRAG-----------LGLNLD---ELVNVTTQSSNQSYCSNVQLPTTEQPFTID 897

  Fly   268 ---RLNTFGDELFGDSQVLKSYFYAISDIAVGARCKCNG-------------HASKCVPSTGMHG 316
               |....|:.::...|..|.....:.          ||             ::.||        
  Fly   898 FQTRRRIGGNGIYNAYQKTKMELQHLH----------NGQLNAFTFEYLEPYYSGKC-------- 944

  Fly   317 ERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANLFNRTGHG 381
              |....|.|......|..| ||.|....:     .|||.:.|....|  ..|..:.|.::....
  Fly   945 --TQYSNCLHCLTDASCAWC-PLTNICHLR-----SVNETEVCKMETL--DTFHWSYLISQPSQC 999

  Fly   382 GHCLDCRENRDGPNCERCKENFYMRDDGYC----VNCACDPVG--SRSLQCNSHGKCQCKPGVTG 440
            .:|.:.      .:||.|..:      |.|    .:..|..:|  :.|::...|....|:     
  Fly  1000 SNCTNY------VSCEACARS------GECEWWTEDARCGRIGKTNSSVRAVEHCPRSCR----- 1047

  Fly   441 DKCDRCDNNYYQFGPHGCQQCGCDSGGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLDK 505
               :|          ||||:|..:.|                         ||..|:        
  Fly  1048 ---ER----------HGCQECLGERG-------------------------RCVWCE-------- 1066

  Fly   506 NNRFGCTPCFCYG-HTSECMTAPGYSIVSVTSNFNKFKERWTAADLNQREVDIKYNQYSRSIGTT 569
                ....||.:. :|||             ..|...:| |         ||...::.::.|.  
  Fly  1067 ----ASAQCFSFSVYTSE-------------YQFGMCRE-W---------VDQVVSRQTQEIA-- 1102

  Fly   570 AQGNEHVYFQAPDRFLGDQRAS--YNRDLKFKLQLVGQVANTG---VSDVILEGAGSRISLPIFA 629
                :|...|.| .||..|..|  .:|:....|:.:    :.|   ..|..:||        |..
  Fly  1103 ----DHKPQQTP-HFLQQQCKSCEQHRNCSSCLRTL----SCGWCFDRDNPIEG--------ICM 1150

  Fly   630 QGNGIPDQGVKEYTFRLHEHHDYQWQPSQSARGFLSILSNLTAIKIRATYSVQGEAILDDVELQT 694
            ||:.....|..........|||.:|..:|                                    
  Fly  1151 QGDFSYSAGNCSLALNSSSHHDAEWAYAQ------------------------------------ 1179

  Fly   695 AHRGAAGHPATWIEQCTCPEGYLGQFCESCAPGYRHSPARGGPFMPCIPCDCHGHADICDSETG- 758
                             ||:      .:.|..|..               |||..|. |.:..| 
  Fly  1180 -----------------CPD------VDECGLGLH---------------DCHKEAK-CTNTQGS 1205

  Fly   759 -RCICQHNTHGDNCDQCAKGFY-----GN-----------ALGGTPNDC-KRCPCPNDGACLQIN 805
             .|.|:....||....|.:..|     ||           |||.|..|| ..|.|.|...|   |
  Fly  1206 YNCHCRRGYIGDGKFSCVRTCYELCQNGNCSGPPDYTCRCALGWTGADCGLSCGCNNHSTC---N 1267

  Fly   806 EDTVICTECPKGYFGSRCEQCSDGFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLK 870
            |....|.:|.....|.:||:|..|.:|:.|...|    |..|:|||:.:.: :|.||.:.|||. 
  Fly  1268 ERLGKCDQCQDWSEGEKCERCRQGSYGNATAPHG----CLPCECNGHGNQD-LGVCNVSNGECY- 1326

  Fly   871 CIHNTAGEHCDQCLSGHFGDPLALPHGRCDRCSCYEAG--------------------------- 908
            |..||.|.:|:.|..|::|||..  .|:| ...|...|                           
  Fly  1327 CKDNTQGLNCELCAPGYYGDPRG--GGKC-YYQCESRGILTNIGKSAIGSYQSYRSPWGASLEVK 1388

  Fly   909 ---------TEQDEQSITR-----------CDQ-----------VTGQCQ--------C----KP 930
                     |.|.|:|:.:           ||:           :||..|        |    .|
  Fly  1389 ECLWILQPKTLQAEKSLLQLEFQWQSLAMDCDENAVYIYDSLPDLTGATQQNQLLAVVCAPYSSP 1453

  Fly   931 NVIGRDCGECQPGYFNIRSGNGCE-------------NCLCDPVGSYNS--TCDRYSGQCHCRPG 980
            .:|     |.:..:..:....|.|             ||:   .||..|  .||... :|.|..|
  Fly  1454 RII-----EARSSHVTVHYKQGSERRHFGFNALYSVMNCV---AGSCISPHICDAQQ-RCVCPAG 1509

  Fly   981 VMGQRCDQCENYFYGFSSEGCKPCECDESGSKGFQCD-QNGQCPC-NDNVEGRRCDRCKENKYDR 1043
            .:|..|:          .|.| |..|:....:|| || :.|:|.| |.|..|             
  Fly  1510 YVGASCE----------IEIC-PSNCNAKRMQGF-CDTEYGRCICSNANYAG------------- 1549

  Fly  1044 HRGCIDCPDCYNLVQDAADLHRAKLFN---LSQTLDEIART 1081
                   .||..||| ...|...:|||   ||::|:.:.:|
  Fly  1550 -------ADCGTLVQ-RNHLVMTELFNTQLLSESLEHLRKT 1582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB2NP_001287009.1 LamNT 61..296 CDD:214532 57/308 (19%)
EGF_Lam 298..347 CDD:238012 12/61 (20%)
Laminin_EGF 359..414 CDD:278482 10/58 (17%)
EGF_Lam 414..458 CDD:214543 7/45 (16%)
Laminin_EGF 461..511 CDD:278482 5/49 (10%)
LamB 572..697 CDD:214597 22/129 (17%)
TNFRSF <721..848 CDD:304602 39/145 (27%)
CRD2 724..771 CDD:276900 12/48 (25%)
EGF_Lam 743..791 CDD:238012 20/66 (30%)
Laminin_EGF 847..897 CDD:278482 20/49 (41%)
Laminin_EGF 902..953 CDD:278482 15/120 (13%)
Laminin_EGF 956..1004 CDD:278482 13/49 (27%)
Laminin_EGF 1004..1050 CDD:278482 11/47 (23%)
V_Alix_like 1122..1443 CDD:187408
Tar 1139..1521 CDD:223910
BAR 1308..1469 CDD:299863
vATP-synt_E 1474..>1629 CDD:304907
Megf8NP_609180.3 CUB 33..141 CDD:238001
KELCH repeat 228..268 CDD:276965
Kelch_4 369..414 CDD:290154
KELCH repeat 370..420 CDD:276965
KELCH repeat 425..476 CDD:276965
KELCH repeat 480..540 CDD:276965
EGF_3 1186..1220 CDD:289699 12/49 (24%)
EGF_Lam 1257..1302 CDD:238012 16/51 (31%)
EGF_Lam 1304..1354 CDD:238012 22/54 (41%)
CUB 1372..1484 CDD:238001 15/116 (13%)
Kelch_4 1584..1628 CDD:290154
KELCH repeat 1585..1638 CDD:276965
KELCH repeat 1642..1685 CDD:276965
Kelch_3 1656..1710 CDD:290151
KELCH repeat 1760..1813 CDD:276965
Kelch_4 1760..1802 CDD:290154
KELCH repeat 1817..1867 CDD:276965
EGF_Lam 2299..2346 CDD:238012
EGF_Lam 2422..2487 CDD:238012
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45445148
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR10574
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.030

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