DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB2 and LanB1

DIOPT Version :9

Sequence 1:NP_001287009.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster
Sequence 2:NP_476618.1 Gene:LanB1 / 34068 FlyBaseID:FBgn0261800 Length:1788 Species:Drosophila melanogaster


Alignment Length:1933 Identity:508/1933 - (26%)
Similarity:792/1933 - (40%) Gaps:505/1933 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 RLLLIGVLFASCSTAILG-------AQRPPINSAGGHELRG------TTFMPALECYDPYGRPQK 66
            ||:::.||      |:|.       :||||     .|..|.      ..|:....|     ....
  Fly     5 RLIVVIVL------ALLSWQWDPVDSQRPP-----QHGRRDRPKYPPNKFIKTHPC-----ERSS 53

  Fly    67 CLPEFIN--AAYQLQIESTNTCGEQNDNHFCIQTMNQNHKNCEFCKYNDHNPSFLTDLHDPQS-- 127
            |.|...|  ...:.::.:::|||..:...|||.:..|: |.|..|...:...      |||..  
  Fly    54 CYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQD-KKCFLCDTREETK------HDPYKNH 111

  Fly   128 ---------------PTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRILFRSPRPESFTIYK 177
                           |||||||...|.      ..:.|.|...:..|::.|.|.:.||.:..|.:
  Fly   112 RIGQIIYKTKPGTNIPTWWQSENGKEN------ATIQLDLEAEFHFTHLIITFTTFRPAAMYIER 170

  Fly   178 RTSESGPWIPYQFYSATCRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRP 242
            .......|..|::::..|::  |.|....:.  |.....:|||.||::.|.|:||:.|..|   |
  Fly   171 SFDFGQTWHIYRYFAYDCKE--SFPGVPTVL--ENITDVMCTSRYSNVEPSRNGEVIFRVL---P 228

  Fly   243 SGINF--ERSGELQEWVTATDIRITLDRLNTFGDELFGDSQV--LKSYFYAISDIAVGARCKCNG 303
            ..||.  ..:..:|..:..|::||.:.:|:..||.|. ||::  .:.|:|.||::.|...|.|.|
  Fly   229 PNINVTDPYAEHVQNQLKMTNLRIQMTKLHKLGDNLL-DSRLENEEKYYYGISNMVVRGSCSCYG 292

  Fly   304 HASKCVP----------STGM-HGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECK 357
            |||:|:|          ..|| ||.    |||.|||.|.:|:.|...:|||.||.:...:.|.||
  Fly   293 HASQCLPLDPAFSQADNEDGMVHGR----CECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACK 353

  Fly   358 ACNCNGLADKCFFDANLFNRTG--HGGHCLDCRENRDGPNCERCKENFYMRD-------DGYCVN 413
            .|.||..|..|.||..:|..:|  .||.|.:|..|..|.:||.|...|| ||       :..|..
  Fly   354 KCECNDHAVSCHFDEAVFTASGFVSGGVCDNCLHNTRGQHCEECMPYFY-RDPEQDITSERVCQP 417

  Fly   414 CACDPVGSRSLQ-CNS---------HGKCQCKPGVTGDKCDRCDNNYYQF---GPHGCQQCGCDS 465
            |.|||.||.... |:|         .|.|.||..|||.:|::|.:.|:..   .|.||:.|.|:.
  Fly   418 CDCDPQGSSDDGICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNP 482

  Fly   466 GGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLDKNNRFGCTPCFC-----YGH-----T 520
            .|:..|: .|...||.|.||:.|.|:.||:|.|..:.|.::.. ||:.|.|     |.:     :
  Fly   483 LGTLNNS-GCVMRTGECKCKKYVTGKDCNQCMPETYGLSESPE-GCSLCNCDAGGSYDNYCDVIS 545

  Fly   521 SECMTAP---GYSIVSVTSNFNKFKERWTAADLNQREVDIKYNQYSRSIGTTAQGNEHVYFQAPD 582
            .:|...|   |.|......|:  |..  ...::::.||      ....|...|.||..:..:.||
  Fly   546 GQCRCRPHMTGRSCSQPKQNY--FIP--LLPEVHEAEV------VDECISYGANGNCSLVAETPD 600

  Fly   583 ---RFLGDQRASYNRDLKFKLQLVGQVANTGVSDVILE--------------------------G 618
               ..:|..|...|.:|.|   .||.:..:...|.::.                          |
  Fly   601 GSFTGIGFTRVPENSELVF---TVGDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGG 662

  Fly   619 AG-------SRISLPIFAQGNGIPD-------------QGVKEYTFRLH---EHHDYQWQPSQSA 660
            .|       |...:|.     .:||             :..|.|.||::   :.||.. .|:.:.
  Fly   663 CGELAAATSSETRIPF-----SLPDRSRQVVALNEVCLEAGKVYKFRIYFERKRHDVD-SPTATI 721

  Fly   661 RGFLSILSNLTAI-KIRATYSVQGEAI------------------------------LDDVELQT 694
                 ::.:||.| :|..|...||..:                              ||::....
  Fly   722 -----LVDSLTLIPRIDVTPIFQGSVLADIRKKDYEKYNCKSSLYDMNYKSDPKCQNLDNILSVF 781

  Fly   695 AHRGAA------------------GH----------------PATW------------------- 706
            .|.||:                  |:                |.|:                   
  Fly   782 VHDGASMCNCNPTGSLSKVCESNGGYCQCKPNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKD 846

  Fly   707 ------IEQCTCPEGYLGQFCESCAPGYRHSPARGGPFMPCIPCDCHGHADICDSETGRCI-CQH 764
                  ..||.|.....|:.|..|.|||.:.|       .|..|.|:|||..||...|.|| ||.
  Fly   847 KYCDLITGQCQCVPNTYGRECNQCQPGYWNFP-------ECRVCQCNGHAATCDPIQGTCIDCQD 904

  Fly   765 NTHGDNCDQCAKGFYGNALGGTPNDCKRCPCPN---------DGACLQINEDTVICTECPKGYFG 820
            :|.|.:||.|..|:|||.|.|:...|:.|.||.         ||..|....:.::| .|.:||.|
  Fly   905 STTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPETVASGLAHADGCSLDTRNNNMLC-HCQEGYSG 968

  Fly   821 SRCEQCSDGFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLS 885
            ||||.|:|.|||:|    ....||..|:|:.|||....|||:|.||.||||::.|.|:||:.|..
  Fly   969 SRCEICADNFFGNP----DNGGTCSKCECSNNVDLYDTGNCDRQTGACLKCLYQTTGDHCELCKD 1029

  Fly   886 GHFGDPLALPHGRCDRCSCYEAGTEQDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIRSG 950
            |.|||.|   ...|.:|.|...||   ..:|..||:.||||.|.|||.|..|.:|...::.|.||
  Fly  1030 GFFGDAL---QQNCQQCECDFLGT---NNTIAHCDRFTGQCPCLPNVQGVRCDQCAENHWKIASG 1088

  Fly   951 NGCENCLCDPVGSYNSTCDRYSGQCHCRPGVMGQRCDQCENYFYGFSSEGCKPCECDESGSKGFQ 1015
            .|||:|.|||:|:.:..|:.|:|||.|:||..|:.|:||:.:::|..:|.|:|||||:.|:..||
  Fly  1089 EGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACNQCQAHYWGNPNEKCQPCECDQFGAADFQ 1153

  Fly  1016 CD-QNGQCPCNDNVEGRRCDRCKENKYDRHRGCIDCPDCYN-------LVQDA--ADLHRAKLFN 1070
            || :.|.|.|::.:.|.:|:.|......:...|..|.:|:|       .::||  |.:.|||   
  Fly  1154 CDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGECFNNWDLILSALEDATTATILRAK--- 1215

  Fly  1071 LSQTLDEIARTPVTND-----DEFEAKLKAVQ-------------EKVAVLAQDARDN-SGDGGQ 1116
                  ||.:...|..     .|.:.||:.::             ||:....|..||. ....|:
  Fly  1216 ------EIKQVGATGAYTSEFSELDKKLQHIRNLLQNTSVSLVDIEKLDYETQSLRDQLQASHGR 1274

  Fly  1117 TYAEVIDDLHKHLDSVREHLVSADKFQADANG-EIDRARQNYTILDQITENAKK---ELQQALDL 1177
                 :.:..::||.:...|        ..:| |::..:.:..::.|:::..|:   :||::   
  Fly  1275 -----LSETEQNLDDIYNSL--------SLSGVELESLQNHSRLVQQLSKELKENGIQLQES--- 1323

  Fly  1178 LNDEGAQALAR-AKEKSVEFGQQSEQISDIS-------REARALADKLESEAQFDLKNAKDAKDA 1234
             |.|||..|.| |.|:........::.::::       :....|::|:::||.....|.|..:|.
  Fly  1324 -NIEGALNLTRHAYERVSNLSTLKDEANELASNTDRNCKRVENLSNKIQAEADDLANNNKLIEDY 1387

  Fly  1235 VEKAHQL----------------------------------------AKSAIDLQLKIGTELRSE 1259
            ..:...|                                        ||:..:..||:..:..:.
  Fly  1388 RAELTSLTSQIPELNNQVCGKPGDPCDSLCGGAGCGHCGGFLSCEHGAKTHSEEALKVAKDAETA 1452

  Fly  1260 VGLELSHVKQSLGTVVQ---TSKEALRKANEVYDTALTLLNDVNRQTQPE----IDISQLKKDAV 1317
            :..:.....|::..:.|   .:.||..||...::.:...||..|...:..    |.::..:::..
  Fly  1453 ITSKKDQADQTIRALTQAKLNASEAYEKAKRGFEQSERYLNQTNANIKLAENLFIALNNFQENKT 1517

  Fly  1318 AANERADELLKQITELSNSNGELFADFETEQELTEAL---LKRAEQQQLEDIE-LLERAKAAHDK 1378
            |:...:.||.::..:|         |.:.|.|..|.|   :.|| ...|:::| ::.|.|...|:
  Fly  1518 ASPSESKELAQKTLDL---------DLKLEPEEIETLGDQINRA-VSSLKNVEAIIYRTKPDLDR 1572

  Fly  1379 ---------ATKAVEQGDNTLKEANNTYEKLA------GFQSD-VQRSSESAEKALQTVPNIEKE 1427
                     |||  |:.|..|..||:..|.||      |...| :|:::.:.|.|.|.:..|::|
  Fly  1573 VNNLQSIANATK--EKADKILDSANSVVESLAAADESQGKAKDAIQQANSNIELAGQDLEKIDEE 1635

  Fly  1428 IQNAESLISQAEEALDGANKNANEAKKNAQEAQLKYAEQASK---DAELIRRKANETKVAARNLR 1489
            ..:||:          .||..|.:.:|.|::.| |......|   ||:.|.::|...|:.|...|
  Fly  1636 TYSAEA----------PANNTAQQVEKLAKKVQ-KLQNNIMKNDRDAKEITKEAGSVKLEAMRAR 1689

  Fly  1490 EEADQLNHRVKLTEMDIFKLEESSTKDDNLVDDAKRKVGQAKADTQEAQKQIEKANADLTAIKDE 1554
            .||:.|......|..   .|.:.:::.:|..:.||:.:       |.|.|.....||       :
  Fly  1690 GEANNLQSATSATNQ---TLTDRASRSENARERAKQLL-------QRASKLTVDTNA-------K 1737

  Fly  1555 LENLKDINTGDLD------RLENRLATVEGEINR--VNLTGRIEKYRE 1594
            |::|.|:.|..|:      ||:..:..:..|:|.  :::..|...||:
  Fly  1738 LKDLNDLQTVYLNKNQQLLRLQAEIGPLNKELNEHLIHIKERGSHYRQ 1785

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB2NP_001287009.1 LamNT 61..296 CDD:214532 66/257 (26%)
EGF_Lam 298..347 CDD:238012 25/59 (42%)
Laminin_EGF 359..414 CDD:278482 23/63 (37%)
EGF_Lam 414..458 CDD:214543 19/56 (34%)
Laminin_EGF 461..511 CDD:278482 17/49 (35%)
LamB 572..697 CDD:214597 34/207 (16%)
TNFRSF <721..848 CDD:304602 54/136 (40%)
CRD2 724..771 CDD:276900 20/47 (43%)
EGF_Lam 743..791 CDD:238012 23/48 (48%)
Laminin_EGF 847..897 CDD:278482 25/49 (51%)
Laminin_EGF 902..953 CDD:278482 21/50 (42%)
Laminin_EGF 956..1004 CDD:278482 20/47 (43%)
Laminin_EGF 1004..1050 CDD:278482 16/46 (35%)
V_Alix_like 1122..1443 CDD:187408 76/399 (19%)
Tar 1139..1521 CDD:223910 94/463 (20%)
BAR 1308..1469 CDD:299863 44/180 (24%)
vATP-synt_E 1474..>1629 CDD:304907 30/129 (23%)
LanB1NP_476618.1 Laminin_N 63..286 CDD:278484 64/243 (26%)
EGF_Lam 287..343 CDD:238012 25/59 (42%)
Laminin_EGF 355..415 CDD:278482 22/60 (37%)
Laminin_EGF 418..475 CDD:278482 19/56 (34%)
EGF_Lam 477..526 CDD:238012 17/50 (34%)
EGF_Lam 529..567 CDD:214543 8/39 (21%)
EGF_Lam 789..834 CDD:214543 3/44 (7%)
Laminin_EGF 837..885 CDD:278482 12/54 (22%)
Laminin_EGF 883..930 CDD:278482 23/46 (50%)
Laminin_EGF 933..988 CDD:278482 21/59 (36%)
Laminin_EGF 991..1043 CDD:278482 26/54 (48%)
Laminin_EGF 1043..1091 CDD:278482 21/50 (42%)
Laminin_EGF 1094..1142 CDD:278482 20/47 (43%)
Laminin_EGF 1142..1190 CDD:278482 16/47 (34%)
COG6 1212..>1398 CDD:303003 40/211 (19%)
TelA 1439..1782 CDD:226371 87/382 (23%)
ApoLp-III_like 1545..1702 CDD:304399 47/170 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45445144
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D2946at50557
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR10574
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.950

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