DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB2 and HSPG2

DIOPT Version :9

Sequence 1:NP_001287009.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster
Sequence 2:XP_011539620.1 Gene:HSPG2 / 3339 HGNCID:5273 Length:4574 Species:Homo sapiens


Alignment Length:858 Identity:235/858 - (27%)
Similarity:337/858 - (39%) Gaps:234/858 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   212 GEAHALCTSEYSDISP--LRDGEIAFST-----LEGRPSGINFERSGELQEWVTATDIRITLDRL 269
            |..:.|.:..::...|  |...::.||.     ..|||     .:..||.:.:.:.:..:.....
Human   657 GAGYRLLSRGHTPTQPGALNQRQVQFSEEHWVHESGRP-----VQRAELLQVLQSLEAVLIQTVY 716

  Fly   270 NTFGDELFGDSQVLKSYFYAISDIAVGARCKCNGHASKCVPSTGMHGERTLV--CECRHNTDGPD 332
            ||            |.....:||||:.....   ||:.       ||....|  |.|.....|..
Human   717 NT------------KMASVGLSDIAMDTTV
T---HATS-------HGRAHSVEECRCPIGYSGLS 759

  Fly   333 CDRCLPLYNDLKWKR-STSTEVNECKACNCNGLADKCFFDANLFNRTGHGGHCLDCRENRDGPNC 396
            |:.|     |..:.| .....:..|..|||||.|..|  |...       ||||:|:.|.:||.|
Human   760 CESC-----DAHFTRVPGGPYLGTCSGCNCNGHASSC--DPVY-------GHCLNCQHNTEGPQC 810

  Fly   397 ERCKENFY---MRDDG-YCVNCACDPV-GSRS------LQCNSHGKCQ-CKPGVTGDKCDRC--- 446
            .:||..|:   |:... .|..|.|..: .||.      |..:....|. |.||.||.:|:.|   
Human   811 NKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAPG 875

  Fly   447 -DNNYYQFG----PHGCQQCGCDSGGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLDKN 506
             :.|..|.|    |...:...||..||      ..|....|.||.||.||.||||..|.|:|...
Human   876 YEGNPIQPGGKCRPVNQEIVRCDERGS------MGTSGEACRCKNNVVGRLCNECADGSFHLSTR 934

  Fly   507 NRFGCTPCFCYGHTSECMTA-------------PG-YSIVSV----TSNFNKFKERWTAADLNQR 553
            |..||..|||.|.:..|.::             || :|:.:.    |:|...|..  |..:|.  
Human   935 NPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEPGHFSLTNAASTHTTNEGIFSP--TPGELG-- 995

  Fly   554 EVDIKYNQYSRSIGTTAQGNEHVYFQAPDRFLGDQRASYNRDLKFKLQLVGQVANT---GVSDVI 615
                 ::.:.|.:      :...::..|.|||||:..||..:|:|.:....|..:|   |...|:
Human   996 -----FSSFHRLL------SGPYFWSLPSRFLGDKVTSYGGELRFTVTQRSQPGSTPLHGQPLVV 1049

  Fly   616 LEGAGSRISLPIFAQGNGIPDQGVKEYTFRLHEHH------------------DYQW-----QPS 657
            |             |||.|           :.|||                  :..|     ||:
Human  1050 L-------------QGNNI-----------ILEHHVAQEPSPGQPSTFIVPFREQAWQRPDGQPA 1090

  Fly   658 QSARGFLSILSNLTAIKIRATYSVQ-GEAILDDVELQTAHRGAAGH-PATWIEQCTCPEGYLGQF 720
             :....|..|:.:..:.|||:|:.| .|:.:..:.:..|.....|. ||..:|||:||.||.|..
Human  1091 -TREHLLMALAGIDTLLIRASYAQQPAESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPS 1154

  Fly   721 CESCAPGYRHSPARGGPFM-PCIPCDCHGHADICDSETGRCI-CQHNTHGDNCDQCAKGFYGNAL 783
            |:.|..||..:|:  |.:: .|..|.||||::.|:.|||.|. |||:|.|..|:||..|:||:|.
Human  1155 CQDCDTGYTRTPS--GLYLGTCERCSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQ 1217

  Fly   784 GGTPNDCKRCPCPNDGA-------CLQINEDTVICTECPKGYFGSRCEQCSDGFFGDPTGLLGEV 841
            .|||.||:.|||..|.|       |....:....|..|..|:.|..||:|:.|::|:|:    :.
Human  1218 RGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPS----QG 1278

  Fly   842 QTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSGHFGDPLALPHGRCDRCSCYE 906
            |.|:    ..:..|..:| ||                 ||             |.|...      
Human  1279 QPCQ----RDSQVPGPIG-CN-----------------CD-------------PQGSVS------ 1302

  Fly   907 AGTEQDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIRSGN--GCENCLCDPVGSY--NST 967
                      ::|| ..||||||..|.|..|..|:|.:|::.:.|  ||..|.|..:...  :|.
Human  1303 ----------SQCD-AAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFCMGITQQCASSA 1356

  Fly   968 CDRYSGQCHCRPG 980
            ..|:....|..||
Human  1357 YTRHLISTHFAPG 1369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB2NP_001287009.1 LamNT 61..296 CDD:214532 18/90 (20%)
EGF_Lam 298..347 CDD:238012 11/50 (22%)
Laminin_EGF 359..414 CDD:278482 22/58 (38%)
EGF_Lam 414..458 CDD:214543 17/59 (29%)
Laminin_EGF 461..511 CDD:278482 20/49 (41%)
LamB 572..697 CDD:214597 34/151 (23%)
TNFRSF <721..848 CDD:304602 52/135 (39%)
CRD2 724..771 CDD:276900 21/48 (44%)
EGF_Lam 743..791 CDD:238012 26/48 (54%)
Laminin_EGF 847..897 CDD:278482 7/49 (14%)
Laminin_EGF 902..953 CDD:278482 15/52 (29%)
Laminin_EGF 956..1004 CDD:278482 7/27 (26%)
Laminin_EGF 1004..1050 CDD:278482
V_Alix_like 1122..1443 CDD:187408
Tar 1139..1521 CDD:223910
BAR 1308..1469 CDD:299863
vATP-synt_E 1474..>1629 CDD:304907
HSPG2XP_011539620.1 SEA 80..193 CDD:214554
LDLa 216..251 CDD:238060
LDLa 302..336 CDD:238060
LDLa 342..376 CDD:238060
LDLa 385..420 CDD:238060
IG 431..507 CDD:214652
Ig_Perlecan_D2_like 438..515 CDD:143220
LamB 608..734 CDD:214597 18/93 (19%)
EGF_Lam 782..824 CDD:238012 21/50 (42%)
EGF_Lam 831..888 CDD:238012 16/56 (29%)
Laminin_EGF 897..939 CDD:278482 20/47 (43%)
LamB 1003..1130 CDD:214597 34/157 (22%)
EGF_Lam 1176..1225 CDD:238012 26/48 (54%)
EGF_Lam 1227..1282 CDD:238012 17/58 (29%)
Laminin_EGF 1293..1340 CDD:278482 21/93 (23%)
LamB 1574..1699 CDD:214597
EGF_Lam 1746..1794 CDD:238012
Laminin_EGF 1796..1851 CDD:278482
Ig_2 1866..1958 CDD:290606
IG_like 1866..1946 CDD:214653
Ig3_Perlecan_like 1954..2039 CDD:143231
IG 1961..2040 CDD:214652
I-set 2049..2133 CDD:254352
Ig 2063..2133 CDD:299845
I-set 2139..2225 CDD:254352
IGc2 2153..2215 CDD:197706
IG_like 2240..2317 CDD:214653
IGc2 2247..2307 CDD:197706
IG 2341..2418 CDD:214652
IGc2 2348..2408 CDD:197706
IG_like 2434..2508 CDD:214653
IGc2 2441..2500 CDD:197706
IG_like 2530..2607 CDD:214653
IGc2 2537..2595 CDD:197706
I-set 2620..2703 CDD:254352
IGc2 2633..2693 CDD:197706
IG 2731..2800 CDD:214652
IGc2 2731..2790 CDD:197706
IG_like 2819..2896 CDD:214653
IGc2 2826..2885 CDD:197706
IG 2916..2993 CDD:214652
IGc2 2923..2983 CDD:197706
IG 3016..3093 CDD:214652
IGc2 3023..3083 CDD:197706
Ig_2 3112..3192 CDD:290606
IG_like 3115..3192 CDD:214653
I-set 3205..3291 CDD:254352
ig 3209..3289 CDD:278476
IG 3303..3385 CDD:214652
Ig 3313..3382 CDD:143165
IG 3404..3478 CDD:214652
IGc2 3409..3468 CDD:197706
I-set 3482..3565 CDD:254352
IGc2 3496..3555 CDD:197706
IG_like 3589..3666 CDD:214653
Ig 3600..3666 CDD:299845
I-set 3676..3755 CDD:254352
IGc2 3686..3745 CDD:197706
I-set 3764..3841 CDD:254352
Ig 3779..3834 CDD:299845
LamG 3848..4008 CDD:238058
EGF_CA <4035..4064 CDD:238011
LamG 4117..4266 CDD:238058
EGF 4291..4321 CDD:278437
EGF_CA 4328..4359 CDD:238011
LamG 4386..4545 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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