DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB2 and Lama1

DIOPT Version :9

Sequence 1:NP_001287009.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster
Sequence 2:NP_001101707.2 Gene:Lama1 / 316758 RGDID:1307207 Length:3083 Species:Rattus norvegicus


Alignment Length:2241 Identity:543/2241 - (24%)
Similarity:814/2241 - (36%) Gaps:751/2241 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 GSSTARLLLIGVLFASCSTAILGAQRPPINSAGGHELRGTTFMPALECYDPYGRPQKCLPEFINA 74
            ||.|...||  ||.||.....:.:|:           ||                  ..|..:|.
  Rat     3 GSGTGVALL--VLLASVLWVTVRSQQ-----------RG------------------LFPAILNL 36

  Fly    75 AYQLQIESTNTCGEQNDNHFC-----IQTMNQNHKNCEFCKYNDHNPSF---LTDLHDPQSPTWW 131
            |....|.:..||||:....||     :......|..|..|..|..||..   :|...|..: .||
  Rat    37 ATNAHISANATCGEKGPEMFCKLVEHVPGRPVRHAQCRVCDGNSTNPRERHPITHAIDGTN-NWW 100

  Fly   132 QSETMFEGIQHPNYVNLTLHLGKSYDITYVRI-LFRSPRPESFTIYKRTSESGPWIPYQFYSAT- 194
            ||.::..|.:: ::|.:||.|.:.:.:.||.| ...:|||.:: |.:|:.:...:.|:|:|:.: 
  Rat   101 QSPSIQNGREY-HWVTVTLDLRQVFQVAYVIIKAANAPRPGNW-ILERSVDGVKFRPWQYYAVSD 163

  Fly   195 --CRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPSGINFERSGELQEWV 257
              |...|.:...|.......:...:|||.||.:.||..|||..|.:.||||.  .:.|.:|.|:.
  Rat   164 TECLTRYKITPRRGPPTYRADNEVICTSYYSKLVPLEHGEIHTSLINGRPSA--DDPSPQLLEFT 226

  Fly   258 TATDIRITLDRLNTFGDELFG---------DSQVLKSYFYAISDIAVGARCKCNGHASKCVPSTG 313
            :|..||:.|.|:.|...:|..         |..|.:.|:|:|.||:||..|.|:||||.|   ..
  Rat   227 SARYIRLRLQRIRTLNADLMTLSHRDLRDLDPIVTRRYYYSIKDISVGGMCICSGHASSC---PW 288

  Fly   314 MHGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANL---- 374
            ....:.|.|:|.|||.|..||||.|.::...|:..|.:..|:|:.|||:..|..|::|.|:    
  Rat   289 DEEAKQLQCQCEHNTCGESCDRCCPGFHQQPWRPGTISSSNQCEECNCHNKAKDCYYDNNVAKER 353

  Fly   375 --FNRTGH---GGHCLDCRENRDGPNCERCKENFYM------RDDGYCVNCACDPVGSRSLQC-- 426
              .|..|.   ||.|::|.:|..|.|||.|.:.:|.      .:|..|..|.||||||.|..|  
  Rat   354 KSLNTAGQYSGGGVCINCLQNTTGINCETCIDQYYRPHKVSPYEDQPCRPCDCDPVGSLSSVCIK 418

  Fly   427 -NSH---------GKCQCKPGVTGDKCDRCDNNYYQFGPHG---CQQCGCDSGGSHQNTPACDTE 478
             :.|         |:|.|:.|..|||||||     |||..|   |..|.|.:.||....|.    
  Rat   419 DDLHADLANGKWPGQCPCRKGYAGDKCDRC-----QFGYRGFPNCVPCDCSTVGSVNEDPC---- 474

  Fly   479 TGICFCKENVEGRRCNECKPGFFNLDKNNRFGCTPCFCYGHTSECMTAPGYSIVSVTSNFNKFKE 543
            |..|.||:||||..|:.|||||:||.:.|..||:.|||:|.:..|.:.. :|:..||:     ..
  Rat   475 TEPCLCKKNVEGENCDRCKPGFYNLKERNPEGCSECFCFGVSDVCDSLT-WSVSQVTN-----MS 533

  Fly   544 RWTAADL-------NQREVDIKYNQYSRSIGTTA---QGNEHVYFQAPDRFLGDQRASYNRDLKF 598
            .|...||       :|::...::.|.  ||..||   :.....|:.||:.:||::..::...||:
  Rat   534 GWLVTDLISPNKIRSQQDALGRHRQI--SINNTAVMHRFTSPYYWAAPEAYLGNKLTAFGGFLKY 596

  Fly   599 KLQL---VGQVANTGVS--DVILEGAGSRISLPIFAQGNGIPDQGVKEY--TFRL--HEHHDYQW 654
            .:..   |..|.:..:|  |||::|.|    |.|..:..|:..|..:||  ..||  ....|:..
  Rat   597 TVSYDIPVETVDSNLMSHADVIIKGNG----LTISTRAEGLSLQPYEEYFNVVRLVPENFRDFNT 657

  Fly   655 QPSQSARGFLSILSNLTAIKIRATYSVQGEAI--LDDVELQTAHRGAAG-HPATWIEQCTCPEGY 716
            :........:::|:|:|.:.|||.|:....|:  ||.|.|..|...|.. ..|..:|.|.||:||
  Rat   658 RREIDRDQLMTVLANVTHLLIRANYNSAKMALYRLDSVSLDIASPNAIDLVVAADVEHCECPQGY 722

  Fly   717 LGQFCESCAPGYRHSPA--RGGPFMPCIPCDCHGHADICDSETGRCI-CQHNTHGDNCDQCAKGF 778
            .|..||:|.|||.....  .||   .|.||:||||:..||.. |.|. |.|||.||:|:||..||
  Rat   723 TGTSCEACLPGYYRVDGILFGG---ICQPCECHGHSSECDIH-GICSGCTHNTTGDHCEQCLPGF 783

  Fly   779 YGNALGGTPNDCKRCPCP-----ND--GACLQINEDTVICTECPKGYFGSRCEQCSDGFFGDPTG 836
            ||....|||.||:.|.||     |:  ..|...:.:.|:|.:|..||.|:.||:|:||::|:||.
  Rat   784 YGTPSRGTPGDCQPCACPLSIDSNNFSPTCHLTDREEVVCDQCAPGYSGAWCERCADGYYGNPTV 848

  Fly   837 LLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSGHFGDPLALPHGRCDR 901
            ..|   ||..|:|:|||||...|:|:..|||||||:.||.|.||::|..|.:||  |:....|..
  Rat   849 PGG---TCVPCNCSGNVDPLEAGHCDSVTGECLKCLWNTDGAHCERCADGFYGD--AVTAKNCRA 908

  Fly   902 CSCYEAGTEQDEQSITR-CDQVTGQCQCKPNVIGRDCGECQPGYFNIRSGNGCENCLCDPVGSYN 965
            |:|:|.|      |::. |...||.|.|||.|.|:.|.:|.|||:.:.:|.||..|.|...||.:
  Rat   909 CNCHENG------SLSGICHLETGLCDCKPYVTGQQCDQCLPGYYGLDTGLGCVPCNCSGEGSIS 967

  Fly   966 STCDRYSGQCHCRPGVMGQRCDQCENYFYGFSSEGCKPCECDESGSKGFQCD-QNGQCPCNDNVE 1029
            ..|.. .|||||.|||.|::||||.:.||.|.:.||.||:|..:.:   .|| .:|:|.|..:..
  Rat   968 DNCTE-EGQCHCVPGVSGKQCDQCSHGFYAFQNGGCTPCDCAHTQN---NCDPDSGECLCPPHTH 1028

  Fly  1030 GRRCDRCKENKY--DRHRGCIDC----------------------------------------PD 1052
            |.:|::|:|..:  |..:||..|                                        ||
  Rat  1029 GLKCEQCEEAFWGLDPEQGCQACNCSVVGSTSPQCDVLSGQCSCKEGFGGQSCHQCSLGYRSFPD 1093

  Fly  1053 CY-------NLVQDAADLHRAK------------------------------------------- 1067
            |.       ..:.|..||.:..                                           
  Rat  1094 CVPCDCDLRGTLADTCDLEQGLCSCTEDSGTCSCKENVLGPQCDKCRAGTFALRADNPLGCSPCF 1158

  Fly  1068 LFNLSQTLDEI---ARTPVT--NDDEF-----EAKLKAVQEKVAVLAQDA--------------- 1107
            .|.|||...|:   .|.|:|  :|...     ::.||...|.|.....|.               
  Rat  1159 CFGLSQLCSELEGYVRAPITLASDQPILHVVSQSNLKGTTEGVHFQPPDTLLDAEAVRQHIYAEP 1223

  Fly  1108 ------RDNSGD---------------------------------GGQTYAEVI----------- 1122
                  :...||                                 ||:|...:|           
  Rat  1224 FYWRLPKQFQGDQLLAYGGKLQYTVAFYSTLGTGTSNYEPQVLIKGGRTRKHIIYMDAPAPENGV 1288

  Fly  1123 ---------DDLHKHLDSVREHLVSADKF------------------------------------ 1142
                     ::..|:.:||.|..|:...|                                    
  Rat  1289 RQDYEVGMKEEFWKYFNSVSEKHVTHSDFMSVLSNIEYILIKASYGQGLQQSRIANISMEVGRKA 1353

  Fly  1143 ----------------------------------------------------------------- 1142
                                                                             
  Rat  1354 VEPAPEGKVALQLELCVCPPGTAGHSCQDCAPGYHRGKLPESSGRGPRPLLAPCVPCNCNNHSDV 1418

  Fly  1143 ----------------------------------------------------------------- 1142
                                                                             
  Rat  1419 CDPETGKCLNCRDHTAGDHCELCTAGYYGKVIGLPGDCTPCTCPHHPPFSFSPTCVLEGDSGFWC 1483

  Fly  1143 -------------------------------------QADANGEIDRAR---------------- 1154
                                                 |...:.:.|||.                
  Rat  1484 DACLPGYEGQYCERCSAGYHGNPRAAGGSCQKCDCNPQGSVHSDCDRASGQCVCKPGATGLHCEE 1548

  Fly  1155 ------------------------------------------------------------QNYTI 1159
                                                                        |.|.:
  Rat  1549 CLPRHILMESHCVSCDDECVGALLNDLDSIGDAVLSLNLAGVSLAPYGTLENLENTTKYFQGYLL 1613

  Fly  1160 ---------------LDQITENAKKELQQALDLLNDEGAQALARAKEKSVEFGQQSEQISDISRE 1209
                           :::.|||.:|||.:.| ..:.:...|:.|...:|.......||   :.|.
  Rat  1614 EENAKKVQAEIQLGGIEEQTENLQKELARVL-RSHQQVNTAMERTSNRSQALATFLEQ---LHRN 1674

  Fly  1210 ARALADKLESEAQFDLKNAKDAKDAVEKAHQLAKSAIDLQLKIG-TELRSEVGLELSHVKQSLGT 1273
            .:.:.:|:.:..|...::.:....|::..||...|.:.|..|.. ||:|....|||...|..|..
  Rat  1675 IKEITEKVATLNQTTGEDFQPPVSALQSLHQNISSLLALIKKRNFTEMRQNATLELKAAKDLLSR 1739

  Fly  1274 V---VQTSKEALRKANEVYDTALTLLNDVNRQTQPEIDISQLKKDAVAANERADELLKQITELSN 1335
            :   .|..:|.|:...|.                     |.|..:.:|..:.|:|||::....:.
  Rat  1740 IQKRFQKPQEKLKALKEA---------------------SSLLSNHIADLQAAEELLREAGSKTQ 1783

  Fly  1336 SNGEL-------FADF-------ETEQELTEALLKRAEQQQLEDIELLERAKAAHDKATKAVEQG 1386
            .:..|       ..||       :.||.||..|:  |:.::..| .....|.||.|..|:.....
  Rat  1784 ESSLLLLLVKANLKDFREKKLHVQEEQNLTSKLI--AQGREWVD-AARTHAAAAQDTLTQLEHHR 1845

  Fly  1387 DNTL-------------------KEANNTYEKLAGFQSDVQRSSESAEKALQTVPNIEKEI---- 1428
            |..|                   :.|.:...:.....|::|.::|:.::.|:.|.|:....    
  Rat  1846 DELLLWASKIRSHVDDLVMQMSKRRARDLVHRAEQHASELQSAAEALDRDLENVRNVSLNATSAV 1910

  Fly  1429 ---QNAESLISQAEEALDGANKNANEAKKNAQ------EAQLKYAEQASKDAELIRR-------K 1477
               .|.::|..:||.....|:|.||:....::      :|.|:.:.:..|::...|:       |
  Rat  1911 HVHTNIQTLTEEAESLAADAHKTANKTSLISESLAPRGKAVLQRSSRFVKESVSTRKKQQGITLK 1975

  Fly  1478 ANETKVAARNLREEAD----QLNHRVKLTEMDIFKLEESSTKDDNLVDDAKRKVGQAKADTQEAQ 1538
            .:|.|......:|..|    |.|..:.:.......:.|.|.|...|...|.....:...|.....
  Rat  1976 LDELKNLTSQFQERVDNITRQANDSLTVLRESPGGMREKSRKVKELAVAANETAARTLEDMLGLS 2040

  Fly  1539 KQIEKANADLTAIKDELENLKDINTGDLDRLENRLATVEGEINRVNLTGRIEKYREQRTIQKNLI 1603
            .::...:.||:.:...::..||:       |.|...|       ..|.||  |.|:.. :|.||:
  Rat  2041 LRVFNTSEDLSRVNATVQETKDL-------LHNSTMT-------TILAGR--KMRDME-MQANLL 2088

  Fly  1604 DKYDAELRELKDEVQNIG--------LISKA 1626
              :| .|:.||...:|:.        |||:|
  Rat  2089 --FD-RLKPLKMLEENLSRNLSEIKLLISRA 2116

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB2NP_001287009.1 LamNT 61..296 CDD:214532 73/255 (29%)
EGF_Lam 298..347 CDD:238012 20/48 (42%)
Laminin_EGF 359..414 CDD:278482 22/69 (32%)
EGF_Lam 414..458 CDD:214543 25/58 (43%)
Laminin_EGF 461..511 CDD:278482 22/49 (45%)
LamB 572..697 CDD:214597 37/135 (27%)
TNFRSF <721..848 CDD:304602 59/136 (43%)
CRD2 724..771 CDD:276900 23/49 (47%)
EGF_Lam 743..791 CDD:238012 27/48 (56%)
Laminin_EGF 847..897 CDD:278482 26/49 (53%)
Laminin_EGF 902..953 CDD:278482 20/51 (39%)
Laminin_EGF 956..1004 CDD:278482 23/47 (49%)
Laminin_EGF 1004..1050 CDD:278482 14/48 (29%)
V_Alix_like 1122..1443 CDD:187408 81/678 (12%)
Tar 1139..1521 CDD:223910 94/736 (13%)
BAR 1308..1469 CDD:299863 41/206 (20%)
vATP-synt_E 1474..>1629 CDD:304907 38/172 (22%)
Lama1NP_001101707.2 LamNT 25..275 CDD:214532 77/283 (27%)
EGF_Lam 277..324 CDD:238012 20/49 (41%)
Laminin_EGF 404..463 CDD:278482 27/63 (43%)
Laminin_EGF 461..507 CDD:278482 22/49 (45%)
Laminin_B 575..703 CDD:278481 37/131 (28%)
EGF_Lam <715..739 CDD:214543 12/23 (52%)
EGF_Lam 748..796 CDD:238012 27/48 (56%)
Laminin_EGF 798..853 CDD:278482 20/57 (35%)
EGF_Lam 855..907 CDD:238012 26/53 (49%)
Laminin_EGF 909..955 CDD:278482 20/51 (39%)
Laminin_EGF 958..1005 CDD:278482 23/47 (49%)
EGF_Lam 1004..1049 CDD:238012 14/47 (30%)
Laminin_EGF 1051..1099 CDD:278482 4/47 (9%)
Laminin_EGF 1097..1154 CDD:278482 3/56 (5%)
Laminin_B 1225..1351 CDD:278481 12/125 (10%)
Laminin_EGF 1410..1456 CDD:278482 0/45 (0%)
Laminin_EGF 1459..1513 CDD:278482 0/53 (0%)
Laminin_EGF 1516..>1553 CDD:278482 4/36 (11%)
Laminin_I 1574..1825 CDD:283627 51/277 (18%)
SPEC 1613..1861 CDD:295325 57/275 (21%)
Laminin_I 1838..2092 CDD:283627 51/273 (19%)
Laminin_II 2018..2152 CDD:283628 27/119 (23%)
LamG 2136..2285 CDD:238058
LamG 2314..2470 CDD:238058
LamG 2495..2659 CDD:238058
Laminin_G_1 2751..2880 CDD:278483
LamG 2900..3053 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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