DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB2 and Lamb3

DIOPT Version :10

Sequence 1:NP_524006.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster
Sequence 2:NP_001094311.1 Gene:Lamb3 / 305078 RGDID:1562668 Length:1172 Species:Rattus norvegicus


Alignment Length:1721 Identity:332/1721 - (19%)
Similarity:547/1721 - (31%) Gaps:725/1721 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 ILGAQRPPINSAGGHELRGTTFMPALECYDPYGRPQKCLPEFINAAYQLQIESTNTCGEQNDNHF 94
            :|.||:|....|               ||.|.|       :.:....|| :.:::|||......:
  Rat    15 LLCAQQPCSRGA---------------CYPPVG-------DLLIGRTQL-LRASSTCGLTKPETY 56

  Fly    95 CIQTMNQNHKNCEFC------KYNDHNPSFLTDLHDPQSPTWWQSETMFEGIQHPNYVNLTLHLG 153
            |.|......|.|: |      .||.|....:.....|.  .||||:      ...:.|:|.|.|.
  Rat    57 CTQYGQWQMKCCK-CDSRLPRNYNSHRVENVVSSSGPM--RWWQSQ------NDVSPVSLQLDLD 112

  Fly   154 KSYDITYVRILFRSPRPESFTIYKRTSESG-PWIPYQFYSATCRDTYSLPDSRAIRKGEGEAHAL 217
            |...:..:.:.|:...|....| :|:|:.| .|..||:.:..|..|:.            :.|..
  Rat   113 KRMQLQDIMMDFKGLMPAGMLI-ERSSDFGKTWRVYQYLATDCASTFP------------QVHQG 164

  Fly   218 CTSEYSDI----------SPLRDGEIAFSTLEGRPSGINFERSGELQEWVTATDIRITLDRLNTF 272
            ....:.|:          ..|..|::..:.:: ..|.|...:|.::||....|::|:...:|...
  Rat   165 QPKNWQDVRCRPLSQRPNGHLTGGKVQLNLMD-LASAIPASQSKKIQELGDITNLRVNFTKLAPV 228

  Fly   273 GDELFGDSQVLKSYFYAISDIAVGARCKCNGHASKCVPST-GMHGERTL-----VCECRHNTDGP 331
            ...    .....|.::|:|.:.:...|.|:|||.:|.|:. |..|..|.     ||.|:|||.||
  Rat   229 PQR----GSYPPSAYFAVSQLRLQGSCFCHGHADRCAPNPGGPTGSTTAVQVNDVCVCQHNTAGP 289

  Fly   332 DCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANLF--NRTGHGGHCLDCRENRDGP 394
            :||||.|.||:..|:.:...:::||:.|:|||.::.|.||..:|  ::...||.|.:|:::.:|.
  Rat   290 NCDRCAPFYNNRPWRPAEGQDIHECQRCDCNGHSETCHFDPAVFAASQGTSGGVCDNCQDHTEGK 354

  Fly   395 NCERCKENFYM-RDDG-----YCVNCACDPVGSRSLQCNSHGKCQCKPGVTGDKCDRCDNNYYQF 453
            |||||:.:::. |..|     .|:.|.|||.|:                |.|..|||.       
  Rat   355 NCERCQLHYFRNRRPGAPIHETCIPCECDPDGA----------------VPGAPCDRL------- 396

  Fly   454 GPHGCQQCGCDSGGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLDKNNRFGCTPCFCYG 518
                                     ||.|.||::|:|.||:.|||||..|...|..||.||.|  
  Rat   397 -------------------------TGQCVCKDHVQGERCDLCKPGFTGLTFANPQGCHPCDC-- 434

  Fly   519 HTSECMTAPGYSIVSVTSNFNKFKERWTAADLNQREVDIKYNQYSRSIGTTAQGNEHVYFQAPDR 583
                                                                             
  Rat   435 ----------------------------------------------------------------- 434

  Fly   584 FLGDQRASYNRDLKFKLQLVGQVANTGVSDVILEGAGSRISLPIFAQGNGIPDQGVKEYTFRLHE 648
                                                                             
  Rat   435 ----------------------------------------------------------------- 434

  Fly   649 HHDYQWQPSQSARGFLSILSNLTAIKIRATYSVQGEAILDDVELQTAHRGAAGHPATWIEQCTCP 713
                            |||                                              
  Rat   435 ----------------SIL---------------------------------------------- 437

  Fly   714 EGYLGQFCESCAPGYRHSPARGGPFMPCIPCDCHGHADICDSETGRCICQHNTHGDNCDQCAKGF 778
                                                                             
  Rat   438 ----------------------------------------------------------------- 437

  Fly   779 YGNALGGTPNDCKRCPCPNDGACLQINEDTVICTECPKGYFGSRCEQCSDGFFGDPTGLLGEVQT 843
                                                                             
  Rat   438 ----------------------------------------------------------------- 437

  Fly   844 CKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSGHFGDPLALPHGRCDRCSCYEAG 908
                                                                            |
  Rat   438 ----------------------------------------------------------------G 438

  Fly   909 TEQDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIRSGNGCENCLCDPVGSYNSTCDRYSG 973
            |.||    ..|::.||:|.|.|||:|..|.:|.|.::.:.||.|||.|.|||..|.:|.|::::|
  Rat   439 TRQD----MPCEEETGRCLCLPNVVGPKCDQCAPSHWKLASGRGCEPCACDPRNSLSSQCNQFTG 499

  Fly   974 QCHCRPGVMGQRCD-----QCENYFYGFSSEGCKPCECDESGSKGFQCDQ-NGQCPCNDNVEGRR 1032
            ||.||.|..|..|.     ||.:..:|..:.||:.|:||..|::|..||: :|:|.|...:.|.|
  Rat   500 QCPCREGFGGLTCSSAAIRQCPDRTHGDVATGCRACDCDFRGTEGPGCDKTSGRCLCRPGLTGPR 564

  Fly  1033 CDRCKENKYDRHRGCIDCPDCYNLVQDAADLHRAKLFNLSQTLDEIARTPVTNDDEFEAKLKAVQ 1097
            ||:|:....||:..|:.|..|:............:|.:|..|.:.:.......|....::|...:
  Rat   565 CDQCQRGYCDRYPVCVACHSCFQAYDTDLQEQAWRLGSLRNTTEGLGTGTGLEDRGLASRLLDAK 629

  Fly  1098 EKVAVLAQDARDNSGDGGQTYAE-VIDDLHKHLDSVREHL----------VSADKFQADANGEID 1151
            .|:..:.|..      ||.:..| .:..:...:.|:|..|          ...:.|..|. |.:|
  Rat   630 SKIEQIRQIL------GGTSVTERDVAQVANAILSIRRTLQGLPLDLPLEEEMESFSGDL-GNLD 687

  Fly  1152 RARQNYTILDQITENAKKELQQALDLLNDEGA-QALARAKEKSVEFGQQSEQISDIS------RE 1209
            |:.....::    ..:|||..:.|..::..|| :.|..|.|:|   .:.::|:||.|      |:
  Rat   688 RSFNRLLLM----YRSKKEQFEKLSSVDPSGAFRMLTMAYEQS---SRAAQQVSDSSSLLSQLRD 745

  Fly  1210 ARALADKLESEA-------------QFDLKNAKDAKDAVEK------------------------ 1237
            :|...:.||.:.             :.::.:..|....:.|                        
  Rat   746 SRREVEGLERQTGEGGAGGAQLMALRLEMASLPDLTPTINKLCGGSRQTACTPGDCPGLLCPQDN 810

  Fly  1238 ----------AHQLAKSAIDLQLKIGTELRSEVGLELSHVKQSLGTVVQTSKEALRKANEVYDTA 1292
                      |...|:.|:.:..::..:||            |..|.:|.:::.:|.|.|   .|
  Rat   811 GTACGSHCRGALPRARGALHMAGQVAEQLR------------SFNTQLQQTRQMIRAAEE---AA 860

  Fly  1293 LTLLNDVNR-QTQPEIDISQLKKDAVAANERADELLKQITELSNSNGEL---FADFETEQELTEA 1353
            ..:.:|..| :||......|:::|.    .|...|::|:      .|.|   ..|..|.|:::||
  Rat   861 SKVQSDAQRLETQVSTSRLQMEEDV----RRTRLLIQQV------RGFLTDPHTDAATIQQVSEA 915

  Fly  1354 LL-------------KRAEQQ----QLEDIEL--------LERAKAAHDKATKA----------- 1382
            :|             |..|.|    :|.:::|        :.||:....:|.||           
  Rat   916 VLALWLPTDSATVLRKMKEIQDIAARLPNVDLVLSQTKQDIARARRLQAEAEKARSRAHVVEGQV 980

  Fly  1383 ------VEQGDNTLKEANNTYEKLAGFQSDVQRSSESAEKALQTVPNIEKEIQNAESLISQAEEA 1441
                  :.||...|:||.:|          :|.:..|.....:.|..:::.:..||.|:...:|.
  Rat   981 DDVVGNLRQGTVALQEAQDT----------MQGTGRSLRLIQERVTEVQQVLVPAERLVKGMKEQ 1035

  Fly  1442 LDGANKNANEAKKNAQEAQLKYAEQASKDAELIRRKANETKVAARNLREEADQLNHRVKLTEMDI 1506
            :.|......|.:..|||.|    .||.|..:|....:|:    |.|.:|..::|..|  .||:. 
  Rat  1036 MSGFWARVKELRHQAQEEQ----AQAMKAQQLAEGASNQ----AMNAQEGFERLKQR--YTELK- 1089

  Fly  1507 FKLEESSTKDDNLVDDAKRKVGQAKADTQ----EAQKQIEKANADLTAIKD-ELENLKD-----I 1561
            .:|.:||     ::.:...::...||:.:    |..:.::|       :|| |.|.|:.     :
  Rat  1090 DRLGQSS-----MLGEQGNRILSIKAEAEELFGETMEMMDK-------MKDMESELLRGSQAIML 1142

  Fly  1562 NTGDLDRLENRLATVEGEINRVNLTGRIEKY 1592
            .:.||..||.|:..:...||     ||:..|
  Rat  1143 RSADLSGLEKRVEQIRSYIN-----GRVLYY 1168

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB2NP_524006.1 LamNT 61..296 CDD:214532 50/251 (20%)
EGF_Lam 298..347 CDD:238012 26/54 (48%)
Laminin_EGF 359..414 CDD:395007 21/62 (34%)
EGF_Lam 414..458 CDD:214543 10/43 (23%)
Laminin_EGF 461..511 CDD:395007 16/49 (33%)
LamB 572..697 CDD:214597 3/124 (2%)
EGF_Lam 743..791 CDD:238012 0/47 (0%)
EGF_Lam 793..836 CDD:214543 0/42 (0%)
Laminin_EGF 847..897 CDD:395007 0/49 (0%)
Laminin_EGF 902..953 CDD:395007 18/50 (36%)
EGF_Lam 956..1001 CDD:214543 18/49 (37%)
Laminin_EGF 1004..1046 CDD:395007 17/42 (40%)
SMC_prok_B <1054..1621 CDD:274008 130/660 (20%)
Lamb3NP_001094311.1 Laminin_N 21..249 CDD:470680 55/277 (20%)
EGF_Lam 250..305 CDD:238012 26/54 (48%)
Laminin_EGF 317..367 CDD:395007 18/49 (37%)
Laminin_EGF 380..429 CDD:395007 26/96 (27%)
EGF_Lam 431..480 CDD:238012 25/440 (6%)
Laminin_EGF 482..535 CDD:395007 20/52 (38%)
EGF_Lam 535..572 CDD:214543 15/36 (42%)
SMC_prok_B <834..1115 CDD:274008 72/331 (22%)
cc_LAMB_C 1102..1172 CDD:424069 19/79 (24%)

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