DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanB2 and ntn1a

DIOPT Version :9

Sequence 1:	NP_001287009.1	Gene:	LanB2 / 39118	FlyBaseID:	FBgn0267348	Length:	1639	Species:	Drosophila melanogaster
Sequence 2:	NP_571104.1	Gene:	ntn1a / 30227	ZFINID:	ZDB-GENE-990415-169	Length:	603	Species:	Danio rerio

Alignment Length:	417	Identity:	194/417 - (46%)
Similarity:	266/417 - (63%)	Gaps:	27/417 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 PALECYDPYGRPQKCLPEFINAAYQLQIESTNTCGEQNDNHFCIQTM--NQNHKNCEFCKYND-- 113
            |...|||..|.|::|:|:|:|||:..::.:::||| :..:.:|:.|.  ::.|:||..|..:|
Zfish    36 PPDPCYDENGHPRRCIPDFVNAAFGKEVRASSTCG-KTPSRYCVVTEKGDERHRNCHTCDASDPK 99

  Fly   114 --HNPSFLTDLHDPQSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRILFRSPRPESFTIY 176
              |.|::||||::|.:.|.|||:..   :|:|..|.|||.|||.:::|||.:.|.||||||..|:
Zfish   100 KNHPPAYLTDLNNPHNLTCWQSDNY---LQYPQNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIF 161

  Fly   177 KRTSESGPWIPYQFYSATCRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGR 241
            |.......|:|:|:||..||..|:.|....|.| :.|..|:||..::|:.||..|.||||||:||
Zfish   162 KSMDYGKSWVPFQYYSTQCRKMYNKPSKATITK-QNEQEAICTDSHTDMHPLSGGLIAFSTLDGR 225

  Fly   242 PSGINFERSGELQEWVTATDIRITLDRLNTFGDELFGDSQVLK-SYFYAISDIAVGARCKCNGHA 305
            ||..:|:.|..||:|||||||::|..||:|||||...||::.: |||||:||:.||.||||||||
Zfish   226 PSAHDFDNSPVLQDWVTATDIKVTFSRLHTFGDENEDDSELARDSYFYAVSDLQVGGRCKCNGHA 290

  Fly   306 SKCVPSTGMHGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFF 370
            |:||...    :..|||||:|||.||:||||.|.:.|..|:|:|:.|.|||.|||||..|.:|.|
Zfish   291 SRCVKDR----DGNLVCECKHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRF 351

  Fly   371 DANLFNRTGH--GGHCLDCRENRDGPNCERCKENFYMRDDG-------YCVNCACDPVGSRSLQC 426
            :..|:..:|.  ||.||:||.|..|.:|..|||.:| ||..       .|..|.|.|||:....|
Zfish   352 NMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGYY-RDMSKPISHRKACKACDCHPVGAAGKTC 415

  Fly   427 N-SHGKCQCKPGVTGDKCDRCDNNYYQ 452
            | :.|:|.||.||||..|:||.|.|.|
Zfish   416 NQTTGQCPCKDGVTGITCNRCANGYQQ 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB2	NP_001287009.1	LamNT	61..296	CDD:214532	107/241 (44%)
		EGF_Lam	298..347	CDD:238012	28/48 (58%)
		Laminin_EGF	359..414	CDD:278482	25/63 (40%)
		EGF_Lam	414..458	CDD:214543	21/40 (53%)
		Laminin_EGF	461..511	CDD:278482
		LamB	572..697	CDD:214597
		TNFRSF	<721..848	CDD:304602
		CRD2	724..771	CDD:276900
		EGF_Lam	743..791	CDD:238012
		Laminin_EGF	847..897	CDD:278482
		Laminin_EGF	902..953	CDD:278482
		Laminin_EGF	956..1004	CDD:278482
		Laminin_EGF	1004..1050	CDD:278482
		V_Alix_like	1122..1443	CDD:187408
		Tar	1139..1521	CDD:223910
		BAR	1308..1469	CDD:299863
		vATP-synt_E	1474..>1629	CDD:304907
ntn1a	NP_571104.1	LamNT	45..282	CDD:214532	108/241 (45%)
		EGF_Lam	283..328	CDD:238012	28/48 (58%)
		Laminin_EGF	340..393	CDD:278482	24/53 (45%)
		EGF_Lam	402..450	CDD:238012	21/41 (51%)
		NTR_netrin-1_like	486..600	CDD:239634
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910