Protein Alignment LanB2 and Lamb1

DIOPT Version :10

• Sequence 1: NP_524006.1
• Gene: LanB2 / 39118
• FlyBaseID: FBgn0267348
• Length: 1639
• Species: Drosophila melanogaster
• Sequence 2: XP_003750185.1
• Gene: Lamb1 / 298941
• RGDID: 1306311
• Length: 1834
• Species: Rattus norvegicus
• Alignment Length: 1939
• Identity: 522/1939 - (26%)
• Similarity: 822/1939 - (42%)
• Gaps: 489/1939 - (25%)

  Fly     7 SHSGSSTARLLLIGVL--FASCSTAILG----AQRPPINSAGGHELRGTTFMPALECYDPYGRPQ 65
            |.:.|...:.|.:|||  ||....|:.|    ||.|..:                     ||..:
  Rat    37 SRAASPRLQGLDMGVLQVFAFGVLALWGTRVCAQEPEFS---------------------YGCAE 80

  Fly    66 -KCLPE----FINAAYQLQIESTNTCGEQNDNHFCIQTMNQNHKNCEFCKYND--H---NP---- 116
             .|.|.    .|..|.:|.:  |:|||......:||.:..|..|.|..|...|  |   ||
  Rat    81 GSCYPATGDLLIGRAQKLSV--TSTCGLHKPEPYCIVSHLQEDKKCFICDSRDPYHETLNPDSHL 143

  Fly   117 --SFLTDLHDPQSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRILFRSPRPESFTIYKRT 179
              :.:|.....:...|||||   .|:::   |.:.|.|...:..|::.:.|::.||.:..| :|:
  Rat   144 IENVVTTFAPNRLKIWWQSE---NGVEN---VTVQLDLEAEFHFTHLIMTFKTFRPAAMLI-ERS 201

  Fly   180 SESG-PWIPYQFYSATCRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPS 243
            |:.| .|..|::::..|..::....:..::|.:   ..:|.|.||||.|..:||:.|..|:  |:
  Rat   202 SDFGKTWGVYRYFAYDCESSFPGISTGPMKKVD---DIICDSRYSDIEPSTEGEVIFRALD--PA 261

  Fly   244 -GINFERSGELQEWVTATDIRITLDRLNTFGDELFGDS--QVLKSYFYAISDIAVGARCKCNGHA 305
             .|....|..:|..:..|::||...:|:|.||.|. ||  ::.:.|:||:.|:.|...|.|.|||
  Rat   262 FKIEDPYSPRIQNLLKITNLRIKFVKLHTLGDNLL-DSRMEIREKYYYAVYDMVVRGNCFCYGHA 325

  Fly   306 SKCVPSTG--------MHGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCN 362
            |:|.|..|        :||.    |.|||||.|.:|:.|:..|:||.|:.:.....|.||.||||
  Rat   326 SECAPVDGFNEEVEGMVHGH----CMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNCN 386

  Fly   363 GLADKCFFDANLFNRTGH--GGHCLDCRENRDGPNCERCKENFY------MRDDGYCVNCACDPV 419
            ..:..|.||..:|..||:  ||.|.:|:.|..|.|||:||..::      :||...|..|.|||.
  Rat   387 EHSSSCHFDMAVFLATGNVSGGVCDNCQHNTMGRNCEQCKPFYFQHPERDIRDPNLCEPCTCDPA 451

  Fly   420 GSRSLQ-CNSH---------GKCQCKPGVTGDKCDRCDNNYYQFG---PHGCQQCGCDSGGSHQN 471
            ||.:.. |:.:         |:|:||..|.|::||.|...:|...   |.||:.|.|:..|:...
  Rat   452 GSENGGICDGYTDFSVGLIAGQCRCKLHVEGERCDVCKEGFYDLSAEDPFGCKSCACNPLGTIPG 516

  Fly   472 TPACDTETGICFCKENVEGRRCNECKPGFFNLDKNNRFGCTPC----------FCYGHTSECMTA 526
            ...||:|||.|:||..|.|:||::|.|..:.| .|:..||.||          .|...:.:|...
  Rat   517 GNPCDSETGYCYCKRLVTGQRCDQCLPQHWGL-SNDLDGCRPCDCDLGGALNNSCSEDSGQCSCL 580

  Fly   527 P------------GYSIVSVTSNFNKFKE--------------------RWTAADL--------- 550
            |            ||...::.....:.:|                    .||....
  Rat   581 PHMIGRQCNEVESGYYFTTLDHYIYEAEEANLGPGVVVVERRYIQDRIPSWTGPGFVRVPEGAYL 645

  Fly   551 ----------NQREVDIKY-----NQYSRSI---------------GTT-----------AQGNE 574
                      .:.|:.|:|     :.:.:::               |.|           :.|:.
  Rat   646 EFFIDNIPHSMEYEILIRYEPQLPDHWEKAVITVQRPGRIPTSSRCGNTVPDDDNQVVSLSPGSR 710

  Fly   575 HVYFQAPDRFLGDQRASYNRDLKFKLQL-VGQVANTGVSDVILEGAGSRI----------SLPIF 628
            :|....|        ..:.:.:.:.::| :.|...:| |||  |...:.|          ||.||
  Rat   711 YVVLPRP--------VCFEKGMNYTVRLELPQYTASG-SDV--ESPYTLIDSLVLMPYCKSLDIF 764

  Fly   629 AQGNGIPDQGVKEYTFRLHEHHDYQWQPSQ------SARGFL---------SILSNLTAIKIRAT 678
            ..|.    .|..|.|       :..|:..|      ::|..:         :|:.:::|:..:|.
  Rat   765 TVGG----SGDGEVT-------NSAWETFQRYRCLENSRSVVKTPMTDVCRNIIFSISALIHQAG 818

  Fly   679 YSV----QG--EAILD----------DVELQTAHRGAAGHPATW--------------------- 706
            .:.    ||  .::.|          :|..:|.:|.|   |.|:
  Rat   819 LACECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNRCA---PGTFGFGPNGCKPCDCHLQGSVSAF 880

  Fly   707 ----IEQCTCPEGYLGQFCESCAPGYRHSPARGGPFMPCIPCDCHGHADICDSETGRCI-CQHNT 766
                ..||.|.:|...:.|:.|.||:...|:       |.||.|:|||:.||:.||.|: ||..|
  Rat   881 CDAVTGQCHCFQGIYARQCDRCLPGFWGFPS-------CQPCQCNGHAEDCDTVTGECLSCQDYT 938

  Fly   767 HGDNCDQCAKGFYGNALGGTPNDCKRCPCPNDG---------ACLQINEDTVICTECPKGYFGSR 822
            .|.||::|..|:||:.:.|:.:.|:.|||| ||         :|.|......:...|..||.|||
  Rat   939 TGHNCERCLAGYYGDPIIGSGDHCRPCPCP-DGPDSGRQFARSCYQDPVTLQLACVCDPGYIGSR 1002

  Fly   823 CEQCSDGFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSGH 887
            |:.|:.|:||:|:...|   :|:.|.|:.|:|......|::.||.||||:::|.|:||..|..|:
  Rat  1003 CDGCASGYFGNPSDFGG---SCQPCQCHHNIDTTDPEACDKETGRCLKCLYHTEGDHCQFCQHGY 1064

  Fly   888 FGDPLALPHGRCDRCSCYEAGT--EQDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIRSG 950
            :||.|   ...|.:|.|...||  |....|...||:.||||.|.|||||::|..|.|..:.:.||
  Rat  1065 YGDAL---RQDCRKCVCNYLGTVREHCNGSDCHCDKTTGQCSCLPNVIGQNCDRCAPHTWQLASG 1126

  Fly   951 NGCENCLCDPVGSYNSTCDRYSGQCHCRPGVMGQRCDQCENYFYGFSSEGCKPCECDESGSKGFQ 1015
            .|||.|.|:.|.|:..:|:.::|||.|.||..|:.|.:|:..|:|.....|:.|:||..|.:..|
  Rat  1127 TGCEPCNCNAVHSFGPSCNEFTGQCQCMPGFGGRTCSECQELFWGDPDVECRACDCDPRGIETPQ 1191

  Fly  1016 CDQN-GQCPCNDNVEGRRCDRCKENKYDRHRGCIDCPDCYNL----VQDAAD-----LHRAKLFN 1070
            |||: |||.|.:.|||.|||:|..........|..|..|:.|    :.:..:     |.:||...
  Rat  1192 CDQSTGQCVCVEGVEGPRCDKCTRGYSGVFPDCTPCHQCFALWDVIIGELTNRTHKFLEKAKALK 1256

  Fly  1071 LS-------QTLDEI---------------ARTPVTN----DDEFEAKLKAVQEKVAVLAQDARD 1109
            :|       :|:|.:               |..|:.|    .:|.|...|.|.||:|.:.....|
  Rat  1257 ISGVIGPYRETVDSVEKKVNEIRDILAQSPAAEPLKNIGILFEEAEKLTKDVTEKMAQVEVKLSD 1321

  Fly  1110 NSGDGGQTYAEVIDDLHKH---LDSVREHLVSADKFQADANGEIDRARQNYTILDQITENAKKEL 1171
            .:.....|..| :|.|...   ||.....|  |::.:...|.:|..|..:.|...||:..|:|.:
  Rat  1322 TASRSNSTAGE-LDALQAEAGSLDKTVNEL--AEQLEFIKNSDIQGALDSITKYFQISLEAEKRV 1383

  Fly  1172 QQALDLLNDEGAQ-ALARAK------EKSVEFGQQSEQISDISREARALADKLESEAQFDLKNAK 1229
            ..:....|....| ||.|.:      |:..:|.::.|:.:.:..|   ||.||:|   .||..|.
  Rat  1384 NASTTDPNSTVEQSALTRDRVEDLMLERESQFKEKQEEQARLLDE---LAGKLQS---LDLSAAA 1442

  Fly  1230 DAKDAVEKAHQLAKSAIDLQLKIGTELRSEVG------------LELSH------------VKQS 1270
            :...........::|...     |...|::.|            :.::|            |..:
  Rat  1443 EMTCGTHPGADCSESECG-----GPNCRTDEGEKKCGGPGCGGLVTVAHSAWQKAMDFDRDVLNA 1502

  Fly  1271 LGTVVQTSK---EALRKANEVYDTALTLLNDVNRQTQPEIDISQLKKDAVAANERADELLKQITE 1332
            |..|.|.||   ||..:|:|....|..:|...| .|:.::|.|         ||....|:|||.:
  Rat  1503 LAEVEQLSKMVSEAKVRADEAKQNAQDVLLKTN-ATREKVDRS---------NEDLRNLIKQIRD 1557

  Fly  1333 LSNSNGELFADFET-------------------EQELTEALLKRAE---------QQQLEDIE-- 1367
            ....:.   ||.::                   .|.|||.:.:|.|         ||...||.
  Rat  1558 FLTEDS---ADLDSIEAVANEVLKMEMPSTPQQLQNLTEDIRERVETLSQVEVILQQSAADIARA 1619

  Fly  1368 --LLERAKAAHDKATKAVEQGDNTLKEANNTYEKLAGFQSDVQRSSESAEKALQTVPNIEKEIQN 1430
              |||.||.|...||......| .:|||          ..:.:::..:||||::   ..:::||.
  Rat  1620 ELLLEEAKRASKSATDVKVTAD-MVKEA----------LEEAEKAQVAAEKAIK---QADEDIQG 1670

  Fly  1431 AESLISQ-------AEEALDGANKNANEAKKNAQEAQLKYAEQASKDAELIRRKANETKVAARNL 1488
            .::|::.       :||.|..|::..::.::|.:|.:.| |.|.|.:|:.|.:.....|.:|..:
  Rat  1671 TQNLLTSIESETAASEETLTNASQRISKLERNVEELKRK-AAQNSGEADYIEKVVYSVKQSADEV 1734

  Fly  1489 REEAD-QLNHRVKLTEMDIF-KLEESSTKDDNLVDDAKRKVGQAKADTQEAQKQIEKANADLTAI 1551
            ::..| :|:.:.|..|..|. |.|||:        ||:||   |:....||:..:.:||:.|..:
  Rat  1735 KKTLDGELDEKYKKVESLIAQKTEESA--------DARRK---AELLQNEAKTLLAQANSKLQLL 1788

  Fly  1552 KDELENLKDINTGDLDRLENRLATVEGEINRVNLTGRIEKYREQRTIQKNLIDK 1605
            :| ||...:.|...|:.....|..:|||:               |::.|::.:|
  Rat  1789 ED-LERKYEDNQKYLEDKAQELVRLEGEV---------------RSLLKDISEK 1826

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanB2	NP_524006.1	LamNT	61..296	CDD:214532	72/254 (28%)
		EGF_Lam	298..347	CDD:238012	24/56 (43%)
		Laminin_EGF	359..414	CDD:395007	24/62 (39%)
		EGF_Lam	414..458	CDD:214543	18/56 (32%)
		Laminin_EGF	461..511	CDD:395007	19/49 (39%)
		LamB	572..697	CDD:214597	30/166 (18%)
		EGF_Lam	743..791	CDD:238012	22/48 (46%)
		EGF_Lam	793..836	CDD:214543	20/51 (39%)
		Laminin_EGF	847..897	CDD:395007	20/49 (41%)
		Laminin_EGF	902..953	CDD:395007	23/52 (44%)
		EGF_Lam	956..1001	CDD:214543	16/44 (36%)
		Laminin_EGF	1004..1046	CDD:395007	19/42 (45%)
		SMC_prok_B	<1054..1621	CDD:274008	154/665 (23%)
Lamb1	XP_003750185.1	Laminin_N	83..317	CDD:459653	71/248 (29%)
		EGF_Lam	319..371	CDD:238012	24/55 (44%)
		EGF_Lam	383..435	CDD:238012	21/51 (41%)
		Laminin_EGF	446..503	CDD:395007	18/56 (32%)
		EGF_Lam	505..556	CDD:238012	20/51 (39%)
		EGF_Lam	557..>596	CDD:238012	6/38 (16%)
		EGF_Lam	821..866	CDD:214543	9/47 (19%)
		Laminin_EGF	869..917	CDD:395007	12/54 (22%)
		EGF_Lam	914..959	CDD:238012	22/44 (50%)
		Laminin_EGF	965..1021	CDD:395007	21/59 (36%)
		Laminin_EGF	1024..1068	CDD:395007	18/43 (42%)
		Laminin_EGF	1076..1129	CDD:395007	23/52 (44%)
		Laminin_EGF	1132..1180	CDD:395007	17/47 (36%)
		Laminin_EGF	1180..>1219	CDD:395007	19/38 (50%)
		YhaN	1250..>1723	CDD:443752	119/514 (23%)
		SMC_prok_B	1504..>1824	CDD:274008	95/374 (25%)
		cc_LAMB1_C	1762..1834	CDD:411971	22/84 (26%)