Protein Alignment LanB2 and lamb1a

DIOPT Version :10

• Sequence 1: NP_524006.1
• Gene: LanB2 / 39118
• FlyBaseID: FBgn0267348
• Length: 1639
• Species: Drosophila melanogaster
• Sequence 2: NP_775382.1
• Gene: lamb1a / 286830
• ZFINID: ZDB-GENE-021226-1
• Length: 1785
• Species: Danio rerio
• Alignment Length: 1903
• Identity: 476/1903 - (25%)
• Similarity: 772/1903 - (40%)
• Gaps: 505/1903 - (26%)

  Fly    67 CLPE----FINAAYQLQIESTNTCGEQNDNHFCIQTMNQNHKNCEFC----KYND-------HN- 115
            |.|.    .|..|.||.  :|:|||......|||.:..|..|.|..|    .||:       |:
Zfish    31 CYPATGDLLIGRAQQLL--ATSTCGVHKPEPFCIVSHLQEEKKCFVCDSRQAYNETAHQVTSHSI 93

  Fly   116 PSFLTDLHDPQSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRILFRSPRPESFTIYKRTS 180
            .:.:|.....:..||||||...|.      |.:.|.|...:..|::.:.|::.||.:..|.:...
Zfish    94 ENVVTTFAPNRLKTWWQSENGLEN------VTIQLDLEAEFHFTHLIMTFKTFRPAAMVIERSAD 152

  Fly   181 ESGPWIPYQFYSATCRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPS-G 244
            ....|..|::::..|..::.......:.|.:   ..:|.:.||||.|..:||:.|..|:  |: .
Zfish   153 FGNTWQVYRYFAYDCESSFPSVSHGPMTKVD---DVICDTRYSDIEPSTEGEVIFRVLD--PAFR 212

  Fly   245 INFERSGELQEWVTATDIRITLDRLNTFGDELFGDS--QVLKSYFYAISDIAVGARCKCNGHASK 307
            |....|..:|..:..|::|:...:|:|.||.|. ||  ::.:.|:|||.|:.|...|.|.||||:
Zfish   213 IEDPYSPRIQNMLKITNLRVKFTKLHTLGDNLL-DSRIEIKEKYYYAIYDMVVRGNCFCYGHASE 276

  Fly   308 CVPSTG--------MHGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGL 364
            |.|..|        :||.    |.|.|||.|.:|:||...|:||.|:.:.....|.||.|:||..
Zfish   277 CAPVDGTGEAVEGMVHGH----CMCNHNTIGLNCERCQDFYHDLPWRPAEGRNTNACKKCHCNHH 337

  Fly   365 ADKCFFDANLFNRTGH--GGHCLDCRENRDGPNCERCKENFY------MRDDGYCVNCACDPVGS 421
            :..|.||..::..:|:  ||.|.||:.|..|.|||:||..|:      :||...|..|.||||||
Zfish   338 SHSCHFDMAVYRASGNVSGGVCDDCQHNTMGHNCEQCKPFFHQHPEKDIRDPNICEPCNCDPVGS 402

  Fly   422 R-----------SLQCNSHGKCQCKPGVTGDKCDRCDNNYYQFG--PHGCQQCGCDSGGSHQNTP 473
            .           ||...| |:|:|||.|.|::||:|...:|...  |.|||.|.|::.|:.....
Zfish   403 LNGGVCDPMTDVSLGLIS-GQCRCKPNVEGERCDQCKQGHYGLSEDPLGCQPCTCNALGTVPGGS 466

  Fly   474 ACDTETGICFCKENVEGRRCNECKPGFFNLDKNNRFGCTPCFC---------------------- 516
            .|||::|.|:||..|.||.|::|.|..:.| .|:..||.||.|
Zfish   467 PCDTDSGNCYCKRLVTGRNCDQCLPQHWGL-SNDMDGCRPCDCDHGGAINNNCSPVSGQCQCREH 530

  Fly   517 -YG--------------------HTSECMTAPGYSIVSVTSNFNKFKER---WTAADL------- 550
             :|                    ...|....||.::|.    .|..::|   ||....
Zfish   531 MFGRRCDQVESGFYFIALDHYTYEAEEAKFGPGVTVVP----RNHPQDRSPTWTGIGFVNVPEGA 591

  Fly   551 ------------NQREVDIKY-----NQYSRSIGTTAQ--------------------------G 572
                        .:.::.|:|     .|:...:.|..:                          |
Zfish   592 FLEFSIDNIPYSMEYDLIIRYEPQLPEQWEEVLMTVIRPRVITADSRCANTMPDDDNQMVSLHPG 656

  Fly   573 NEHVYFQAPDRFLGDQRASYNRDLKFKLQLVGQVAN-----TGVSDVIL----------EGAGSR 622
            :.:|....|..|    ....|..::..|.|...:::     |.:..::|          .|:|:.
Zfish   657 SRYVVLPRPVCF----EEGLNYTVRLSLSLYSALSDVQSPYTLIDSIVLMPHCKNLDIFSGSGTE 717

  Fly   623 ISLPIFAQGNGIPDQGVKEY-TFRLHEHHDYQWQPSQS---------ARGFLSILSNLTAIKIRA 677
                   .||.:.:...:.: .:|..|:       ||:         .|.::..:|.|....::|
Zfish   718 -------GGNLVTNSAWENFQRYRCLEN-------SQAVVKTPMTDICRNYIFSVSALLHQGVKA 768

  Fly   678 TY-SVQGEAILDDVELQTAHRGAAGH----------------PATWI------------------ 707
            .. ..||       .|.|....:.|.                |||::
Zfish   769 CQCDPQG-------SLSTVCDPSGGQCQCRPNVVGRNCDRCAPATFLFXPQGCRPCDCSPEGSVH 826

  Fly   708 -------EQCTCPEGYLGQFCESCAPGYRHSPARGGPFMPCIPCDCHGHADICDSETGRCI-CQH 764
                   .||.|..|..|:.|:.|.|||       ..|..|.||.|:|||:.||.:||:|: |:.
Zfish   827 SYCHEATGQCECIAGAYGRQCDRCLPGY-------WGFPNCRPCTCNGHAEQCDPQTGQCLSCRD 884

  Fly   765 NTHGDNCDQCAKGFYGNALGGTPNDCKRCPCPN--------DGACLQINEDTVICTECPKGYFGS 821
            :|.|.||::|..|:||:.:.|:.:.|:.|.||:        .|||.:..:.:.:...|.:||.|:
Zfish   885 HTTGHNCERCLGGYYGDPVLGSGDHCRPCMCPDGPGSGRQFSGACYKSPDSSQVFCVCNQGYKGA 949

  Fly   822 RCEQCSDGFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSG 886
            |||:|:.|::|:|..:.||   |:.|.||.|:|.....:|:..||.|:||:::|.||.|::|..|
Zfish   950 RCEECAPGYYGNPHEVGGE---CRPCQCNSNIDMMDPESCDARTGACVKCLYHTEGESCNRCRLG 1011

  Fly   887 HFGDPLALPHGRCDRCSCYEAGTEQD---EQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIR 948
            ::|:.|.   ..|.:|.|.:.||.::   ......||..:|||.|.|||:|:.|.:|.|..:|:.
Zfish  1012 YYGNALT---QSCRKCVCNQMGTVEEMCPSPGNCNCDLTSGQCLCLPNVVGQHCDQCAPDTWNMA 1073

  Fly   949 SGNGCENCLCDPVGSYNSTCDRYSGQCHCRPGVMGQRCDQCENYFYGFSSEGCKPCECDESGSKG 1013
            ||.|||:|.|||..|:.|:|:...|||.|:||..|:.|.:|...|:|.....|..|:||..|...
Zfish  1074 SGKGCEDCDCDPNHSFGSSCNEIMGQCSCKPGFGGRTCRECRELFWGNPEVKCHACDCDPRGIAE 1138

  Fly  1014 FQCDQ-NGQCPCNDNVEGRRCDRCKENKYDRHRGCIDCPDCY---------------NLVQDAAD 1062
            .||:: .|.|.|.:.|.|.|||.|..........|..|..|:               .|||....
Zfish  1139 QQCNKVTGHCVCVEGVSGPRCDTCARGYTGEFPQCERCHQCFAEWDIIVGDLTNQTHRLVQKVNT 1203

  Fly  1063 L--------HRAKLFNLSQTLDEI----ARTPVTND---------------DEFEAKLKAVQEKV 1100
            :        ::|.:.|:..:.:.|    |:.|.|..               .|..:.|...:|.:
Zfish  1204 IKATGITGPYQATINNVENSANSIRNILAQNPATQPLTEIQGLLEQATALMAEMNSNLNLTEETL 1268

  Fly  1101 AVLAQDARDNSGD--------GGQTYAEVIDDLHKHLDSVREHLVSADKFQADANGEIDRARQNY 1157
            :.::.|  :||.|        ..|...:.:.||.:.::.|:             |.:|..||.:.
Zfish  1269 SEISSD--NNSTDTKLKSLKEEAQKLEQTVKDLREQVEFVK-------------NSDIRGARASV 1318

  Fly  1158 TILDQITENAK----KELQQALDLLND------EGAQALARAKEKSVEFGQQSEQISDISREARA 1212
            |...:.::||:    .......:|:|.      |..:.:.:.||   ||.|:.:   :.|::...
Zfish  1319 TRYYEQSQNAEIRANASTTDPYNLVNQSATLRTETEELMNQTKE---EFNQRQD---EFSKKLDN 1377

  Fly  1213 LADKLESEAQFDL--------------KNAKDAKDAVEKAHQLAKSAIDLQ--LKIGTE------ 1255
            ||.:||:   .||              :|..|::..       ..|.:|:|  .|.|.|
Zfish  1378 LAGQLET---LDLSELSEKTCGSPAGSENCADSRCG-------GLSCVDMQGSRKCGGEGCDGLT 1432

  Fly  1256 --------LRSEVGLELSHVKQSLGTVVQTSKEALRKANEVYDTALTLLNDVNRQTQPEIDISQL 1312
                    ...:..||:....:.:..:.:...||..||:|....|..:|...| :|:..:|
Zfish  1433 TLAHNAWQKAKDFDLEIISAMEEVDKLSKMVSEAKVKADEAKLNAQEVLAKTN-ETKKRVD---- 1492

  Fly  1313 KKDAVAANERADELLKQITELSNSNGELFADFET-------------------EQELTEALLKRA 1358
                 ::||...:|:|||.:....:|   ||.|:                   .|.|||.:.:|.
Zfish  1493 -----SSNEELRQLIKQIRDFLTQDG---ADLESIEAVANEVLQMQMPTTPAQLQNLTEEIRERV 1549

  Fly  1359 EQQQLEDIE-LLERAKAAHDKATKAVEQGDNTLKEANNTYEKLAGFQSDVQRSSESAEKALQTVP 1422
              ..|.|:| :|.::.|...:|...:||.....|||           |||:.::|..::|||...
Zfish  1550 --GSLTDVEDILNQSAADILRAESLLEQARKARKEA-----------SDVKSTAEMVKEALQHAE 1601

  Fly  1423 NIEKEIQNAESLISQAEEALDGANKNANEAKKNAQEAQLKYAE------QASKDAELIRRKANET 1481
            ..:..:..|   :.||...:.|........:....:::||.:.      :...|..|::.||..|
Zfish  1602 RAQNSVAEA---LKQAAVDIKGTQDLLVSVESETSDSELKLSNATRRLLKLESDVALLKEKALNT 1663

  Fly  1482 KVAARNLREEADQLNHRVKLTEMDIFKLEESSTKDDNLVDDAKRKVGQAKADTQEAQKQIEKANA 1546
            .::|.:..:||:.:|...:..:.|:    :|..||.  ....:..:.|......||:|:.||
Zfish  1664 SISANSTEKEAESINALAEQLKKDL----DSELKDK--YSTVEELITQKAEGVAEAKKRAEK--- 1719

  Fly  1547 DLTAIKDELENLKDINTGDLDRLENRLATVEGEINRVNLTGRIEKYREQRTIQKNLIDKYDAELR 1611
                :::|..||                              :.:..|:..:.|||...||...:
Zfish  1720 ----LQEEARNL------------------------------LLQASEKLQLLKNLEKNYDQNQK 1750

  Fly  1612 ELKDEVQNIGLISKALPD 1629
            .|:|:...:..:.||:.:
Zfish  1751 LLEDKANELVDLEKAVKE 1768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanB2	NP_524006.1	LamNT	61..296	CDD:214532	68/247 (28%)
		EGF_Lam	298..347	CDD:238012	24/56 (43%)
		Laminin_EGF	359..414	CDD:395007	23/62 (37%)
		EGF_Lam	414..458	CDD:214543	22/56 (39%)
		Laminin_EGF	461..511	CDD:395007	18/49 (37%)
		LamB	572..697	CDD:214597	25/150 (17%)
		EGF_Lam	743..791	CDD:238012	21/48 (44%)
		EGF_Lam	793..836	CDD:214543	17/50 (34%)
		Laminin_EGF	847..897	CDD:395007	19/49 (39%)
		Laminin_EGF	902..953	CDD:395007	20/53 (38%)
		EGF_Lam	956..1001	CDD:214543	18/44 (41%)
		Laminin_EGF	1004..1046	CDD:395007	15/42 (36%)
		SMC_prok_B	<1054..1621	CDD:274008	131/682 (19%)
lamb1a	NP_775382.1	Laminin_N	31..266	CDD:459653	69/248 (28%)
		EGF_Lam	268..320	CDD:238012	24/55 (44%)
		Laminin_EGF	<353..382	CDD:395007	13/28 (46%)
		EGF_Lam	394..452	CDD:238012	23/58 (40%)
		EGF_Lam	453..504	CDD:238012	19/51 (37%)
		EGF_Lam	505..548	CDD:238012	4/42 (10%)
		EGF_Lam	769..814	CDD:214543	8/51 (16%)
		Laminin_EGF	817..865	CDD:395007	14/54 (26%)
		EGF_Lam	862..907	CDD:238012	21/44 (48%)
		Laminin_EGF	<934..969	CDD:395007	13/37 (35%)
		Laminin_EGF	972..1018	CDD:395007	18/45 (40%)
		Laminin_EGF	1024..1078	CDD:395007	20/53 (38%)
		Laminin_EGF	1081..1129	CDD:395007	19/47 (40%)
		Laminin_EGF	1129..>1168	CDD:395007	15/38 (39%)
		Myosin_tail_1	1247..>1756	CDD:460256	122/611 (20%)
		cc_LAMB1_C	1712..1784	CDD:411971	18/94 (19%)