DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LanB2 and Lamc3

DIOPT Version :9

Sequence 1:NP_001287009.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster
Sequence 2:NP_035966.2 Gene:Lamc3 / 23928 MGIID:1344394 Length:1581 Species:Mus musculus


Alignment Length:1686 Identity:610/1686 - (36%)
Similarity:863/1686 - (51%) Gaps:247/1686 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 CYDPYGRPQKCLPEFINAAYQLQIESTNTCGEQNDNHFC---------IQTMNQNHKNCEFCKYN 112
            |||..||.|:|||||.|||:..:.|:::|||...:: ||         :|        |:.|...
Mouse    34 CYDGVGRAQRCLPEFENAAFGRRAEASHTCGRPPED-FCPHVGAPGAGLQ--------CQRCDDA 89

  Fly   113 D----HNPSFLTDLHDPQSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRILFRSPRPESF 173
            |    |:.|:|||.|.|...|||||.:|..|:|:|..|||||.|||:|:|||||:.|.:.|||||
Mouse    90 DPGRRHDASYLTDFHSPDDSTWWQSPSMAFGVQYPTSVNLTLSLGKAYEITYVRLKFHTSRPESF 154

  Fly   174 TIYKRTSESGPWIPYQFYSATCRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTL 238
            .|||||..||||.|||:|||:|:.||..|:...:|.||.|..|.||||:||||||..|.:|||||
Mouse   155 AIYKRTYASGPWEPYQYYSASCQKTYGRPEGHYLRPGEDERVAFCTSEFSDISPLNGGNVAFSTL 219

  Fly   239 EGRPSGINFERSGELQEWVTATDIRITLDRLNTFGDELFGDSQVLKSYFYAISDIAVGARCKCNG 303
            |||||..|||.|..||||||:|||.|:|||||||||::|.|.:||:||:||:||.:||.||||||
Mouse   220 EGRPSAYNFEESPVLQEWVTSTDILISLDRLNTFGDDIFKDPRVLQSYYYAVSDFSVGGRCKCNG 284

  Fly   304 HASKCVPSTGMHGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKC 368
            |||:|.|:..  |:  |.|.|:|||.|.||:||||.:.|..|.|.|:.:.|||..|||:|.:::|
Mouse   285 HASECEPNAA--GQ--LACRCQHNTTGVDCERCLPFFQDRPWARGTAEDANECLPCNCSGHSEEC 345

  Fly   369 FFDANLFNRTGHGGHCLDCRENRDGPNCERCKENFY-MRDDGYCVNCACDPVGSRSLQCNSHGKC 432
            .||..|:..|||||||..||::..||:||||::|:| ......|..|.|.|.||.||||::.|.|
Mouse   346 TFDRELYRSTGHGGHCQRCRDHTTGPHCERCEKNYYRWSPKTPCQPCDCHPAGSLSLQCDNSGVC 410

  Fly   433 QCKPGVTGDKCDRCDNNYYQFGPHGCQQCGCDSGGSHQNTPACDTETGICFCKENVEGRRCNECK 497
            .|||.|||.|||||...::.....||:.|.|:..||   ...||..:|.|.|||||||..|:.|:
Mouse   411 PCKPTVTGWKCDRCLPGFHSLSEGGCRPCACNVAGS---LGTCDPRSGNCPCKENVEGSLCDRCR 472

  Fly   498 PGFFNLDKNNRFGCTPCFCYGHTSECMTAPGYSIVSVTSNFNKFKERWTAADLNQREVDIKYNQY 562
            ||.|||..:|..||:.||||||:..|..|.|:....:.|:|......|....:...:..::::|.
Mouse   473 PGTFNLQPHNPVGCSSCFCYGHSKVCSPAAGFQEHHIRSDFRHGAGGWQIRSMGVSKRPLQWSQS 537

  Fly   563 SRSIGTTAQGNEHVYFQAPDRFLGDQRASYNRDLKFKLQLVGQVANTGVSDVI---LEGAGSRIS 624
            ...:|  .:|.|.:  .||.:||||||.||.:.:...|    ||...|....|   |||||..:|
Mouse   538 GLLLG--LRGGEEL--SAPKKFLGDQRLSYGQPVILTL----QVPPGGSPPPIQLRLEGAGLALS 594

  Fly   625 LPIFAQGNGIPD-QGVK-----EYTFRLHEHHDYQWQPSQSARGFLSILSNLTAIKIRAT----- 678
            |    :.:.:|. |..:     :..|.|.|..:....|..:.. |..:||||||:.|..:     
Mouse   595 L----RPSSLPSPQDTRQPRRVQLQFLLQETSEEAESPLPTFH-FQRLLSNLTALSIWTSGQGPG 654

  Fly   679 YSVQGEAILDDVELQTA--HRGAAGHPATWIEQCTCPEGYLGQFCESCAPGYRHSPARGGPFMPC 741
            :|  |:.:|.:|:|.:|  .|..| .||:|:|.|.||:||.|||||.||.||:.....|||:..|
Mouse   655 HS--GQVLLCEVQLTSAWPQRELA-PPASWVETCLCPQGYTGQFCEFCALGYKREIPHGGPYANC 716

  Fly   742 IPCDCHGHADICDSETGRCICQHNTHGDNCDQCAKGFYGNALGGTPNDCKRCPCPNDGACLQINE 806
            |||.|:.|. .||..||.|:|.|:|.|.:|::|..||||||..|..:||:.||||...||..|.|
Mouse   717 IPCTCNQHG-TCDPNTGICLCGHHTEGPSCERCMPGFYGNAFSGRADDCQPCPCPGQSACATIPE 780

  Fly   807 D-TVICTECPKGYFGSRCEQCSDGFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLK 870
            . .|:||.||.|..|.|||.|.|||||||.||.|..|.|:.|.|:||||.||||||:..:|.||:
Mouse   781 SGDVVCTHCPPGQRGRRCESCEDGFFGDPLGLSGAPQPCRRCQCSGNVDLNAVGNCDPHSGHCLR 845

  Fly   871 CIHNTAGEHCDQCLSGHFGDPLAL-PHGRCDRCSCYEAGTEQDEQSITRCDQVTGQCQCKPNVIG 934
            |::||.|.||:.|..|.:|..:|. |..:|..|||...|:..::    .|:.|||||.|.|.|.|
Mouse   846 CLYNTTGAHCEHCREGFYGSAVATRPVDKCAPCSCDLRGSVSEK----TCNPVTGQCVCLPYVSG 906

  Fly   935 RDCGECQPGYFNIRSGNGCENCLCDPVGSYNSTCDRYSGQCHCRPGVMGQRCDQCENYFYGFSSE 999
            |||..|.||:::::||.||::|.|.|:||..:.|...:|||.|||||.||.||:|:..|:|||.:
Mouse   907 RDCSRCSPGFYDLQSGRGCQSCKCHPLGSLENKCHPKTGQCPCRPGVTGQACDRCQLGFFGFSIK 971

  Fly  1000 GCKPCECDESGSKGFQCDQNGQCPCNDNVEGRRCDRCKENKY--DRHRGCIDCPDCYNLVQDAAD 1062
            ||:.|.|...|:...||.:|..|.|.....|.:||||::|.:  |...||.:||.||.||::.| 
Mouse   972 GCRDCRCSPLGAASSQCHENSTCVCRPGFVGYKCDRCQDNFFLADGDTGCQECPTCYALVKEEA- 1035

  Fly  1063 LHRAKLFNLSQTLDEIARTPVTNDDEFEAKLKAVQEKVAVLAQDARDNSGDGGQTYAEVIDDLHK 1127
                                        |||||     .::..:......|.|..:..       
Mouse  1036 ----------------------------AKLKA-----RLMLMEGWLQRSDCGSPWGP------- 1060

  Fly  1128 HLDSVREHLVSADKFQA-----DANGEIDRARQNYTILDQIT--ENAKKELQQALDLLNDEGAQA 1185
             ||.::......|.:|.     :..|         |.|.|:.  |::.|...:.|.:|......|
Mouse  1061 -LDILQGEAPLGDVYQGHHLLQETRG---------TFLQQMVGLEDSVKATWEQLQVLRGHVHCA 1115

  Fly  1186 LARAKEKSVEFGQQSEQI----SDISREARALA---------------DKLESEAQFDLKNAKDA 1231
            .|.|::..::..:..|.:    .::.|.|.||:               ..|.||||...::.:|.
Mouse  1116 QAGAQKTCIQLAELEETLQSSEEEVLRAASALSFLASLQKGSSTPTNWSHLASEAQILARSHRDT 1180

  Fly  1232 KDAVEKAHQLAKSAID--------LQLKIGTELRSEVG---LELSHVKQSLGTVVQTSKEALRKA 1285
            ...:|...:.|..|.:        ::.::.:|.:.|:.   .|:...:.:||..|   .|||.||
Mouse  1181 ATKIEATSERALLASNASYELLKLMEGRVASEAQQELEDRYQEVQAAQTALGIAV---AEALPKA 1242

  Fly  1286 NEVYDTALTLLND----VNRQTQPEIDISQLKKDAVAANERADELLKQITELSNSNGELFADFET 1346
            .:...|...::.|    :.....||....|.:..:........:|.::..|:..|.|.|      
Mouse  1243 EKALATVKQVIGDAAPHLGLLVTPEAMNFQARGLSWKVKALEQKLEQKEPEVGQSVGAL------ 1301

  Fly  1347 EQELTEALLKRAEQQQLEDIELLERAKAAHDKATKAVEQGDNTLKEANNTYEKLAG--FQSDVQR 1409
            :.|...||.|.....||.:     :..||..:|:.||:....|:..|......|.|  .:|.:.:
Mouse  1302 QVEAGRALEKMEPFMQLRN-----KTTAAFTRASSAVQAAKVTVIGAETLLADLEGMKLRSPLPK 1361

  Fly  1410 SSESAEKALQTVPNIEKEIQNAESLISQAEEALDGANKNANEAKKNAQEAQLKYAEQASKDAELI 1474
            ...:.:|...::..  :.:::.:....|||..|..|...::..||.::||:|...:.|.....|:
Mouse  1362 EQAALKKKAGSIRT--RLLEDTKRKTKQAERMLGNAASLSSSTKKKSKEAELMSKDNAKLSRALL 1424

  Fly  1475 R----------RKANETKVAARNLR-------------EEADQLNHRVKLTEMDIFKLEESSTKD 1516
            |          |.|::|:...|...             |||.|:...:...|..|.:...|..||
Mouse  1425 REGKQGYRHASRLASQTQATLRRASRLLLTSEAHKQELEEAKQVTSGLSTVERQIRESRISLEKD 1489

  Fly  1517 DNLVDDAKRKVG-----QAKADT-QEAQKQIEKANADLT---AIKDELENLKDINTGDLDRLENR 1572
            ..::.:...|:|     ||.|.| .|.|:.:|.....|.   |:..:|..|::            
Mouse  1490 TKVLSELLVKLGSLGVHQAPAQTLNETQRALESLRLQLDSHGALHHKLRQLEE------------ 1542

  Fly  1573 LATVEGEINRVNLTGRIEKYREQRTIQKNLIDKYDAELRELKDEVQNIGLISKALPDSCFS 1633
                             |..|::..||     .::.:|.|::.:..|:..|..:||::|.|
Mouse  1543 -----------------ESARQELQIQ-----SFEDDLAEIRADKHNLETILSSLPENCAS 1581

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB2NP_001287009.1 LamNT 61..296 CDD:214532 135/247 (55%)
EGF_Lam 298..347 CDD:238012 27/48 (56%)
Laminin_EGF 359..414 CDD:278482 26/55 (47%)
EGF_Lam 414..458 CDD:214543 22/43 (51%)
Laminin_EGF 461..511 CDD:278482 23/49 (47%)
LamB 572..697 CDD:214597 44/140 (31%)
TNFRSF <721..848 CDD:304602 66/127 (52%)
CRD2 724..771 CDD:276900 22/46 (48%)
EGF_Lam 743..791 CDD:238012 23/47 (49%)
Laminin_EGF 847..897 CDD:278482 26/50 (52%)
Laminin_EGF 902..953 CDD:278482 22/50 (44%)
Laminin_EGF 956..1004 CDD:278482 25/47 (53%)
Laminin_EGF 1004..1050 CDD:278482 17/47 (36%)
V_Alix_like 1122..1443 CDD:187408 70/363 (19%)
Tar 1139..1521 CDD:223910 91/447 (20%)
BAR 1308..1469 CDD:299863 34/162 (21%)
vATP-synt_E 1474..>1629 CDD:304907 36/186 (19%)
Lamc3NP_035966.2 Laminin_N 53..278 CDD:278484 125/233 (54%)
EGF_Lam 279..326 CDD:238012 28/50 (56%)
Laminin_EGF 336..392 CDD:278482 26/55 (47%)
EGF_Lam 391..437 CDD:238012 23/45 (51%)
Laminin_EGF 439..486 CDD:278482 23/49 (47%)
Laminin_B 550..669 CDD:278481 41/129 (32%)
EGF_Lam 718..765 CDD:238012 23/47 (49%)
EGF_Lam 766..814 CDD:238012 28/47 (60%)
Laminin_EGF 822..>864 CDD:278482 23/41 (56%)
Laminin_EGF 878..925 CDD:278482 22/50 (44%)
Laminin_EGF 928..976 CDD:278482 25/47 (53%)
EGF_Lam 976..1022 CDD:238012 16/45 (36%)
Domain II and I 1025..1581 130/656 (20%)
Laminin_I 1225..1470 CDD:283627 56/260 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1382..1413 10/30 (33%)
GluZincin 1433..>1506 CDD:301352 15/72 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 290 1.000 Domainoid score I1542
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48740
OrthoDB 1 1.010 - - D156553at2759
OrthoFinder 1 1.000 - - FOG0002861
OrthoInspector 1 1.000 - - otm43551
orthoMCL 1 0.900 - - OOG6_102334
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.730

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