DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanB2 and Lamc1

DIOPT Version :9

Sequence 1:	NP_001287009.1	Gene:	LanB2 / 39118	FlyBaseID:	FBgn0267348	Length:	1639	Species:	Drosophila melanogaster
Sequence 2:	NP_034813.2	Gene:	Lamc1 / 226519	MGIID:	99914	Length:	1607	Species:	Mus musculus

Alignment Length:	1625	Identity:	688/1625 - (42%)
Similarity:	959/1625 - (59%)	Gaps:	98/1625 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 ECYDPYGRPQKCLPEFINAAYQLQIESTNTCGEQNDNHFCIQT-MNQNHKNCEFC----KYNDHN 115
            ||.|..||||:|:|||:|||:.:.:.:|||||...: .:|:|| :....|:|..|    ::..|.
Mouse    37 ECADEGGRPQRCMPEFVNAAFNVTVVATNTCGTPPE-EYCVQTGVTGVTKSCHLCDAGQQHLQHG 100

  Fly   116 PSFLTDLHDPQSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRILFRSPRPESFTIYKRTS 180
            .:||||.::....|||||:||..|:|:||.:||||||||::||||||:.|.:.|||||.|||||.
Mouse   101 AAFLTDYNNQADTTWWQSQTMLAGVQYPNSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTR 165

  Fly   181 ESGPWIPYQFYSATCRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPSGI 245
            |.|||||||:||.:|.:|||..:...||.|..|..||||.|:||||||..|.:||||||||||..
Mouse   166 EDGPWIPYQYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAY 230

  Fly   246 NFERSGELQEWVTATDIRITLDRLNTFGDELFGDSQVLKSYFYAISDIAVGARCKCNGHASKCVP 310
            ||:.|..|||||||||||:||:||||||||:|.|.:|||||:|||||.|||.|||||||||:||.
Mouse   231 NFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECVK 295

  Fly   311 STGMHGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANLF 375
            :.    ...|:|.|:|||.|.||::|||.:||..|:|:|:...:||..|:|||.:.:|:||..|:
Mouse   296 NE----FDKLMCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELY 356

  Fly   376 NRTGHGGHCLDCRENRDGPNCERCKENFY-MRDDGYCVNCACDPVGSRSLQCNSHGKCQCKPGVT 439
            ..|||||||.:||:|.||..||||:|||: :.:...|..|.|.||||.|.||:|:|:|.|||||.
Mouse   357 RSTGHGGHCTNCRDNTDGAKCERCRENFFRLGNTEACSPCHCSPVGSLSTQCDSYGRCSCKPGVM 421

  Fly   440 GDKCDRCDNNYYQFGPHGCQQCGCDSGGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLD 504
            |||||||...::.....||:.|.||..||   |..|:.|||.|.||:||||..|..||||||||:
Mouse   422 GDKCDRCQPGFHSLTEAGCRPCSCDPSGS---TDECNVETGRCVCKDNVEGFNCERCKPGFFNLE 483

  Fly   505 KNNRFGCTPCFCYGHTSECMTAPGYSIVSVTSNFNKFKERWTAADLNQREVDIKYNQYSRSIGTT 569
            .:|..|||||||:||:|.|..|.|||:..::|.|...::.|.....:..|..::::...:.|...
Mouse   484 SSNPKGCTPCFCFGHSSVCTNAVGYSVYDISSTFQIDEDGWRVEQRDGSEASLEWSSDRQDIAVI 548

  Fly   570 AQGNEHVYFQAPDRFLGDQRASYNRDLKFKLQLVGQVANTGVSDVILEGAGSRISLPIFAQGNGI 634
            :......||.||.:|||:|..||.::|.|..::..:.......|::|||||.|:|:|:.||||..
Mouse   549 SDSYFPRYFIAPVKFLGNQVLSYGQNLSFSFRVDRRDTRLSAEDLVLEGAGLRVSVPLIAQGNSY 613

  Fly   635 PDQGVKEYTFRLHEHHDYQWQPSQSARGFLSILSNLTAIKIRATYSVQGEAILDDVELQTAHRGA 699
            |.:...:|.|||||..||.|:|:.|...|..:|:|||:||||.|||.:....||||.||:|..|
Mouse   614 PSETTVKYIFRLHEATDYPWRPALSPFEFQKLLNNLTSIKIRGTYSERSAGYLDDVTLQSARPG- 677

  Fly   700 AGHPATWIEQCTCPEGYLGQFCESCAPGYRHSPARGGPFMPCIPCDCHGHADICDSETGRCICQH 764
            .|.||||:|.||||.||.|||||:|.||||......||:.||:.|.|:||::.||.|||.|.|:.
Mouse   678 PGVPATWVESCTCPVGYGGQFCETCLPGYRRETPSLGPYSPCVLCTCNGHSETCDPETGVCDCRD 742

  Fly   765 NTHGDNCDQCAKGFYGNALGGTPNDCKRCPCPNDGACLQI-NEDTVICTECPKGYFGSRCEQCSD 828
            ||.|.:|::|:.|:||::..||.:||:.||||...:|..: ....|:||.||.|..|.|||.|.|
Mouse   743 NTAGPHCEKCSDGYYGDSTLGTSSDCQPCPCPGGSSCAIVPKTKEVVCTHCPTGTAGKRCELCDD 807

  Fly   829 GFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSGHFGDPLA 893
            |:||||.|..|.|:.|:.|.||.|:||||||||||.||||||||:||||.:||:|..|.||:|||
Mouse   808 GYFGDPLGSNGPVRLCRPCQCNDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKEGFFGNPLA 872

  Fly   894 -LPHGRCDRCSCYEAGTEQDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIRSGNGCENCL 957
             .|..:|..|:|...||.|.:.|   |:.|||||||.|:|.|||||.|.|||:|::||.|||.|.
Mouse   873 PNPADKCKACACNPYGTVQQQSS---CNPVTGQCQCLPHVSGRDCGTCDPGYYNLQSGQGCERCD 934

  Fly   958 CDPVGSYNSTCDRYSGQCHCRPGVMGQRCDQCENYFYGFSSEGCKPCECDESGSKGFQCDQNGQC 1022
            |..:||.|..||..:|||.|:||:.||.|::||...:||..||||||:|...||...||.::|:|
Mouse   935 CHALGSTNGQCDIRTGQCECQPGITGQHCERCETNHFGFGPEGCKPCDCHHEGSLSLQCKEDGRC 999

  Fly  1023 PCNDNVEGRRCDRCKENK-YDRH-RGCIDCPDCYNLVQDAADLHRAKLFNLSQTLDEIARTPVTN 1085
            .|.:...|.|||:|:||. |:|. .||.:||.||.||:|....||.||    |.|:.:.....|.
Mouse  1000 ECREGFVGNRCDQCEENYFYNRSWPGCQECPACYRLVKDKVAEHRVKL----QELESLIANLGTG 1060

  Fly  1086 DD-----EFEAKLKAVQEKVAVL---AQDARDNSGDGGQTYAEVIDDLH---KHLDSVREHLVSA 1139
            ||     .||.:||..:.:|..|   ||:.:|...:.......|...||   ..|.::|..:
Mouse  1061 DDMVTDQAFEDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNSSLHSQISRLQNIRNTI--- 1122

  Fly  1140 DKFQADANGEI-DRARQNYTILDQITENAKKELQQALDLLNDEGAQALARAKEKSVEFGQQSEQI 1203
                 :..|.: :|||......:|:.|.|.:||::|        ..|.|.......|...:...:
Mouse  1123 -----EETGILAERARSRVESTEQLIEIASRELEKA--------KMAAANVSITQPESTGEPNNM 1174

  Fly  1204 SDISREARALADKLESEAQFDLKNAKDAKDAVEKAHQLA--------KSAIDL-QLKIGTELRSE 1259
            :.::.|||.||::.:.||...::.||.|.:...:|:.|.        ::|::: :|....|....
Mouse  1175 TLLAEEARKLAERHKQEADDIVRVAKTANETSAEAYNLLLRTLAGENQTALEIEELNRKYEQAKN 1239

  Fly  1260 VGLELSHVKQSLGTVVQTSKEALRKANEVYDTALTLLNDVNRQTQPEIDISQLKKDAVAANERAD 1324
            :..:|.  ||: ..|.:.:|.|..||.|:| .::..|..|:.:.. |.:.:::||:|...:...|
Mouse  1240 ISQDLE--KQA-ARVHEEAKRAGDKAVEIY-ASVAQLTPVDSEAL-ENEANKIKKEAADLDRLID 1299

  Fly  1325 ELLKQITEL-SNSNGELFADFETEQELTEALLKRAEQQQLEDIELLERAKAAHDKATKAVEQGDN 1388
            :.||...:| .:..|:       |.|:...|.|...:||..| :||.||.||...|.:|.::|.:
Mouse  1300 QKLKDYEDLREDMRGK-------EHEVKNLLEKGKAEQQTAD-QLLARADAAKALAEEAAKKGRS 1356

  Fly  1389 TLKEANNTYEKLAGFQSDVQRSSESAEKALQTVPNIEKEIQNAESLISQAEEALDGANKNANEAK 1453
            ||:|||:....|..|...|..:..:||:||:.:|.|.:.|..|.....:|:.||..|..:|.|||
Mouse  1357 TLQEANDILNNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAADATEAK 1421

  Fly  1454 KNAQEAQLKYAEQASKDAELIRRKANETKVAARNLREEADQLNHRVK--LTEMDIFKLEESSTKD 1516
            ..|.||:        :.|..:::.|..||..|.....|...|::.|.  |.:::..:.|....:|
Mouse  1422 NKAHEAE--------RIASAVQKNATSTKADAERTFGEVTDLDNEVNGMLRQLEEAENELKKKQD 1478

  Fly  1517 DNLVDDAKRKVGQAKADTQEAQKQIEKANADLTAIKDELENLKDINTGDLDRLE-NRLATVEGEI 1580
            |  .|......|.|....|||:....||...::::..:|.||.| ..|.||.:: |:|..:||.:
Mouse  1479 D--ADQDMMMAGMASQAAQEAELNARKAKNSVSSLLSQLNNLLD-QLGQLDTVDLNKLNEIEGSL 1540

  Fly  1581 NRV-------NLTGRIEKYREQRTIQKNLIDKYDAELRELKDEVQNIGLISKALPDSCFSRNRLE 1638
            |:.       :|..::.....:...|:..|..|:.::.|:..::.|:..|.|.||..||:...:|
Mouse  1541 NKAKDEMKASDLDRKVSDLESEARKQEAAIMDYNRDIAEIIKDIHNLEDIKKTLPTGCFNTPSIE 1605

Fly 1639 1638
Mouse 1606 1605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB2	NP_001287009.1	LamNT	61..296	CDD:214532	140/239 (59%)
		EGF_Lam	298..347	CDD:238012	26/48 (54%)
		Laminin_EGF	359..414	CDD:278482	28/55 (51%)
		EGF_Lam	414..458	CDD:214543	24/43 (56%)
		Laminin_EGF	461..511	CDD:278482	27/49 (55%)
		LamB	572..697	CDD:214597	56/124 (45%)
		TNFRSF	<721..848	CDD:304602	60/127 (47%)
		CRD2	724..771	CDD:276900	23/46 (50%)
		EGF_Lam	743..791	CDD:238012	22/47 (47%)
		Laminin_EGF	847..897	CDD:278482	36/50 (72%)
		Laminin_EGF	902..953	CDD:278482	28/50 (56%)
		Laminin_EGF	956..1004	CDD:278482	24/47 (51%)
		Laminin_EGF	1004..1050	CDD:278482	20/47 (43%)
		V_Alix_like	1122..1443	CDD:187408	87/334 (26%)
		Tar	1139..1521	CDD:223910	104/394 (26%)
		BAR	1308..1469	CDD:299863	51/161 (32%)
		vATP-synt_E	1474..>1629	CDD:304907	40/164 (24%)
Lamc1	NP_034813.2	LamNT	42..282	CDD:214532	141/240 (59%)
		EGF_Lam	283..328	CDD:238012	26/48 (54%)
		Laminin_EGF	340..394	CDD:278482	27/53 (51%)
		Laminin_EGF	396..443	CDD:278482	26/46 (57%)
		Laminin_EGF	443..490	CDD:278482	27/49 (55%)
		LamB	551..676	CDD:214597	56/124 (45%)
		Laminin_EGF	722..761	CDD:278482	19/38 (50%)
		EGF_Lam	770..818	CDD:238012	23/47 (49%)
		Laminin_EGF	826..873	CDD:278482	34/46 (74%)
		Laminin_EGF	882..930	CDD:278482	28/50 (56%)
		EGF_Lam	933..978	CDD:214543	21/44 (48%)
		EGF_Lam	980..1027	CDD:238012	20/46 (43%)
		Domain II and I	1029..1607		167/621 (27%)
		SPEC	1047..1252	CDD:295325	51/227 (22%)
		MA	1089..1300	CDD:214599	50/231 (22%)
		V_Alix_like	1178..>1310	CDD:187408	35/136 (26%)
		DUF5089	1198..1403	CDD:293607	61/217 (28%)
		SH3BP5	1359..1585	CDD:283045	62/236 (26%)
		ATP-synt_B	<1391..1503	CDD:304375	32/121 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	290	1.000	Domainoid score	I1542
eggNOG	1	0.900	-	-		E1_KOG1836
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1724
Inparanoid	1	1.050	1314	1.000	Inparanoid score	I153
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48740
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002861
OrthoInspector	1	1.000	-	-		otm43551
orthoMCL	1	0.900	-	-		OOG6_102334
Panther	1	1.100	-	-	LDO	PTHR10574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2603
SonicParanoid	1	1.000	-	-		X4311
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.900