DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LanB2 and Ccdc186

DIOPT Version :9

Sequence 1:	NP_001287009.1	Gene:	LanB2 / 39118	FlyBaseID:	FBgn0267348	Length:	1639	Species:	Drosophila melanogaster
Sequence 2:	NP_739563.1	Gene:	Ccdc186 / 213993	MGIID:	2445022	Length:	917	Species:	Mus musculus

Alignment Length:	896	Identity:	165/896 - (18%)
Similarity:	327/896 - (36%)	Gaps:	283/896 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   881 DQCLSGHFGDPLALPHGR------CDRCSCYEAGTEQDEQSITRCDQVTGQCQCKPNVIGRDCGE 939
            |.|:|....:...|..|.      .||..|         |:...|.|:..|....|     |||
Mouse    43 DSCISVSGDESSRLETGAELLSLDSDRILC---------QTNEHCSQIEVQESHIP-----DCG- 92

  Fly   940 CQPGYFNIRSG-NGCENCLCDPVGSYNSTCDRYSGQCHCRPGVMGQRCDQCENYFYGFSSEGCKP 1003
                     || |.|.|         ..||...|||....||  |.           |:.:..|.
Mouse    93 ---------SGENSCAN---------TDTCPEDSGQIDDFPG--GD-----------FTEQVSKT 126

  Fly  1004 CECDESGSKGFQCDQNGQCPCNDNVEGRRCDRCKENKYDRHRGCIDCPDCYNLVQDAADLHRAKL 1068
            .|.:::.:: ...:.....|    .|.........:.||        .||           ..||
Mouse   127 KEPEQTVTQ-ILAELKSSAP----AEAANPKTASASLYD--------TDC-----------TRKL 167

  Fly  1069 FNLSQTLDEIARTPVTNDD---EFEAKL-------------------------------KAVQEK 1099
            .:..:|:.       .:||   |.|::|                               :.:|::
Mouse   168 ISEMKTVS-------ASDDLLGEIESELLSAEFAEGHQVPNGLNKGEQALALFEKCVHSRYLQQE 225

  Fly  1100 VAVLAQDARDNSGDGGQTYAEVI-----------DDLHKHLDSVREHLVSADKFQ---ADANGEI 1150
            :.| .|..::|     :.:.|:|           ::|.|..::.::|:.:..:.:   .:.|.||
Mouse   226 LTV-KQLIKEN-----KNHQELILNICSEKDSLREELRKRTETEKQHMNTIKQLELRIEELNKEI 284

  Fly  1151 DRARQNYTILDQITENA----KKELQQALDLLNDEGAQALARAKEKSVEFGQQSEQISDISREAR 1211
            ..::......|...:||    .||:.|.:|..|.:..:|....:...:::.:..::..|:.:|..
Mouse   285 KASKDQLVAQDVTAKNAIQQIHKEMAQRMDQANKKCEEARQEKEAMVMKYVRGEKEALDLRKEKE 349

  Fly  1212 ALADKLESEAQFDLKNAKDAKDAVEKAHQL-----AKSAIDLQL-----KIGTELRSEVGLELSH 1266
            .|..||...::...||....|...::..:|     :|.....:|     |:..|:.|:| :::..
Mouse   350 TLERKLRDASKELEKNTNKIKQLSQEKGRLQQLYESKEGETTRLIREIEKLKEEMNSQV-IKVKW 413

  Fly  1267 VKQSLGTVVQTSKEALRKANEVYDTALTLLNDVNRQTQPEIDISQLKKDAVAANERADELLK--Q 1329
            .:..|...:.:.||...|..|. .|.||                |.|::|....:...:::|  |
Mouse   414 AQNKLKAEMDSHKETKDKLKET-TTKLT----------------QAKEEAEQIRQNCQDMIKTYQ 461

  Fly  1330 ITELSNSNGELFADFE-TEQELTEALLKRAEQ--------QQLEDI-----ELLERAKAAHDKAT 1380
            .:|...|| ||.|... |:.||.:.:.::::|        ::|||:     |.::..:....||
Mouse   462 ESEEIKSN-ELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKA- 524

  Fly  1381 KAVEQGDNTLKEANNTYEKLAGFQSDVQRSS-----------------ESAEKALQTVPNIEKEI 1428
            |.:|  |..|:    |.::|:.::..:.|..                 |..:...|.:.::::|:
Mouse   525 KCLE--DERLR----TEDELSKYREIINRQKSEIQNLLDKVKITDQLHEQLQSGKQEIEHLKEEM 583

  Fly  1429 QNAESLISQAEEALDGANKNANE-----AKKNAQEAQLKYAEQASKDAELIRRKANETKVAARNL 1488
            ::..|||:..::.::|:.|..:|     .|..::.|||: :|.::..:::......|::     |
Mouse   584 ESLNSLINDLQKDIEGSRKRESELLLFTEKLTSKNAQLQ-SESSALQSQVDNLSCTESQ-----L 642

  Fly  1489 REEADQLNHRVKLTEMDIFKLEESSTKDDNLVDDAKRKVGQAKADTQEAQKQIEKANADLTAIKD 1553
            :.:..|:....:..|..:.|.||.          .|.:|...:|:...||.:::..:..:..:||
Mouse   643 QSQCQQMGQANRNLESKLLKEEEL----------RKEEVQTLQAELSAAQTEVKALSTQVEELKD 697

  Fly  1554 EL--------ENLKDI-------------------------------NTGDL-------DRL-EN 1571
            ||        .|:||:                               ::|.|       ||. ||
Mouse   698 ELVTQRRKHASNVKDLSKQLQQARRKLEQTENGNHDKDISSMGSRSSSSGSLNARISAEDRSPEN 762

  Fly  1572 RLATVE----GEINRVNLTGRIEKYREQRTIQKNLIDKYDAELRELKDEVQ 1618
            ..::|.    .|:::..|..||.:.::....:...|:..:..:::|.:|::
Mouse   763 TSSSVAVDNFPEVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIR 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB2	NP_001287009.1	LamNT	61..296	CDD:214532
		EGF_Lam	298..347	CDD:238012
		Laminin_EGF	359..414	CDD:278482
		EGF_Lam	414..458	CDD:214543
		Laminin_EGF	461..511	CDD:278482
		LamB	572..697	CDD:214597
		TNFRSF	<721..848	CDD:304602
		CRD2	724..771	CDD:276900
		EGF_Lam	743..791	CDD:238012
		Laminin_EGF	847..897	CDD:278482	4/15 (27%)
		Laminin_EGF	902..953	CDD:278482	12/51 (24%)
		Laminin_EGF	956..1004	CDD:278482	10/47 (21%)
		Laminin_EGF	1004..1050	CDD:278482	5/45 (11%)
		V_Alix_like	1122..1443	CDD:187408	73/381 (19%)
		Tar	1139..1521	CDD:223910	84/436 (19%)
		BAR	1308..1469	CDD:299863	42/198 (21%)
		vATP-synt_E	1474..>1629	CDD:304907	33/196 (17%)
Ccdc186	NP_739563.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		3/8 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..118		9/31 (29%)
		Taxilin	315..645	CDD:286771	69/361 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	701..769		10/67 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1836
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900