DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB2 and epi-1

DIOPT Version :9

Sequence 1:NP_001287009.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster
Sequence 2:NP_001294008.1 Gene:epi-1 / 177956 WormBaseID:WBGene00001328 Length:3715 Species:Caenorhabditis elegans


Alignment Length:1675 Identity:422/1675 - (25%)
Similarity:650/1675 - (38%) Gaps:421/1675 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 QNDNHFCIQTMNQNHKNCEFCKYNDHNPSFLTDLHDPQSPTWWQSETMFEGIQHPNYVNLTLHLG 153
            ||:::|...:.|      .|..||.::..|:                          .|.::.|.
 Worm  1284 QNEHYFQGDSCN------SFACYNKYSSRFI--------------------------FNASVPLA 1316

  Fly   154 KSYDITYVRILFR-SPRPE----------SFTIYKRTSESGP-------WIPYQFYSATCRDTYS 200
            ....|:..|.|.| ..|||          :.|.|..:|:.||       .:||..|    :|...
 Worm  1317 FCPSISGCRALIRDKERPEVIQFYMDDKYTATFYHNSSQKGPIYIDSITAVPYNSY----KDKLM 1377

  Fly   201 LPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPSGINFERSGELQEWVTATDIRIT 265
            .|                                                             :.
 Worm  1378 EP-------------------------------------------------------------LA 1381

  Fly   266 LDRLNTFGDELFGDSQVLKSYFYAISDI-------------AVGARCKCNGHASKCVPSTGMHGE 317
            ||..|.|..|...|:  ||::..::||.             |....|.|....|:........|:
 Worm  1382 LDLSNEFLKECSEDN--LKNHPESVSDFCKQKIFSLTTDFNAAALSCDCVAQGSESFQCEQYGGQ 1444

  Fly   318 RTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANLFNRTGHGG 382
                |:|:....|..|:||.|.|.:..          ||..|.||. ..:|      ..||   |
 Worm  1445 ----CKCKPGVIGRRCERCAPGYYNFP----------ECIKCQCNA-GQQC------DERT---G 1485

  Fly   383 HCLDCRENRDGPNCERCKENFYMRDDGY-----CVNCACDPVGSR--SLQCN-SHGKCQCKPGVT 439
            .|. |..:.:|..|:||..|.:    ||     |..|.|.|.||.  :|.|: ..|:|.|:..:.
 Worm  1486 QCF-CPPHVEGQTCDRCVSNAF----GYDPLIGCQKCGCHPQGSEGGNLVCDPESGQCLCRESMG 1545

  Fly   440 GDKCDRCDNNYYQFGPHGCQQCGCDSGGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLD 504
            |.:||||...:|.| || |..|.|:..|:.:.  .||.....|.|||||.|.||..||.|.|:|.
 Worm  1546 GRQCDRCLAGFYGF-PH-CYGCSCNRAGTTEE--ICDATNAQCKCKENVYGGRCEACKAGTFDLS 1606

  Fly   505 KNNRFGCTPCFCYGHTSECMTAPGYSIVSVTSNFNKFKERWTAADLNQREVDIKYNQYSRSIGTT 569
            ..|..||..|||:|.|..|.::. |.:..::.:.:.|........::.::..:.|.....|..: 
 Worm  1607 AENPLGCVNCFCFGVTDSCRSSM-YPVTIMSVDMSSFLTTDDNGMVDNKDDTVIYTSEETSPNS- 1669

  Fly   570 AQGNEHVYFQAPDRFLGDQRASYNRDLKFKLQLV---GQVANTGVSDVILEGAGSRISLPIFAQG 631
                  |||..|.. ..|...||...|.|||..|   |:.:....:||.|.||...|......| 
 Worm  1670 ------VYFNVPIE-KKDYTTSYGLKLTFKLSTVPRGGRKSMNADADVRLTGANMTIEYWASEQ- 1726

  Fly   632 NGIPDQGVKEYTFRLHEHHDYQWQPSQ--SARG-------FLSILSNLTAIKIRATYSVQGEAIL 687
               |....:::|.:.      :..|..  :|.|       .:.:|.:|..|.::|:|       .
 Worm  1727 ---PTNPEEQFTVKC------KLVPENFLTAEGKTVTREELMKVLHSLQNITLKASY-------F 1775

  Fly   688 DDVELQTAHRGA--AGHP--------ATWIEQCTCPEGYLGQFCESCAPGYRHSPARGGPFM-PC 741
            |..:..|.:...  ...|        |:.:|||.||..|.|..|:.||.||..  .:.|.|: .|
 Worm  1776 DHPKTSTLYEFGLEISEPNGVDSVIKASSVEQCQCPAPYTGPSCQLCASGYHR--VQSGSFLGAC 1838

  Fly   742 IPCDCHGHADICDSETGRCI-CQHNTHGDNCDQCAKGFYGNALGGTPNDCKRCPCP--------- 796
            :||:|:||:..||.:||.|. |:|||:||:|:.|.:|.||||..|:|.||..|.||         
 Worm  1839 VPCECNGHSATCDPDTGICTDCEHNTNGDHCEFCNEGHYGNATNGSPYDCMACACPFAPTNNFAK 1903

  Fly   797 -----NDGACLQINEDTVICTECPKGYFGSRCEQCSDGFFGDPTGLLGEVQTCKSCDCNGNVDPN 856
                 .:|..||.|        |..||.|.||::|:.||||.|. :.||  :|..|.||||.:..
 Worm  1904 SCDVSEEGQLLQCN--------CKPGYTGDRCDRCASGFFGHPQ-ISGE--SCSPCQCNGNNNLT 1957

  Fly   857 AVGNCNRTTGECLKCIHNTAGEHCDQCLSGHFGDPLALPHGRCDRCSCYEAGTEQDEQSITRCDQ 921
            ...:|:..:|:|..|..||.|.||:.|.:..:||  |:....|..|.|.:.|::.       ||.
 Worm  1958 DSRSCHPNSGDCYLCEQNTDGRHCESCAAWFYGD--AVTAKNCSSCECSQCGSQY-------CDN 2013

  Fly   922 VTGQCQCKPNVIGRDCGECQPGYFNIRSGNGCENCLCDPVGSYNSTCDRYSGQCHCRPGVMGQRC 986
            .:|.|:||.||.|..|..|:|.::......||:.|.|. ..::|:.|:..:|||.||||..|.||
 Worm  2014 KSGGCECKINVEGDSCDRCKPDHWGFSKCQGCQGCHCG-TAAFNTQCNVENGQCTCRPGATGMRC 2077

  Fly   987 DQCENYFYGFSSEGCKPCECDESGSKGFQCD-QNGQCPCNDNVEGRRCDRCKENKYDR--HRGCI 1048
            :.||:.::.:...||..|:|:...|.|..|| :.|||.|.:...|.|||:|..: |.|  ..||.
 Worm  2078 EHCEHGYWNYGEHGCDKCDCEADLSMGTVCDVRTGQCHCQEGATGSRCDQCLPS-YLRIPTYGCR 2141

  Fly  1049 DCPDC-YNLVQDAADL-------------------------HRAKLFNLSQTLDEIARTPVTNDD 1087
            .|.:| ::|:.|..:|                         ...|.||   .::||  |.:.||:
 Worm  2142 RCDECVHHLIGDVDNLELEIDVLGTAIANISSATIVGARLARNKKEFN---DINEI--TKMLNDE 2201

  Fly  1088 EFEAKLKAVQEKVAVLAQDARDNSGDGGQTYAEVIDDLHKHLDSVREHLVSADKFQADANGEIDR 1152
            |...      ..|...|||...||.................:.|.:...::..:|..:......|
 Worm  2202 ENSF------GNVFGDAQDILTNSTQIQNKLVRTKTHSQNSVSSAKNITLNGTEFLQEVMKRAQR 2260

  Fly  1153 ARQNYTILDQIT----ENAK---------KELQQALDLLN-------DEGAQAL--------ARA 1189
            |||:...|.:|.    .::|         ||.::.|..|.       .|.||.:        .:.
 Worm  2261 ARQSVRSLAEIALAIGSSSKAVNVDPRLLKEAEETLMTLEAASADQYPEKAQTVPGKLEEIQKKI 2325

  Fly  1190 KEKSVEFGQQSEQISDISREARALADKLESEAQFDLKNAKDAKDAVEKAHQLAKSAIDLQLKIGT 1254
            :|::.:..:|.|......:.|..||..|.|..|.    .|::|...:|::.:||.   |||....
 Worm  2326 QEETEKLDKQKETFEAQKKRAEELAAYLNSAQQL----LKESKSKADKSNNIAKM---LQLTKVE 2383

  Fly  1255 ELRSEVGLELSHVK------QSLGTVVQTSKEALRKANEVYDTALTLLNDVNRQTQPEIDISQLK 1313
            .|.:.:..:|..|:      |.|...:....|.|:...|....|:|.||:........::.::.:
 Worm  2384 NLVAAITDDLERVEAAKGEFQKLNVAIGNITENLKDKREEMTHAVTTLNETRNDVAEALEAAKKR 2448

  Fly  1314 -------KDAVAANERADELLKQITELSNSNGELFADFETEQELTEALLKRAEQ-QQLEDIELLE 1370
                   .|....|.:|.||..|.|.|..:       |:..::.|:..::.|.. ..|.|  .|:
 Worm  2449 VRRDEKSVDMQLVNAKAHELHLQATTLRQT-------FDNNKDNTDQAVEAANAFSNLTD--TLK 2504

  Fly  1371 RAKAAHDKATKAVEQGDNTLKEANN---------TYEKLAGFQSDVQ---RSSESAEKALQTVPN 1423
            .|||..|.|.:|:.......:...|         |.||:......|.   :.:|..:|.|:.:..
 Worm  2505 NAKAQIDNAYEALSAEPAFAESVQNARDKPFPDETKEKIDALSKTVSQDLKETEKLKKQLEQLTE 2569

  Fly  1424 IEKEIQNAESLI-----SQAEEALDGANKNANEAKK-------NAQEAQLKYAEQASKDAELIRR 1476
            :.::::..:..:     ..::..||..::...|.:|       |.:|.:.|.:|.|.| ||.|..
 Worm  2570 LSEKLRKRKEAVKAGIPKYSKNTLDSIDEKVQEVEKLKAEIDANIEETRAKISEIAGK-AEEITE 2633

  Fly  1477 KANETKVAARNLREEADQLNHRVKLTEMDIFKLEESSTKDDNLVDDAKRKVGQAKADTQEAQKQI 1541
            |||......|..|..:.|||   ||..:.:.|.||            .:|:..|:          
 Worm  2634 KANSAMEGIRLARRNSVQLN---KLAPVIVSKFEE------------LKKLSSAR---------- 2673

  Fly  1542 EKANADLTAIKDELENLKDINTGDLDRLENRLATVEGEINRVNLTGRIEK 1591
               :|.:.::.|::..:|::           :|......||:.|....||
 Worm  2674 ---SAKVDSVSDKVSQIKEM-----------IAVARDAANRIKLGAHFEK 2709

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB2NP_001287009.1 LamNT 61..296 CDD:214532 38/237 (16%)
EGF_Lam 298..347 CDD:238012 12/48 (25%)
Laminin_EGF 359..414 CDD:278482 17/59 (29%)
EGF_Lam 414..458 CDD:214543 19/46 (41%)
Laminin_EGF 461..511 CDD:278482 20/49 (41%)
LamB 572..697 CDD:214597 32/136 (24%)
TNFRSF <721..848 CDD:304602 57/142 (40%)
CRD2 724..771 CDD:276900 23/48 (48%)
EGF_Lam 743..791 CDD:238012 26/48 (54%)
Laminin_EGF 847..897 CDD:278482 18/49 (37%)
Laminin_EGF 902..953 CDD:278482 15/50 (30%)
Laminin_EGF 956..1004 CDD:278482 18/47 (38%)
Laminin_EGF 1004..1050 CDD:278482 19/48 (40%)
V_Alix_like 1122..1443 CDD:187408 73/379 (19%)
Tar 1139..1521 CDD:223910 98/447 (22%)
BAR 1308..1469 CDD:299863 37/192 (19%)
vATP-synt_E 1474..>1629 CDD:304907 25/118 (21%)
epi-1NP_001294008.1 LamNT 24..296 CDD:214532
EGF_Lam 297..345 CDD:238012
Laminin_EGF 427..474 CDD:278482
EGF_Lam 471..520 CDD:238012
EGF_Lam 519..564 CDD:214543
Laminin_EGF 564..612 CDD:278482
Laminin_EGF 610..658 CDD:278482
Laminin_EGF 656..703 CDD:278482
Laminin_EGF 701..753 CDD:278482
Laminin_EGF 756..806 CDD:278482
EGF_Lam 808..854 CDD:238012
CBM6-CBM35-CBM36_like 855..988 CDD:271143
EGF_Lam 1425..1468 CDD:238012 12/56 (21%)
EGF_Lam 1472..1515 CDD:238012 16/57 (28%)
Laminin_EGF 1517..1567 CDD:278482 21/51 (41%)
Laminin_EGF 1565..1613 CDD:278482 20/49 (41%)
LamB 1669..1793 CDD:214597 32/148 (22%)
EGF_Lam 1840..1883 CDD:238012 23/42 (55%)
Laminin_EGF 1891..1945 CDD:278482 21/64 (33%)
EGF_Lam 1947..1998 CDD:238012 18/52 (35%)
EGF_Lam 2001..2045 CDD:214543 15/50 (30%)
EGF_Lam 2048..2092 CDD:214543 16/44 (36%)
EGF_Lam 2095..2140 CDD:214543 17/45 (38%)
Tar <2145..2378 CDD:223910 49/250 (20%)
BAR 2289..2486 CDD:299863 45/210 (21%)
Apolipoprotein 2289..2472 CDD:279749 41/189 (22%)
COG1340 2414..2690 CDD:224259 66/313 (21%)
ApoLp-III_like 2510..2635 CDD:304399 24/125 (19%)
Laminin_II 2589..2730 CDD:283628 37/161 (23%)
LamG 2704..2875 CDD:238058 2/6 (33%)
LamG 2909..3057 CDD:238058
LamG 3353..3510 CDD:238058
LamG 3532..3682 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 61 1.000 Domainoid score I6930
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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