DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB2 and lam-3

DIOPT Version :9

Sequence 1:NP_001287009.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster
Sequence 2:NP_492775.2 Gene:lam-3 / 172952 WormBaseID:WBGene00002248 Length:3102 Species:Caenorhabditis elegans


Alignment Length:2277 Identity:540/2277 - (23%)
Similarity:813/2277 - (35%) Gaps:804/2277 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 PEFINAAYQLQIESTNTCGEQNDNHFC--------IQTMNQNHKNCEFCKYND----HNPSFLTD 121
            |...|.|....|.:|:|||:.....:|        .:|.|.....|:.|..|:    |...:..|
 Worm    50 PNIFNLATNSLITATDTCGQYTAEEYCKLVEHVLLRKTTNTQSPQCDICDANNVHKRHPIEYAID 114

  Fly   122 LHDPQSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRI-LFRSPRPESFTIYKRTSESG-- 183
                .:..||||.::..|::... ||:|:.|.:.|.:.|:.: :..||||.::.:.|  |..|  
 Worm   115 ----GTRRWWQSPSLANGLRFEK-VNITIDLRQEYQVAYIILKMGNSPRPGTWVLEK--SLDGEY 172

  Fly   184 --PWIPYQFYSATCRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPSGIN 246
              ||..|....|.|...:.:|.:..:.:.:.|....||||||.|:||.:|||..|.:.|||...|
 Worm   173 YEPWQYYAMQDAECMRQFGIPATTGVPRFQKEDEVHCTSEYSKITPLENGEIHTSLVNGRPGAEN 237

  Fly   247 FERSGELQEWVTATDIRI------TLDR----LNTFGDELFGDSQVLKSYFYAISDIAVGARCKC 301
              .|.|||::..|..:|:      ||:.    :|...|.|  |..|...|||:||||::|.:|.|
 Worm   238 --TSLELQKFTRARFVRLRLISPRTLNADLMIINKKSDSL--DKSVTMRYFYSISDISIGGQCIC 298

  Fly   302 NGHASKCVPSTGMHGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLAD 366
            .|||..| ||..:.|:  ..|||||||.|..|:||.||:|.|.||..|::..|.|:.|.|...|.
 Worm   299 YGHAESC-PSDPVTGQ--FKCECRHNTCGESCNRCCPLFNQLPWKPGTNSHPNVCQQCQCFNHAH 360

  Fly   367 KCFF----DANLFNRTGH-----GGHCLDCRENRDGPNCERCKENFY-------MRDDGYCVNCA 415
            .|.:    |.|.::.|..     ||.||:|..|.:|.||||||:.:|       .|:|. |..|.
 Worm   361 SCVYDDELDRNKWSITPEGVYEGGGRCLECAHNTEGFNCERCKDGYYRPSGLSHYREDA-CRTCE 424

  Fly   416 CDPVGSRSLQC----------NSHGKCQCKPGVTGDKCDRCDNNYYQFGPHGCQQCGCDSGGSHQ 470
            ||||||.|..|          ...|.|.||||..|.:|:||...|.....  |:.|.|:..|| .
 Worm   425 CDPVGSVSDACVRDDQSAENGQKPGDCICKPGFGGRRCERCAPGYRNHPT--CEPCPCNRAGS-V 486

  Fly   471 NTPACDTETGICFCKENVEGRRCNECKPGFFNLDKNNRFGCTPCFCYGHTSECMTAPGYSIVSVT 535
            |...||..:  |.||.||||..|:.||.|..:|..:|..||.||||:||:|.| |...::...:.
 Worm   487 NFDTCDGAS--CQCKANVEGIYCDRCKAGTIHLSASNPLGCQPCFCFGHSSTC-TQGKWNKAQII 548

  Fly   536 SNFNKFKERWTAADLNQREVDIKYNQYSRSI----GTTAQGNEHVYFQAPDRFLGDQRASYNRDL 596
            :|..     |...||...: |:|....:..:    ....|.....|::|||.|.|:...||...|
 Worm   549 NNIG-----WHLTDLTGGK-DVKPEVENGEVLMFNANQNQDRSLYYWKAPDSFKGNMLNSYGGYL 607

  Fly   597 KFKLQLV--GQVANTGVSDVILEGAGSRIS-------LPIFAQGNGIPDQGVKEYTFRLHEHHDY 652
            .:.:..|  .|.|...|:||.:||.|.:|.       ||.......||       ...|...::.
 Worm   608 HYDVYYVPTEQGATVFVADVAIEGNGIKIEYHSRIEFLPREKMTVAIP-------MSELSGWYNA 665

  Fly   653 QWQPSQSARGFLSILSNLTAIKIRATY-------SVQGEAILDD--------VELQTAHRGAAGH 702
            :.:........:..|:|:....:||||       |:.|.: ||.        ||..|:.:..|.|
 Worm   666 EARSPVDKADMMRALANVDRFTVRATYHQPQLQSSIFGLS-LDTAVPAPDEIVEEDTSLKALAYH 729

  Fly   703 PAT----WIEQCTCPEGYLGQFCESCAPGYR--HSPARGGPFMPCIPCDCHGHADICDSETGRCI 761
            ...    .:|.|.|||.:.|..||||.||||  ::...||   .|..|||||:::.||..||.|:
 Worm   730 TQDTLMGGVEVCECPENFAGNSCESCVPGYRRVNNQLYGG---RCEKCDCHGNSEECDPFTGECL 791

  Fly   762 -CQHNTHGDNCDQCAKGFYGN-ALGGTPNDCKRCPCPN-----DGACLQI----------NEDTV 809
             |:|||.|..|:.|..|..|| :.||....|::|.||:     :..|:..          |||..
 Worm   792 NCRHNTTGSRCELCKPGHVGNPSRGGELGACEQCECPSLDLNPNPECISTELAVLGSVASNEDNY 856

  Fly   810 ICTECPKGYFGSRCEQCSDGFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHN 874
            :|..||.||.|::||.||||||.||  |.|:   |..|.||||:||..:|||:..||:|||||.:
 Worm   857 VCINCPLGYEGNKCEYCSDGFFEDP--LTGK---CIECTCNGNIDPMGIGNCDSETGKCLKCIGH 916

  Fly   875 TAGEHCDQCLSGHFGDP---LALPHG---------------------------RCDRCSCYEAGT 909
            |.|:.|:.|...|:|:.   ...|.|                           :||||.......
 Worm   917 TTGDSCESCKEHHWGNAQLHTCKPCGCHTQGAVNPQCSEENGECECKENYIGAQCDRCKENHGDV 981

  Fly   910 E--------QDEQSI-TRCDQVTGQCQCKPNVIGRDCGECQP----------------------- 942
            |        .|..|| :.||||:|||.||..|.|:.|.:|:|                       
 Worm   982 ENGCPACDCNDTGSIGSDCDQVSGQCNCKQGVFGKQCDQCRPSYFNFTDAGCQFCHCNIYGSIED 1046

  Fly   943 --------------------------GYFNIRSGNGCENCLCDPVGSYNSTCDRYSGQCHCRPGV 981
                                      |||||.||:|||:|.|||.||.:.:|:..:|||.|:|||
 Worm  1047 GKCDQTTGKCECRENVEGTMCEKCADGYFNITSGDGCEDCGCDPTGSEDVSCNLVTGQCVCKPGV 1111

  Fly   982 MGQRCDQCENYFYGFSSEG---------------------------------------------- 1000
            .|.:||.|...|||.:|||                                              
 Worm  1112 TGLKCDSCLPNFYGLTSEGCTECEPCPAPGQVCDPIDGSCVCPPNTVGEMCENCTTNAWDYHPLN 1176

  Fly  1001 -----------------------------------------------CKPCECDESGSKGFQ--- 1015
                                                           |:||.|:.:|:...|   
 Worm  1177 GCKLCDCSDIGSDGGMCNTFTGQCKCKAAYVGLKCDLCTHGFFNFPTCEPCGCNAAGTDPLQCKD 1241

  Fly  1016 ----CDQNGQCPCNDNVEGRRCDRCKENKY----DRHRGCIDCPDCYNLVQ-------------- 1058
                |::.|:|||..||.|.:||:|.|..:    ...:||.:| .|:|...              
 Worm  1242 GQCLCNEIGECPCKKNVHGTKCDQCGEGTFSLDSSNLKGCTEC-FCFNRTSNCEQSDLVWQQMYA 1305

  Fly  1059 -----------------------------------DAADLH-------------------RAKLF 1069
                                               ||..|:                   |.|::
 Worm  1306 EDRRAVFQEPWEFYTKKHNINLLREKPSHFNSYPTDATPLYWPLPSTMLGDRTASYNGFLRFKIW 1370

  Fly  1070 N-------------------------LSQTLDEIARTPV-TNDD--------------EFEAKLK 1094
            |                         ......|:...|: .|||              ....:|.
 Worm  1371 NEDNRRGLHGIRPDQQYFRHFPQVIIFGNNRIELEHIPMEINDDGIYKIRLHESEWRVRHSPELT 1435

  Fly  1095 AVQEKVAVLAQDAR----------DNSGDG----------------------------------- 1114
            ..::::.|..||.:          ...||.                                   
 Worm  1436 LTRKQMMVALQDTQGIYIRGTYTYPARGDAINIQEVSLDVAVPESKIVAGLSTTKAIGVEKCLGC 1500

  Fly  1115 --GQT------------------YAEVIDDL-----------HKHLDSVR--------------- 1133
              |.|                  |....||:           |.|..:..               
 Worm  1501 PQGYTGLSCQNPEVGYYRKKHREYLNQADDIALIGWSEPCSCHGHSQTCNPDTSVCTDCEHNTFG 1565

  Fly  1134 ---EHLVS---ADKFQADANG------------------EIDRAR-------------------- 1154
               ||.:.   .|..:..||.                  .:|..|                    
 Worm  1566 DFCEHCLPGYIGDAREGGANACTKCACPLVENSFSDSCVAVDHGRGYVCNSCKPGYTGQYCETCV 1630

  Fly  1155 ---------------------------------------------------QNYTILDQITENAK 1168
                                                               :.:..::::..:..
 Worm  1631 AGYYGDPQHIGGTCSPCDCHPDGSLHGACNPLSGQCECKPGVTGRTCSMCQERHAFINRVCTSCD 1695

  Fly  1169 K----ELQQALDLLNDE-GAQALARAK----EKSVEFGQQSEQISDI----------------SR 1208
            :    .|.:.:|.:.:. |.|..:..|    ::....|.:|:.:|..                ::
 Worm  1696 QGCYLPLMETMDTMEEHLGRQNFSGLKPIPWKRVWRIGNESQDLSTFVGGIDKDGEIVKDSKWAK 1760

  Fly  1209 EARALADKLESEAQFDLKNAKDAKDAVEKAHQLAKSAIDLQLKIGTELRSEVGLEL--SHVKQSL 1271
            :|.||.|::..:.....|:|...|.....|.||   .:|.|:.......:...|::  .|...::
 Worm  1761 DAFALLDEVNFQMGRSNKSAVSIKQFTGIAEQL---ILDAQIHYANAFNTTNFLKMFAEHGATTV 1822

  Fly  1272 GTVVQTS--KEALRKANEVYDTALTLLNDVNRQTQPEIDISQLKKDAVAANERADELLKQITELS 1334
            |......  .||....|...:....:...:||..|              .:::|:||||.:| ..
 Worm  1823 GGAALDGMLMEAEAHLNATVERGEYVEKRLNRAQQ--------------EHKKAEELLKMVT-AQ 1872

  Fly  1335 NSNGELFADFETEQELTEALLKRAEQQQLEDIELLERAKAAHDKATKAVEQGDNTLKEANNTYEK 1399
            ..|..:|.|.:...::.|..: ...::.:.|:...:.|.|  ::.:..|.:..|..||.:|..||
 Worm  1873 KLNETIFEDLKNRIDVLEQWM-NDYRETIYDVSKKDTADA--ERMSLVVGKRINRYKEVSNEIEK 1934

  Fly  1400 L-AGFQSDVQRSSESAEKA------------------LQTVPNIEKEIQN--------------- 1430
            | ...:..:..|..|.|||                  |..:|::.::.||               
 Worm  1935 LRVEAEDQIAYSRNSIEKARSEELMNMFEDKEKINMTLAELPDLVEQCQNITLLYSQLIDEYDEE 1999

  Fly  1431 --------AESLISQAEEALD----------------GANKNANEAKKNAQEAQLKYAEQASKDA 1471
                    ||.|..||::.:|                .|.:|..||.|||.||....||.:...:
 Worm  2000 YVQTAGRHAEKLEVQAQKIVDRFVDTRTETENPLKASHAYENIVEALKNATEAVDSAAEASEAVS 2064

  Fly  1472 ELIRRKANETKVA-ARNLREEADQLNHRVKLTEMD------------------------------ 1505
            :::..:.:|:..| ..:||.:.::|.:...|:.:|                              
 Worm  2065 KMLGSEGSESGDANEESLRSQLEKLKNESSLSNVDNSNAVKIVEELKKEKKDLTDRLGHLNELKT 2129

  Fly  1506 -------IFKLEESS--TKDDNLVDDAKRKVGQAKADTQEAQKQIEKANADLTAIKDELENLKDI 1561
                   :.|.|.||  .|.|.:....|.....|...:...:|:.|....:::|||.|:|.|.:.
 Worm  2130 SIVKRLGVIKNEASSWDDKHDRMHSILKNGAKTAHERSANVKKESEGIKTEVSAIKAEVEKLMNS 2194

  Fly  1562 NTG----DLDRLENRLATVEGEINRVNLTG------RIEKYREQRTIQKNLIDKYDAELRELKDE 1616
            .:.    |::::            |.:.||      ::.|..:..|..:...||....:..||.:
 Worm  2195 TSSGVQEDMEKI------------RASRTGMEYGAQKLTKVNKLSTANQGRTDKMARNIAILKAK 2247

  Fly  1617 VQ 1618
            ::
 Worm  2248 IE 2249

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB2NP_001287009.1 LamNT 61..296 CDD:214532 78/253 (31%)
EGF_Lam 298..347 CDD:238012 25/48 (52%)
Laminin_EGF 359..414 CDD:278482 24/70 (34%)
EGF_Lam 414..458 CDD:214543 20/53 (38%)
Laminin_EGF 461..511 CDD:278482 20/49 (41%)
LamB 572..697 CDD:214597 37/148 (25%)
TNFRSF <721..848 CDD:304602 60/145 (41%)
CRD2 724..771 CDD:276900 23/49 (47%)
EGF_Lam 743..791 CDD:238012 22/49 (45%)
Laminin_EGF 847..897 CDD:278482 24/52 (46%)
Laminin_EGF 902..953 CDD:278482 26/108 (24%)
Laminin_EGF 956..1004 CDD:278482 25/140 (18%)
Laminin_EGF 1004..1050 CDD:278482 18/56 (32%)
V_Alix_like 1122..1443 CDD:187408 75/512 (15%)
Tar 1139..1521 CDD:223910 94/597 (16%)
BAR 1308..1469 CDD:299863 47/218 (22%)
vATP-synt_E 1474..>1629 CDD:304907 33/195 (17%)
lam-3NP_492775.2 LamNT 42..294 CDD:214532 78/254 (31%)
EGF_Lam 296..343 CDD:238012 26/49 (53%)
EGF_Lam <384..411 CDD:214543 14/26 (54%)
Laminin_EGF 423..480 CDD:278482 22/58 (38%)
EGF_Lam 477..526 CDD:238012 21/51 (41%)
LamB 583..711 CDD:214597 34/135 (25%)
EGF_Lam 774..818 CDD:238012 21/43 (49%)
Laminin_EGF 889..943 CDD:278482 24/53 (45%)
EGF_Lam 941..985 CDD:214543 6/43 (14%)
EGF_Lam 988..1033 CDD:214543 17/44 (39%)
EGF_Lam 1036..1083 CDD:214543 7/46 (15%)
Laminin_EGF 1086..1134 CDD:278482 24/47 (51%)
EGF_Lam 1133..1179 CDD:238012 0/45 (0%)
Laminin_EGF 1181..1229 CDD:278482 3/47 (6%)
Laminin_EGF 1227..1281 CDD:278482 16/53 (30%)
LamB 1341..1478 CDD:214597 17/136 (13%)
EGF_Lam 1539..1583 CDD:238012 5/43 (12%)
EGF_Lam 1590..1637 CDD:214543 2/46 (4%)
EGF_Lam 1646..1694 CDD:238012 0/47 (0%)
BAR 1848..2058 CDD:299863 48/227 (21%)
PspA 1864..2121 CDD:224755 53/260 (20%)
Laminin_II 2157..2286 CDD:283628 20/105 (19%)
LamG 2285..2443 CDD:214598
LamG 2471..2622 CDD:238058
LamG 2655..2821 CDD:238058
LamG 2919..3065 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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