DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanB2 and Lamc2

DIOPT Version :9

Sequence 1:	NP_001287009.1	Gene:	LanB2 / 39118	FlyBaseID:	FBgn0267348	Length:	1639	Species:	Drosophila melanogaster
Sequence 2:	NP_032511.3	Gene:	Lamc2 / 16782	MGIID:	99913	Length:	1193	Species:	Mus musculus

Alignment Length:	1357	Identity:	402/1357 - (29%)
Similarity:	614/1357 - (45%)	Gaps:	228/1357 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 CLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANLFNRTGHGGHCLDCRENRDGPNCERCK 400
            ||.:...|...::||..    :.|:|||.:.:|.||..|..:||.|..||:|.:|..|.:||||:
Mouse     9 CLGVALLLPAAQATSRR----EVCDCNGKSRQCVFDQELHRQTGSGFRCLNCNDNTAGVHCERCR 69

  Fly   401 ENFYM-RDDGYCVNCACDPVGSRSLQCNSHGKCQCKPGVTGDKCDRCDNNYYQFGPHGC------ 458
            |.||. ||...|:.|.|...||.|..|::.|:|:|||||||.:||||...::.....||
Mouse    70 EGFYRHRDRDRCLPCNCHSKGSLSAGCDNSGQCRCKPGVTGQRCDRCQPGFHMLTDAGCTRDQGQ 134

  Fly   459 --QQCGCDSGGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLDKNNRFGCTPCFCYGHTS 521
              .:|.||..|.   :..||  :|.|.||..|.|.||:.|:||:::||:.|..|||.||||||::
Mouse   135 LDSKCDCDPAGI---SGPCD--SGRCVCKPAVTGERCDRCRPGYYHLDRANPEGCTQCFCYGHSA 194

  Fly   522 ECMTAPGYSIVSVTSNFNKFKERWTAADLNQREVDIKYNQYSRSIGTTAQGNEHVYFQAPDRFLG 586
            .|..:..:|:..:||.|::..:.|.|...|.....:.::|..|.:.::|:.::.|||.||.:|||
Mouse   195 SCHASADFSVHKITSTFSQDVDGWKAVQRNGAPAKLHWSQRHRDVFSSARRSDPVYFVAPAKFLG 259

  Fly   587 DQRASYNRDLKFKLQLVGQVANTGVSDVILEGAGSRISLPIFAQGNGIPDQGVKEYTFRLHEHHD 651
            :|:.||.:.|.|..::..........||||||||.:|..|:.|.|..:|....|.|||||:||..
Mouse   260 NQQVSYGQSLSFDYRVDRGGRQPSAYDVILEGAGLQIRAPLMAPGKTLPCGITKTYTFRLNEHPS 324

  Fly   652 YQWQPSQSARGFLSILSNLTAIKIRATYSVQGEAILDDVELQTAHRGAAGHPATWIEQCTCPEGY 716
            ..|.|..|...:..:|.||||:.|||||.......:|:|.|.:| |..:|.||.|:|:|.||.||
Mouse   325 SHWSPQLSYFEYRRLLRNLTALLIRATYGEYSTGYIDNVTLVSA-RPVSGAPAPWVERCVCPAGY 388

  Fly   717 LGQFCESCAPGYRHSPARGGPFMPCIPCDCHGHADICDSETGRCICQHNTHGDNCDQCAKGFYGN 781
            .||||:.||.||:...||.|||..|:||:|.| ...||.:||.|..........|..|..|||.:
Mouse   389 KGQFCQECASGYKRDSARLGPFGACVPCNCQG-GGACDPDTGDCYSGDENPDIECADCPIGFYND 452

  Fly   782 ALGGTPNDCKRCPCPNDGACLQINE-DTVICTECPKGYFGSRCEQCSDGFFGDPTGLLGEVQTCK 845
            .  ..|..||.|||.|..:|..:.| :.|:|..||.|..|:|||.|:|||||||.|..|.|:.|:
Mouse   453 P--HDPRSCKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGFFGDPFGERGPVRPCQ 515

  Fly   846 SCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSGHFGDPLALPHGRCDRCSCYEAGTE 910
            .|.||.||||||.|||::.||.|||||:||||.:||||.:|:||||||
Mouse   516 RCQCNNNVDPNASGNCDQLTGRCLKCIYNTAGVYCDQCKAGYFGDPLA----------------- 563

  Fly   911 QDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIRSGNGCENCLCDPVGSYNSTCDRYSGQC 975
                               ||                 ..:.|..|.|.|:||....| |..|.|
Mouse   564 -------------------PN-----------------PADKCRACNCSPMGSEPGEC-RGDGSC 591

  Fly   976 HCRPGVMGQRCDQCENYFYGFSSEGCKPCECDESGSKGFQCDQNGQCPCNDNVEGRRCDRCKENK 1040
            .|:||..|..||
Mouse   592 VCKPGFGGLNCD----------------------------------------------------- 603

  Fly  1041 YDRHRGCIDCPDCYNLVQDAADLHRAKLFNLSQTLDEIARTP-------VTNDDEFEAKLKAVQE 1098
               |.....||.|||.|:...|....:|    |:|:.:....       .....|.|.:::..::
Mouse   604 ---HAALTSCPACYNQVKIQMDQFTQQL----QSLEALVSKAQGGGGGGTVPSGELEGRMQQAEQ 661

  Fly  1099 KVAVLAQDARDNSG-------------DGGQTYAEVIDDLHKHLDSVREHLVSADKFQADANGEI 1150
            .:..:.::|:.:.|             .....|...:|||.          ::|::.:|     :
Mouse   662 ALRDILREAQISEGAMRALGFRLAKARSQENDYKTRLDDLK----------MTAERIRA-----L 711

  Fly  1151 DRARQNYTILDQITENAKKELQQALDLLNDEGAQALARAKEKSVEFGQQSEQISDISREARALAD 1215
            ....||     ::.:.::...|..|.|...|.  :|......|.|..........:::||..|||
Mouse   712 GSQHQN-----RVQDTSRLISQMRLSLAGSEA--SLQNTNIHSSEHYVGPNGFKSLAQEATRLAD 769

  Fly  1216 KLESEAQFDLKNAKDAKDAVEKAHQLAKSAIDLQLKIGTELRSEVGLELSHVKQSLGTVVQT--- 1277
            .....|....:.|::.:|..::|..||:.|:......|.       |:.|.|:..:|.:.:|
Mouse   770 SHAESANAMKQLARETEDYSKQALSLARKALSGGGGSGV-------LDSSVVQGLMGKLEKTKSL 827

  Fly  1278 ----SKEALR---KANEVYDTALTLLNDVNRQTQPEIDISQLKKDAVAANERADELLKQITELSN 1335
                |:|..:   :|:..|..:|.||:..: |.|...|:| .:.:|....::||.|...:|..::
Mouse   828 SQQLSREGTQADIEADRSYQHSLRLLDSAS-QLQGVSDLS-FQVEAKRIRQKADSLSNLVTRQTD 890

  Fly  1336 SNGELFADFETEQELTEALLKRAEQQQLEDIELLERAKAAHDKATKAVEQGDNTLKEANNTYEKL 1400
            :...:..:....::.|..||:..:.::....:||.||..|.::|.:|:..|:.|..|..|..:.|
Mouse   891 AFTRVRNNLGNWEKETRQLLQTGKDRRQTSDQLLSRANLAKNRAQEALSMGNATFYEVENILKNL 955

  Fly  1401 AGFQSDVQRSSESAEKALQTVPNIEKEIQNAESLISQAEEALDGANKNANEAKKNAQEAQLKYAE 1465
            ..|...|:.....||:|::.:.:|.:::.:|.....|||.||..|..:...||..|:|| |:.:.
Mouse   956 REFDLQVEDRKAEAEEAMKRLSSISQKVADASDKTQQAETALGSATADTQRAKNAAREA-LEISS 1019

  Fly  1466 QASKDAELIRRKANETKVAARNLREEADQLNHRVKLTEMDIFKLE-ESSTKDDNLVDDAKRKVGQ 1529
            :..::...:..:||.|...|..:.:....|...::..|.::.:.| |..|..|.:
Mouse  1020 EIEQEIGSLNLEANVTADGALAMEKGLATLKSEMREMEGELARKELEFDTDKDTV---------- 1074

  Fly  1530 AKADTQEAQKQIEKANADLTAIKDELENLKDI-----NTGDLDR-----LENRLATVEGEIN--- 1581
             :....|||:...:|.:....|:|.|..|..|     ..|.:|.     ||..|...:.:||
Mouse  1075 -QLVITEAQQADARATSAGVTIQDTLNTLDGILHLIDQPGSVDEEGMMLLEQGLFQAKTQINSRL 1138

  Fly  1582 RVNLTGRIEKYREQRTIQKNLIDKYDAELRELKDEVQNIGLISKALPDSCFSRNRLE 1638
            |..::...|:.|.||    |.:...:..:..:..:|:|:..|...||..|::...||
Mouse  1139 RPLMSDLEERVRRQR----NHLHLLETSIDGILADVKNLENIRDNLPPGCYNTQALE 1191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB2	NP_001287009.1	LamNT	61..296	CDD:214532
		EGF_Lam	298..347	CDD:238012	3/10 (30%)
		Laminin_EGF	359..414	CDD:278482	26/55 (47%)
		EGF_Lam	414..458	CDD:214543	19/43 (44%)
		Laminin_EGF	461..511	CDD:278482	20/49 (41%)
		LamB	572..697	CDD:214597	51/124 (41%)
		TNFRSF	<721..848	CDD:304602	55/127 (43%)
		CRD2	724..771	CDD:276900	19/46 (41%)
		EGF_Lam	743..791	CDD:238012	15/47 (32%)
		Laminin_EGF	847..897	CDD:278482	34/49 (69%)
		Laminin_EGF	902..953	CDD:278482	2/50 (4%)
		Laminin_EGF	956..1004	CDD:278482	15/47 (32%)
		Laminin_EGF	1004..1050	CDD:278482	1/45 (2%)
		V_Alix_like	1122..1443	CDD:187408	74/330 (22%)
		Tar	1139..1521	CDD:223910	89/392 (23%)
		BAR	1308..1469	CDD:299863	41/160 (26%)
		vATP-synt_E	1474..>1629	CDD:304907	36/168 (21%)
Lamc2	NP_032511.3	Laminin_EGF	28..86	CDD:365839	27/57 (47%)
		EGF_Lam	83..127	CDD:238012	19/43 (44%)
		Laminin_EGF	139..184	CDD:365839	20/49 (41%)
		Laminin_B	245..370	CDD:383018	51/125 (41%)
		EGF_Lam	461..509	CDD:238012	24/47 (51%)
		Laminin_EGF	517..564	CDD:365839	34/82 (41%)
		EGF_Lam	572..>604	CDD:238012	15/88 (17%)
		Cell attachment site. /evidence=ECO:0000255	586..588		1/1 (100%)
		SMC_prok_B	<614..1192	CDD:274008	134/629 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	174	1.000	Domainoid score	I3660
eggNOG	1	0.900	-	-		E1_KOG1836
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D156553at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102334
Panther	1	1.100	-	-	O	PTHR10574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820