DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LanB2 and Lamb1

DIOPT Version :10

Sequence 1:NP_524006.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster
Sequence 2:NP_032508.3 Gene:Lamb1 / 16777 MGIID:96743 Length:1786 Species:Mus musculus


Alignment Length:1884 Identity:518/1884 - (27%)
Similarity:799/1884 - (42%) Gaps:472/1884 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 YGRPQ-KCLPE----FINAAYQLQIESTNTCGEQNDNHFCIQTMNQNHKNCEFCKYND--H---N 115
            ||..: .|.|.    .|..|.:|.:  |:|||......:||.:..|..|.|..|...|  |   |
Mouse    28 YGCAEGSCYPATGDLLIGRAQKLSV--TSTCGLHKPEPYCIVSHLQEDKKCFICDSRDPYHETLN 90

  Fly   116 P------SFLTDLHDPQSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRILFRSPRPESFT 174
            |      :.:|.....:...|||||   .|:::   |.:.|.|...:..|::.:.|::.||.:..
Mouse    91 PDSHLIENVVTTFAPNRLKIWWQSE---NGVEN---VTIQLDLEAEFHFTHLIMTFKTFRPAAML 149

  Fly   175 IYKRTSESG-PWIPYQFYSATCRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTL 238
            | :|:|:.| .|..|::::..|..::....:..::|.:   ..:|.|.||||.|..:||:.|..|
Mouse   150 I-ERSSDFGKAWGVYRYFAYDCESSFPGISTGPMKKVD---DIICDSRYSDIEPSTEGEVIFRAL 210

  Fly   239 EGRPS-GINFERSGELQEWVTATDIRITLDRLNTFGDELFGDS--QVLKSYFYAISDIAVGARCK 300
            :  |: .|....|..:|..:..|::||...:|:|.||.|. ||  ::.:.|:||:.|:.|...|.
Mouse   211 D--PAFKIEDPYSPRIQNLLKITNLRIKFVKLHTLGDNLL-DSRMEIREKYYYAVYDMVVRGNCF 272

  Fly   301 CNGHASKCVPSTG--------MHGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECK 357
            |.||||:|.|..|        :||.    |.|||||.|.:|:.|:..|:||.|:.:.....|.||
Mouse   273 CYGHASECAPVDGVNEEVEGMVHGH----CMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACK 333

  Fly   358 ACNCNGLADKCFFDANLFNRTGH--GGHCLDCRENRDGPNCERCKENFY------MRDDGYCVNC 414
            .||||..:..|.||..:|..||:  ||.|.:|:.|..|.|||:||..::      :||...|..|
Mouse   334 KCNCNEHSSSCHFDMAVFLATGNVSGGVCDNCQHNTMGRNCEQCKPFYFQHPERDIRDPNLCEPC 398

  Fly   415 ACDPVGSRSLQ-CNSH---------GKCQCKPGVTGDKCDRCDNNYYQFG---PHGCQQCGCDSG 466
            .|||.||.:.. |:.:         |:|:||..|.|::||.|...:|...   |:||:.|.|:..
Mouse   399 TCDPAGSENGGICDGYTDFSVGLIAGQCRCKLHVEGERCDVCKEGFYDLSAEDPYGCKSCACNPL 463

  Fly   467 GSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLDKNNRFGCTPC----------FCYGHTS 521
            |:......||:|||.|:||..|.|:||::|.|..:.| .|:..||.||          .|...:.
Mouse   464 GTIPGGNPCDSETGYCYCKRLVTGQRCDQCLPQHWGL-SNDLDGCRPCDCDLGGALNNSCSEDSG 527

  Fly   522 ECMTAP------------GYSIVSVTSNFNKFKERWTAADLNQREVDIKYNQY--SRSIGTTAQG 572
            :|...|            ||...::.....:.:|    |:|....:.:: .||  .|....|..|
Mouse   528 QCSCLPHMIGRQCNEVESGYYFTTLDHYIYEAEE----ANLGPGVIVVE-RQYIQDRIPSWTGPG 587

  Fly   573 NEHV-------YF------------------QAPDRFLGDQRASYNRDLKFKLQLVGQVANTGVS 612
            ...|       :|                  |.||.:   ::|........|:....:..||...
Mouse   588 FVRVPEGAYLEFFIDNIPYSMEYEILIRYEPQLPDHW---EKAVITVQRPGKIPASSRCGNTVPD 649

  Fly   613 D---VILEGAGSR-ISLP---IFAQGNGIPDQGVKEYTFRLH----------------------- 647
            |   |:....||| :.||   .|.:|        ..||.||.                       
Mouse   650 DDNQVVSLSPGSRYVVLPRPVCFEKG--------MNYTVRLELPQYTASGSDVESPYTFIDSLVL 706

  Fly   648 ------------------EHHDYQWQPSQSARGFLSILSN--------LTAIKIRATYSV----- 681
                              |..:..|:..|..|    .|.|        :|.:.....:|:     
Mouse   707 MPYCKSLDIFTVGGSGDGEVTNSAWETFQRYR----CLENSRSVVKTPMTDVCRNIIFSISALIH 767

  Fly   682 ----------QG--EAILD----------DVELQTAHRGAAGHPATW------------------ 706
                      ||  .::.|          :|..:|.:|.|   |.|:                  
Mouse   768 QTGLACECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNRCA---PGTFGFGPNGCKPCDCHLQGSA 829

  Fly   707 -------IEQCTCPEGYLGQFCESCAPGYRHSPARGGPFMPCIPCDCHGHADICDSETGRCI-CQ 763
                   ..||.|.:|...:.|:.|.|||...|:       |.||.|:|||..||:.||.|: ||
Mouse   830 SAFCDAITGQCHCFQGIYARQCDRCLPGYWGFPS-------CQPCQCNGHALDCDTVTGECLSCQ 887

  Fly   764 HNTHGDNCDQCAKGFYGNALGGTPNDCKRCPCPNDG---------ACLQINEDTVICTECPKGYF 819
            ..|.|.||::|..|:||:.:.|:.:.|:.|||| ||         :|.|......:...|..||.
Mouse   888 DYTTGHNCERCLAGYYGDPIIGSGDHCRPCPCP-DGPDSGRQFARSCYQDPVTLQLACVCDPGYI 951

  Fly   820 GSRCEQCSDGFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCL 884
            ||||:.|:.||||:|:...|   :|:.|.|:.|:|......|::.||.||||:::|.|:||..|.
Mouse   952 GSRCDDCASGFFGNPSDFGG---SCQPCQCHHNIDTTDPEACDKETGRCLKCLYHTEGDHCQLCQ 1013

  Fly   885 SGHFGDPLALPHGRCDRCSCYEAGT--EQDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNI 947
            .|::||.|   ...|.:|.|...||  |....|...||:.||||.|.|||||::|..|.|..:.:
Mouse  1014 YGYYGDAL---RQDCRKCVCNYLGTVKEHCNGSDCHCDKATGQCSCLPNVIGQNCDRCAPNTWQL 1075

  Fly   948 RSGNGCENCLCDPVGSYNSTCDRYSGQCHCRPGVMGQRCDQCENYFYGFSSEGCKPCECDESGSK 1012
            .||.||..|.|:...|:..:|:.::|||.|.||..|:.|.:|:..|:|.....|:.|:||..|.:
Mouse  1076 ASGTGCGPCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCSECQELFWGDPDVECRACDCDPRGIE 1140

  Fly  1013 GFQCDQN-GQCPCNDNVEGRRCDRCKENKYDRHRGCIDCPDCYNLVQDA----------ADLHRA 1066
            ..||||: |||.|.:.|||.|||:|..........|..|..|:.| .||          ..|.:|
Mouse  1141 TPQCDQSTGQCVCVEGVEGPRCDKCTRGYSGVFPDCTPCHQCFAL-WDAIIGELTNRTHKFLEKA 1204

  Fly  1067 KLFNLS-------QTLDEI---------------ARTPVTN----DDEFEAKLKAVQEKVAVL-- 1103
            |...:|       :|:|.:               |..|:.|    .:|.|...|.|.||:|.:  
Mouse  1205 KALKISGVIGPYRETVDSVEKKVNEIKDILAQSPAAEPLKNIGILFEEAEKLTKDVTEKMAQVEV 1269

  Fly  1104 -----AQDARDNSGDGG--QTYAEVIDDLHKHLDSVREHLVSADKFQADANGEIDRARQNYTILD 1161
                 |..:...:|:.|  |..||.:|...|.|         |::.:...|.:|..|..:.|...
Mouse  1270 KLTDTASQSNSTAGELGALQAEAESLDKTVKEL---------AEQLEFIKNSDIQGALDSITKYF 1325

  Fly  1162 QITENAKKELQQALDLLNDEGAQ-ALARAK------EKSVEFGQQSEQISDISREARALADKLE- 1218
            |::..|:|.:..:....|....| ||.|.:      |:...|.:|.|:.:.:..|   ||.||: 
Mouse  1326 QMSLEAEKRVNASTTDPNSTVEQSALTRDRVEDLMLERESPFKEQQEEQARLLDE---LAGKLQS 1387

  Fly  1219 -------------------SEAQFDLKNAKDAKDAVEK-------------AHQLAKSAIDLQLK 1251
                               ||::....|.:  .|..||             ||...:.|:|....
Mouse  1388 LDLSAVAQMTCGTPPGADCSESECGGPNCR--TDEGEKKCGGPGCGGLVTVAHSAWQKAMDFDRD 1450

  Fly  1252 IGTELR---------SEVGLELSHVKQSLGTVV---QTSKEALRKANEVYDTALTLLNDV-NRQT 1303
            :.:.|.         ||..:.....||:...|:   ..:||.:.|:||   ....|:..: |..|
Mouse  1451 VLSALAEVEQLSKMVSEAKVRADEAKQNAQDVLLKTNATKEKVDKSNE---DLRNLIKQIRNFLT 1512

  Fly  1304 QPEIDISQLKKDAVAANERADELLKQITELSNSNGELFADFETEQELTEALLKRAE--------- 1359
            :...|:..:  :||     |:|:||.  |:.::..:|       |.|||.:.:|.|         
Mouse  1513 EDSADLDSI--EAV-----ANEVLKM--EMPSTPQQL-------QNLTEDIRERVETLSQVEVIL 1561

  Fly  1360 QQQLEDIE----LLERAKAAHDKATKAVEQGDNTLKEANNTYEKLAGFQSDVQRSSESAEKALQT 1420
            ||...||.    |||.||.|...||......| .:|||          ..:.:::..:||||:: 
Mouse  1562 QQSAADIARAELLLEEAKRASKSATDVKVTAD-MVKEA----------LEEAEKAQVAAEKAIK- 1614

  Fly  1421 VPNIEKEIQNAESLISQ-------AEEALDGANKNANEAKKNAQEAQLKYAEQASKDAELIRRKA 1478
              ..:::||..::|::.       :||.|..|::..::.::|.:|.:.| |.|.|.:||.|.:..
Mouse  1615 --QADEDIQGTQNLLTSIESETAASEETLTNASQRISKLERNVEELKRK-AAQNSGEAEYIEKVV 1676

  Fly  1479 NETKVAARNLREEAD-QLNHRVKLTEMDIF-KLEESSTKDDNLVDDAKRKVGQAKADTQEAQKQI 1541
            ...|..|.::::..| :|:.:.|..|..|. |.|||:        ||:||   |:....||:..:
Mouse  1677 YSVKQNADDVKKTLDGELDEKYKKVESLIAQKTEESA--------DARRK---AELLQNEAKTLL 1730

  Fly  1542 EKANADLTAIKDELENLKDINTGDLDRLENRLATVEGEINRVNLTGRIEKYREQRTIQKNLIDK 1605
            .:||:.|..::| ||...:.|...|:.....|..:|||:               |::.|::.:|
Mouse  1731 AQANSKLQLLED-LERKYEDNQKYLEDKAQELVRLEGEV---------------RSLLKDISEK 1778

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB2NP_524006.1 LamNT 61..296 CDD:214532 72/254 (28%)
EGF_Lam 298..347 CDD:238012 24/56 (43%)
Laminin_EGF 359..414 CDD:395007 24/62 (39%)
EGF_Lam 414..458 CDD:214543 18/56 (32%)
Laminin_EGF 461..511 CDD:395007 19/49 (39%)
LamB 572..697 CDD:214597 36/232 (16%)
EGF_Lam 743..791 CDD:238012 22/48 (46%)
EGF_Lam 793..836 CDD:214543 21/51 (41%)
Laminin_EGF 847..897 CDD:395007 20/49 (41%)
Laminin_EGF 902..953 CDD:395007 23/52 (44%)
EGF_Lam 956..1001 CDD:214543 15/44 (34%)
Laminin_EGF 1004..1046 CDD:395007 19/42 (45%)
SMC_prok_B <1054..1621 CDD:274008 158/672 (24%)
Lamb1NP_032508.3 Laminin_N 35..269 CDD:459653 71/248 (29%)
EGF_Lam 271..323 CDD:238012 24/55 (44%)
EGF_Lam 335..387 CDD:238012 21/51 (41%)
Laminin_EGF 398..455 CDD:395007 18/56 (32%)
EGF_Lam 457..508 CDD:238012 20/51 (39%)
EGF_Lam 509..>548 CDD:238012 6/38 (16%)
EGF_Lam 773..818 CDD:214543 9/47 (19%)
Laminin_EGF 821..869 CDD:395007 13/54 (24%)
EGF_Lam 866..911 CDD:238012 22/44 (50%)
Laminin_EGF 917..973 CDD:395007 22/59 (37%)
Laminin_EGF 976..1020 CDD:395007 18/43 (42%)
Laminin_EGF 1028..1082 CDD:395007 24/53 (45%)
Laminin_EGF 1084..1132 CDD:395007 16/47 (34%)
Laminin_EGF 1132..>1171 CDD:395007 19/38 (50%)
Domain II 1179..1397 52/230 (23%)
YhaN 1188..>1675 CDD:443752 123/534 (23%)
Domain alpha 1398..1430 6/33 (18%)
Domain I 1431..1786 102/409 (25%)
SMC_prok_B 1456..>1776 CDD:274008 96/380 (25%)
cc_LAMB1_C 1714..1786 CDD:411971 22/84 (26%)

Return to query results.
Submit another query.