DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanB2 and Lama5

DIOPT Version :9

Sequence 1:NP_001287009.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster
Sequence 2:XP_006500638.1 Gene:Lama5 / 16776 MGIID:105382 Length:3745 Species:Mus musculus


Alignment Length:2851 Identity:516/2851 - (18%)
Similarity:780/2851 - (27%) Gaps:1412/2851 - (49%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 GVLFASCSTAILG----AQRPPINSAGGHELRGTTFMPALECYDPYGRPQKCLPEFINAAYQLQI 80
            |.|.|..:...||    |.||.:....|..|.|       |...|.|......|.:.|.|...:|
Mouse     6 GQLCAGSAPGALGPRSPAPRPLLLLLAGLALVG-------EARTPGGDGFSLHPPYFNLAEGARI 63

  Fly    81 ESTNTCGEQ---------NDNHFC------------IQTMNQNHKNCEFCKYNDHNPSFLTDLHD 124
            .::.||||:         .::.:|            .||:...:  |:.|...:.|.:.......
Mouse    64 TASATCGEEAPTRSVSRPTEDLYCKLVGGPVAGGDPNQTIQGQY--CDICTAANSNKAHPVSNAI 126

  Fly   125 PQSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRILF-RSPRPESFTIYKRTSESGPWIPY 188
            ..:..||||..:..|::: |.||:||.||:.:.:.||.|.| .||||:.:.:.:.|.....:.|:
Mouse   127 DGTERWWQSPPLSRGLEY-NEVNVTLDLGQVFHVAYVLIKFANSPRPDLWVLERSTDFGHTYQPW 190

  Fly   189 QFYSATCRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPSGINFERSGEL 253
            ||::::.||.......|.:.:...:...:||:|||.|.||.:|||..|.:.|||..:||..|..|
Mouse   191 QFFASSKRDCLERFGPRTLERITQDDDVICTTEYSRIVPLENGEIVVSLVNGRPGALNFSYSPLL 255

  Fly   254 QEWVTATDIRITLDRLNTFGDELFG----DSQVLKSYFYAISDIAVGARCKCNGHASKCVPSTGM 314
            :::..||:||:...|.||....|.|    |..|.:.|:|:|.||::|.||.|:|||..|.....:
Mouse   256 RDFTKATNIRLRFLRTNTLLGHLMGKALRDPTVTRRYYYSIKDISIGGRCVCHGHADVCDAKDPL 320

  Fly   315 HGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANLFNRTG 379
            ...| |.|.|:|||.|..||||.|.:|...||.:|:...|||::|||:|.|..|::|..:..|..
Mouse   321 DPFR-LQCACQHNTCGGSCDRCCPGFNQQPWKPATTDSANECQSCNCHGHAYDCYYDPEVDRRNA 384

  Fly   380 H---------GGHCLDCRENRDGPNCERCKENFYMRDD--------------------------- 408
            .         ||.||||:.:..|.|||||...|:...|                           
Mouse   385 SQNQDNVYQGGGVCLDCQHHTTGINCERCLPGFFRAPDQPLDSPHVCRPCDCESDFTDGTCEDLT 449

  Fly   409 ----------------------------------------------------------------- 408
                                                                             
Mouse   450 GRCYCRPNFTGELCAACAEGYTDFPHCYPLPSFPHNDTREQVLPAGQIVNCDCNAAGTQGNACRK 514

  Fly   409 ----------------------------------------------------------------- 408
                                                                             
Mouse   515 DPRLGRCVCKPNFRGAHCELCAPGFHGPSCHPCQCSSPGVANSLCDPESGQCMCRTGFEGDRCDH 579

  Fly   409 ---------------------------------------------------GY--CVNCACDPVG 420
                                                               ||  |..|||||.|
Mouse   580 CALGYFHFPLCQLCGCSPAGTLPEGCDEAGRCQCRPGFDGPHCDRCLPGYHGYPDCHACACDPRG 644

  Fly   421 SRSLQCNSHGKCQCKPGVTGDKCDRCDNNYYQF-------------------------------- 453
            :...||...|.|.|:||.||..|..|...:|.|                                
Mouse   645 ALDQQCGVGGLCHCRPGYTGATCQECSPGFYGFPSCIPCHCSADGSLHTTCDPTTGQCRCRPRVT 709

  Fly   454 ------------------------------------------------GP--------------- 455
                                                            ||               
Mouse   710 GLHCDMCVPGAYNFPYCEAGSCHPAGLAPANPALPETQAPCMCRAHVEGPSCDRCKPGYWGLSAS 774

  Fly   456 ------------------------------------------------------HGCQQCGCDSG 466
                                                                  .||:.|.||.|
Mouse   775 NPEGCTRCSCDPRGTLGGVTECQGNGQCFCKAHVCGKTCAACKDGFFGLDYADYFGCRSCRCDVG 839

  Fly   467 G---------------------------------------------------------------- 467
            |                                                                
Mouse   840 GALGQGCEPKTGACRCRPNTQGPTCSEPAKDHYLPDLHHMRLELEEAATPEGHAVRFGFNPLEFE 904

  Fly   468 ----------------------------------------------------------------- 467
                                                                             
Mouse   905 NFSWRGYAHMMAIQPRIVARLNVTSPDLFRLVFRYVNRGSTSVNGQISVREEGKLSSCTNCTEQS 969

  Fly   468 ----------------------------------------------------------------- 467
                                                                             
Mouse   970 QPVAFPPSTEPAFVTVPQRGFGEPFVLNPGIWALLVEAEGVLLDYVVLLPSTYYEAALLQHRVTE 1034

  Fly   468 ----------------------------------------------------------------- 467
                                                                             
Mouse  1035 ACTYRPSALHSTENCLVYAHLPLDGFPSAAGTEALCRHDNSLPRPCPTEQLSPSHPPLATCFGSD 1099

  Fly   468 -------------------------SHQ------NTP---------------------------- 473
                                     |||      :||                            
Mouse  1100 VDIQLEMAVPQPGQYVLVVEYVGEDSHQEMGVAVHTPQRAPQQGVLNLHPCPYSSLCRSPARDTQ 1164

  Fly   474 ----------------------------------------------------------------- 473
                                                                             
Mouse  1165 HHLAIFYLDSEASIRLTAEQAHFFLHSVTLVPVEEFSTEFVEPRVFCVSSHGTFNPSSAACLASR 1229

  Fly   474 ----------------------------------------------------------------- 473
                                                                             
Mouse  1230 FPKPPQPIILKDCQVLPLPPDLPLTQSQELSPGAPPEGPQPRPPTAVDPNAEPTLLRHPQGTVVF 1294

  Fly   474 ----------------------------------------------------------------- 473
                                                                             
Mouse  1295 TTQVPTLGRYAFLLHGYQPVHPSFPVEVLINGGRIWQGHANASFCPHGYGCRTLVLCEGQTMLDV 1359

  Fly   474 ----------------------------------------------------------------- 473
                                                                             
Mouse  1360 TDNELTVTVRVPEGRWLWLDYVLIVPEDAYSSSYLQEEPLDKSYDFISHCATQGYHISPSSSSPF 1424

  Fly   474 ----------------------------------------------------------------- 473
                                                                             
Mouse  1425 CRNAATSLSLFYNNGALPCGCHEVGAVSPTCEPFGGQCPCRGHVIGRDCSRCATGYWGFPNCRPC 1489

  Fly   474 ----------------------------------------------------------------- 473
                                                                             
Mouse  1490 DCGARLCDELTGQCICPPRTVPPDCLVCQPQSFGCHPLVGCEECNCSGPGVQELTDPTCDMDSGQ 1554

  Fly   474 --------------------------------------ACDTETGICFCKENVEGRRCNECKPGF 500
                                                  .||..||.|.|||||:|.||::|:.|.
Mouse  1555 CRCRPNVAGRRCDTCAPGFYGYPSCRPCDCHEAGTMASVCDPLTGQCHCKENVQGSRCDQCRVGT 1619

  Fly   501 FNLDKNNRFGCTPCFCYGHTSEC----------MTAPGYSIVSVTSNFNKFKERWTAADLNQREV 555
            |:||..|..|||.|||:|.|..|          :...|:.::|        .:|......::.|:
Mouse  1620 FSLDAANPKGCTRCFCFGATERCGNSNLARHEFVDMEGWVLLS--------SDRQVVPHEHRPEI 1676

  Fly   556 DIKYNQYSRSIGTTAQGNEHVYFQAPDRFLGDQRASYNRDLKFKLQLVGQVANTGV-----SDVI 615
            ::.:... ||:..|.   ..:|:|||..:|||:.:||...|.::|....|..:..:     .||:
Mouse  1677 ELLHADL-RSVADTF---SELYWQAPPSYLGDRVSSYGGTLHYELHSETQRGDIFIPYESRPDVV 1737

  Fly   616 LEGAGSRISLPIFAQGNGIPDQ------GVKEYTFRLHEHHDYQWQPSQSARGFLSILSNLTAIK 674
            |:  |:::|:.........|.|      .:.|..||..|.|:     ..|....:.:|:.|..::
Mouse  1738 LQ--GNQMSIAFLELAYPPPGQVHRGQLQLVEGNFRHLETHN-----PVSREELMMVLAGLEQLQ 1795

  Fly   675 IRATYSVQGEAI-LDDVELQTAHRGAAGHPATWIEQCTCPEGYLGQFCESCAPGYRHSPARGGPF 738
            |||.:|....:: |..|.|:.|.....|.||:.:|.|.||..|.|..|:.||||| :...:|...
Mouse  1796 IRALFSQTSSSVSLRRVVLEVASEAGRGPPASNVELCMCPANYRGDSCQECAPGY-YRDTKGLFL 1859

  Fly   739 MPCIPCDCHGHADICDSETGRCI-CQHNTHGDNCDQCAKGFYGNALGGTPNDCKRCPCP------ 796
            ..|:||.||||:|.|...:|.|: |||||.||.|::|..||..:......:.|..||||      
Mouse  1860 GRCVPCQCHGHSDRCLPGSGICVGCQHNTEGDQCERCRPGFVSSDPSNPASPCVSCPCPLAVPSN 1924

  Fly   797 --NDGACLQINEDTVICTECPKGYFGSRCEQCSDGFFGDPTGLLGEVQTCKSCDCNGNVDPNAV- 858
              .||..|:......:|.   .||.|:.||:|:.||||:|. :||  .:|:.|||:||.|||.: 
Mouse  1925 NFADGCVLRNGRTQCLCR---PGYAGASCERCAPGFFGNPL-VLG--SSCQPCDCSGNGDPNMIF 1983

  Fly   859 GNCNRTTGECLKCIHNTAGEHCDQCLSGHFGDPLALPHGRCDRCSCYEAGTEQDEQSITRCDQVT 923
            .:|:..||.|..|:.:|.|.||::|..|.:|:.| || |.|.||.|...|||       .||..:
Mouse  1984 SDCDPLTGACRGCLRHTTGPHCERCAPGFYGNAL-LP-GNCTRCDCSPCGTE-------TCDPQS 2039

  Fly   924 GQCQCKPNVIGRDCGECQPGYFNIRSGNGCENCLCDPVGSYNSTCDRYSGQCHCRPGVMGQRCDQ 988
            |:|.||..|.|:.|..|..|||......||..|.|.|... .|.|...||||||:||..|.:|.:
Mouse  2040 GRCLCKAGVTGQRCDRCLEGYFGFEQCQGCRPCACGPAAK-GSECHPQSGQCHCQPGTTGPQCLE 2103

  Fly   989 CENYFYGFSSEGCKPCECDESGSKGFQCD-QNGQCPCNDNVEGRRCDRCKENKYDRHR------- 1045
            |...::|...:||:.|:|...     .|| ..|.|.|...:.|.|||.|.:    :|:       
Mouse  2104 CAPGYWGLPEKGCRRCQCPRG-----HCDPHTGHCTCPPGLSGERCDTCSQ----QHQVPVPGKP 2159

  Fly  1046 -----GCIDCPDCYNLVQDAADLHR----------------------AKLFNLSQTLDEI---AR 1080
                 .|..|..|..|:.|  ||.|                      |:|..|:.::.::   .|
Mouse  2160 GGHGIHCEVCDHCVVLLLD--DLERAGALLPAIREQLQGINASSAAWARLHRLNASIADLQSKLR 2222

  Fly  1081 TPVTNDDEFEAKLKAVQEKVAVLAQD-------ARDNSGDGGQ---TYAEVIDDLHKHLDSVR-- 1133
            :|.....:...:|:.::::...|.||       |....|..||   |....:....|.|:|||  
Mouse  2223 SPPGPRYQAAQQLQTLEQQSISLQQDTERLGSQATGVQGQAGQLLDTTESTLGRAQKLLESVRAV 2287

  Fly  1134 -----------------EHLVSADKFQADANGEIDRARQNYTILDQITENAKKELQQALDLLNDE 1181
                             :.||.:.:....|..|::|...:....|...:.|..|.:.|      |
Mouse  2288 GRALNELASRMGQGSPGDALVPSGEQLRWALAEVERLLWDMRTRDLGAQGAVAEAELA------E 2346

  Fly  1182 GAQALARAKEKSVEFGQQSEQISDISREARALADKLESEAQFDLKNAKDAKDAVEKAHQLAKSAI 1246
            ..:.:||.:|:...|.::::.:      |..:.|:|   ||:: ....|.::|:.:|....:.|.
Mouse  2347 AQRLMARVQEQLTSFWEENQSL------ATHIRDQL---AQYE-SGLMDLREALNQAVNTTREAE 2401

  Fly  1247 DL------QLKIGTELRSEV--------------GLELSHVKQSLGTVVQTSKEALRKANEVYDT 1291
            :|      :||...:.:.|:              .|.|.||.:.|..:.| :||.|.......|.
Mouse  2402 ELNSRNQERLKEALQWKQELSQDNATLKATLQAASLILGHVSELLQGIDQ-AKEDLEHLAASLDG 2465

  Fly  1292 ALTLLNDVNRQTQPEIDISQLKKDAVAANERADELLKQITELSNSNGELFADFETEQELTEALLK 1356
            |.|.|....:...|    :..|.|.|.|.|...:.|.|:.  .|.:|.:....:      :..::
Mouse  2466 AWTPLLKRMQAFSP----ASSKVDLVEAAEAHAQKLNQLA--INLSGIILGINQ------DRFIQ 2518

  Fly  1357 RAEQQQLEDIELLERAKAAHDKATKAVEQGDNTLKEANNTYEKLAGFQSDVQRS-SESAEKALQT 1420
            ||.:.......:|:..:||.|.|.:|       |::|:.|:|.:      |||. :..|.:.|..
Mouse  2519 RAVEASNAYSSILQAVQAAEDAAGQA-------LRQASRTWEMV------VQRGLAAGARQLLAN 2570

  Fly  1421 VPNIEKEIQNAESLISQAEEALDGANKNANE--AKKN-----AQEAQLKYAEQASKDAELI---R 1475
            ...:|:.|...:..:..|:..|..|....:.  |:||     .||||...|...|:.:|.|   :
Mouse  2571 SSALEETILGHQGRLGLAQGRLQAAGIQLHNVWARKNQLAAQIQEAQAMLAMDTSETSEKIAHAK 2635

  Fly  1476 RKANETKVAARNLREEADQLNHRVKLTEMDIFKLEESSTKDDNLVDDAKRKVGQAKADTQEAQKQ 1540
            ..|.|....|.:::.:...:...|:..:..:..|:             .:.:.|.:.|...:...
Mouse  2636 AVAAEALSTATHVQSQLQGMQKNVERWQSQLGGLQ-------------GQDLSQVERDASSSVST 2687

  Fly  1541 IEKANADLTAIKDELENLKDINTGDLDRLENRLATVEGEINRVNLT-----GRIEK 1591
            :||....|.|              .|.|||||      .::..:|.     ||:.|
Mouse  2688 LEKTLPQLLA--------------KLSRLENR------GVHNASLALSANIGRVRK 2723

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB2NP_001287009.1 LamNT 61..296 CDD:214532 77/260 (30%)
EGF_Lam 298..347 CDD:238012 22/48 (46%)
Laminin_EGF 359..414 CDD:278482 25/273 (9%)
EGF_Lam 414..458 CDD:214543 21/192 (11%)
Laminin_EGF 461..511 CDD:278482 29/795 (4%)
LamB 572..697 CDD:214597 35/136 (26%)
TNFRSF <721..848 CDD:304602 52/135 (39%)
CRD2 724..771 CDD:276900 24/47 (51%)
EGF_Lam 743..791 CDD:238012 21/48 (44%)
Laminin_EGF 847..897 CDD:278482 23/50 (46%)
Laminin_EGF 902..953 CDD:278482 18/50 (36%)
Laminin_EGF 956..1004 CDD:278482 19/47 (40%)
Laminin_EGF 1004..1050 CDD:278482 14/58 (24%)
V_Alix_like 1122..1443 CDD:187408 75/360 (21%)
Tar 1139..1521 CDD:223910 86/412 (21%)
BAR 1308..1469 CDD:299863 39/168 (23%)
vATP-synt_E 1474..>1629 CDD:304907 22/126 (17%)
Lama5XP_006500638.1 Laminin_N 59..303 CDD:365840 73/246 (30%)
EGF_Lam 304..352 CDD:238012 22/48 (46%)
EGF_Lam 363..426 CDD:238012 22/62 (35%)
EGF_Lam 433..474 CDD:238012 0/40 (0%)
EGF_Lam 500..547 CDD:214543 0/46 (0%)
EGF_Lam 546..589 CDD:238012 0/42 (0%)
Laminin_EGF 593..640 CDD:365839 4/46 (9%)
Laminin_EGF 638..685 CDD:365839 19/46 (41%)
EGF_Lam 682..724 CDD:238012 0/41 (0%)
EGF_Lam 781..832 CDD:238012 1/50 (2%)
EGF_Lam 833..>872 CDD:238012 5/38 (13%)
Laminin_EGF 1443..1491 CDD:365839 0/47 (0%)
Laminin_EGF 1533..1584 CDD:365839 0/50 (0%)
Laminin_EGF 1582..1630 CDD:365839 19/47 (40%)
Laminin_B 1694..1830 CDD:365838 38/142 (27%)
EGF_Lam 1864..>1900 CDD:238012 19/35 (54%)
Laminin_EGF 1915..1968 CDD:365839 21/58 (36%)
EGF_Lam 1970..2023 CDD:238012 24/54 (44%)
EGF_Lam 2025..2069 CDD:214543 18/50 (36%)
EGF_Lam 2071..2117 CDD:238012 18/46 (39%)
Laminin_EGF 2119..>2147 CDD:365839 11/32 (34%)
Laminin_I 2194..2452 CDD:310534 52/274 (19%)
DUF3584 <2355..>2618 CDD:378817 66/298 (22%)
Laminin_II 2642..2764 CDD:368703 19/115 (17%)
LamG 2783..2912 CDD:214598
LamG 2969..3130 CDD:214598
LamG 3182..3300 CDD:214598
LamG 3364..3522 CDD:238058
LamG 3569..3696 CDD:214598
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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