DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LanB2 and Lama3

DIOPT Version :9

Sequence 1:NP_001287009.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster
Sequence 2:XP_006525748.1 Gene:Lama3 / 16774 MGIID:99909 Length:3331 Species:Mus musculus


Alignment Length:2541 Identity:505/2541 - (19%)
Similarity:789/2541 - (31%) Gaps:1116/2541 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 LLLIGVLFASCSTAILGAQRPPINSAGGHELRGTTFMPALECYDPYGRPQKCLPEFINAAYQLQI 80
            |||:.:|..|.|.:::| |..|::|...|                        |.:.|.|...:|
Mouse    18 LLLLLLLRMSPSWSVVG-QDHPMSSRSLH------------------------PPYFNLAQAARI 57

  Fly    81 ESTNTCGEQN-------DNHFC-----IQTMNQNH----KNCEFCKYND----HNPSFLTDLHDP 125
            .:|.||||::       ...||     .......|    :.|::|...|    |..|...|    
Mouse    58 WATATCGERDPEVSRPRPELFCKLVGGPAAQGSGHTIQGQFCDYCNSEDSRKAHPASHAID---- 118

  Fly   126 QSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRILF-RSPRPESFTIYKRTSESGPWIPYQ 189
            .|..||||..:..|.|: |.|||||.||:.:.:.|:.|.| .||||:.:.:.:.......:.|:|
Mouse   119 GSERWWQSPPLSSGTQY-NQVNLTLDLGQLFHVAYILIKFANSPRPDLWILERSVDFGSTYSPWQ 182

  Fly   190 FYSAT---CRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPSGINFERSG 251
            :::.:   |.:.:....:.||.:.:   ..||.:|||.|.||.:|||..|.:.|||....|..|.
Mouse   183 YFAHSRRDCVEQFGQEANMAITQDD---QMLCVTEYSRIVPLENGEIVVSLINGRPGAKKFAFSD 244

  Fly   252 ELQEWVTATDIRITLDRLNTFGDELFG----DSQVLKSYFYAISDIAVGARCKCNGHASKCVPST 312
            .|:|:..||:||:...|.||....|..    |..|.:.|:|:|.||:||.||.|||||..|   :
Mouse   245 TLREFTKATNIRLRFLRTNTLLGHLISKAERDPTVTRRYYYSIKDISVGGRCVCNGHAEAC---S 306

  Fly   313 GMHGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANL--- 374
            ..:.|:...|||:|:|.|..|:||...||..:|:.:...:.|||:||||:|.|..|::|.::   
Mouse   307 ADNPEKQFRCECQHHTCGDTCNRCCAGYNQRRWQPAGQEQHNECEACNCHGHAVDCYYDPDVEHQ 371

  Fly   375 ---FNRTG---HGGHCLDCRENRDGPNCERCKENFYMRDDGY-------CVNCACDP-------- 418
               .|..|   .||.|::|:.|..|.|||:|.:. |.|..|.       |:.|:|||        
Mouse   372 QASLNSKGVYAGGGVCINCQHNTAGVNCEKCAKG-YFRPHGVPVDALHGCIPCSCDPERADDCDQ 435

  Fly   419 ----------------------------------------------------------------- 418
                                                                             
Mouse   436 GSGHCHCKPNFSGDYCETCADGYYNFPFCLRIPVFPNYTPSPEDPVAGNIKGCDCNLEGVLPEIC 500

  Fly   419 -------------------------------------VGSRSLQCN-SHGKCQCKPGVTGDKCDR 445
                                                 :||..:.|: .:|:|.|.||:||.:|||
Mouse   501 DDRGRCLCRPGVEGPQCDSCRSGSYSFPICQACQCSTIGSYPVPCDPGNGQCDCLPGITGRQCDR 565

  Fly   446 CDNNYYQF-----------------------------------------------GPHGCQQCGC 463
            |.:..|.|                                               .|.||.:|.|
Mouse   566 CLSGAYDFPYCQGSGSVCHPAGTLDSSLGYCQCKQHVASPTCSVCKPLYWNLAKENPRGCSECQC 630

  Fly   464 DSGGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLDKNNRFGCTPC----------FCYG 518
            ...|:......|..|.|.|.||.:|.|..|:.|:.|||:|:|:|.|||..|          .|.|
Mouse   631 HEAGTLSGIGECGQEDGDCSCKAHVTGDACDTCEDGFFSLEKSNYFGCQGCQCDIGGALTTMCSG 695

  Fly   519 HTSECM--------------------------------TAP--------------------GYSI 531
            .:..|.                                |.|                    ||:.
Mouse   696 PSGVCQCREHVEGKQCQRPENNYYFPDLHHMKYEVEDGTGPNGRNLRFGFDPLVFPEFSWRGYAP 760

  Fly   532 VSVTSN----------------------------------------------------FNKFKE- 543
            ::...|                                                    |...|| 
Mouse   761 MTSVQNEVRVRLSVRQSSLSLFRIVLRYISPGTEAISGRITLYSSQGDSDALQSRKITFPPSKEP 825

  Fly   544 -------------------RWTA------------------------------------------ 547
                               .|.|                                          
Mouse   826 AFVTVPGNGFAGPFSITPGTWIACIQVEGVLLDYLVLLPRDYYEAFTLQVPVTEPCAHTGSPQDN 890

  Fly   548 --------------------------------------------ADLNQREVDIKYN-------- 560
                                                        .||:.|||:::..        
Mouse   891 CLLYQHLPLTAFSCTLACEARHFLLDGELRPLAMRQPTPTHPAMVDLSGREVELQLRLRVPQVGH 955

  Fly   561 -----QYS-------------RSIGTTAQGNEHVY---FQAPDR--------------FLGDQRA 590
                 :|:             :|.|:...|..::|   :..|.|              .|.|   
Mouse   956 YVVLLEYATEVEQLFVVDVNLKSSGSALAGQVNIYSCKYSIPCRSVVIDSLSRTAVHELLAD--- 1017

  Fly   591 SYNRDLKFKLQLV------------------------------GQVANTGVSDVILEGAGSRISL 625
               .|::.|..:.                              .|.||...|.|.|.......:.
Mouse  1018 ---ADIQLKAHMAHFLLYHICIIPAEEFSTEYLRPQVHCIASYRQHANPSASCVSLAHETPPTAS 1079

  Fly   626 PIFAQGNGI----------PDQGVK------------------EYTFRLH----EHHDY------ 652
            .:.|...|:          |..||.                  .:.|.:|    ||..:      
Mouse  1080 ILDATSRGLFSALPHEPSSPADGVTLKAPQSQVTLKGLIPHLGRHVFVIHFYQAEHPGFPTEVIV 1144

  Fly   653 ----QWQPSQSARGFLS------------ILS-----------------------NLTAIKIRAT 678
                ||..|     ||:            ::|                       :||.:::...
Mouse  1145 NGGRQWSGS-----FLASFCPHLLGCRDQVISDGQVEFDISEAEVAVTVKIPDGKSLTLVRVLVV 1204

  Fly   679 ------YSVQGEAILDD--------------VELQTA---------------HRGA--------- 699
                  |.:..:..:|.              ::.|.|               |.||         
Mouse  1205 PAENYDYQILHKTTVDKSSEFISSCGGDSFYIDPQAASGFCKNSARSLVAFYHNGAIPCECDPAG 1269

  Fly   700 -AGH---PATWIEQCTCPEGYLGQFCESCAPGYRHSPARGGPFMPCIPCDC-------------- 746
             |||   |..  .||.|....:|:.|..||.||     .|.|:  |.||:|              
Mouse  1270 TAGHHCSPEG--GQCPCRPNVIGRQCSRCATGY-----YGFPY--CKPCNCGRRLCEEVTGKCLC 1325

  Fly   747 -------------------HGHA--DI---------------CDSETGRCICQHNTHGDNCDQCA 775
                               |..|  |:               ||.::|:|.|:....|..||:||
Mouse  1326 PPHTVRPQCEVCEMNSFNFHPVAGCDVCNCSRKGTIEAAVSECDRDSGQCRCKPRVTGQQCDKCA 1390

  Fly   776 KGFYGNALGGTPNDCKRCPCPNDG----ACLQINEDTVICTECPKGYFGSRCEQCSDG-FFGDPT 835
            .|||...      :|..|.|..||    .|   :.:|..|. |.:...|.:|:.|.:| |:.|||
Mouse  1391 PGFYQFP------ECVPCSCNRDGTEPSVC---DPETGACM-CKENVEGPQCQLCREGSFYLDPT 1445

  Fly   836 GLLGEVQTCKSCDCNG-NVD--------------------------------------------- 854
            ...|    |..|.|.| |.|                                             
Mouse  1446 NPKG----CTKCFCFGVNTDCQSSHKQRAKFVDMMGWRLETADGVDVPVSFNPGSNSMVADLQEL 1506

  Fly   855 PNAVGNCN-----------------------------------------RTTGECLKCIH----- 873
            |.:|.:.:                                         :.||:.:..||     
Mouse  1507 PPSVHSASWVAPPSYLGDKVSSYGGYLTYHAKSFGLPGDMVLLGKQPDVQLTGQHMSLIHKEPSD 1571

  Fly   874 ----------------------------------------------------------------- 873
                                                                             
Mouse  1572 PRPDRLHHGRVQVIEGNFRHEGSSAPVSREELMTVLSRLERLHIRGLHFTETQRLTLGEVGLEEA 1636

  Fly   874 -------------------NTAGEHCDQCLSGHFGDPLALPHGRCDRCSCYEAGTEQDEQSITRC 919
                               :..|:.|..|..|::.|..:||.|||..|:|        .....||
Mouse  1637 SDTGSGPRAHLVEMCACPPDYTGDSCQGCRPGYYWDNKSLPVGRCVPCNC--------NGHSNRC 1693

  Fly   920 DQVTGQC-QCKPNVIGRDCGECQPGYFNIRSGNGCENCLCDPVGSYNSTC--DRYSGQCHCRPGV 981
            ...:|.| .|:.|..|..|..||.|::.......|..|.|....|:.:.|  |..:.:|.|:||.
Mouse  1694 QDGSGICINCQHNTAGEHCERCQAGHYGNAIHGSCRVCPCPHTNSFATGCAVDGGAVRCACKPGY 1758

  Fly   982 MGQRCDQCENYFYGFSSE---GCKPCECDESGSKGFQCDQ-NGQCPCNDNVEGRRCDRCKENKYD 1042
            .|.:|::|...::|...:   .|:||.|:.:|..| .||. .|.|...:..:|...:.|.     
Mouse  1759 TGTQCERCAPGYFGNPQKFGGSCQPCNCNSNGQLG-PCDPLTGDCVNQEPKDGSPAEECD----- 1817

  Fly  1043 RHRGCIDCPDC-YNLVQDAAD------LHRAKLFNLSQT---LDEIARTPVTNDDEFEAKLKAVQ 1097
                  ||..| ..|:.|.|.      |.::||..||.:   |::|...      |.:||     
Mouse  1818 ------DCDSCVMTLLNDLASMGEELRLVKSKLQGLSVSTGALEQIRHM------ETQAK----- 1865

  Fly  1098 EKVAVLAQDARD--------NSGDGGQTYAEVIDDLHKHLDSV-REHLVSADKFQADANGEIDRA 1153
                    |.|:        .|..|.:     :|||.|.|..: ||.....:|.|.::.    :|
Mouse  1866 --------DLRNQLLGFRSATSSHGSK-----MDDLEKELSHLNREFETLQEKAQVNSR----KA 1913

  Fly  1154 RQNYTILDQITENAK------KELQQALDLLNDEGAQALARAKEKSVEFGQQSEQISDISREARA 1212
            :..|..:||..::||      |.:.|.:.:|..:.|:......:..|  |..|.::::..|..|.
Mouse  1914 QTLYNNIDQTIQSAKELDMKIKNIVQNVHILLKQMARPGGEGTDLPV--GDWSRELAEAQRMMRD 1976

  Fly  1213 L-------------ADKLESEAQFD----------------LKNAKDAKDAVEKAHQLAKSAIDL 1248
            |             |:|:|::....                |||.:|:.:..|...|..:|.:. 
Mouse  1977 LRSRDFKKHLQEAEAEKMEAQLLLHRIRTWLESHQVENNGLLKNIRDSLNDYEDKLQDLRSILQ- 2040

  Fly  1249 QLKIGTELRSEVGLELSHVKQS-LGTVVQTSKEALRKANE------VYDTALTLLNDVNRQTQPE 1306
              :...:.:...|  ::|..:. ||.:.:..||.....|:      ..|::|...|::.:|    
Mouse  2041 --EAAAQAKQATG--INHENEGVLGAIQRQMKEMDSLKNDFTKYLATADSSLLQTNNLLQQ---- 2097

  Fly  1307 IDISQLKKDAVAA--NERADELLKQITELSNSNGE--LFADFETEQELTEALLKRAEQQQLEDIE 1367
            :|.||.:.:::||  |....||..::.|||.|.|:  |..:.|...:..:.|.|     |||:|:
Mouse  2098 MDKSQKEYESLAAALNGARQELSDRVRELSRSGGKAPLVVEAEKHAQSLQELAK-----QLEEIK 2157

  Fly  1368 LL----ERAKAAHDKATKAVEQGDNTLKEANNTYEKLAGFQSDVQRSSESAEKALQTVPNIEKEI 1428
            ..    |..:.|.|.|| |.|...|.::.|.:...|          ::.:::.|.|||  |::::
Mouse  2158 RNTSGDELVRCAVDAAT-AYENILNAIRAAEDAASK----------ATSASKSAFQTV--IKEDL 2209

  Fly  1429 -QNAESLISQAEEALDGANKNANEAKKNAQEAQLKYAEQASKDAELIRRKANETKVAARNLREEA 1492
             :.|::|.|.:||.|       ||||...:..|           :.:....|..:...:.:..:.
Mouse  2210 PKRAKTLSSDSEELL-------NEAKMTQKRLQ-----------QEVSPALNSLQQTLKTVSVQK 2256

  Fly  1493 DQLNHRVKLTEMDIFKLEESSTKDDNLVDDAKRKVGQAKADTQEAQKQIEKANADLTAIKDELEN 1557
            |.|:..:.:...|:..::....  |::|..||..|.:|...|.|....:.....||..|||..|:
Mouse  2257 DLLDANLTVARDDLHGIQRGDI--DSVVIGAKSMVREANGITSEVLDGLNPIQTDLGRIKDSYES 2319

  Fly  1558 ---------LKDINTGDLDRLENRLATVEGEINRVNLTGRIEKYREQRTIQKNLIDKYDAELREL 1613
                     |.|.| ..:.:|..:|.         :|..:||...:|.....|:.|..| .:|||
Mouse  2320 ARREDFSKALVDAN-NSVKKLTRKLP---------DLFIKIESINQQLLPLGNISDNVD-RIREL 2373

  Fly  1614 KDEVQN 1619
            ..:.::
Mouse  2374 IQQARD 2379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB2NP_001287009.1 LamNT 61..296 CDD:214532 79/262 (30%)
EGF_Lam 298..347 CDD:238012 21/48 (44%)
Laminin_EGF 359..414 CDD:278482 23/70 (33%)
EGF_Lam 414..458 CDD:214543 21/201 (10%)
Laminin_EGF 461..511 CDD:278482 20/49 (41%)
LamB 572..697 CDD:214597 35/283 (12%)
TNFRSF <721..848 CDD:304602 46/181 (25%)
CRD2 724..771 CDD:276900 19/96 (20%)
EGF_Lam 743..791 CDD:238012 19/97 (20%)
Laminin_EGF 847..897 CDD:278482 18/225 (8%)
Laminin_EGF 902..953 CDD:278482 13/51 (25%)
Laminin_EGF 956..1004 CDD:278482 14/52 (27%)
Laminin_EGF 1004..1050 CDD:278482 10/46 (22%)
V_Alix_like 1122..1443 CDD:187408 87/372 (23%)
Tar 1139..1521 CDD:223910 91/432 (21%)
BAR 1308..1469 CDD:299863 47/169 (28%)
vATP-synt_E 1474..>1629 CDD:304907 33/155 (21%)
Lama3XP_006525748.1 LamNT 40..294 CDD:214532 82/285 (29%)
EGF_Lam 295..343 CDD:238012 21/50 (42%)
EGF_Lam 352..420 CDD:238012 23/68 (34%)
EGF_Lam 422..462 CDD:238012 4/39 (10%)
Laminin_EGF 488..535 CDD:365839 0/46 (0%)
EGF_Lam 532..574 CDD:238012 15/41 (37%)
Laminin_EGF 628..678 CDD:365839 20/49 (41%)
EGF_Lam 681..724 CDD:238012 4/42 (10%)
Laminin_EGF 1263..1311 CDD:365839 18/56 (32%)
EGF_Lam 1308..1349 CDD:238012 4/40 (10%)
Laminin_EGF 1353..1404 CDD:365839 15/56 (27%)
EGF_Lam 1401..1451 CDD:238012 17/57 (30%)
LamB 1509..1638 CDD:214597 5/128 (4%)
EGF_Lam 1683..1729 CDD:238012 13/53 (25%)
EGF_Lam 1731..1782 CDD:238012 13/50 (26%)
Laminin_I 1844..2101 CDD:310534 59/295 (20%)
SMC_prok_B <2062..>2329 CDD:274008 72/308 (23%)
Laminin_II 2285..2413 CDD:368703 27/106 (25%)
LamG 2432..2567 CDD:214598
LamG 2599..2739 CDD:238058
LamG 2766..2898 CDD:238058
LamG 2990..3132 CDD:238058
LamG 3156..3307 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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