DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanB2 and Lamc1

DIOPT Version :9

Sequence 1:	NP_001287009.1	Gene:	LanB2 / 39118	FlyBaseID:	FBgn0267348	Length:	1639	Species:	Drosophila melanogaster
Sequence 2:	NP_446418.1	Gene:	Lamc1 / 117036	RGDID:	621052	Length:	1607	Species:	Rattus norvegicus

Alignment Length:	1622	Identity:	691/1622 - (42%)
Similarity:	961/1622 - (59%)	Gaps:	92/1622 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 ECYDPYGRPQKCLPEFINAAYQLQIESTNTCGEQNDNHFCIQT-MNQNHKNCEFCK----YNDHN 115
            ||.|..||||:|:|||:|||:.:.:.:|||||...: .:|:|| :....|:|..|.    :..|.
  Rat    37 ECADEGGRPQRCMPEFVNAAFNVTVVATNTCGTPPE-EYCVQTGVTGVTKSCHLCDAGQLHLQHG 100

  Fly   116 PSFLTDLHDPQSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRILFRSPRPESFTIYKRTS 180
            .:||||.::....|||||:||..|:|:||.:||||||||::||||||:.|.:.|||||.|||||.
  Rat   101 AAFLTDYNNQADTTWWQSQTMLAGVQYPNSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTR 165

  Fly   181 ESGPWIPYQFYSATCRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPSGI 245
            |.|||||||:||.:|.:|||..:...||.|..|..||||.|:||||||..|.:||||||||||..
  Rat   166 EDGPWIPYQYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAY 230

  Fly   246 NFERSGELQEWVTATDIRITLDRLNTFGDELFGDSQVLKSYFYAISDIAVGARCKCNGHASKCVP 310
            ||:.|..|||||||||||:||:||||||||:|.|.:|||||:|||||.|||.|||||||||:||.
  Rat   231 NFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECVK 295

  Fly   311 STGMHGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANLF 375
            :.  .|:  |||.|:|||.|.||::|||.:||..|:|:|:...|:|..|:|||.:.:|:||..|:
  Rat   296 NE--FGK--LVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESANQCLPCDCNGRSQECYFDPELY 356

  Fly   376 NRTGHGGHCLDCRENRDGPNCERCKENFY-MRDDGYCVNCACDPVGSRSLQCNSHGKCQCKPGVT 439
            ..|||||||.:||:|.||..||||:|||: :.:...|..|.|.||||.|.||:|:|:|.|||||.
  Rat   357 RSTGHGGHCTNCRDNTDGAKCERCRENFFRLGNTEACSPCHCSPVGSLSTQCDSYGRCSCKPGVM 421

  Fly   440 GDKCDRCDNNYYQFGPHGCQQCGCDSGGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLD 504
            |||||||...::.....||:.|.||..||   |..|:.|||.|.||:||||..|..||||||||:
  Rat   422 GDKCDRCQPGFHSLTEAGCRPCSCDPSGS---TDECNVETGRCVCKDNVEGFSCERCKPGFFNLE 483

  Fly   505 KNNRFGCTPCFCYGHTSECMTAPGYSIVSVTSNFNKFKERWTAADLNQREVDIKYNQYSRSIGTT 569
            .:|..|||||||:||:|.|..|.|||:..::|.|...::.|.....:..|..::::...:.|...
  Rat   484 SSNPKGCTPCFCFGHSSVCTNAVGYSVYDISSTFQIDEDGWRVEQRDGSEASLEWSSDRQDIAVI 548

  Fly   570 AQGNEHVYFQAPDRFLGDQRASYNRDLKFKLQLVGQVANTGVSDVILEGAGSRISLPIFAQGNGI 634
            :......||.||.:|||:|..||.::|.|..::..:.......|::|||||.|:|:|:.||||..
  Rat   549 SDTYFPRYFVAPAKFLGNQVLSYGQNLSFSFRVDRRDTRLSAEDLVLEGAGLRVSVPLIAQGNSY 613

  Fly   635 PDQGVKEYTFRLHEHHDYQWQPSQSARGFLSILSNLTAIKIRATYSVQGEAILDDVELQTAHRGA 699
            |.:...:|.|||||..||.|:|:.|...|..:|:|||:||||.|||.:....||||.||:|..|
  Rat   614 PSETTVKYIFRLHEATDYPWRPALSPFEFQKLLNNLTSIKIRGTYSERSAGYLDDVTLQSARPG- 677

  Fly   700 AGHPATWIEQCTCPEGYLGQFCESCAPGYRHSPARGGPFMPCIPCDCHGHADICDSETGRCICQH 764
            .|.||||:|.||||.||.|||||:|.||||......||:.||:.|.|:||::.||.|||.|.|:.
  Rat   678 PGVPATWVESCTCPVGYGGQFCETCLPGYRRETPSLGPYSPCVLCTCNGHSETCDPETGVCDCRD 742

  Fly   765 NTHGDNCDQCAKGFYGNALGGTPNDCKRCPCPNDGACLQI-NEDTVICTECPKGYFGSRCEQCSD 828
            ||.|.:|::|:.|:||::..||.:||:.||||...:|..: ....|:||.||.|..|.|||.|.|
  Rat   743 NTAGPHCEKCSDGYYGDSTLGTSSDCQPCPCPGGSSCAIVPKTKEVVCTHCPTGTAGKRCELCDD 807

  Fly   829 GFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSGHFGDPLA 893
            |:||||.|..|.|:.|:.|.||.|:||||||||||.||||||||:||||.:||:|..|.||:|||
  Rat   808 GYFGDPLGSNGPVRLCRPCQCNDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKEGFFGNPLA 872

  Fly   894 -LPHGRCDRCSCYEAGTEQDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIRSGNGCENCL 957
             .|..:|..|:|...||.|.:.|   |:.|||||||.|:|.|||||.|.||::|::||.|||:|.
  Rat   873 PNPADKCKACACNPYGTVQQQSS---CNPVTGQCQCLPHVSGRDCGACDPGFYNLQSGQGCESCD 934

  Fly   958 CDPVGSYNSTCDRYSGQCHCRPGVMGQRCDQCENYFYGFSSEGCKPCECDESGSKGFQCDQNGQC 1022
            |..:||.|..||..:|||.|:||:.||.|::||...:||..||||||:|...||...||..:|:|
  Rat   935 CHALGSTNGQCDIRTGQCECQPGITGQHCERCETNHFGFGPEGCKPCDCHHEGSLSLQCKDDGRC 999

  Fly  1023 PCNDNVEGRRCDRCKENK-YDRH-RGCIDCPDCYNLVQDAADLHRAKLFNLSQTLDEIARTPVT- 1084
            .|.:...|.|||:|:||. |:|. .||.:||.||.||:|....||.||..|...:..:.....|
  Rat  1000 ECREGFVGNRCDQCEENYFYNRSWPGCQECPACYRLVKDKVAEHRVKLQELESLIANLGTGDETV 1064

  Fly  1085 NDDEFEAKLKAVQEKVAVL---AQDARDNSGDGGQTYAEVIDDLHKHLDSVREHLVSADKFQADA 1146
            .|..||.:||..:.:|..|   ||:.:|...:.......|.:.||..:.  |.|.:   :...:.
  Rat  1065 TDQAFEDRLKEAEREVTDLLREAQEVKDVDQNLMDRLQRVNNSLHSQIS--RLHNI---RNTIEE 1124

  Fly  1147 NGEI-DRARQNYTILDQITENAKKELQQALDLLNDEGAQALARAKEKSVEFGQQSEQISDISREA 1210
            .|.: :|||......:|:.|.|.:||::|        ..|.|.......|...:...::.::.||
  Rat  1125 TGILAERARSRVESTEQLIEIASRELEKA--------KMAAANVSITQPESTGEPNNMTLLAEEA 1181

  Fly  1211 RALADKLESEAQFDLKNAKDAKDAVEKAHQLA--------KSAIDL-QLKIGTELRSEVGLELSH 1266
            |.||::.:.||...::.||.|.:...:|:.|.        ::|::: :|....|....:..:|.
  Rat  1182 RRLAERHKQEADDIVRVAKTANETSAEAYNLLLRTLAGENQTALEIEELNRKYEQAKNISQDLE- 1245

  Fly  1267 VKQSLGTVVQTSKEALRKANEVYDTALTLLNDVNRQTQPEIDISQLKKDAVAANERADELLKQIT 1331
             ||: ..|.:.:|.|..||.|:| .::..|..|:.:.. |.:.:::||:|...:...|:.||...
  Rat  1246 -KQA-ARVHEEAKRAGDKAVEIY-ASVAQLTPVDSEAL-ESEANKIKKEAADLDRLIDQKLKDYE 1306

  Fly  1332 EL-SNSNGELFADFETEQELTEALLKRAEQQQLEDIELLERAKAAHDKATKAVEQGDNTLKEANN 1395
            :| .:..|:       |.|:...|.|...:||..| :||.||.||...|.:|.::|.|||:|||:
  Rat  1307 DLREDMRGK-------EHEVKNLLEKGKAEQQTAD-QLLARADAAKALAEEAAKKGRNTLQEAND 1363

  Fly  1396 TYEKLAGFQSDVQRSSESAEKALQTVPNIEKEIQNAESLISQAEEALDGANKNANEAKKNAQEAQ 1460
            ....|..|...|..:..:||:||:.:|.|.:.|..|.....:|:.||..|..:|.|||..|.||:
  Rat  1364 ILNNLKDFDRRVNDNKTAAEEALRRIPAINRTIAEANEKTREAQLALGNAAADATEAKNKAHEAE 1428

  Fly  1461 LKYAEQASKDAELIRRKANETKVAARNLREEADQLNHRVKLTEMDIFKLEESSTKDDNLVDDAKR 1525
                    :.|..:::.|..||..|.....|...|::.|...   :.:|||:..:.....|||.:
  Rat  1429 --------RIASGVQKNATSTKADAERTFSEVTDLDNEVNGM---LRQLEEAENELKRKQDDADQ 1482

  Fly  1526 KV---GQAKADTQEAQKQIEKA----NADLTAIKDELENLKDINTGDLDRLENRLATVEGEINRV 1583
            .:   |.|....|||:....||    ::.|:.:.|.||.|..::|.||    |:|..:||.:|:.
  Rat  1483 DMMMAGMASQAAQEAELNARKAKNSVSSLLSQLTDLLEQLGQLDTVDL----NKLNEIEGSLNKA 1543

  Fly  1584 -------NLTGRIEKYREQRTIQKNLIDKYDAELRELKDEVQNIGLISKALPDSCFSRNRLE 1638
                   :|..::.....:...|:..|..||.::.|:..::.|:..|.|.||..||:...:|
  Rat  1544 KDEMKVSDLDRKVSNLENEARKQEAAILDYDRDIAEIIKDIHNLEDIKKTLPTGCFNTPSIE 1605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB2	NP_001287009.1	LamNT	61..296	CDD:214532	140/239 (59%)
		EGF_Lam	298..347	CDD:238012	28/48 (58%)
		Laminin_EGF	359..414	CDD:278482	28/55 (51%)
		EGF_Lam	414..458	CDD:214543	24/43 (56%)
		Laminin_EGF	461..511	CDD:278482	27/49 (55%)
		LamB	572..697	CDD:214597	56/124 (45%)
		TNFRSF	<721..848	CDD:304602	60/127 (47%)
		CRD2	724..771	CDD:276900	23/46 (50%)
		EGF_Lam	743..791	CDD:238012	22/47 (47%)
		Laminin_EGF	847..897	CDD:278482	36/50 (72%)
		Laminin_EGF	902..953	CDD:278482	27/50 (54%)
		Laminin_EGF	956..1004	CDD:278482	24/47 (51%)
		Laminin_EGF	1004..1050	CDD:278482	20/47 (43%)
		V_Alix_like	1122..1443	CDD:187408	88/331 (27%)
		Tar	1139..1521	CDD:223910	104/392 (27%)
		BAR	1308..1469	CDD:299863	52/161 (32%)
		vATP-synt_E	1474..>1629	CDD:304907	43/168 (26%)
Lamc1	NP_446418.1	LamNT	42..282	CDD:214532	141/240 (59%)
		EGF_Lam	283..328	CDD:238012	28/48 (58%)
		Laminin_EGF	340..394	CDD:278482	27/53 (51%)
		Laminin_EGF	396..443	CDD:278482	26/46 (57%)
		Laminin_EGF	443..490	CDD:278482	27/49 (55%)
		LamB	552..676	CDD:214597	56/123 (46%)
		Laminin_EGF	722..761	CDD:278482	19/38 (50%)
		EGF_Lam	770..818	CDD:238012	23/47 (49%)
		Laminin_EGF	826..873	CDD:278482	34/46 (74%)
		Laminin_EGF	882..930	CDD:278482	27/50 (54%)
		EGF_Lam	933..978	CDD:214543	21/44 (48%)
		EGF_Lam	980..1027	CDD:238012	20/46 (43%)
		FlgN	<1048..1121	CDD:298847	17/77 (22%)
		MA	1089..1300	CDD:214599	50/228 (22%)
		Tropomyosin	1355..1586	CDD:278679	68/245 (28%)
		Prefoldin	1416..1551	CDD:298833	41/149 (28%)
		SPX	<1518..1588	CDD:271919	18/73 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	291	1.000	Domainoid score	I1479
eggNOG	1	0.900	-	-		E1_KOG1836
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1724
Inparanoid	1	1.050	1321	1.000	Inparanoid score	I136
OMA	1	1.010	-	-		QHG48740
OrthoDB	1	1.010	-	-		D156553at2759
OrthoFinder	1	1.000	-	-		FOG0002861
OrthoInspector	1	1.000	-	-		otm45618
orthoMCL	1	0.900	-	-		OOG6_102334
Panther	1	1.100	-	-	LDO	PTHR10574
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4311
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880