DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanB2 and lamc2

DIOPT Version :9

Sequence 1:	NP_001287009.1	Gene:	LanB2 / 39118	FlyBaseID:	FBgn0267348	Length:	1639	Species:	Drosophila melanogaster
Sequence 2:	XP_002937413.3	Gene:	lamc2 / 100489162	XenbaseID:	XB-GENE-990048	Length:	1172	Species:	Xenopus tropicalis

Alignment Length:	1334	Identity:	385/1334 - (28%)
Similarity:	586/1334 - (43%)	Gaps:	230/1334 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 TEVNECKACNCNGLADKCFFDANLFNRTGHGGHCLDCRENRDGPNCERCKENFYMRDDGYCVNCA 415
            ||.:..:.|||||.:.:|.||.:|..:||.|..|::|....|||:||.|.|.:|.:.||.|..|.
Frog    21 TETHGREVCNCNGRSQQCVFDPDLLAQTGSGFRCINCNGGTDGPHCEHCIEGYYPQPDGTCGPCL 85

  Fly   416 CDPVGSRSLQCNSHGKCQCKPGVTGDKCDRCDNNYYQFGPHGCQQ--CGCDSGGSHQNTPACDTE 478
            |..|||.:.||:::|:|:|||||.|.|||:|...::.....||::  |.|::.||   :.:||.
Frog    86 CHTVGSLNQQCDNNGQCRCKPGVMGSKCDQCQPGFHSLSDTGCRRDGCQCEAAGS---SGSCDA- 146

  Fly   479 TGICFCKENVEGRRCNECKPGFFNLDKNNRFGCTPCFCYGHTSECMTAPGYSIVSVTSNFNKFKE 543
            .|.|.||..|.|.||:.||||:::||.:...||..|||:||::.|.::..:|:..:.|:|.|..|
Frog   147 GGRCVCKPTVTGERCDRCKPGYYHLDGSRPEGCLQCFCHGHSATCSSSSLHSVHKIISSFQKDTE 211

  Fly   544 RWTAA--DLNQREVDIKYNQYSRSIGTTAQGNEHVYFQAPDRFLGDQRASYNRDLKFKLQLVGQV 606
            .|::.  |.:...|.::.:::.:.:...::..|.:||.||.:|||||..||.:.|....::....
Frog   212 GWSSVQRDGSTAPVPLRMSRHQKEVYIASRQQEPLYFNAPAQFLGDQSLSYGQALSISFRVDRGR 276

  Fly   607 ANTGVSDVILEGAGSRISLPIFAQGNGIPDQGVKEYTFRLHEHHDYQWQPSQSARGFLSILSNLT 671
            ...|..|::|||.|.|::..:.:..|.:|.:..:.|||||.|.....|.|..|...|..:|.|:|
Frog   277 YRAGTEDLVLEGNGLRVTATLTSSKNSLPCRIPQTYTFRLDELSRSPWTPHLSHFDFRRLLRNVT 341

  Fly   672 AIKIRATYSVQGEAILDDVELQTAHRGAAGHPATWIEQCTCPEGYLGQFCESCAPGYRHSPARGG 736
            :|.|||||.......|.:|.|.:| |...|.||.|:|||.||.||.|||||.||.|||......|
Frog   342 SIHIRATYGEYSTGYLQNVTLISA-RPVQGEPAPWVEQCVCPSGYQGQFCERCARGYRRESPGLG 405

  Fly   737 PFMPCIPCDCHGHADICDSETGRCICQHNTHGDNCDQCAKGFYGNALGGTPNDCKRCPC-PNDGA 800
            ....|:.|:|.|... ||.:||.|........::|..|.:|.|.:.  ..|..|..||| ...|.
Frog   406 ALSSCVSCNCPGGGH-CDPDTGDCYSGDENQNNDCADCPQGQYNDP--RDPMSCLPCPCSAGIGC 467

  Fly   801 CLQINEDTVICTECPKGYFGSRCEQCSDGFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTT 865
            .|.......:|.|||.|..|.|||.|::|:||||.|..|..:.|:.|.||.|:|.:..|:|:|.|
Frog   468 SLSPETQEPVCDECPVGLNGPRCEICAEGYFGDPQGERGAPRPCRPCQCNNNIDRSVEGSCDRVT 532

  Fly   866 GECLKCIHNTAGEHCDQCLSGHFGDPLALPHGRCDRCSCYEAGTEQDEQSITRCDQVTGQCQCKP 930
            ||||||||||||.:||.|..|.||:|||                            ...:.:||.
Frog   533 GECLKCIHNTAGYYCDLCKDGFFGNPLA----------------------------TAPELKCKA 569

  Fly   931 NVIGRDCGECQPGYFNIRSGNGCENCLCDPVGSYNSTCDRYSGQCHCRPGVMGQRCDQCENYFYG 995
                                     |.|.|||:.:..|.: .|.|.|:.|..|:.|||.:
Frog   570 -------------------------CYCHPVGTVHQGCQK-DGSCQCKTGFEGRSCDQPQ----- 603

  Fly   996 FSSEGCKPCECDESGSKGFQCDQNGQCPCNDNVEGRRCDRCKENKYDRHRGCIDCPDCYNLVQDA 1060
                                                                  |||||:.|...
Frog   604 ------------------------------------------------------CPDCYSQVSTK 614

  Fly  1061 ADLHRAKLFNLSQTLDEIARTPVTNDDEFEAKLKAVQEKVAVLAQD-ARDNSGDGGQTYAEVIDD 1124
            .:|::.:|..|  |.:...::|...  |.|.:::    |....||. .||:....|...
Frog   615 LNLYKRQLLKL--TGENNGQSPARG--ELEERMR----KAEAAAQGLQRDSEAANGAAL------ 665

  Fly  1125 LHKHLDSVREHLVSADKFQADANGEIDRARQNYTILDQITENAKKELQQ-------ALDLLNDEG 1182
                  |::.........|:|....:|:|::....|.......:.:||.       ||..|  :|
Frog   666 ------SLQRQFSGLQGTQSDTQNVLDQAKEKLQGLQTQKNQYQGQLQDMGRKINIALQQL--QG 722

  Fly  1183 AQ-ALARAKEKSVEFGQQSEQISDISREARALADKLESEAQFDLKNAKDAKDAVEKAHQLAKS-A 1245
            :| .|.|....|......|...|.:.:||:.:|::|..|||...::|.:|:...|:|.|:.:: .
Frog   723 SQEELNRMTFPSTNLPLDSGSYSKLRQEAQEIANRLAQEAQTVAQDAAEAQGDTERALQILRTGG 787

  Fly  1246 IDLQLKIGTELRSEVGLELSHVKQSLGT-VVQTSKEALRKANEVYDTALTLLNDVNRQTQP---- 1305
            .|.:.....:.|.|   |.....:||.| .:|.:..|.|..::...||...     .|..|
Frog   788 ADPETADKLKARME---EARTQARSLETEAIQAAAAAERAHHDSMQTARAF-----GQLPPITSV 844

  Fly  1306 --EIDISQLKKDAVAANERADELLKQITELSNSNGELFADFETEQELTEALLKRAEQQQLEDIEL 1368
              :.::.:||.::.|.....|..|.|...|...       |.|.::..|..|:..:|.:|...:|
Frog   845 AFQAELERLKGESTALKTNVDADLAQSKALQRK-------FTTWEQDAEQQLQEGQQNRLLADQL 902

  Fly  1369 LERAKAAHDKATKAVEQGDNTLKEANNTYEKLAGFQSDVQRSSESAEKALQTVPNIEKEIQNAES 1433
            |.||.||..|||:|:..|:.|..|.:.....|.||...|......||.|::.:|.|...:|:|..
Frog   903 LSRANAAKTKATQAMNTGNATFYEIDGILMSLKGFGDQVGDRRSEAEDAMRRLPEIRLRVQDATD 967

  Fly  1434 LISQAEEALDGANKNANEAKKNAQEA----------QLKYAEQASKDAEL----------IRRKA 1478
            ...:.|.||.||..:|:.|:.||:||          .|:.::.|:..||:          |||.|
Frog   968 STKRTETALKGAASDASRAEGNAREANNIASEIQLNMLQMSQDANNSAEMALALERDLAEIRRLA 1032

  Fly  1479 NETKVAARNLREEADQLNHRVKLTEMDIFKLEESSTKDDNLVDDAKRKVGQAKADTQEAQKQIEK 1543
            .:|..:.....:.|:                     :|..:.|:..||..:|:|........:..
Frog  1033 IDTGASLDGKNQAAE---------------------RDSAVADEVARKALEAEASALGVHDAVTA 1076

  Fly  1544 ANADLTAIKDELENLKDINTGDLDRLENRLATVEGEINRVNLTGR----IEKYREQRTIQKNLID 1604
            ..:.|..:...|:...:||...|..||..:...     |..|.||    ::.......:||..:.
Frog  1077 TLSTLDRMLHILDQPLNINEEGLKALEASMGAA-----RTQLNGRLKPAVQDLELAAQLQKQNMI 1136

  Fly  1605 KYDAELRELKDEVQNIGLISKALPDSCFSRNRLE 1638
            ..:.|:.:...::||:..|...||..|:|...:|
Frog  1137 TVEKEISQTLIDIQNLRDIRDNLPPGCYSTTAIE 1170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB2	NP_001287009.1	LamNT	61..296	CDD:214532
		EGF_Lam	298..347	CDD:238012
		Laminin_EGF	359..414	CDD:278482	25/54 (46%)
		EGF_Lam	414..458	CDD:214543	19/43 (44%)
		Laminin_EGF	461..511	CDD:278482	20/49 (41%)
		LamB	572..697	CDD:214597	45/124 (36%)
		TNFRSF	<721..848	CDD:304602	46/127 (36%)
		CRD2	724..771	CDD:276900	15/46 (33%)
		EGF_Lam	743..791	CDD:238012	13/47 (28%)
		Laminin_EGF	847..897	CDD:278482	30/49 (61%)
		Laminin_EGF	902..953	CDD:278482	2/50 (4%)
		Laminin_EGF	956..1004	CDD:278482	14/47 (30%)
		Laminin_EGF	1004..1050	CDD:278482	0/45 (0%)
		V_Alix_like	1122..1443	CDD:187408	83/336 (25%)
		Tar	1139..1521	CDD:223910	102/417 (24%)
		BAR	1308..1469	CDD:299863	50/170 (29%)
		vATP-synt_E	1474..>1629	CDD:304907	30/158 (19%)
lamc2	XP_002937413.3	EGF_CA	29..84	CDD:419698	25/54 (46%)
		EGF_Lam	84..128	CDD:214543	19/43 (44%)
		EGF_Lam	133..179	CDD:214543	20/49 (41%)
		Laminin_B	247..377	CDD:395006	49/130 (38%)
		EGF_Lam	<378..403	CDD:214543	16/24 (67%)
		exchanger_TraA	<409..608	CDD:411343	87/314 (28%)
		Laminin_EGF	514..558	CDD:395007	27/43 (63%)
		EGF_Lam	569..>608	CDD:238012	17/123 (14%)
		Smc	636..>1029	CDD:224117	104/427 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5624
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D156553at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10574
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.110