DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LanB2 and lamb3

DIOPT Version :9

Sequence 1:NP_001287009.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster
Sequence 2:XP_012826649.2 Gene:lamb3 / 100125073 XenbaseID:XB-GENE-983491 Length:1157 Species:Xenopus tropicalis


Alignment Length:1656 Identity:320/1656 - (19%)
Similarity:532/1656 - (32%) Gaps:657/1656 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 IESTNTCGEQNDNHFCIQTMNQNHKNCEFCKYNDHNPSFLTDLH---DPQSPT----WWQSETMF 137
            :.:::|||.:....:| ....:....|  |:.:...| |....|   :..|||    ||||.   
 Frog    40 LRASSTCGIEKPETYC-SPYGEMQMKC--CRCDSRQP-FTEISHRITNVLSPTGHLRWWQSS--- 97

  Fly   138 EGIQHPNYVNLTLHLGKSYDITYVRILFRSPRPESFTIYKRTSESGPWIPYQFYSATCRDT---- 198
            .||   |.|:|...|.|.:.::.|.:.||||||.|..|.:.:.....|..||:.:..|..:    
 Frog    98 NGI---NDVSLQFDLNKKFQLSDVILDFRSPRPASMLIERSSDHGKTWQVYQYLAYDCAASFPHI 159

  Fly   199 -----YSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPSGINFERSGELQEWVT 258
                 |.|.|.|            |...:.|  |.:.|:|.||.:| ....:....|..:|....
 Frog   160 RRGVPYDLQDVR------------CQELHGD--PTQGGKIRFSPME-LAFSVPLSHSQRVQHLAD 209

  Fly   259 ATDIRITLDRLNTFGDELFGDSQVLKSYFYAISDIAVGARCKCNGHASKCVPSTGM----HGERT 319
            .|::|:...:|.......:.:    .|.||::..:.|...|.|.|||.:|:||..:    :|:..
 Frog   210 FTNLRLNFTQLVRLPPRRYRE----PSTFYSVDVMRVHGSCFCYGHADRCMPSGALDRDHYGDIQ 270

  Fly   320 LV--CECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANLFNRTGH-- 380
            :.  |.|:|||.|.:|:||..|::||.|:.:.....|||:.||||..||||.||..::..:|.  
 Frog   271 VYDKCICQHNTVGENCERCADLFHDLPWRPADDNYPNECRRCNCNNHADKCHFDPAVYEASGRVS 335

  Fly   381 GGHCLDCRENRDGPNCERCKENFY------MRDDGYCVNCACDPVGSRSLQCNSHGKCQCKPGVT 439
            ||.|.:||:...|.|||||:.::|      |.....|::|.|||.||                  
 Frog   336 GGVCDNCRDGTTGRNCERCRSDYYRNPNKDMSHRDACISCDCDPEGS------------------ 382

  Fly   440 GDKCDRCDNNYYQFGPHGCQQCGCDSGGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLD 504
                                    ..|||      ||..||.|.|||||.|.||::||||::.|.
 Frog   383 ------------------------IDGGS------CDDLTGRCNCKENVGGERCDQCKPGYYLLS 417

  Fly   505 KNNRFGCTPCFCYGHTSECMTAPGYSIVSVTSNFNKFKERWTAADLNQREVDIKYNQYSRSIGTT 569
            .:|..|||                                                         
 Frog   418 ASNPQGCT--------------------------------------------------------- 425

  Fly   570 AQGNEHVYFQAPDRFLGDQRASYNRDLKFKLQLVGQVANTGVSDVILEGAGSRISLPIFAQGNGI 634
                                                                             
 Frog   426 ----------------------------------------------------------------- 425

  Fly   635 PDQGVKEYTFRLHEHHDYQWQPSQSARGFLSILSNLTAIKIRATYSVQGEAILDDVELQTAHRGA 699
                                                                             
 Frog   426 ----------------------------------------------------------------- 425

  Fly   700 AGHPATWIEQCTCPEGYLGQFCESCAPGYRHSPARGGPFMPCIPCDCHGHADICDSETGRCICQH 764
                                                                             
 Frog   426 ----------------------------------------------------------------- 425

  Fly   765 NTHGDNCDQCAKGFYGNALGGTPNDCKRCPCPNDGACLQINEDTVICTECPKGYFGSRCEQCSDG 829
                                                                             
 Frog   426 ----------------------------------------------------------------- 425

  Fly   830 FFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSGHFGDPLAL 894
                                                                             
 Frog   426 ----------------------------------------------------------------- 425

  Fly   895 PHGRCDRCSCYEAGTEQDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIRSGNGCENCLCD 959
                  :|:|...|.|:|:.    ||..||||:|.|||:|:.|.:|...::|:.||.|||.|.|.
 Frog   426 ------KCTCNPQGMERDQP----CDSETGQCKCLPNVLGQRCDQCATNHWNLASGRGCERCGCH 480

  Fly   960 PVGSYNSTCDRYSGQCHCRPGVMGQRCDQCENYFYGFSSEGCKPCECDESGSKGFQCDQ-NGQCP 1023
            |..||:..|::.:|||.||.|..|:.|.:|.:..||....||:.|.||..|:....||: ||:|.
 Frog   481 PRNSYSLQCNQATGQCLCREGFGGRFCTECPDRMYGSLQTGCRACNCDFQGTLEQGCDKANGRCL 545

  Fly  1024 CNDNVEGRRCDRCKENKYDRHRGCIDCPDCYNLVQ---DAADLHRAKLFNLS------------- 1072
            |...:.|.|||.|:....|....|..|..|::...   :|...|...|.|::             
 Frog   546 CRPGITGVRCDSCQRGYSDPFPTCRACHQCFHFYDHEINALRSHTQSLLNMTTGQGQDSDLGLGP 610

  Fly  1073 ------QTLDEIAR----TPVTNDDEFEAKLKAVQEKVAVLAQDAR--DNSGDGGQTYAEVIDDL 1125
                  ..|..:.|    ||:.:::     |...:.|::.:..||:  :.:....:::|.:.:::
 Frog   611 RMAAVEAALQRVQRISTGTPIPDNE-----LSRAESKLSRMRGDAQQLNTNLPEPESFAPLSNNI 670

  Fly  1126 HKHLDSVREHLVSADKFQADANGEIDRARQNYTILDQITENAKKELQQALDLLNDEGA--QALAR 1188
            |    |:|              |:.:|....|        .:||| |.:..:.||...  .|:..
 Frog   671 H----SLR--------------GQFNRINLLY--------QSKKE-QHSSSISNDASGIFMAVNS 708

  Fly  1189 AKEKSVEFGQQ---SEQISDISREARALADKLE---SEAQFDLKNAKDAKDAVEKAHQLAKSAID 1247
            |.:.|:|..:.   :|.:...|:::|.:|..||   :|...||:..|:     |.::......|:
 Frog   709 AYQSSLESAKSIAAAEGVLSQSKDSRRVALGLEGKSTELLADLETLKE-----ELSYPNLTPTIN 768

  Fly  1248 LQLKIGTELRSEVGLELSHVKQSLGTVVQTSKEALRKANEVYDTALTL--------------LND 1298
                   .:...|.::....::..|.|.|.:..:|.|...:...|..|              |.|
 Frog   769 -------RICEGVRIDPCTPEECPGPVCQRNNNSLCKVGSLCRGAFPLSSNALRNTEKTSQDLQD 826

  Fly  1299 VNRQTQPE-IDISQLKKDAVAANERADELLKQIT--------ELSNSNG--ELFADFETEQELTE 1352
            :|.:.|.. :.|...:|.|....:.|.:|.:|::        ::.:|..  :...||.||.....
 Frog   827 INNKLQKNALMIQDAEKTASQIQDNAKQLTEQVSRARSRMEEDMGHSRQFIQQVRDFLTEPSTDP 891

  Fly  1353 ALLKRAEQQQLEDIELLERAKAAHDKATKAVEQGDNTLKEANNTYEKLAGFQSDVQRSSESAEKA 1417
            |.::...:..| .::|...|.:...|           :.|..:...||....|.:.::.:...||
 Frog   892 ATIQEVSEYIL-SLKLPTDASSILRK-----------MNEIRSIAGKLPNIDSVLSQTKDDIAKA 944

  Fly  1418 LQTVPNIEKEIQNAESLISQAEEALDGANKNANEAKKNAQEAQLKYAEQASKDAELIRRKANETK 1482
                ..::.|.:.|.:.....|:.:||...|.::||...|||:.| ...:|...:.|:.:.:|.:
 Frog   945 ----KKLQSEAELARNKAKDVEDGVDGVIMNLSQAKTALQEAEDK-IRGSSSSLQQIQNRMHEIE 1004

  Fly  1483 ----VAARNLREEADQLNHRVKLTEMDIFKLEESSTKDDNLVDDAKRKVGQAKADTQEAQKQIEK 1543
                .|.|.|.:..||:.......|    ||.|.:.::..|..:|.:....|.....|||:.::.
 Frog  1005 EVLSPAERGLTDMHDQIQQFTAQVE----KLREKTVENQRLASEAHQAAQGANGKALEAQQGLDA 1065

  Fly  1544 ANADLTAIKDEL----------ENLKDINTGDLDRL-------ENRLATVEGEINRVNLTGRIEK 1591
            .......:|..|          |.:.:|.. :.|||       .|::..:|.|         :::
 Frog  1066 MKTKYALLKSRLGQSSNLGAQGEKIANIKM-EADRLIQESIQMMNKMKVIETE---------LQE 1120

  Fly  1592 YREQRTIQKNLIDKYDAELRELKDEVQNIGL 1622
            .||...::.:.::..:.|.:.::|.:....|
 Frog  1121 GRETLLMKFSQLEGLEEEAKLIRDNISERAL 1151

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanB2NP_001287009.1 LamNT 61..296 CDD:214532 56/231 (24%)
EGF_Lam 298..347 CDD:238012 22/54 (41%)
Laminin_EGF 359..414 CDD:278482 25/62 (40%)
EGF_Lam 414..458 CDD:214543 6/43 (14%)
Laminin_EGF 461..511 CDD:278482 22/49 (45%)
LamB 572..697 CDD:214597 0/124 (0%)
TNFRSF <721..848 CDD:304602 0/126 (0%)
CRD2 724..771 CDD:276900 0/46 (0%)
EGF_Lam 743..791 CDD:238012 0/47 (0%)
Laminin_EGF 847..897 CDD:278482 0/49 (0%)
Laminin_EGF 902..953 CDD:278482 21/50 (42%)
Laminin_EGF 956..1004 CDD:278482 19/47 (40%)
Laminin_EGF 1004..1050 CDD:278482 17/46 (37%)
V_Alix_like 1122..1443 CDD:187408 65/353 (18%)
Tar 1139..1521 CDD:223910 84/418 (20%)
BAR 1308..1469 CDD:299863 34/170 (20%)
vATP-synt_E 1474..>1629 CDD:304907 32/170 (19%)
lamb3XP_012826649.2 Laminin_N 26..244 CDD:395009 57/232 (25%)
EGF_Lam 245..302 CDD:238012 22/56 (39%)
EGF_Lam 311..369 CDD:238012 24/57 (42%)
Laminin_EGF 375..424 CDD:395007 28/96 (29%)
Laminin_EGF 427..474 CDD:395007 21/50 (42%)
Laminin_EGF 477..525 CDD:395007 19/47 (40%)
EGF_Lam 525..569 CDD:214543 16/43 (37%)
Smc <815..1149 CDD:224117 70/364 (19%)
cc_LAMB_C 1087..1157 CDD:424069 13/75 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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