Protein Alignment LanB2 and lama2

DIOPT Version :10

• Sequence 1: NP_524006.1
• Gene: LanB2 / 39118
• FlyBaseID: FBgn0267348
• Length: 1639
• Species: Drosophila melanogaster
• Sequence 2: XP_073788193.1
• Gene: lama2 / 100049705
• ZFINID: ZDB-GENE-060119-1
• Length: 3211
• Species: Danio rerio
• Alignment Length: 2286
• Identity: 559/2286 - (24%)
• Similarity: 825/2286 - (36%)
• Gaps: 800/2286 - (34%)

  Fly    62 GRPQKCL-PEFINAAYQLQIESTNTCGEQNDNHFC-----IQTMNQNHKNCEFC------KYNDH 114
            |.||:.| |..:|.|...:|::..||||.....:|     :......:..|..|      .|..|
Zfish    18 GAPQRGLFPAVLNLASMAEIKTNATCGETGPEMYCKLVEHVPGRPVKNPQCRTCDLNSDYDYERH 82

  Fly   115 NPSFLTDLHDPQSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRI-LFRSPRPESFTIYKR 178
            ...|..|    .:..||||.::..|:. .::|.:||.|.:.:.|.||.: ...||||.:: |.:|
Zfish    83 PIEFAID----GTNRWWQSPSIMNGMD-LHHVTVTLDLQQVFQIAYVILKAANSPRPGNW-ILER 141

  Fly   179 TSESGPWIPYQFYSAT---CRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEG 240
            :.:...::|:|:|:.|   |...|::...........:...:|||.||.|.||.:|||..|.:.|
Zfish   142 SLDGETFMPWQYYAITDTECITRYNIIPRTGPPSYTHDDEVICTSFYSKIHPLENGEIHTSLING 206

  Fly   241 RPSGINFERSGELQEWVTATDIRITLDRLNTFGDELFG---------DSQVLKSYFYAISDIAVG 296
            |||.  .:.|..|..:.:|..||:...|:.|...:|..         |..|.:.|:|:|.||:||
Zfish   207 RPSA--DDPSPTLLNFTSARFIRLQFQRIRTLNADLMTLALHDPRDIDPIVTRRYYYSIKDISVG 269

  Fly   297 ARCKCNGHASKCVPSTGMHGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNC 361
            ..|.|.|||..|..:|  |.:: ..|||.|||.|..||||.|.||...|...|....:.|:.|||
Zfish   270 GMCICYGHAKACPLNT--HTKK-FSCECEHNTCGESCDRCCPAYNQKPWMAGTFLTRHVCEKCNC 331

  Fly   362 NGLADKCFF-----DANL-FNRTGH---GGHCLDCRENRDGPNCERCKENFYMRDDGY------- 410
            :..:::|::     ||.| .|..|.   ||.||.|.||..|.||:.|.:.|| |..|.
Zfish   332 HNKSEECYYNQTVADAKLSLNIHGEYEGGGVCLGCSENTGGINCQSCIDGFY-RPSGVSPLEPWP 395

  Fly   411 CVNCACDPVGSRSLQCNSH----------GKCQCKPGVTGDKCDRCDNNYYQFGPHGCQQCGCDS 465
            |..|.||..|:....|...          |.|.||||..|:.||||...|..| |. |::|.|.|
Zfish   396 CTPCTCDLRGALHSTCVPDESQATTDLPVGSCICKPGYAGEHCDRCVFGYAGF-PQ-CERCRCSS 458

  Fly   466 GGSHQNTPACDTETGICFCKENVEGRRCNECKPGFFNLDKNNRFGCTPCFCYGHTSECMTAPGYS 530
            .||....| |...   |.|||:||||.|:.||.||::|......||..|:|.|..|.|..:. :.
Zfish   459 DGSINQDP-CQPP---CVCKEHVEGRDCDRCKQGFYHLSGGRVRGCDKCYCSGVASLCAESQ-WD 518

  Fly   531 IVSVTSNFNKFKERW--TAADLN-------QREV--DIKYNQYSRSIGTTAQGNEHVYFQAPDRF 584
            ..:||.     ...|  |.||..       .||.  .:..:|.......||.    .|:.||..:
Zfish   519 YTNVTD-----MSGWYLTGADGEGLVWAEPSRETAHQVTVSQSDAQTHLTAP----YYWSAPSAY 574

  Fly   585 LGDQRASYNRDLKFKL----QLVGQVANTGVSDVILEGAGSRIS---LPIFAQGNGIPDQGVKEY 642
            ||.:..:|...|.:.:    :.:..|......||||||.|.|:.   ..:..:.....::|| :.
Zfish   575 LGKKLLAYGGRLVYSISHDTESLEAVHTLRAPDVILEGGGLRLVHRWSEVLLKSLSSSERGV-DL 638

  Fly   643 TFRLHEHHDYQWQPSQSARGFLSILSNLTAIKIRATYSVQ--GEAI--LDDVELQTAHRGA-AGH 702
            ...|.:|.  ....|.|.|.|.|:|.::..:.:||.:|:|  ..||  |..|.:..|...: :|.
Zfish   639 LPELFQHQ--ASGQSVSRRDFHSVLQHIQRLMLRAEHSLQEHTHAIYRLGSVRMSVADEDSRSGI 701

  Fly   703 PATWIEQCTCPEGYLGQFCESCAPGYRH---SPARGGPFMPCIPCDCHGHADICDSETGRCI-CQ 763
            .|..:|.|.||.||.|..||.||.|||.   :..||    .|..|.||||.:.||..||.|: |:
Zfish   702 QARAVEVCQCPPGYDGTSCEMCALGYRRVNGTIYRG----VCELCQCHGHTERCDDLTGHCLGCR 762

  Fly   764 HNTHGDNCDQCAKGFYGNALGGTPNDCKRCPCP-----ND--GACLQINEDTVICTECPKGYFGS 821
            .:|.|.||.|||.|:||:|..||.:||:.|.||     |:  ..|.......|||..||.||.||
Zfish   763 DHTVGPNCGQCAPGYYGDATRGTADDCQPCACPLLSPANNFSPTCRVDGRGEVICDRCPPGYTGS 827

  Fly   822 RCEQCSDGFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSG 886
            ||::||:|:||.|....|   :|:.|.|:||:|..|..:|:..||.||:|.....|..|::|..|
Zfish   828 RCDRCSNGYFGRPNIPGG---SCQPCVCSGNLDQTAPLSCDPLTGACLRCREGYGGADCERCADG 889

  Fly   887 HFGDPLALPHGRCDRCSCYEAGTEQDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYF------ 945
            :|||  ||....|..|.|:..|:..:     .|.|.||||||:.:||||.|.||.|..:
Zfish   890 YFGD--ALIAKNCQACQCHSNGSVSE-----LCHQETGQCQCRQHVIGRQCDECMPNCWWDGESQ 947

  Fly   946 -------NIR------------------------------------------------------- 948
                   |:|
Zfish   948 RCRPCECNVRGSVSQRCDSEGRCVCRAGFVGRRCELMRPPHSRRETRRPVQQVPIQHVQRWESRG 1012

  Fly   949 ------------SGN------GCENCLCDPVGSYNSTCDRYSGQCHCRPGVMGQRCDQCENYFYG 995
                        :|:      ||..|.|:..||.:..||. ||||.|:|||.||:||:|....:.
Zfish  1013 GCPRGAYRPGTGAGSHLQGALGCVPCHCNSFGSKSFDCDE-SGQCRCQPGVTGQKCDRCAAGHFS 1076

  Fly   996 FS----------------------------------------------SEGCKPCECDESGSKGF 1014
            |.                                              |.|||||.|:..||...
Zfish  1077 FQEGGCTPCQCAHVGNNCDASTGQCICPPNTVGERCDKCAPNHWGHDISTGCKPCGCNALGSVAQ 1141

  Fly  1015 QC--------------------------------------------------------DQNGQCP 1023
            ||                                                        |::|||.
Zfish  1142 QCNLNTGCCMCREQFRGEKCDECKLGYRDFPQCISCQCSAAGSSLDTCDSESGLCACADRSGQCS 1206

  Fly  1024 CNDNVEGRRCDRCKENKYD-RHRGCIDCPDCY-----NLVQDAADLHRAKLFNL-SQT----LDE 1077
            |..||||::|:|||...:. .||..:.|..||     :...:|..|.|.:|..: .||    :|.
Zfish  1207 CKANVEGQKCERCKSGSFGLSHRNPLGCSRCYCFGLSSSCTEATGLIRMRLTLMPEQTVLPLVDR 1271

  Fly  1078 IARTPVTNDDEFE-----AKLKAVQEKVA-------------------------VLAQDARDNSG 1112
            ......|....|:     |....||::::                         .:..:||:.:|
Zfish  1272 SGHQETTAGITFQHPDIIATADVVQQQLSEPYYWRLPKQFKRSMITAYGGKLRYAIYYEAREETG 1336

  Fly  1113 ----------DGGQTYAEV---------IDDLHKHLDSVREH--------LVSADKFQ------- 1143
                      .||....::         |..|.:|...:.||        .:|.:.|.
Zfish  1337 RTSYEPQVIIKGGPNKDKIMVRHMPALQIGQLTRHEIDITEHEWKHKDDRPMSREDFMDVLFHVE 1401

  Fly  1144 ------ADAN--------------GEIDRARQNYTILDQI------------------------- 1163
                  :..|              .|:.||.|:..|..||
Zfish  1402 YILIKASHGNVMRHSRISEITLEVAEVGRASQDSEIAHQIEKCVCPQGYAGLSCEECAAGFYRLS 1466

  Fly  1164 ------------------------------------------------------------TENAK 1168
                                                                        |::.|
Zfish  1467 VLAGGSASRAGFGSCVRCQCNGHSDSCDPETSICQNCQHNTVGDKCERCAAGFYGVVRGFTDDCK 1531

  Fly  1169 KELQQALDLLNDE---------------------------------------------------- 1181
               ..|..|||.|
Zfish  1532 ---PCACPLLNPENNFSPTCQTEGFNEYRCTACPEGYEGKHCERCAPGFHGDPGVLGGRCEECKC 1593

  Fly  1182 ---GA----------QALARAKEKSVEFGQQSEQ-------------------ISDISREARALA 1214
               ||          |...|.....::..|..|:                   |.|:.|..|.:.
Zfish  1594 DPYGAFPSACDSRSGQCQCRPGASGLKCDQCMERHVCGPEGIVSCDDDCAGLLIRDMERLLRLIG 1658

  Fly  1215 D---------------KLESEAQFDLKNAKDAKDAVEKAHQLAKS-------AIDLQLKIGTEL- 1256
            .               :.|:..: :||:....:.|.|:..|||.|       .:|..|...|::
Zfish  1659 SVNLTLPLPLPYKVLYRFENVTE-ELKHMLSPQRAPERLMQLADSNLGSLVTEMDELLNRATKVS 1722

  Fly  1257 --------------RSEVGLELSHVKQSLGTVVQTSKEALR-KANEVYDT----------ALTLL 1296
                          ::...||| :|:.:|     .:.|||| ||.::..|          ::..:
Zfish  1723 ADGEQTAADAERSRKAAEELEL-YVRNTL-----LAAEALRDKARDLNATLGLRDGTLEKSVNEM 1781

  Fly  1297 NDVNRQTQPEIDISQLKKDAVAANER---ADELLKQITELSNSNGELFADFETE--QELTEALLK 1356
            ||..::...|:...||......|:|.   |:.||.::..|.....:..||.:.|  |::::..||
Zfish  1782 NDEIQEMLAELRKRQLTGKKHMADEELGAAEALLSRVKRLFGDPQQATADLKQEVGQKMSDHKLK 1846

  Fly  1357 RAEQQQL-----------EDIELLERAKAAH-----DKATKAVEQ-------GDNTLKEAN---- 1394
            ..|.|:|           ||:.|..:.|..|     |.|.|..||       |:.:|.|||
Zfish  1847 LQEAQELLEEALTHTRQAEDLTLNNQLKLQHLQGKRDAAVKQKEQTEGVLLEGEKSLDEANALSD 1911

  Fly  1395 ------NTYEKLAG-----------FQSDVQRS-------------------------------- 1410
                  ...|::||           ..||:.|.
Zfish  1912 AITRGKEELEEMAGELGPLRDQLRDKVSDLSRGLDESVPELLLRAEDHAAQLNHSAAILDSILAE 1976

  Fly  1411 ----SESAEKALQTVPNIEKEIQNAE----------------------SLISQAEEALDGANKNA 1449
                |.:|..|.....||:..|:.|:                      ||..||:.:|..::...
Zfish  1977 AKNLSFNATAAFSAYTNIKNYIEEADRVAKDAKKTSAEALQLASGPKGSLKDQAKGSLQKSHYLL 2041

  Fly  1450 NEAKK------------NAQEAQLKYAEQASKDAELIRRKANET-------------KVAARNLR 1489
            ||||.            .|.:.:||.|.:.:||   ::::.|:|             |:.|..|:
Zfish  2042 NEAKDLQKDVTENGENLGALQLRLKGANKQNKD---LQKRLNDTVEKLNSIPDDMALKIQATKLK 2103

  Fly  1490 -EEA-----DQLNHRVKLTEMDIF-------KLEESSTKDDNLVDDAKRKVGQAKADTQEAQKQI 1541
             .||     |.|| |:|...:::.       |||:...|.:||:.|.::.:..|.|..::.:.:.
Zfish  2104 AAEANDTALDVLN-RLKDMNLNLMGLKKNYDKLEDDVRKTNNLIKDPEKNIHAAGAKVKDLENEA 2167

  Fly  1542 EKANADLTAIKDELENLKDINTGDLDRLENRLATVEGEINRVNLTGR---IEKYREQRTIQKNLI 1603
            ::....|..|::..:|||. |...:..|.|: |..:....:|:::..   |..||.:  |:|.
Zfish  2168 DRLMEKLKPIQELQDNLKK-NISQIKELINQ-ARKQANSIKVSVSSGGDCIRTYRPE--IKKG-- 2226

  Fly  1604 DKYDAELRELK 1614
             :|:..:..||
Zfish  2227 -RYNTIILHLK 2236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanB2	NP_524006.1	LamNT	61..296	CDD:214532	74/258 (29%)
		EGF_Lam	298..347	CDD:238012	23/48 (48%)
		Laminin_EGF	359..414	CDD:395007	25/70 (36%)
		EGF_Lam	414..458	CDD:214543	19/53 (36%)
		Laminin_EGF	461..511	CDD:395007	21/49 (43%)
		LamB	572..697	CDD:214597	35/135 (26%)
		EGF_Lam	743..791	CDD:238012	25/48 (52%)
		EGF_Lam	793..836	CDD:214543	22/49 (45%)
		Laminin_EGF	847..897	CDD:395007	21/49 (43%)
		Laminin_EGF	902..953	CDD:395007	22/136 (16%)
		EGF_Lam	956..1001	CDD:214543	21/90 (23%)
		Laminin_EGF	1004..1046	CDD:395007	20/98 (20%)
		SMC_prok_B	<1054..1621	CDD:274008	176/1020 (17%)
lama2	XP_073788193.1	None