DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LanB2 and lamc1

DIOPT Version :9

Sequence 1:	NP_001287009.1	Gene:	LanB2 / 39118	FlyBaseID:	FBgn0267348	Length:	1639	Species:	Drosophila melanogaster
Sequence 2:	NP_001090659.1	Gene:	lamc1 / 100036631	XenbaseID:	XB-GENE-478553	Length:	1592	Species:	Xenopus tropicalis

Alignment Length:	1641	Identity:	674/1641 - (41%)
Similarity:	962/1641 - (58%)	Gaps:	89/1641 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RPPINSAGGHELRGTTFMPALECYDPYGRPQKCLPEFINAAYQLQIESTNTCGEQNDNHFCIQT- 98
            |.|:.:.....|.||......|||:. |.||:|:|||:|||:...:.:|||||...: .:|:||
Frog     2 RAPVLAVLAVLLLGTVRAAMDECYEE-GSPQRCMPEFVNAAFNATVVATNTCGTPPE-EYCVQTG 64

  Fly    99 MNQNHKNCEFCK----YNDHNPSFLTDLHDPQSPTWWQSETMFEGIQHPNYVNLTLHLGKSYDIT 159
            :....|:|..|.    :..|...:|||.::....|||||:||..|||:|:.:||||||||::|||
Frog    65 VTGVTKSCHICDSGQFHLQHGAEYLTDYNNQAEITWWQSQTMLAGIQYPSTINLTLHLGKAFDIT 129

  Fly   160 YVRILFRSPRPESFTIYKRTSESGPWIPYQFYSATCRDTYSLPDSRAIRKGEGEAHALCTSEYSD 224
            |||:.|.:.|||||.:||||.|.|||||||:||.:|..||...:...||.||.|..||||.|:||
Frog   130 YVRLKFHTSRPESFALYKRTHEDGPWIPYQYYSGSCEKTYQKFNRGFIRTGEDEQQALCTDEFSD 194

  Fly   225 ISPLRDGEIAFSTLEGRPSGINFERSGELQEWVTATDIRITLDRLNTFGDELFGDSQVLKSYFYA 289
            ||||..|.:||||||||||..||:.|..|||||||||||:||:||||||||:|.|.:|||||:||
Frog   195 ISPLTGGNVAFSTLEGRPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFSDPKVLKSYYYA 259

  Fly   290 ISDIAVGARCKCNGHASKCVPSTGMHGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVN 354
            |||.|||.|||||||||:||    .:....:||.|:|||.|.||::|||.|||..|:|||:...|
Frog   260 ISDFAVGGRCKCNGHASECV----RNEFEKIVCNCKHNTFGSDCEKCLPFYNDRPWRRSTADSPN 320

  Fly   355 ECKACNCNGLADKCFFDANLFNRTGHGGHCLDCRENRDGPNCERCKENFYMRDDGY-CVNCACDP 418
            ||..|||||.:.:|:||..|:..|||||||..|.:|.||||||||:||:|.:|:.. |..|.|:|
Frog   321 ECLPCNCNGRSQECYFDPELYRSTGHGGHCTGCADNTDGPNCERCRENYYRQDNNEPCHACQCNP 385

  Fly   419 VGSRSLQCNSHGKCQCKPGVTGDKCDRCDNNYYQFGPHGCQQCGCDSGGSHQNTPACDTETGICF 483
            |||.|.||:::|:|.|||||.|:|||||...::.....||:.|.|:..||   |..|:.|||.|.
Frog   386 VGSLSTQCDNYGRCSCKPGVMGEKCDRCQPGFHSLTEAGCRPCACNPAGS---TDECNVETGRCS 447

  Fly   484 CKENVEGRRCNECKPGFFNLDKNNRFGCTPCFCYGHTSECMTAPGYSIVSVTSNFNKFKERWTAA 548
            ||:||||..|..||||||:||:.|..||||||||||:|.|.:|.||.:.|:.|.|....|.|||.
Frog   448 CKDNVEGFNCERCKPGFFHLDEANPRGCTPCFCYGHSSVCSSAEGYRVSSIVSTFESGVEGWTAQ 512

  Fly   549 DLNQREVDIKYNQYSRSIGTTAQGNEHVYFQAPDRFLGDQRASYNRDLKFKLQLVGQVANTGVSD 613
            ..:..|..:.:...|.::...::....:||.||.:|||:|.|||.::|.|..::..:.......|
Frog   513 QRDGSEYSLSWVSDSSAVSVISESYFPIYFIAPAKFLGNQGASYGQNLTFSFRVERRDTRLSAED 577

  Fly   614 VILEGAGSRISLPIFAQGNGIPDQGVKEYTFRLHEHHDYQWQPSQSARGFLSILSNLTAIKIRAT 678
            ::|||||.|:|:|:.||||..|.:..:.|.||:||..||.|:||.|...|..:|.||||||||.:
Frog   578 LVLEGAGLRVSVPLIAQGNSYPSETTQRYIFRMHEATDYPWRPSVSPFEFQKMLQNLTAIKIRGS 642

  Fly   679 YSVQGEAILDDVELQTAHRGAAGHPATWIEQCTCPEGYLGQFCESCAPGYRHSPARGGPFMPCIP 743
            ||.:....|::|.|.||..| ||..|.|:|.|:||.||:|||||.||||||......||:.||:.
Frog   643 YSERSAGFLEEVSLVTAVAG-AGPSAPWVEICSCPTGYIGQFCERCAPGYRRENPSQGPYSPCVL 706

  Fly   744 CDCHGHADICDSETGRCICQHNTHGDNCDQCAKGFYGNALGGTPNDCKRCPCPNDGACLQI-NED 807
            |.|:||:|.||.|:|.|.|||||.|.:|::|::|:||::..|:.:||:.||||...:|..: ...
Frog   707 CTCNGHSDTCDPESGVCDCQHNTAGPHCERCSEGYYGDSTTGSASDCQPCPCPGGSSCAVVPRTK 771

  Fly   808 TVICTECPKGYFGSRCEQCSDGFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCI 872
            .|:||.||.|..|.|||.|.||:||||.|..|..:.|:.|:|:.|:||||||||:|.||||||||
Frog   772 EVVCTNCPLGTTGKRCELCDDGYFGDPLGENGAPRPCRICECSNNIDPNAVGNCDRLTGECLKCI 836

  Fly   873 HNTAGEHCDQCLSGHFGDPLAL-PHGRCDRCSCYEAGTEQDEQSITRCDQVTGQCQCKPNVIGRD 936
            :||.|.:||:|..|.:|:|||. |..:|..|||...||.:.:..   |:||||||:|.|:|..||
Frog   837 YNTGGFYCDRCRDGFYGNPLAQNPDLKCRACSCNPYGTVKGQSG---CNQVTGQCECLPHVTERD 898

  Fly   937 CGECQPGYFNIRSGNGCENCLCDPVGSYNSTCDRYSGQCHCRPGVMGQRCDQCENYFYGFSSEGC 1001
            |..|:||::|:.||.|||.|.|..:||.:..||..:|||.|.||:.||:|.|||...:||..|||
Frog   899 CSACEPGFYNLLSGRGCERCDCHSLGSTSGQCDVRTGQCECHPGISGQQCQQCEPNHFGFGPEGC 963

  Fly  1002 KPCECDESGSKGFQCDQNGQCPCNDNVEGRRCDRCKENK-YDRH-RGCIDCPDCYNLVQDAADLH 1064
            |||:||..||...||.::|:|.|.....|.|||:|:||. |:|. .||.:||.||.||:|..:..
Frog   964 KPCDCDPEGSGSLQCKEDGRCECKSGFVGTRCDQCEENYFYNRSGPGCQECPACYRLVKDKVNEQ 1028

  Fly  1065 RAKLFNLSQTLDEIARTPVT-----NDDEFEAKLKAVQEKVAVLAQDARDNSGDGGQTYAEVIDD 1124
            |.||    |.|:::.:...|     .|..||.:|:..::.|..|..||: :|.|..|...:.:.:
Frog  1029 RGKL----QELEDLLKNLSTGEENITDQAFEERLREAEKAVNDLLLDAQ-SSKDVDQGMLDRLAE 1088

  Fly  1125 LH-------KHLDSVREHLVSADKFQADANGEIDRARQNYTILDQITENAKKELQQALDLLNDEG 1182
            ::       :.|.::|:.:...||...:|.   ||......|:|    :|:.:|::|
Frog  1089 INTTLSFQLERLQNIRDMIRDTDKQAQEAR---DRVENTEFIID----SARVQLEKA-------- 1138

  Fly  1183 AQALARAKEKSVEFGQQSEQISDISREARALADKLESEAQFDLKNAKDAKDAVEKAHQLAKSAID 1247
            ..|:|.......|.......::.::.|||.||::...||:...|.||:|.|...:|.:|
Frog  1139 KMAIANVSITPPESTGDPNNMTLLAEEARKLAERHMQEARDIEKAAKEANDTANEALRL------ 1197

  Fly  1248 LQLKIGTELRSEVGLELSHVKQSLGTVVQTSKEALRKANEVY-------DTALTLLNDVNRQTQP 1305
            ||..:.:|  ::..|::..:.:........::|..::|::|:       :.||.:.  .|..:.|
Frog  1198 LQKTLASE--NQTALDIEELNRKYAQAKDIARELEKQASKVHAEAEEAGNRALQIY--ANLTSVP 1258

  Fly  1306 EIDISQLKKDAVAANERADELLKQITELSNSNGELFADFE--------TEQELTEALLKRAEQQQ 1362
            .||.:.|:.:       ||::.|:..||.:.......|:|        .|.|:...|.|...:||
Frog  1259 SIDTTALQNE-------ADKIQKEAEELDSLIDRKLRDYEDLREDMRGREMEVKNLLDKGKTEQQ 1316

  Fly  1363 LEDIELLERAKAAHDKATKAVEQGDNTLKEANNTYEKLAGFQSDVQRSSESAEKALQTVPNIEKE 1427
            ..| :||.||.||..:|.:|.::|..||:|||:...||..|...|..:..:||.||:.:|.|.:.
Frog  1317 TAD-QLLARADAAKAQAEEAAKKGRETLQEANDILNKLRDFDKRVNDNKTAAEAALRKIPMIAQT 1380

  Fly  1428 IQNAESLISQAEEALDGANKNANEAKKNAQEAQLKYAEQASKDAELIRRKANETKVAARNLREEA 1492
            |..|.:...|||.||..||.:|..||..|:||: ..|....|.|...|.:|:.|.....:|..|.
Frog  1381 IAEANNKTRQAESALGNANADARGAKSKAEEAE-ALANTVQKKAATARAEADNTFKEVTDLDGEL 1444

  Fly  1493 DQLNHRVKLTEMDIFKLEESSTKDDNLVDDAKRKVGQAKADTQEAQKQIEKANADLTAIKDELEN 1557
            ..:..:::..|..:.|.:..:..|:.:.:.|......|:::...::|.:....|.:..:...|..
Frog  1445 QDMLQQLQEAENQLKKKQAEAESDEKMAEMASNATKDAESNANNSKKSVNGVLATIDELLSRLGQ 1509

  Fly  1558 LKDINTGDLDRLENRLATVEGEINRVNLTGRIEKYREQRTIQKNLIDKYDAELRELKDEVQNIGL 1622
            |..::.|.|..||..|...:.::...:|..::.:.:|...:|:..:|.|..::.::..::.|:..
Frog  1510 LDSVDVGQLTVLEKTLDDAKNQLRDSDLDRKLAELQESSNLQRVALDSYSRDIDQILRDIANLED 1574

  Fly  1623 ISKALPDSCFSRNRLE 1638
            |...||..|::...:|
Frog  1575 IKNTLPAGCYNTPIIE 1590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanB2	NP_001287009.1	LamNT	61..296	CDD:214532	137/239 (57%)
		EGF_Lam	298..347	CDD:238012	27/48 (56%)
		Laminin_EGF	359..414	CDD:278482	31/55 (56%)
		EGF_Lam	414..458	CDD:214543	22/43 (51%)
		Laminin_EGF	461..511	CDD:278482	26/49 (53%)
		LamB	572..697	CDD:214597	55/124 (44%)
		TNFRSF	<721..848	CDD:304602	61/127 (48%)
		CRD2	724..771	CDD:276900	26/46 (57%)
		EGF_Lam	743..791	CDD:238012	23/47 (49%)
		Laminin_EGF	847..897	CDD:278482	32/50 (64%)
		Laminin_EGF	902..953	CDD:278482	24/50 (48%)
		Laminin_EGF	956..1004	CDD:278482	24/47 (51%)
		Laminin_EGF	1004..1050	CDD:278482	21/47 (45%)
		V_Alix_like	1122..1443	CDD:187408	87/342 (25%)
		Tar	1139..1521	CDD:223910	105/396 (27%)
		BAR	1308..1469	CDD:299863	56/168 (33%)
		vATP-synt_E	1474..>1629	CDD:304907	27/154 (18%)
lamc1	NP_001090659.1	LamNT	27..267	CDD:214532	138/241 (57%)
		EGF_Lam	268..313	CDD:238012	27/48 (56%)
		Laminin_EGF	325..381	CDD:278482	31/55 (56%)
		Laminin_EGF	381..428	CDD:278482	24/46 (52%)
		Laminin_EGF	428..475	CDD:278482	26/49 (53%)
		Laminin_B	541..662	CDD:278481	55/120 (46%)
		Laminin_EGF	707..753	CDD:278482	22/45 (49%)
		EGF_Lam	755..803	CDD:238012	23/47 (49%)
		Laminin_EGF	811..855	CDD:278482	28/43 (65%)
		EGF_Lam	866..916	CDD:238012	25/52 (48%)
		EGF_Lam	918..963	CDD:214543	21/44 (48%)
		EGF_Lam	965..1012	CDD:238012	21/46 (46%)
		Domain II and I. /evidence=ECO:0000250	1013..1592		153/617 (25%)
		SPX	<1017..1073	CDD:271919	18/59 (31%)
		COG1340	1023..1322	CDD:224259	75/336 (22%)
		ATP-synt_B	<1100..1229	CDD:304375	33/151 (22%)
		COG1340	1259..1546	CDD:224259	79/295 (27%)
		DUF3829	1347..1571	CDD:289644	53/224 (24%)
		ATP-synt_B	<1376..1479	CDD:304375	28/103 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1456..1489		4/32 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1584
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1724
Inparanoid	1	1.050	1315	1.000	Inparanoid score	I152
OMA	1	1.010	-	-		QHG48740
OrthoDB	1	1.010	-	-		D156553at2759
OrthoFinder	1	1.000	-	-		FOG0002861
OrthoInspector	1	1.000	-	-		otm48711
Panther	1	1.100	-	-	LDO	PTHR10574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2603
SonicParanoid	1	1.000	-	-		X4311
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110