DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3306 and JPH3

DIOPT Version :9

Sequence 1:	NP_648335.1	Gene:	CG3306 / 39116	FlyBaseID:	FBgn0036016	Length:	288	Species:	Drosophila melanogaster
Sequence 2:	NP_065706.2	Gene:	JPH3 / 57338	HGNCID:	14203	Length:	748	Species:	Homo sapiens

Alignment Length:	283	Identity:	56/283 - (19%)
Similarity:	87/283 - (30%)	Gaps:	102/283 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 TGSR----YVGPSDELGMQEMGVYIYPDGTCYTGEFLNNRFHGKGTIQIPDSLGVTYQVTHHNGR 79
            ||.:    |.| |...|.:.:|||.:|.|..|.|.:...:.||.|              ....|:
Human    31 TGPKGQGEYTG-SWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIG--------------LESKGK 80

  Fly    80 LVSIDQVNFNDSLPVDFEMKDHYTMSFKPWTY----CTPEDRRFYQETKEPMDAVGPNKFQSKDG 140
            .|                .|..:|..|| ..|    |.....::        :....|..|.
Human    81 WV----------------YKGEWTHGFK-GRYGVRECAGNGAKY--------EGTWSNGLQD--- 117

  Fly   141 PNPLNLGRNIFDLGFGLLGNRGFMLDTKTFSNQSIYLGCREARRW---------IRENCAHGPLS 196
                         |:|          |:|:|:...|.|     :|         :|::..:|
Human   118 -------------GYG----------TETYSDGGTYQG-----QWVGGMRQGYGVRQSVPYG--- 151

  Fly   197 KRHHKQKLLARFAREIIRNNQENAGCSQREFMTKIHPCKHSTSLDSFASER--LHLASTTDSTTS 259
                    :|...|..:|.: .|:..|:....|.:||........|.|..|  ..|.:.:||...
Human   152 --------MAAVIRSPLRTS-INSLRSEHTNGTALHPDASPAVAGSPAVSRGGFVLVAHSDSEIL 207

  Fly   260 EAQAMGLRHEEFHGNWTRAKSES 282
            :::..||............||||
Human   208 KSKKKGLFRRSLLSGLKLRKSES 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3306	NP_648335.1	COG4642	<36..90	CDD:226989	12/53 (23%)
JPH3	NP_065706.2	MORN 1	15..37		2/5 (40%)
		MORN 2	39..60		9/21 (43%)
		MORN 3	61..82		6/34 (18%)
		MORN 4	83..105		6/22 (27%)
		MORN	107..129	CDD:280628	7/55 (13%)
		MORN 5	107..129		7/55 (13%)
		MORN 6	130..152		5/37 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..259		1/1 (100%)
		MORN 7	288..310
		MORN	311..333	CDD:280628
		MORN 8	311..333
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..496
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..597
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..649
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4642
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900