DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3088 and PROC

DIOPT Version :9

Sequence 1:	NP_648334.1	Gene:	CG3088 / 39115	FlyBaseID:	FBgn0036015	Length:	252	Species:	Drosophila melanogaster
Sequence 2:	XP_024308770.1	Gene:	PROC / 5624	HGNCID:	9451	Length:	576	Species:	Homo sapiens

Alignment Length:	253	Identity:	62/253 - (24%)
Similarity:	106/253 - (41%)	Gaps:	30/253 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KKDSEDP----DHIITNGSPAYEGQAPYVVGMAFGQSNIWCSGTIIGDTWILTSAQCLTGSSGVT 79
            |:|:||.    |..:.:|.....|.:|:.|.:...:..:.|...:|..:|:||:|.|:..|..:.
Human   313 KRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLL 377

  Fly    80 IYFGATRLSQ----------AQFTVTVGTSEYVTGNQHLALVRVPR-VGFSNRVNRVALP--SLR 131
            :..|...|.:          .:..|....|:..|.|. :||:.:.: ...|..:..:.||  .|.
Human   378 VRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDND-IALLHLAQPATLSQTIVPICLPDSGLA 441

  Fly   132 NRSQRYENWWANVCGWGVTT-----FSNGLTDALQCVDLQIMSNNECIAFYGSTTVSDQILCTRT 191
            .|..........|.|||..:     .....|..|..:.:.::.:|||.... |..||:.:||...
Human   442 ERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVM-SNMVSENMLCAGI 505

  Fly   192 PSGR-STCFGDAGSPLITKQDST--VVGISAFVASNGCTLGLPAG-FARITSALDWIH 245
            ...| ..|.||:|.|::.....|  :||:.::  ..||.|....| :.:::..|||||
Human   506 LGDRQDACEGDSGGPMVASFHGTWFLVGLVSW--GEGCGLLHNYGVYTKVSRYLDWIH 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3088	NP_648334.1	Tryp_SPc	29..246	CDD:238113	57/239 (24%)
CG3088	NP_648334.1	Tryp_SPc	29..244	CDD:214473	54/236 (23%)
PROC	XP_024308770.1	GLA	117..168	CDD:214503
		EGF_CA	182..213	CDD:238011
		FXa_inhibition	255..290	CDD:317114
		Tryp_SPc	328..563	CDD:238113	57/238 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910