DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VSIG8 and klg

DIOPT Version :9

Sequence 1:	NP_001013683.1	Gene:	VSIG8 / 391123	HGNCID:	32063	Length:	414	Species:	Homo sapiens
Sequence 2:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	149	Identity:	38/149 - (25%)
Similarity:	61/149 - (40%)	Gaps:	38/149 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   110 SINLMNLQVSDTATYEC----RVKKTTMATRKVIVTVQARPAVPMCWTEGHM--TYGNDVVLKCY 168
            ::.:.:|:..|...|.|    ::.:..:.|.:::|....| |:|   |.|.:  ..|..:.|:|.
  Fly   161 NLEISDLEPQDAGDYVCQISDKINRDQVHTVEILVPPSVR-AIP---TSGQLQARKGGPITLECK 221

Human   169 ASGGSQPLSYKWAKISGHHYPYRAGSYTSQHSYHSELSYQESFHSSINQGLNNGD-LVLKDISRA 232
            .||...|..| |.|.||      |...|::                    :.:|. |.|:.:.|.
  Fly   222 GSGNPVPSIY-WTKKSG------ANKSTAR--------------------IGDGPILTLEKLERQ 259

Human   233 DDGLYQCTVANNVGYSVCV 251
            ..|:||||..|.||..|.|
  Fly   260 QAGVYQCTADNGVGDPVTV 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VSIG8	NP_001013683.1	V-set	35..142	CDD:311561	6/35 (17%)
VSIG8	NP_001013683.1	IG_like	160..256	CDD:214653	27/93 (29%)
klg	NP_524454.2	DUF1370	63..>124	CDD:284518
		IG_like	109..195	CDD:214653	5/33 (15%)
		Ig	118..191	CDD:143165	4/29 (14%)
		IG_like	205..274	CDD:214653	25/95 (26%)
		IGc2	213..273	CDD:197706	23/86 (27%)
		IGc2	301..367	CDD:197706
		FN3	392..486	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910