DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VSIG8 and side-V

DIOPT Version :9

Sequence 1:	NP_001013683.1	Gene:	VSIG8 / 391123	HGNCID:	32063	Length:	414	Species:	Homo sapiens
Sequence 2:	NP_611765.2	Gene:	side-V / 37679	FlyBaseID:	FBgn0085400	Length:	1174	Species:	Drosophila melanogaster

Alignment Length:	313	Identity:	74/313 - (23%)
Similarity:	114/313 - (36%)	Gaps:	80/313 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    26 GDGQEVLYLAEGDNVRLGCPYVLDPEDYGPNGLDIEWMQVNSDPAHHRE------NVFLSYQDKR 84
            |...|:| .|.|..|.|.|..|..........|.|.:.|.|..|.:..:      |:.:.:.|:.
  Fly    39 GPLSEIL-TAVGSEVALPCDLVPGTGIVDKVQLVIWYRQGNVKPIYTFDARGRPLNLGIPWADES 102

Human    85 INHGSLPHLQQRVRF-AASDPSQYDASINLMNLQVSDTATYECRVKKTTMATR--KVIVTVQARP 146
            :       ..::..| ..:||    .::.:.|:|.||...|:|||......||  ::.|||...|
  Fly   103 V-------FNKKAHFHHDTDP----PALRIKNIQTSDAGLYKCRVDFHKSPTRNWRINVTVLVPP 156

Human   147 ----------AVPMCWTEGHMTYGNDVVLKCYASGGSQPLSYKWAKISGHHYPYRAGSYTSQHSY 201
                      |.....|.|....|:.:.|.|.:|||..|....|.:               :|:.
  Fly   157 TALTILDHHGAEIRDQTAGPYLEGDSIDLTCLSSGGVPPPRVSWWR---------------EHAL 206

Human   202 HSELSYQESFHSSINQGLNNGDLVLKDISRAD-DGLYQCTVANNVGYSVCVVEVKVSDSRRI--- 262
            ..: |:|.....|:...|.     ||:|.|.| ..:|.|..:|  |:.|..:..||.....:
  Fly   207 IDD-SFQVLPDGSVRNVLR-----LKNIQRKDLLTMYTCQASN--GHVVPALTKKVILDMNLPPL 263

Human   263 -----GVIIGIVLGSLLALGCLAVG-------IWGLVCCCCGGSGAGG-ARGA 302
                 |:...::.|:...:.|.|:|       ||         |.||. .|||
  Fly   264 SLLLQGLNHAVIAGTRSHVTCTAIGARPPPEIIW---------SKAGQIVRGA 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VSIG8	NP_001013683.1	V-set	35..142	CDD:311561	27/115 (23%)
VSIG8	NP_001013683.1	IG_like	160..256	CDD:214653	23/96 (24%)
side-V	NP_611765.2	Ig	42..153	CDD:299845	30/122 (25%)
		IG_like	42..152	CDD:214653	29/121 (24%)
		IGc2	179..245	CDD:197706	21/88 (24%)
		IG_like	179..245	CDD:214653	21/88 (24%)
		Ig	<282..348	CDD:299845	11/35 (31%)
		IGc2	400..459	CDD:197706
		FN3	719..798	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910