Protein Alignment CG42673 and MAPK8IP2

DIOPT Version :10

• Sequence 1: NP_729510.1
• Gene: CG42673 / 39111
• FlyBaseID: FBgn0261555
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: XP_011528981.1
• Gene: MAPK8IP2 / 23542
• HGNCID: 6883
• Length: 825
• Species: Homo sapiens
• Alignment Length: 624
• Identity: 121/624 - (19%)
• Similarity: 203/624 - (32%)
• Gaps: 219/624 - (35%)

  Fly   324 GLAIADCDNLCNNRTKDAISCG--------CATSDPESQAMRIVRTVGQAFEVCHKFNLHKNSLE 380
            ||.::...:.|.   ||::|.|        |:..|.           .|.||:          ::
Human    45 GLGLSYDSDHCE---KDSLSLGRSEQPHPICSFQDD-----------FQEFEM----------ID 85

  Fly   381 PNDERSDISSSELLDVEQISEQQLSEDGE-RGGGD--NETPKKEHLAITPDLNHTQPQRPNHL-- 440
            .|:|..|       :.|:..|::...||| :.|||  :|.|....|..:|.:......||..|
Human    86 DNEEEDD-------EDEEEEEEEEEGDGEGQEGGDPGSEAPAPGPLIPSPSVEEPHKHRPTTLRL 143

  Fly   441 ---------------DIM------------PSHSSLRK---------------SNSLL---CDVD 460
                           |::            |:..:||.               :.|.:   ||.:
Human   144 TTLGAQDSLNNNGGFDLVRPASWQETALCSPAPEALRAELPGPLPATDTGPGGAQSPVRPGCDCE 208

  Fly   461 DKSPGSPSSPRSEITQLKDQLEAQALQTRQALGQLMLVREQLISETNARIEAQARTQQLLQQNRE 525
            ...|..|.:|..........:||. |::|.:.|                           :..|.
Human   209 GNRPAEPPAPGGTSPSSDPGIEAD-LRSRSSGG---------------------------RGGRR 245

  Fly   526 LLEHLASLGAYNEQQTAGLTSANIGMAPQQSQLQMLLQATSNNNNLATINQQISNLGSINQQLTS 590
            ..:.|:|.|  ::.:.||  .|.:|                         :.||::.....:|:|
Human   246 SSQELSSPG--SDSEDAG--GARLG-------------------------RMISSISETELELSS 281

  Fly   591 LSHQLSGLNQQSQHLQNLQQQQQQQQQQQQQQTQAAPTAATPP--PAAGGSSPYPSMSALQSISN 653
            ...  |..:.:|.||.|..::......:.:...:       ||  ||.....|..:.|..:|.|
Human   282 DGG--SSSSGRSSHLTNSIEEASSPASEPEPPRE-------PPRRPAFLPVGPDDTNSEYESGS- 336

  Fly   654 QLQQQQQQQQQDALSKDLFQVNQELLNRL------------QALN-LNANPGQ-----------S 694
               :.:....:||.|..|.   ..|::|:            |.|: ....||:           |
Human   337 ---ESEPDLSEDADSPWLL---SNLVSRMISEGSSPIRCPGQCLSPAPRPPGEPVSPAGGAAQDS 395

  Fly   695 QPTPSATAHNSFFYVN------PLSCTPATPNNNAGGAGGFNFLTSPAATGTLTP---SPLGTMN 750
            |...:|........|:      |....||.|.......|...||::| ...|:||   :| |...
Human   396 QDPEAAAGPGGVELVDMETLCAPPPPAPAAPRPGPAQPGPCLFLSNP-TRDTITPLWAAP-GRAA 458

  Fly   751 RNSFAGSSSLNEDIRLSIEQNLNNLEEQLKAAVSNGNLAGLACGGSTSTRDTS------RSSSTL 809
            |...|.|::.:|      |::..:.||:..|..|.|:..|...|.| :.||.|      :.:..:
Human   459 RPGRACSAACSE------EEDEEDDEEEEDAEDSAGSPGGRGTGPS-APRDASLVYDAVKYTLVV 516

  Fly   810 DSPSSPRLRSSNNNISPGSSNGNQNHNNNSNSNSSSSRE 848
            |..:...|.|.......|       |::..:|...:|.|
Human   517 DEHTQLELVSLRRCAGLG-------HDSEEDSGGEASEE 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42673	NP_729510.1	PH-like	<352..386	CDD:473070	5/33 (15%)
MAPK8IP2	XP_011528981.1	SH3_JIP2	609..663	CDD:212875
		PTB_JIP	680..825	CDD:269923