Protein Alignment CG42673 and Numbl

DIOPT Version :10

• Sequence 1: NP_729510.1
• Gene: CG42673 / 39111
• FlyBaseID: FBgn0261555
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: NP_001403961.1
• Gene: Numbl / 18223
• MGIID: 894702
• Length: 608
• Species: Mus musculus
• Alignment Length: 474
• Identity: 109/474 - (22%)
• Similarity: 156/474 - (32%)
• Gaps: 138/474 - (29%)

  Fly   333 LCNNRTKDAISCGCATSDPESQAMRIVRTVGQAFEVCHKFNLHKNSLEPNDER-SDISSSELLDV 396
            :|.:.|.....|.|..:..:| ..|:...||.||..|         ||....| .:...:...|.
Mouse   164 ICRDGTTRRWICHCFLALKDS-GERLSHAVGCAFAAC---------LERKQRREKECGVTAAFDA 218

  Fly   397 EQIS-----EQQLSEDG---ERGGGDNETPKKEHLAITPDLNHTQPQRPNHLDIMPSHSSLRKSN 453
            .:.|     ..:||..|   ||..||.   ||...|..|.: ...|.:|.|:...|:.:
Mouse   219 SRTSFAREGSFRLSGGGRPAEREAGDK---KKAEAAAAPAV-APGPAQPGHVSPTPATT------ 273

  Fly   454 SLLCDVDDKSPGSPSSPRSEITQLKDQLEAQALQTRQALGQLMLVREQLISETNARIEAQARTQQ 518
                     |||......:.:.         |..|..|:.:.....|||:.:.:.| ...|.:|:
Mouse   274 ---------SPGEKGEAGTPVA---------AGTTAAAIPRRHAPLEQLVRQGSFR-GFPALSQK 319

  Fly   519 LLQQNRELLEHLASLGAYNEQQTAGLTSANIGMAPQQSQLQMLLQATSNNNNLATINQQISNLGS 583
            .....|:|...|..|.:..:::|.....   |..|     :|....|.:::.:..:..|||:
Mouse   320 NSPFKRQLSLRLNELPSTLQRRTDFQVK---GTVP-----EMEPPGTGDSDGINALCTQISS--- 373

  Fly   584 INQQLTSLSHQLSG------------------------------------LNQQSQHLQNLQQQQ 612
               ...|.....||                                    |.:.||..:..||||
Mouse   374 ---SFASAGAPASGPPPATTGTSAWGEPSVPAAAAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQ 435

  Fly   613 QQQQQQQQQQTQAAPTAATPPPAAGGSSPYPSMS-ALQSISNQLQQQQQQQQQDALSKDLFQVNQ 676
            ||||||||||..:.|             |.|:|: .||..|..:........|.|:
Mouse   436 QQQQQQQQQQATSVP-------------PMPTMAPTLQPFSAPVGPFDTAAAQVAV--------- 478

  Fly   677 ELL--NRLQALNLNANPGQSQP----------TPSATAHNSFFYVNPLSCTPATPNNNAGGAGGF 729
             .|  ..:|...:.|.||...|          |||....|:|.....|...|||   ..|.||.|
Mouse   479 -FLPPTHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPAT---LLGKAGAF 539

  Fly   730 NFLTSPAAT-GTLTPSPLG 747
            ....:|:|. |...|.|.|
Mouse   540 PPPAAPSAPGGQARPRPNG 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42673	NP_729510.1	PH-like	<352..386	CDD:473070	10/34 (29%)
Numbl	NP_001403961.1	PTB_Numb	68..202	CDD:241298	12/47 (26%)
		PHA03247	<263..594	CDD:223021	81/361 (22%)
		NumbF	291..375	CDD:461874	19/98 (19%)